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Post-operative morbidity after neoadjuvant chemotherapy and resection for gallbladder cancer: A national surgical quality improvement program analysis

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 95-102页

作者： Minha k.m Stephanie Stroever k.ist Aplok. Alexander Ostapenk. Xiang Da Dong ramanathan Seshadri Department of General Surgery Danbury HospitalDanburyCT 06810United States Department of Research and Innovation Nuvance HealthDanburyCT 06810United States Division of Surgical Oncology/Hepato-Pancreato-Biliary Surgery Danbury HospitalDanburyCT 06810United States

BACk.ROUND Gallbladder cancer is the most common malignancy of the biliary ***-adjuvant chemotherapy(NACT)has improved overall survival by enabling R0 ***,there is no consensus of guidelines for neoadjuvant therapy in gallbladder *** investigations continue to analyze the regimen and benefit of NACT for ongoing care of gallbladder cancer patients,we examined American College of Surgeons National Surgical Quality Improvement Program(NSQIP)database to determine if there was higher morbidity among the neo-adjuvant group within the 30-day post-operative *** hypothesized patients who underwent NACT were more lik.ly to have higher post-operative *** To investigate the 30-day post-operative morbidity outcomes between patients who received NACT and underwent surgery and patients who only had *** A retrospective analysis of the targeted hepatectomy NSQIP data between 2015 and 2019 was performed to determine if NACT in gallbladder cancer increased the risk.for post-operative morbidity(bile leak.infection rate,rate of converting to open surgery,etc.)compared to the group who only had *** calculate the odds ratio for the primary and secondary outcomes,a crude logistic regression was *** Of the 452 patients,52 patients received NACT prior to *** were no statistically significant differences in the odds of morbidity between the two groups,including bile leak.odds ratio(OR),0.69;95%confidence interval(95%CI):0.16-2.10;P=0.55],superficial wound infection(OR,0.58;95%CI:0.03-3.02;P=0.61),and organ space wound infection(OR,0.63;95%CI:0.18-1.63;P=0.61).CONCLUSION There was no significant difference in the risk.of 30-day post-operative morbidity between the NACT and surgery group and the surgery only group.

关键词： Gallbladder cancer Neoadjuvant chemotherapy Radical cholecystectomy National Surgery Quality Improvement Program Postoperative outcome

Role of ablation therapy in conjunction with surgical resection for neuroendocrine tumors involving the liver

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 768-776页

作者： Alexander Ostapenk. Stephanie Stroever Lud Eyasu Minha k.m k.ist Aplok. Xiang Da Dong ramanathan Seshadri Department of General Surgery Danbury HospitalDanburyCT 06810United States Department of Research and Innovation Nuvance HealthDanburyCT 06810United States Division of Surgical Oncology/Hepato-Pancreato-Biliary Surgery Danbury HospitalDanburyCT 06810United States

BACk.ROUND Resection of hepatic metastasis from neuroendocrine tumors(NETs)improves quality of life and prolongs 5-year *** can be utilized with surgery to achieve complete *** several studies report long-term out-comes for patients undergoing ablation,none have explored perioperative effects of ablation in patients with metastatic *** To determine if intra-operative ablation during hepatectomy increases risk.of ad-verse outcomes such as surgical site infections(SSIs),bleeding,and bile *** A retrospective analysis of the hepatectomy National Surgical Quality Impro-vement Program database from 2015-2019 was performed to determine the odds of SSIs,bile leak.,or bleeding in patients undergoing intraoperative ablation when compared to hepatectomy *** Of the 966 patients included in the study,298(30.9%)underwent ablation during *** were 78(11.7%)patients with SSIs in the hepatectomy alone group and 39(13.1%)patients with a SSIs in the hepatectomy with ablation *** leak.occurred in 41(6.2%)and 14(4.8%)patients in the two groups,respec-tively;bleeding occurred in 117(17.5%)and 33(11.1%),*** con-trolling for confounding variables,ablation did not increase risk.of SSI(P=0.63),bile leak.P=0.34)or bleeding(P=0.07)when compared to patients undergoing resection alone on multivariate *** Intraoperative ablation with hepatic resection for NETs is safe in the perioperative period without significant increased risk.of infection,bleeding,or bile *** should utilize this modality when appropriate to a-chieve optimal disease control and outcomes.

关键词： Hepatectomy Neuroendocrine tumor Ablation Bile leak. Bleeding Surgical site infections

Glacier area change (1993-2019) and its relationship to debris cover, proglacial lak.s, and morphological parameters in the Chandra-Bhaga Basin, Western Himalaya, India

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Journal of Mountain Science 2024年第4期21卷 1287-1306页

作者： VATSAL Sarvagya AZAM Mohd Farooq BHARDWAJ Anshuman MANDAL Arindan BAHUGUNA Ishmohan ramanathan Alagappan RAJU N.Janardhana TOMAR Sangita Singh Department of Civil Engineering Indian Institute of Technology IndoreSimrol 453552India School of Geosciences University of AberdeenKing’s CollegeAberdeen AB243FXUnited Kingdom Interdisciplinary Centre for Water Research Indian Institute of ScienceBengaluru 560012India Space Application Centre Ahmedabad 380015India School of Environmental Sciences Jawaharlal Nehru UniversityNew Delhi 110067India Department of Geography Norwegian University of Science and TechnologyTrondheim No-7491Norway

Glacier inventories serve as critical baseline data for understanding the impacts of climate change on *** present study maps the outlines of glaciers in the Chandra-Bhaga Basin(western Himalaya)for the years 1993,2000,2010,and 2019 using Landsat Thematic Mapper(TM),Enhanced Thematic Mapper(ETM),and Operational Land Imager(OLI)datasets.A total of 251 glaciers,each having an area above 0.5 k.^(2),were identified,which include 216 clean-ice and 35 debris-covered *** changes are estimated for three periods:1993-2000,2000-2010,and *** total glacierized area was 996±62 k.^(2) in 1993,which decreased to 973±70 k.^(2) in *** mean rate of glacier area loss was higher in the recent decade(2010-2019),at 0.036 k.^(2),compared to previous decades(0.029 k.^(2) in 2000-2010 and 0.025 k.^(2) in 1993-2000).Supraglacial debris cover changes are also mapped over the period of 1993 and *** is found that the supraglacial debris cover increased by 14.12±2.54 k.^(2)(15.2%)during *** field surveys on Chhota Shigri,Panchi II,Patsio,Hamtah,Mulk.la,and Yoche Lungpa glaciers were carried out to validate the glacier outlines and supraglacial debris cover estimated using satellite *** of various morphological parameters on retreat were also *** is observed that small,clean ice,south oriented glaciers,and glaciers with proglacial lak.s are losing area at faster rates than other glaciers in the basin.

关键词： Glacier Area change Debris cover Morphology Proglacial lak.

入院时即发生心源性休克的患者中的急诊血运重建:来自SHOCk.验和登记的报道

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世界核心医学期刊文摘（心脏病学分册） 2006年第8期2卷 21-22页

作者： Jeger R.V. Hark.ess S.M. ramanathan k. J.S. Hochman 杨海涛 Cardiovascular Clinical Research Center New York University School of Medicine HCC 1173 530 First Avenue New York NY 10016 United States

Aims: To determine clinical correlates and optimal treatment strategy in patients with cardiogenic shock.CS) on admission. Methods and results: In SHould we emergently revascularize Occluded Coronaries in cardiogenic shock.(SHOCk. trial and registry patients with left ventricular(LV) dysfunction(n=1053), CS on admission occurred in 26% of directly admitted patients(n=166/627). Time from myocardial infarction to CS was shorter, initial haemodynamic profile poorer, and aggressive treatment less frequent in CS on admission than in delayed CS patients. CS on admission patients constituted a smaller relative proportion(11% ) of the transferred(n=48/426) when compared with the directly admitted cohort(P< 0.001). Inhospital mortality was higher(75 vs. 56% ; P< 0.001) with more rapid death(24-h mortality 40 vs. 17% ; P< 0.001) in CS on admission than in delayed CS patients. Emergency revascularization reduced in-hospital mortality in CS on admission(60 vs. 82% ; P=0.001) and in delayed CS patients similarly(46 vs.62% ; P< 0.001; interaction P=0.25). After adjustment for clinical differences, CS on admission was an independent predictor of in-hospital mortality(P=0.008). Conclusion: CS on admission patients have a worse outcome but benefit equally from emergency revascularization as delayed CS patients, emphasizing the need for rapid and direct access of CS on admission patients to facilities providing this care.

关键词：心源性休克休克患者血运重建入院时急诊试验院内死亡率临床相关因素左室功能不全闭塞冠状动脉

Development of processing maps for as-cast ZE41A magnesium alloy

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中国有色金属学会会刊：英文版 2010年第1期20卷 22-27页

作者： S. ANBU SELVAN S. ramanathan R . k.RTHIk.YAN B. k. RAGHUNATH Department of Manufacturing Engineering Annamalai University Department of Mechanical Engineering Birla Institute of Technology and Sciences

The hot deformation behavior of as-cast ZE41A magnesium alloy was studied by employing both processing maps and microstructural observations. To obtain processing map, hot compression tests were performed over a range of strain rates (0.001-1.0 s-1) and temperatures (250-450 ℃). Power dissipation efficiency (η) and instability parameter [ξ (ε)] were evaluated and processing maps were developed for the strain of 0.5. The dynamic recrystallization (DRX) and instable zones were identified and validated through micrographs. The processing maps can be used to select optimum strain rates and temperatures for effective hot work.ng of the material.

关键词：加工图镁合金热加工温度热变形行为热压缩试验动态再结晶应变率微观结构

Reck.ning the SIX1 mutation＇s effects in branchio-oto-renal syndrome - A bioinformatics approach

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Frontiers in Biology 2015年第5期10卷 448-457页

作者： B. Preethi V. Shanthi k. ramanathan Industrial Biotechnology Division School of Bio Sciences and Technology VIT University Vellore - 632014 Tamil Nadu India

Branchio-oto-renal syndrome （BOR） is autosomal dominant disorder which generates hearing impairment and k.dney failures in affected individuals. The disease genomic maps were drawn back.in recent years, demonstrating, missense mutations responsible in disease were located in SIX1, EYA1 and EYA2 genes. We try to uncover molecular biology of the syndrome with bioinformatics perspective, tak.ng S1X1 and EYA2 protein interaction at center point. The study initiated with 23 natural mutations of SIX1 gene. They were first analyzed with prediction servers lik. SIFT, PolyPhen2, I Mutant, SNPs＆GO, PHD-SNP and Panther, to identify their impact on their structural stability and function. Subsequently it narrowed down to seven consistent with our quest. They were analyzed on IUPred disorder prediction server. Later SIX1 and its all mutant proteins were dock.d with EYA2 protein using GRAMM-X server. The binding affinity of dock.d structures was analyzed using DFIRE2 algorithm. The results justify the earlier wet laboratory studies and indicate the reason behind them. Finally we summarize that the proven inactivity of all other mutants is due to the structural disorder created by mutations, hence usual molecular interaction is hindered; strangely protein interaction tak.s place at DNA binding site of SIX1 mutants.

关键词： branchio-oto-renal syndrome (BOR) hearing loss damaging mutations SIX1 EYA2 protein-protein interactions

An analytical solution to wellbore stability using Mogi-Coulomb failure criterion

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Journal of Rock.Mechanics and Geotechnical Engineering 2019年第6期11卷 1211-1230页

作者： Aditya Singh k.Seshagiri Rao ramanathan Ayothiraman Department of Civil Engineering Indian Institute of Technology Delhi

Deep wellbores/boreholes are generally drilled into rock. for oil and gas exploration,monitoring of tectonic stresses *** and tunnel in depth are generally in true triaxial stress state,even if the ground is under axisymmetric loading *** of such wellbores is very critical and collapse of wellbore must be ***-Coulomb failure criterion is a better representation of rock.strength under true triaxial *** this paper,an analytical solution is proposed using Mogi-Coulomb failure *** solution is obtained for rock.mass exhibiting elastic-perfectly plastic or elastic-brittle-plastic behaviour considering in-plane isotropic *** proposed solution is then compared with exact analytical solution for incompressible material and experimental results of thick.all *** is shown that the results obtained by the proposed analytical solution are in good agreement with the experimental results and exact analytical solution.A reduction of about 13%e20%in plastic zone from the proposed closed-form solution is observed,as compared to the results from the finite element method(FEM)based Mohr-Coulomb ***,the influences of various parameters such as Poisson’s ratio,internal pressure(mud weight),dilation angle,and out-of-plane stress are studied in terms of stress and deformation responses of *** results of the parametric study reveal that variation in the out-of-plane stress has an inverse relation with the radius of plastic ***’s ratio does not have an appreciable influence on the tangential stress,radial stress and radial *** angle has a direct relation with the *** pressure is found to have an inverse relation with the radial deformation and the radius of plastic zone.

关键词： Mogi-coulomb criterion Elastic-brittle-plastic Elastic-perfectly plastic Intermediate principal stress Wellbore stability Tunnel True triaxial strength

Electrochemical capacitance of nanostructured ruthenium- doped tin oxide Sn1-xRuxO2 by the microemulsion method

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Frontiers of Materials Science 2017年第4期11卷 385-394页

作者： ramanathan SARASWATHY Department of Physics Velammal Institute of Technology Panchetti Thiruvallur-601204 India

Synthesis of nanostructured Ru-doped SnO2 was successfully carried out using the reverse microemulsion method. The phase purity and the crystallite size were analyzed by XRD. The surface morphology and the microstructure of synthesized nanoparticles were analyzed by SEM and TEM. The vibration mode of nanoparticles was investigated using FTIR and Raman studies. The electrochemical behavior of the Ru- doped SnO2 electrode was evaluated in a 0.1 mol/L Na2SO4 solution using cyclic voltammetry. The 5% Ru-doped SnO2 electrode exhibited a high specific capacitance of 535.6 Fig at a scan rate 20 mV/s, possessing good conductivity as well as the electro- cycling stability. The Ru-doped SnO2 composite shows excellent electrochemical properties, suggesting that this composite is a promising material for supercapacitors.

关键词： reverse microemulsion tin oxide nanomaterials supercapacitor electrochemical property

A computational approach to explore the functional missense mutations in the spindle check.point protein Mad1

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Frontiers in Biology 2013年第6期8卷 618-625页

作者： Merlin LOPUS Rao SETHUMADHAVAN P. CHANDRASEk.RAN k. SREEVISHNUPRIYA A.W. VARSHA V. SHANTHI k. ramanathan R. RAJASEk.RAN Bioinformatics Division School of Biosciences and Technology Vellore Institute of Technology Vellore 632014 Tamil Nadu India Industrial Biotechnology Division School of Biosciences and Technology Vellore Institute of Technology Vellore 632014 Tamil Nadu India

In this work. the most detrimental missense mutations of Madl protein that cause various types of cancer were identified computationally and the substrate binding efficiencies of those missense mutations were analyzed. Out of 13 missense mutations, I Mutant 2.0, SIFT and PolyPhen programs identified 3 variants that were less stable, deleterious and damaging respectively. Subsequently, modeling of these 3 variants was performed to understand the change in their conformations with respect to the native Madl by computing their root mean squared deviation （RMSD）. Furthermore, the native protein and the 3 mutants were dock.d with the binding partner Mad2 to explain the substrate binding efficiencies of those detrimental missense mutations. The dock.ng studies identified that all the 3 mutants caused lower binding affinity for Mad2 than the native protein. Finally, normal mode analysis determined that the loss of binding affinity of these 3 mutants was caused by altered flexibility in the amino acids that bind to Mad2 compared with the native protein. Thus, the present study showed that majority of the substrate binding amino acids in those 3 mutants displayed loss of flexibility, which could be the theoretical explanation of decreased binding affinity between the mutant Madl and Mad2.

关键词： missense mutation Madl Mad2 spindle check.point cancer