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Genetics of endometriosis and its association with ovarian cancer

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Gynecology and Obstetrics Clinical Medicine 2021年第4期1卷 177-185页

作者： B.K.Iyshwarya Vajagathali Mohammed ramakrishnan Veerabathiran Human Cytogenetics and Genomics Laboratory Faculty of Allied Health SciencesChettinad Hospital and Research Institute(CHRI)Chettinad Academy of Research and Education(CARE)KelambakkamTamilnadu603103India

Endometriosis is a chronic and destructive developmental gynecologic condition that affects approximately 10%percent of females worldwide,and is one of the most frequent causes of extreme pelvic *** endometriumlike tissue,glands,and stroma outside the uterine cavity are often affected by *** is estrogendependent and frequently affects the ovaries,fallopian tubes,and pelvic *** such as chronic pelvic pain,infertility,dyspareunia,as well as digestive and urinary symptoms often accompany *** overall condition shares characteristics with ovarian carcinoma such as enhanced vascular activation of the endothelial growth factor,local invasion,lymph angiogenesis,neoangiogenic,mechanism tolerance to apoptosis,and genome *** studies have shown that endometriotic lesions contain gene mutations related directly to malignancies,particularly the ARID1A,p53,KRAS,and PTEN ***,women with endometriosis have a lower risk of ovarian cancer than the general population,where endometriosis was seen in only 1.3%,and did not diagnose ovarian cancer progression among *** need to look into the connection between endometriosis and uterine carcinomas,as well as the common lesions and correlations in the uterine microenvironment,which may play a role in mutations and malignant *** endometriosis is a risk factor of ovarian cancer,malignant cells from the uterus can migrate to the ovary and cause endometriosis-related ovarian *** purpose of this article is to examine current data on genetic phenomena and molecular changes for endometriosis associated with ovarian cancer,focusing primarily on the proliferation of uterine and precise cell biomarkers.

关键词： Endometriosis Ovarian carcinoma Genetic polymorphism Malignant transformation Biomarkers

Evaluating the exchange rate and commodity price nexus in Malaysia: evidence from the threshold cointegration approach

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Financial Innovation 2020年第1期6卷 392-410页

作者： Shamaila Butt Suresh ramakrishnan Nanthakumar Loganathan Muhammad Ali Chohan Azman Hashim International Business School Universiti Teknologi Malaysia81310 Johor BahruJohorMalaysia

This paper examines the long-and short-run dynamics of asymmetric adjustment between the nominal exchange rate and commodity prices,namely oil,palm oil,rubber,and natural gas prices,in Malaysia using monthly data from January 1994 to December *** relationship between exchange rate and each commodity price is examined in terms of Engle-Granger and threshold *** estimated results provide evidence of long-run threshold cointegration and show that the adjustments towards the long-run equilibrium position are asymmetric in the short ***,this study finds evidence of a unidirectional causal relationship running from the nominal exchange rate to oil price in the long and short run using a spectral frequency domain causality *** is also empirical evidence of bidirectional causality between the nominal exchange rate and palm oil price,rubber price,and natural gas price in the long and short ***,the findings have significant implications for the current debate on the future of primary commodities in Malaysia.

关键词： Commodity prices Exchange rate Threshold cointegration

Differential regulation of basal expression of inflammatory genes by NF-κB family subunits

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Cellular & Molecular Immunology 2019年第8期16卷 720-723页

作者： Tristan J.de Jesús Joshua T.Centore Parameswaran ramakrishnan Department of Pathology School of MedicineCase Western Reserve UniversityClevelandOH 44106USA Department of Biochemistry School of MedicineCase Western Reserve UniversityClevelandOH 44106USA The Case Comprehensive Cancer Center School of MedicineCase Western Reserve UniversityClevelandOH 44106USA

The nuclear factor kappaB(NF-κB)family of transcription factors regulates immune and inflammatory responses and controls cell survival,proliferation,differentiation,and apoptosis.1 The five subunits of the NF-κB family,(RelA,RelB,c-Rel,p105/p50,and p100/p52),are categorized as activating(RelA,RelB,and c-Rel),or inhibitory(p105/p50 and p100/p52),based on the presence or absence of the transactivation domain and form homo-and ***-dependent activation of NF-κB,either by the classical pathway involving the degradation of the inhibitor of NF-κB(IκB)or by the alternative pathway involving the partial degradation of p100 to p52 and formation of the p52/RelB dimer,has emerged as a central theme in the regulation of NF-κBdependent genes.2–4 However,in Sertoli cells and some neurons,lymphocytes,and malignant cells,NF-κB has been shown to be constitutively active in the nucleus5,6(***/nf-kb).Moreover,several recent studies have also identified disease-associated mutations in the NF-κB subunits that affect their expression level and transcriptional activity.2,7 Our understanding of the ways in which the changes in the basal level of NF-κB affect the subsequent basal regulation of the expression of NF-κBdependent genes remain poorly defined.

关键词： inflammatory constitutive subsequent

p-Coumaric acid ameliorates ethanol-induced kidney injury by inhibiting inflammatory cytokine production and NF-κB signaling in rats

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Asian Pacific Journal of Tropical Biomedicine 2019年第5期9卷 188-195页

作者： ramakrishnan Sabitha Kumari Nishi Vinoth Prasanna Gunasekaran Govindhan Annamalai Balupillai Agilan Mathan Ganeshan Department of Biomedical Science Bharathidasan University Department of Biochemistry and Biotechnology Annnamalai UniversityAnnamalainagar

Objective: To examine the effects of p-coumaric acid on ethanol-induced kidney injury in Swiss Wistar ***: Ethanol(25% v/v) was used to induce nephrotoxicity in rats. p-Coumaric acid was orally administered at 50, 100, or 200 mg/kg body weight. The levels of oxidative parameters were determined; pro-inflammatory biomarkers were analyzed by Western blotting and apoptotic protein was analyzed by immunohistochemistry. Results: Ethanol treated rats showed decreased levels of antioxidants and aberrant production of pro-inflammatory cytokines(IL-6, IL1β, TNF-α), NF-κB activation and imbalance of proand anti-apoptotic proteins(Bcl-2, Bax, caspase 3). Meanwhile, p-coumaric acid restored antioxidant levels and decreased the levels of inflammatory cytokines, NF-κB, and proapoptotic proteins and increased Bcl-2 expression. Conclusions: p-Coumaric acid ameliorates ethanol-induced kidney injury by restoring antioxidant production and suppressing cellular apoptosis and inhibiting NF-κB expression.p-Coumaric acid should be further investigated as a promising candidate for ethanol-induced kidney toxicity.

关键词： p-Coumaric acid Apoptosis Alcohol Cytokine Inflammation Nephrotoxicity

Influence of an oxygenated additive on emission of an engine fueled with neat biodiesel

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Petroleum Science 2017年第4期14卷 791-797页

作者： Amith Kishore Pandian Dinesh Babu Munuswamy Santhanakrishnan Radhakrishana Ramesh Bapu Bathey ramakrishnan Beemkumar Nagappan Yuvarajan Devarajans Department of Mechanical Engineering Sathyabama UniversityChennaiIndia Department of Mechanical Engineering Panimalar Engineering CollegeChennaiIndia Department of Mechanical Engineering SRM UniversityKattankulathurChennaiIndia Department of Mechanical Engineering Chennai Institute of TechnologyChennaiIndia Department of Mechanical Engineering Vel Tech Dr.RR&Dr.SR UniversityChennaiIndia

Biodiesel obtained from mustard seed is found to be a promising alternative for petroleum diesel fuel owing to its similarity in physical and chemical properties. In this work, TiO2nano-fluid which acts as an oxygen buffer during combustion was added to mustard oil biodiesel(MOBD) to study its effect on emission characteristics of MOBD. TiO2nano-fluid can provide high surface energy during the course of combustion and reduces the limitations of neat biodiesel. A four-stroke, multi-cylinder,water-cooled, diesel engine was used in the experiments and was fueled with diesel, neat MOBD and MOBD with TiO2nanoparticles at 100 ppm(MOBDT100), 200 ppm(MOBDT200) and 300 ppm(MOBDT300). Experimental results revealed that the TiO2nanoparticles had positive effect on the emission characteristics of MOBD as it acted as an oxidation buffer. MOBDT300 showed a reduction in HC, CO and smoke emissions as compared to pure *** addition, NOxemissions were also reduced by the catalytic activity of the TiO2nanoparticles which reduce the peak combustion temperature. Therefore, TiO2nano-fluid had a positive effect on reducing the emissions associated with neat biodiesel.

关键词： Emissions Nano-fluid Turbulence

Emission and performance analysis of a diesel engine burning cashew nut shell oil bio diesel mixed with hexanol

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Petroleum Science 2018年第1期15卷 176-184页

作者： Amith Kishore Pandian Dinesh Babu Munuswamy Santhanakrishnan Radhakrishanan Yuvarajan Devarajan Ramesh Bapu Bathey ramakrishnan Beemkumar Nagappan Department of Mechanical Engineering Sathyabama University Department of Mechanical Engineering Panimalar Engineering College Department of Mechanical Engineering SRM University Department of Mechanical Engineering Vel Tech Dr. RR &Dr. SR University Department of Mechanical Engineering Chennai Institute of Technology

In this study, the effect of doping hexanol into biodiesel which is from neat cashew nut shell biodiesel oil on the emissions and the performance characteristics was studied in a constant speed diesel engine. The main purpose of this work is to reduce various emissions and also to improve the performance of the diesel engine when fueled with blends of hexanol and neat cashew nut shell biodiesel. Cashew nut shell oil is not edible, and hence it can be used as a viable alternative to *** nut shell biodiesel is prepared by conventional transesterification. Hexanol with 99.2% purity was employed as an oxygenated additive. Experimental studies were conducted by fueling diesel as a baseline and by fueling hexanol and neat cashew nut shell biodiesel mixture. A fuel comprising 10%（by volume） of hexanol and 90%（by volume） neat cashew nut shell biodiesel was referred to as CNSBD900 H100 and fuel comprising 20%（by volume） of hexanol and 80%（by volume）of neat cashew nut shell biodiesel was referred to as CNSBD800 H200. This study also investigated the possibility of using pure biofuel in an unmodified naturally aspirated diesel engine. The outcome of this study showed that adding hexanol at10% and 20%（by volume） to cashew nut shell biodiesel results in a reduction in emissions. In addition, a significant improvement in brake thermal efficiency and reduction in brake-specific fuel consumptions were achieved. Hence, it could be concluded that hexanol could be a viable and promising additive for improving the drawbacks of biodiesel when it was used to fuel an unmodified diesel engine.

关键词： Hexanol Biodiesel Engine performance Emission

RSMD-repeat searcher and motif detector

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The Journal of Biomedical Research 2014年第5期28卷 416-422页

作者： Udayakumar Mani Vaidhyanathan Mahaganapathy Sadhana Ravisankar Sai Mukund ramakrishnan Department of Bioinformatics School of Chemical and BiotechnologySASTRA University

The functionality of a gene or a protein depends on codon repeats occurring in *** a consequence of their vitality in protein function and apparent involvement in causing diseases,an interest in these repeats has developed in recent *** analysis of genomic and proteomic sequences to identify such repeats requires some algorithmic support from informatics ***,we proposed an offline stand-alone toolkit Repeat Searcher and Motif Detector（RSMD）,which uncovers and employs few novel approaches in identification of sequence repeats and motifs to understand their functionality in sequence level and their disease causing *** tool offers various features such as identifying motifs,repeats and identification of disease causing *** was designed to provide an easily understandable graphical user interface（GUI）,for the tool will be predominantly accessed by biologists and various researchers in all platforms of life *** was developed using the scripting language Perl and its graphical module *** covers algorithmic foundations of computational biology by combining theory with practice.

关键词： motif repeats genomic sequence proteomic sequence computational biology combination algorithm

Study of engineering electronic structure modulated non-noble metal oxides for scaled-up alkaline blend seawater splitting

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Journal of Energy Chemistry 2023年第11期86卷 167-179,I0004页

作者： Natarajan Logeshwaran Subramanian Vijayapradeep Ae Rhan Kim Prabhakaran Sampath Shanmugam ramakrishnan Milan Babu Poudel Do Hwan Kim Dong Jin Yoo Graduate School Department of Energy Storage/Conversion Engineering(BK21 FOUR)Hydrogen and Fuel Cell Research CenterJeonbuk National University567-Baekje-daeroDeokjin-guJeonju-siJeollabuk-do 54896Republic of Korea Department of Life Science Jeonbuk National University567-Baekje-daeroDeokjin-guJeonju-siJeollabuk-do 54896Republic of Korea Division of Science Education and Institute of Fusion Science Jeonbuk National University567-Baekje-daeroDeokjin-guJeonju-siJeollabuk-do 54896Republic of Korea Department of Nano Convergence Engineering Jeonbuk National University567-Baekje-daeroDeokjin-guJeonju-siJeollabuk-do 54896Republic of Korea School of Engineering Merz CourtNewcastle UniversityNE17RUUnited Kingdom

Scaled-up industrial water electrolysis equipment that can be used with abundant seawater is key for affordable hydrogen *** search for highly stable,dynamic,and economical electrocatalysts could have a significant impact on hydrogen ***,we prepared energy-efficient,scalable,and engineering electronic structure modulated Mn-Ni bimetal oxides(Mn_(0.25)Ni_(0.75)O)through simple hydrothermal followed by calcination ***-optimized Mn_(0.25)Ni_(0.75)O displayed enhanced oxygen and hydrogen evolution reaction(OER and HER)performance with overpotentials of 266 and115 mV at current densities of 10 mA cm^(-2)in alkaline KOH added seawater electrolyte ***,Mn-Ni oxide catalytic benefits were attributed to the calculated electronic configurations and Gibbs free energy for OER,and HER values were estimated using first principles *** real-time practical application,we mimicked industrial operating conditions with modified seawater electrolysis using Mn_(0.25)Ni_(0.75)O‖Mn_(0.25)Ni_(0.75)O under various temperature conditions,which performs superior to the commercial IrO_(2)‖Pt-C *** findings demonstrate an inexpensive and facile technique for feasible large-scale hydrogen production.

关键词： Waterel ectrolysis Mn-Ni oxide complex Chlorine evolution reaction Industrial seawater operations Density functional theory calculations

Hepatitis B Vaccine and Immunoglobulin: Key Concepts

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Journal of Clinical and Translational Hepatology 2019年第2期7卷 165-171页

作者： Saibal Das Kirubakaran ramakrishnan Sapan Kumar Behera Mahalakshmi Ganesapandian Alphienes Stanley Xavier Sandhiya Selvarajan Department of Clinical Pharmacology Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)PuducherryIndia

Hepatitis B virus(HBV)immunization is safe and has been accepted worldwide as a routine *** target of such vaccination is to induce the immune response in the host,resulting in the prevention of replication of *** are several immunological and clinical factors which determine the clinical efficacy and safety of the HBV *** this article we have highlighted the response of the host immune system to HBV vaccination(immunogenicity),efficacy,and safety of the vaccine,issues with booster dosing,paths of development(preclinical and clinical)of the HBV vaccine,novel and upcoming strategies for improvement of HBV vaccination,and the concept of therapeutic HBV *** different aspects and regulatory recommendations pertaining to HBV vaccine development are also *** new strategies for improvement of HBV vaccination include pre-S1 and pre-S2 portions of the HBV surface antigen,increasing the antigen dose,accelerated vaccination schedules,alternative vaccination route,use of adjuvants like immunostimulatory DNA sequences,*** vaccination is being explored for initiation of a multifunctional and multispecific T cell response against the major HBV antigens and also effective activation of humoral immunity for viral control.

关键词： Antibody Development Immune response Immunoglobulin Vaccine