检索结果-南通市图书馆

Epigenetic regulation−The guardian of cellular homeostasis and lineage commitment

BIOCELL 2021年第3期45卷 501-515页

作者： KAVITHA GOVARTHANAN PIYUSH K UMAR GUPTA BINITA ZIPPORAHE REKHA GAHTORI SOUMYA PANDIT ram prasad Department of Biotechnology Indian Institute of Technology MadrasChennai600036India Department of Life Sciences Sharda UniversityGreater NoidaUttar Pradesh201310India Department of Biotechnology Campus–BhimtalKumaun UniversityNainitalUttarakhand263136India Department of Botany Mahatma Gandhi Central UniversityMotihariBihar845401India

Stem cells constitute the source of cells that replenishes the worn out or damaged cells in our tissue and enable the tissue to carry out the destined ***-specific stem cells are compartmentalized in a niche,which keeps the stem cells under quiescent ***,understanding the molecular events driving the successful differentiation of stem cells into several lineages is essential for its better manipulation of human *** the developmental aspects of the cell,the cellular function is greatly dependent on the epigenomics signature that in turn governs the expression profile of the *** stable inheritance of the epigenome is crucial for the development,modulation,and maintenance of the cell and its complex tissue-specific *** evidence suggesting that stem cell chromatin comprises a specialized state in which self-renewing genes and its downstream lineage-specific genes are kept paralleled poised for ***,the epigenetic regulatory network and pathway dictate lineage commitment and *** mainly modifies the chromatin landscape to facilitate euchromatin and heterochromatin architecture,which in turn alters the accessibility of transcription factors to the gene *** methylation and histone marks are the two widely studied epigenetic modifications regulating the transcriptome profile of a specific *** in the epigenetic landscape lead to diseases or ***,we emphasize the prominence of the epigenetic network and its regulation in normal tissue functioning and in the diseased ***,we highlighted the emerging role of epigenetic modifiers in lineage differentiation and epigenetic markers as novel druggable targets for cancer therapy.

关键词： Epigenetics Chromatin Genome Methylation Inheritance Modulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis of Metallic Nanoparticles Based on Green Chemistry and Their Medical Biochemical Applications:Synthesis of Metallic Nanoparticles

引用

Journal of Renewable Materials 2023年第6期11卷 2575-2591页

作者： Kakudji Kisimba Anand Krishnan Mbuso Faya Kahumba Byanga Kabange Kasumbwe Kaliyapillai Vijayakumar ram prasad Department of Pharmaceutical Sciences University of Kwazulu-NatalPrivate Bag X54001DurbanSouth Africa Department of Chemical Pathology School of PathologyFaculty of Health SciencesUniversity of the Free StateBloemfonteinSouth Africa Faculty of Pharmaceutical Sciences University of LubumbashiLubumbashiDemocratic Republic of Congo Department of Biotechnology and Food Sciences Durban University of TechnologyDurbanSouth Africa Department of Chemistry M.Kumarasamy College of EngineeringKarurTamilnaduIndia Department of Botany Mahatma Gandhi Central UniversityMotihariBiharIndia

Nanoparticles have distinct properties that make them potentially valuable in a variety of *** a result,emerging approaches for the manufacture of nanoparticles are gaining a lot of scientific *** biological pathway of nanoparticle synthesis has been suggested as an effective,affordable,and environmentally safe *** of nanoparticles through physical and chemical processes uses unsafe materials,expensive equipment and adversely affects the *** a result,in order to support the increased utilization of nanoparticles across many sectors,nanotechnology research activities have shifted toward environmentally safe and cost-effective techniques that outperform chemical and/or biological *** use of organisms to produce metal nanoparticles is among the most frequently discussed *** appear to be the best candidates among these organisms for large-scale nanoparticle *** plants have been employed as reducing agents and NP stabilizers to minimize the toxicity of NPs in both the environment and the human ***,the presence of certain functional components in plant extracts may be extremely useful and effective for the human ***,for example,which may have antioxidant properties,might intercept free radicals before they interact with other biomolecules and cause considerable *** current article analyzes the most recent developments and improvements in the green synthesis of metal nanoparticles by different plants and the use of these nanoparticles for various biomedical applications and hopes to provide insights into this exciting research frontier.

关键词： Biosynthesis nanoparticles antimicrobial anticancer antioxidant medicinal plants

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Implications of tree species–environment relationships for the responsiveness of Himalayan krummholz treelines to climate change

引用

Journal of Mountain Science 2017年第3期14卷 453-473页

作者： Niels SCHWAB Udo SCHICKHOFF Birgit BURZLE Michael MULLER Jurgen BOHNER ram prasad CHAUDHARY Thomas SCHOLTEN Jens OLDELAND CEN Center for Earth System Research and Sustainability Institute of GeographyUniversity of HamburgBundesstrafle 5520146 HamburgGermany Department of Geosciences Chair of Soil Science and CeomorphologyUniversity of TübingenGermany Research Centre for Applied Science and Technology&Central Department of Botany Tribhuvan UniversityNepal Biocentre Klein Flottbek University of HamburgOhnhorststr.1822609 HamburgGermany

Climate warming is expected to advance treelines to higher elevations. However, empirical studies in diverse mountain ranges give evidence of both advancing alpine treelines as well as rather insignificant responses. In this context, we aim at investigating the sensitivity and responsiveness of the near-natural treeline ecotone in Rolwaling Himal, Nepal, to climate warming. We analysed population densities of tree species along the treeline ecotone from closed forest stands via the krummholz belt to alpine dwarf shrub heaths （3700-4200 m） at 50 plots in 2013 and 2014. We quantified species - environment relationships, i.e. the change of environmental conditions （e.g., nutrient and thermal deficits, plant interactions） across the ecotone by means of redundancy analyses, variation partitioning and distance-based Moran＇s eigenvector maps. In particular, we focus on explaining the high competitiveness of Rhododendron campanulatum forming a dense krummholz belt and on the implications for the responsiveness of Himalayan krummholz treelines to climate change. Results indicate that treeline trees in the ecotone show species-specific responses to the influence of environmental parameters, and that juvenile and adult tree responses are modulated by environmental constraints in differing intensity. Moreover, the species - environment relationships suggest that the investigated krummholz belt will largely prevent the upward migration of other tree constrain the future response species and thus of Himalayan krummholz treelines to climate warming.

关键词： Himalaya Nepal Population structure Rhododendron campanulatum Spatial patterns Species-environment relationships Stand density Variation partitioning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Comprehensive Review on Oxygen Reduction Reaction in Microbial Fuel Cells

引用

Journal of Renewable Materials 2022年第3期10卷 665-697页

作者： Pooja Dange Nishit Savla Soumya Pandit rambabu Bobba Sokhee P.Jung Piyush Kumar Gupta Mohit Sahni ram prasad Amity Institute of Biotechnology Amity UniversityMumbai410206India Department of Life Sciences School of Basic Sciences and ResearchSharda UniversityGreater Noida201306India Department of Physics Southern University and A&M CollegeBaton Rouge70813USA Department of Environment and Energy Engineering Chonnam National UniversityGwangju61186Korea Department of Physics School of Basic Sciences and ResearchSharda UniversityGreater Noida201306India Department of Botany Mahatma Gandhi Central UniversityBihar845401India

The focus of microbial fuel cell research in recent years has been on the development of materials,microbes,and transfer of charges in the system,resulting in a substantial improvement in current density and improved power *** cathode is generally recognized as the limiting factor due to its high-distance proton transfer,slow oxygen reduction reaction(ORR),and expensive *** heterogeneous reaction determines power gen-eration in *** comprehensive review describes-recent advancements in the development of cathode mate-rials and catalysts associated with *** recent studies indicated the utilization of different metal oxides,the ferrite-based catalyst to overcome this *** studies conclude that some cathode materials,in parti-cular,graphene-based conductive polymer composites with non-precious metal catalysts provide substantial ben-efits for sustainable development in the field of ***,it also highlights the potentiality to replace the conventional platinum air cathode for the large-scale production of the next generation of *** was evi-dent from the experiments that cathode catalyst needs to be blended with conductive carbon materials to make cathode conductive and efficient for *** review discusses various antifouling strategies for cathode biofoul-ing and its effect on the MFC ***,it also depicts cost estimations of various catalysts essential for further scale-up of MFC technology.

关键词： Cathode catalyst microbial fuel cell(MFC) nanomaterials oxygen reduction reaction(ORR) biofouling biocathode

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

从H1N1血凝素序列提取的沙门氏菌传递的COBRA-HA1抗原对甲型流感亚型产生广谱保护作用

引用

Engineering 2024年第1期32卷 41-56页

作者： ram prasad Aganja Amal Senevirathne Chandran Sivasankar John Hwa Lee Department of Veterinary Public Health College of Veterinary MedicineJeonbuk National UniversityIksan 54596Republic of Korea Department of Preventive Medicine College of Veterinary MedicineChungnam National UniversityDaejeon 34134Republic of Korea

A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenza *** this study,a strategy called computationally optimized broadly reactive antigen(COBRA)was used to generate a consensus sequence of the hemagglutinin globular head portion(HA1)of influenza virus samples collected from 1918 to 2021 to trace evolutionary changes and incorporate them into the designed *** carrying different HA1regions were delivered into eukaryotic cells by Salmonella-mediated bactofection using a Semliki Forest virus RNA-dependent RNApolymerase(RdRp)-based eukaryotic expression system,*** protein expression was confirmed by Western blot and immunofluorescence *** immunized with the designed constructs produced a humoral response,with a significant increase in immunoglobulin G(IgG)levels,and a cell-mediated immune response,including a 1.5-fold increase in CD4^(+) and CD8^(+)T ***,constructs #1 and #5 increased the production of interferon-γ(IFN-γ)producing CD4^(+)and CD8^(+)T cells,skewing the response toward the T helper type 1 cell(Th1)***,interleukin-4(IL-4)-producing T cells were upregulated *** efficacy was demonstrated,with up to 4-fold higher production of neutralizing antibodies and a hemagglutination inhibition titer>40 against the selected viral *** designed constructs conferred a broadly protective immune response,resulting in a notable reduction in viral titer and minimal inflammation in the lungs of mice challenged with the influenza A/PR8/34,A/Brisbane/59/2007,A/California/07/2009,KBPV VR-92,and NCCP 43021 *** discovery revolutionizes influenza vaccine design and delivery;Salmonella-mediated COBRA-HA1 is a highly effective in vivo antigen presentation *** approach can effectively combat seasonal H1N1 influenza strains and potential pandemic outbreaks.

关键词： COBRA Influenza A Salmonella Vaccine Broad spectral protection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phytochemistry and ethnomedicinal qualities of metabolites from Phyllanthus emblica L.:A review

引用

BIOCELL 2023年第5期47卷 1159-1176页

作者： VIJAY KUMAR PRAVEEN C.ramAMURTHY SIMRANJEET SINGH DALJEET SINGH DHANJAL PARUL PARIHAR DEEPIKA BHATIA ram prasad JOGINDER SINGH Central Ayurveda Research Institute JhansiUttar Pradesh284003India Interdisciplinary Centre for Water Research Indian Institute of SciencesBangalore560012India Department of Biotechnology Lovely Professional UniversityPhagwaraPunjab144411India Department of Botany Lovely Professional UniversityPhagwaraPunjab144411India Department of Biotechnology Baba Farid CollegeBathindaPunjab151001India Department of Botany Mahatma Gandhi Central UniversityMotihari845401India Department of Microbiology Lovely Professional UniversityPhagwaraPunjab144411India

Phyllanthus emblica or Indian gooseberry is an integrated part of Ayurvedic and Traditional Chinese *** several decades,the well-known ancient herb has been extensively utilized in traditional medicine to cure diseases like fever,diabetes,constipation,jaundice,ulcers,biliousness,anemia,anorexia,and *** the traditional system,Indian gooseberry has various ethnomedicinal *** the Ayurvedic system,different methods of administration(anupan)have shown different ethnomedicinal properties of Indian *** well-known chemical components in Indian gooseberry have been identified through phytochemical evaluation,among which the flavonoids and phenols are most *** the toxicity perspective,it is considered a safe herb in India,and is taken as a food supplement in European *** wide-spectrum pharmacological activities of the crude extracts and isolates of Indian gooseberry are attributed to the predominance of phenols and ***,it is important to study the exact mechanism of the activity of the phytochemicals in Indian gooseberry,especially in anti-cancer *** of Indian gooseberry enhances proliferation in several cancer cells in vitro,including stem cells like ovarian cancer(OC)cells,and also has been observed to possess anti-proliferative characteristics in *** review intends to explore the therapeutic potential of Indian gooseberry based on scientific reports and attempts to find the gaps for future research.

关键词： Phyllanthus emblica Amla Vitamin C Antioxidant Stem cells Phytochemistry Pharmacology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impedance Spectroscopy of Ba5GdTi3V7O30

引用

Journal of Modern Physics 2012年第5期3卷 357-361页

作者： Bana Bihari Mohanty Priyadarshini Sanghamitra Sahoo Mohapatra Prakash Kumar Sahoo ram Naresh prasad Choudhary ram Naresh prasad Choudhary ram Naresh prasad Choudhary ram Naresh prasad Choudhary Department of Physics Betnoti College Department of Physics Institute for Technical Education and Research Department of Physics Rajib Gandhi University Indian Institute for Information Technology

The polycrystalline sample of Ba5GdTi3V7O30 , a member of tungsten bronze structural family, was prepared by a high-temperature solid-state reaction technique. A preliminary X-ray diffraction analysis suggests the formation of single-phase compound with orthorhombic structure. The effect of temperature on impedance parameters was studied using an impedance analyzer in a wide frequency range (102- 106 Hz) at different temperatures. The real and imaginary part of complex impedance traces semicircle(s) in the complex plane. The temperature dependent plots reveal the presence of both bulk and grain boundary effects. The bulk resistance of the material decreases with rise in temperature. This exhibits a typical negative temperature coefficient of resistance (NTCR) behavior of the material. The modulus analysis suggests a possible hopping mechanism for electrical transport processes of the material. The nature of variation of dc conductivity suggests Arrhenius type of electrical conductivity.

关键词： Ceramics Dielectric Properties Electrical Conductivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimization of M/M/s/N Queueing Model with Reneging in a Fuzzy Environment

引用

American Journal of Operations Research 2021年第3期11卷 121-140页

作者： Ananda prasad Panta ram prasad Ghimire Dinesh Panthi Shankar Raj Pant Department of Mathematics Tri-Chandra Campus Tribhuvan University Kathmandu Nepal Department of Mathematics Kathmandu University Kavre Nepal Department of Mathematics Valmeeki Campus Nepal Sanskrit University Kathmandu Nepal Central Department of Mathematics Tribhuvan University Kirtipur Nepal

This paper deals with the study of multi-server queueing model in a fuzzy environment with imposition of reneging of customers. Entry of the customers in the system is assumed to be Poisson process and exponential service time distribution under first-come-first-served basis. Specific of this investigation is to derive the various fuzzy performance measures such as fuzzy queue length, fuzzy waiting time in queue, fuzzy response time and fuzzy optimal number of servers in explicit form for the finite capacity multi-server queueing system by using recursive method. For the validity of the model we have obtained the numerical illustrations in tabular form which shows that fuzzy-queue can be more realistic than crisp queue.

关键词： Fuzzy Environment Poisson Optimal Reneging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biosurfactant-assisted phytoremediation of potentially toxic elements in soil:Green technology for meeting the United Nations Sustainable Development Goals

引用

Pedosphere 2022年第1期32卷 198-210页

作者： Songita SONOWAL Amy R.NAVA Sanket J.JOSHI Siddhartha Narayan BORAH Nazim F.ISLAM Soumya PANDIT ram prasad Hemen SARMA Department of Botany School of Life SciencesMahatma Gandhi Central UniversityMotihari 845401India Department of Molecular&Cellular Physiology Stanford UniversityStanfordCA 94305SA Oil&Gas Research Center Central Analytical and Applied Research UnitSultan Qaboos UniversityMuscat 123Oman Centre for the Environment Indian Institute of Technology GuwahatiGuwahati 781039India Institutional Biotech Hub(IBT Hub) Department of BotanyNanda Nath Saikia CollegeTitabar 785630India Department of Life Sciences School of Basic Sciences and ResearchSharda UniversityGreater Noida 201306India

Biosurfactants are biomolecules produced by microorganisms, low in toxicity, biodegradable, and relatively easy to synthesize using renewable waste substrates. Biosurfactants are of great importance with a wide and versatile range of applications, including the bioremediation of contaminated sites. Plants may accumulate soil potentially toxic elements(PTEs), and the accumulation efficacy may be further enhanced by the biosurfactants produced by rhizospheric microorganisms. Occasionally, the growth of bacteria slows down in adverse conditions, such as highly contaminated soils with PTEs. In this context,the plant's phytoextraction capacity could be improved by the addition of metal-tolerant bacteria that produce biosurfactants. Several sources, categories,and bioavailability of PTEs in soil are reported in this article, with the focus on the cost-effective and sustainable soil remediation technologies, where biosurfactants are used as a remediation method. How rhizobacterial biosurfactants can improve PTE recovery capabilities of plants is discussed, and the molecular mechanisms in bacterial genomes that support the production of important biosurfactants are listed. The status and cost of commercial biosurfactant production in the international market are also presented.

关键词： bacterial genome metal-tolerant bacteria phytoextraction technology plant growth-promoting rhizobacteria rhizospheric microorganism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Delineating the role of phytocompounds against anti-bacterial drug resistance–An update

引用

BIOCELL 2021年第6期45卷 1465-1477页

作者： REKHA GAHTORI MOSLEH MOHAMMAD ABOMUGHAID NIDHI NEGI SARAVANAN KRISHNAN SUGAPRIYA DHANASEKARAN SOUMYA PANDIT KANU PRIYA DILLIP KUMAR BISHI ram prasad PIYUSH KUMAR GUPTA Department of Biotechnology Sir J.C.Bose Technical CampusKumaun UniversityNainitalIndia Department of Medical Laboratory Sciences University of BishaBishaSaudi Arabia Department of Chemistry Kumaun UniversityNainitalIndia Dhanvantari Nano Ayushadi Pvt. Ltd.ChennaiIndia Department of Medical Laboratory Sciences(Pathology) College of Applied Medical SciencesPrince Sattam Bin Abdulaziz UniversityRiyadhSaudi Arabia Department of Life Sciences School of Basic Sciences and ResearchSharda UniversityGreater NoidaIndia Department of Biotechnology Rama Devi Women’s UniversityBhubaneswarIndia Department of Botany Mahatma Gandhi Central UniversityMotihariIndia

Antibacterial resistance developed by bacteria due to the unlimited use of antibiotics has posed a challenge for human *** kind of problem is not limited to India only,but it is a global ***,many treatments and medicines for bacterial diseases have been ***,they possess some ***,the alternative medicine has been used to target the drug resistant mechanisms and such medicines have less side effects which is becoming *** products have traditionally or historically been of importance for the development of antibacterial agents and are also known to overcome bacterial drug resistance by directly targeting the drug resistance mechanisms in *** recent years,researchers have also focused on new drug discovery from plant-based *** have looked on various phytocompounds as antibacterial *** the current review,we report various classes of secondary metabolites such as phenolic compounds,flavonoids,alkaloids,saponins,terpenes,quinones,and some essential oils that have been used as an antibacterial *** addition,we also discuss several mechanisms behind bacterial multi-drug resistance that are used during bacterial pathogenesis.

关键词： Drug-resistance Phytocompounds Antibacterial Mechanisms Medicinal plants Natural products

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：