Background and aim:Severe alcoholic hepatitis(sah),the most florid form of alcohol-related liver dis-ease(ALD),has a mortality rate of 16%at 28 *** angiopoietin-Tie 2 system regulates angiogenesis and inflammation,bot...
详细信息
Background and aim:Severe alcoholic hepatitis(sah),the most florid form of alcohol-related liver dis-ease(ALD),has a mortality rate of 16%at 28 *** angiopoietin-Tie 2 system regulates angiogenesis and inflammation,both of which are implicated in the pathogenesis of *** study examined plasma and hepatic gene expression of angiopoietin 1(ANG1)and angiopoietin 2(ANG2)in patients with sah and ALD and investigated their roles as prognostic ***:A case-control study was performed measuring plasma levels of ANG1 and ANG2 by enzyme-linked immunosorbent assay(ELISA)from 30 patients with sah(Maddrey's discriminant function32),32 patients with ALD cirrhosis and 15 healthy controls(HC).RNA sequencing for ANG1,ANG2,TIE1(codes for Tie1 receptor)and TEK(codes for Tie2 receptor)gene expression from a separate cohort study of 79 patients was also ***:Plasma levels of ANG1 were lower(P=0.010)and ANG2 were higher(Psah compared to *** ANG2:ANG1 ratio was higher in those with ALD/sah compared to HC(Psah than that in HC(Psah than that in HC(P=0.070)though was upregulated in severe disease(P=0.0003).Conclusions:Plasma ANG2 is raised in sah and ALD and could be useful as a prognostic biomarker in this patient population.
暂无评论