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Petroleum Science 2021年第5期18卷 1409-1426页

作者： Miguel Angel Roncoroni Pedro Romero Jesús Montes Guido Bascialla Rosario rodríguez ramón rodríguez pons-esparver Luis Felipe Mazadiego María Flor García-Mayoral Universidad Politécnica de Madrid MadridSpain CEPSA Research Center MadridSpain CEPSA E&P MadridSpain

This work presents the design of a robust foam formulation that tolerates harsh reservoir conditions(high salinity,high divalent ion concentration,high temperature,light oil,and hydrocarbon injection gas)in a sandstone *** this,we selected anionic Alpha Olefin Sulfonate(AOS)surfactants and studied their synergistic effects in mixtures with zwitterionic betaines to enhance foam *** laboratory workflow used to define the best formulation followed a de-risking approach in three consecutive ***,(phase 1)the main surfactant(AOS)was selected among a series of commercial candidates in static ***,(phase 2)the betaine booster to be combined with the previously selected AOS was chosen and their ratio optimized in static ***,(phase 3)the surfactant/booster ratio was optimized under dynamic conditions in a porous medium in the absence and the presence of *** a result of this study,a mixture of an AOS C14-C16 and cocamidopropyl hydroxysultaine(CAPHS)was selected as the one having the best *** designed formulation was proven to be robust in a wide range of *** generated a strong and stable foam at reservoir conditions,overcoming variations in salinity and foam quality,and tolerated the presence of oil.

关键词： Gas mobility control Foam enhanced oil recovery(EOR) Foam stability High temperature high salinity reservoir Surfactant formulation

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

Prehospital critical care drug-therapy and 30-day mortality in patients with acute respiratory disease

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World Journal of Emergency Medicine 2025年第1期16卷 43-50页

作者： Jesús Jurado-Palomo JoséLuis Martín-Conty Begoña Polonio-López Cristina Rivera Picón Raúl López-Izquierdo Carlos del Pozo Vegas Pedro Ángel de Santos Castro Ancor Sanz-García Francisco Martín-rodríguez Technological Innovation Applied to Health Research Group(ITAS) Faculty of Health SciencesCastilla-La Mancha UniversityTalavera de la Reina 45600Spain nuestra Señora del Prado General Hospital Talavera de la Reina 45600Spain Emergency Department Rio Hortega University HospitalValladolid 47012Spain CIBER of Respiratory Diseases(CIBERES) Institute of Health Carlos ⅢMadrid 28029Spain Faculty of Medicine University of ValladolidValladolid 470003Spain Emergency Department University Clinical HospitalValladolid 47003Spain Prehospital Emergency Medical Services(SACYL) Valladolid 47007Spain

BACKGROUnD: Prehospital medication is a reality, and the role of these therapies must be explored to assess their validity, especially for acute respiratory diseases, which are usually associated with increased morbidity. The aim of this study was to examine the association of prehospital medication use with mortality in patients with acute respiratory ***: A prospective, multicenter, emergency medical service(EMS) delivery cohort study was carried out in adults with unselected respiratory diseases managed by EMS who were transferred to the emergency department. From January 1, 2019, to October 31, 2023, six advanced life support units, thirty-eight basic life support units, and four hospitals in Spain participated in the study. Demographic data, vital signs, use of mechanical ventilation, prehospital respiratory diagnosis, and prehospital medication were collected. The primary outcome was 30-day in-hospital ***: A total of 961 patients were included, with a mortality rate of 17.5%(168 patients). Age, an increasing number of comorbidities, the use of invasive mechanical ventilation(IMV), the use of major analgesics, hypnotics, and bicarbonate were risk factors. In contrast, elevated systolic blood pressure and Glasgow Coma Scale scores were found to be protective factors against mortality. The predictive capacity of the model reached an area under the curve(AUC) of 0.857(95% confidence interval [95% CI] 0.827–0.888).COnCLUSIOn: Our data revealed that IMV, major analgesics, hypnotics and bicarbonate administration were associated with elevated mortality. Adding prehospital drug therapy information to demographic variables and vital signs could improve EMS decision-making, allowing a better characterization of patients at risk of clinical worsening.

关键词： Drug-therapy Medication Prehospital Mortality Emergency medical services

Value Attributed to the Therapist’s Directiveness and Support in the Psychotherapeutic Process

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International Journal of Mental Health Promotion 2025年第2期27卷 125-136页

作者： Antonio Romero-Moreno Lorenzo rodríguez-Riesco Isaac Lavi Serafín Cruces-Montes Department of Psychology University of CádizPuerto Real11519Spain Institute for Social and Sustainable Development(InDESS) University of CádizJerez de la Frontera11406Spain

Background:Research on therapeutic processes has explored the elements that enhance psychotherapy’s effectiveness,particularly the role of common factors across various *** therapist’s use of directiveness and support,as common variables,is crucial for effective *** therapists adapt their level of directiveness and support according to the treatment phase,the issue being addressed,and the patient’s *** study examines the importance therapists attribute to directiveness and support,as well as its relationship with theoretical orientation,access to research publications,and stance on the similar effectiveness of different psychotherapeutic *** aims to determine whether therapists’attributions regarding this variable are in line with the importance it is given in process ***:Responses from 69 psychotherapists to the Psychotherapeutic Effectiveness Attribution Questionnaire(PEAQ-12),which assesses the importance therapists place on key psychotherapeutic process variables,including the directiveness and support provided,were *** orientations,ages,and experience levels were ***-parametric tests,contingency tables,χ^(2)tests,t-tests,and AnOVAs were used to assess the variation in ***:Common factors were often identified as key contributors to therapeutic healing,though these differences were not statistically significant(χ^(2)(2,n=67)=3.701,p=0.157).For the“directiveness and support from the therapist”variable,significant differences were observed:Cognitive-behavioral therapists valued directiveness and support more than psychodynamic therapists(t(20)=−3.569,p=0.002;Cohen’s d=1.18).Therapists who view cognitive-behavioral therapies as most effective also rated this variable higher(t(38)=3.816,pn’s d=1.21).Those regularly accessing specialized psychotherapy research publications valued this variable less than those who do so occasionally(t(64)=−2.693,p=0.009;Cohen

关键词： Therapist directiveness and support psychotherapeutic effectiveness psychotherapy process research common factors in psychotherapies

Assessment of skeletal muscle alterations and circulating myokines in metabolic dysfunction-associated steatotic liver disease:A crosssectional study

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World Journal of Gastroenterology 2025年第7期31卷 63-73页

作者： Yolanda Real Martinez Carlos Ernesto Fernandez-Garcia Esther Fuertes-Yebra Mario Calvo Soto Angela Berlana Vicente Barrios Maria Caldas Leticia Gonzalez Moreno Luisa Garcia-Buey Begoña Molina Baena Miguel Sampedro-nuñez Maria J Beceiro C García-Monzón Águeda González-rodríguez Servicio Aparato Digestivo Hospital Universitario La PrincesaInstituto de Investigación Sanitaria La PrincesaUniversidad Autónoma de MadridMadrid 28006Spain Unidad de Investigación Hospital Universitario Santa CristinaInstituto de Investigación Sanitaria La PrincesaMadrid 28009Spain Department of Endocrinology Department of PediatricsHospital Infantil Universitario Niño JesúsInstituto de Investigación La PrincesaMadrid 28009Spain Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y nutrición Instituto de Salud Carlos IIIMadrid 28029Spain Servicio de Endocrinología y nutrición Hospital Universitario La PrincesaInstituto de Investigación Sanitaria La PrincesaUniversidad Autónoma de MadridMadrid 28006Spain Instituto de Investigaciones Biomédicas Sols-Morreale(IIBM) CSIC-UAMMadrid 28029Spain Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas Madrid 28029Spain

BACKGROUnD Skeletal muscle alterations(SMAs)are being increasingly recognized in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD)and appear to be associated with deleterious outcomes in these ***,their actual prevalence and pathophysiology remain to be *** To determine the prevalence of SMAs and to assess the significance of circulating myokines as biomarkers in patients with *** Skeletal muscle strength and muscle mass were measured in a cross-sectional study in a cohort of 62 patients fulfilling MASLD criteria,recruited from the outpatient clinics of a tertiary level *** degree of fibrosis and liver steatosis was studied using abdominal ultrasound and transitional *** and metabolic characteristics as well as serum levels of different myokines were also determined in the MASLD *** analysis was performed comparing results according to liver fibrosis and *** no significant differences were found in both skeletal muscle strength and skeletal muscle mass in patients with MASLD between different stages of liver ***,serum levels of fibroblast growth factor-21(FGF21)were significantly higher in patients with MASLD with advanced hepatic fibrosis(F3-F4)than in those with lower fibrosis stages(F0-F2)(197.49±198.27 pg/mL vs 95.62±83.67 pg/mL;P=0.049).In addition,patients with MASLD with severe hepatosteatosis(S3)exhibited significantly higher serum levels of irisin(1116.87±1161.86 pg/mL)than those with lower grades(S1-S2)(385.21±375.98 pg/mL;P=0.001).COnCLUSIOn SMAs were uncommon in the patients with MASLD *** serum levels of irisin and FGF21 were detected in patients with advanced liver steatosis and fibrosis,respectively,with potential implications as biomarkers.

关键词： Skeletal muscle alterations Myokines Metabolic dysfunction-associated steatotic liver disease Liver fibrosis Hepatosteatosis

Application of nanotechnology to dentistry:Impact of graphene nanocomposites on clinical air quality

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World Journal of Clinical Cases 2025年第8期13卷 1-7页

作者： Ruth rodríguez Montaño Mario A Alarcón-Sánchez Melissa Martínez nieto Juan J Varela Hernández Sarah M LomelíMartínez Department of Health and Illness as an Individual and Collective Process University Center of TlajomulcoUniversity of GuadalajaraTlajomulco de Zuñiga 45641JaliscoMexico Institute of Research in Dentistry Department of Integral Dental ClinicsUniversity Center of Health SciencesUniversity of GuadalajaraGuadalajara 44340JaliscoMexico Department of Biomedical Science Faculty of Chemical-Biological SciencesAutonomous University of GuerreroGuerrero 39090Mexico Instituto Odontológico del Pacífico Sur Chilpancingo de los Bravo 39022Mexico Independent Researcher Tijuana 22116Baja CaliforniaMexico Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlan 47810JaliscoMexico Master of Public Health Department of Well-being and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraOcotlan 46200JaliscoMexico

Concerns about air quality in dental clinics where aerosol generation during procedures poses significant health risks,have prompted investigations on advanced disinfection *** editorial describes the strengths and limitations of ventilation and aerosol control measures in dental offices,especially with respect to the use of graphene *** potential of graphene nanocomposites as an innovative solution to aerosol-associated health risks is examined in this review due to the unique properties of graphene(e.g.,high con-ductivity,mechanical strength,and antimicrobial activity).These properties have produced promising results in various fields,but the application of graphene in dentistry remains *** recent study by Ju et al which was published in World Journal of Clinical Cases evaluated the effectiveness of graphene-based air disinfection systems in dental *** study demonstrated that graphene-based disinfection techniques produced significant reductions in suspended particulate matter and bacterial colony counts,when co-mpared with traditional *** these positive results,challenges such as material saturation,frequency of filter replacement,and associated costs must be addressed before widespread adoption of graphene-based disinfection techniques in clinical ***,there is need for further research on material structure optimization,long-term safety evaluations,and broader clinical applications,in order to maximize their positive impact on public health.

关键词： Graphene nanocomposites Antibacterial activity Biomedical applications Air disinfection

Link between caries,periodontitis,and pregnancy:The role of personalized oral hygiene

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World Journal of Clinical Cases 2025年第6期13卷 51-57页

作者： Melissa Martínez nieto Martha Leticia De León rodríguez Francisco Javier Alcaraz Baturoni Alma Alicia Soto Chávez Sarah Monserrat Lomelí Martínez Periodontics Program Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810JaliscoMexico Master of Public Health Department of Well-being and SustainableCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico

Optimal health during pregnancy is crucial for ensuring the well-being of the mother and the developing *** article is focused on the impact of oral health and the role of personalized oral hygiene management in addressing prevalent dental issues among pregnant women,with particular emphasis on periodontal disease and dental *** the high prevalence of these dental problems and their association with obstetric complications such as pre-term birth and low birth weight,many pregnant women do not receive adequate dental *** gap in care is often due to misconceptions about the safety of dental treat-ments during pregnancy and lack of awareness on the part of healthcare *** of the impacts of oral health and personalization of oral hygiene strategies such as tailored education and support,have proven effective in improving oral health in this *** reductions in the incidence of caries and periodontal disease may be achieved by adapting care to the specific needs of each patient,thereby enhancing maternal and fetal health *** of personalized oral hygiene management into maternal health pro-grams and enhancement of ongoing education for pregnant women and healthcare professionals are essential steps in the reduction of pregnancy-related risks and improvement of maternal and neonatal *** Tip:In this article,we reviewed a recent study on the effects of personalized oral hygiene management on the oral health of pregnant women,as discussed in the article by Men et *** study demonstrated that personalized oral hygiene interventions significantly improved oral health outcomes during pregnancy by reducing the prevalence of dental caries and periodontal *** emphasized the importance of individualized oral care programs that integrate education and tailored support,and we highlighted their significance in enhancing maternal and fetal *** approach underscores the need for

关键词： Pregnancy Periodontal disease Periodontitis Dental caries Oral hygiene

neuroprotective effect of neuro-EPO in neurodegenerative diseases:“Alea jacta est”

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neural Regeneration Research 2019年第9期14卷 1519-1521页

作者： ramón rama Fernando Garzón Yamila rodríguez-Cruz Tangui Maurice Julio-César García-rodríguez Department of Cell Biology Physiology and ImmunologyUniversity of BarcelonaBarcelonaSpain Department of Animal Health University of NarinoPastoNarinoColombia Department of Histology University of Medical SciencesHavanaCuba MMDn Univ MontpellierINSERMEPHEUMR_S1198MontpellierFrance CEnPALAB National Center for Animals BreedingHavanaCuba

Our common home,planet Earth,is inhabited by more than 7 billion human *** average life expectancy currently estimated for men is^69 years,with strong differences among ***,neurodegenerative diseases are currently the leading cause of death and disability *** clinical use and neuroscience research,a solution for an effective diagnosis is in progress,but a prophylactic treatment to counteract this long-lasting plague for humanity is still unidentified.

关键词： Our common home neurodegenerative still unidentified

Mapping Spatial Distributions within Pseudoscalar Mesons

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Chinese Physics Letters 2025年第2期 7-18页

作者： Khépani Raya Adnan Bashir José rodríguez-Quintero Department of Integrated Sciences and Center for Advanced Studies in Physics Mathematics and ComputationUniversity of Huelva Instituto de Física y Matemáticas Universidad Michoacana de San Nicolás de Hidalgo Irfu CEAUniversité de Paris-Saclay

Several aspects of the internal structure of pseudoscalar mesons, accessible through generalized parton distributions in their zero-skewness limit, are examined. These include electromagnetic and gravitational form fa...

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Comprehensive view of suicide:A neuro-immune-endocrine approach

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World Journal of Psychiatry 2025年第2期15卷 1-22页

作者： María D Ponce-Regalado Enrique Becerril-Villanueva JoséLuis Maldonado-García Martha C Moreno-Lafont Gabriela Martínez-ramírez Salomón Jacinto-Gutiérrez rodrigo Arreola Karla Sánchez-Huerta Arturo Contis-Montes de Oca Karla María López-Martínez Elizabeth Bautista-rodríguez JoséMiguel Chin-Chan Lenin Pavón Gilberto Pérez-Sánchez Departamento de Ciencias de la Salud Centro Universitario de los AltosUniversidad de GuadalajaraTepatitlán de Morelos 47620JaliscoMexico Laboratorio de Psicoinmunología Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizCiudad de México 11340Mexico Departamento de Bioquímica Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoCoyoacánCiudad de México 04510Mexico Departamento de Inmunología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de México 11350Mexico Facultad de Medicina Facultad de Estudios Superiores IztacalaUniversidad Nacional autónoma de MéxicoTlalnepantla 54090Mexico Subdirección de Investigaciones Clínicas Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizCiudad de México 11340Mexico Laboratorio de neurociencias Subdirección de Medicina ExperimentalInstituto Nacional de PediatríaCiudad de México 04530Mexico Sección de Estudios de Posgrado e Investigación Escuela Superior de MedicinaInstituto Politécnico NacionalCiudad de México 11340Mexico Facultad de Biotecnología Universidad Popular Autónoma de PueblaPuebla 72410Mexico Química Clínica Facultad de Ciencias de la SaludUniversidad Autónoma de TlaxcalaTlaxcala 90750Mexico Facultad de Ciencias Químico-Biológicas Universidad Autónoma de CampecheCampeche 24039Mexico

Suicide is defined as the act of a person attempting to take their own life by causing *** is a complex phenomenon that is influenced by a multitude of factors,including psychosocial,cultural,and religious aspects,as well as genetic,biochemical,and environmental *** a biochemical perspective,it is crucial to consider the communication between the endocrine,immune,and nervous systems when studying the etiology of *** pathologies involve the bidirectional communication between the peripheral activity and the central nervous system by the action of molecules such as cytokines,hormones,and *** humoral signals,when present in optimal quantities,are responsible for maintaining physiological homeostasis,including mood *** elevates the cortisol and proinflammatory cytokines levels and alter neurotransmitters balance,thereby increasing the risk of developing a psychiatric disorder and subsequently the risk of suicidal *** review provides an integrative perspective about the neurochemical,immunological,and endocrinological disturbances associated with suicidal behavior,with a particular focus on those alterations that may serve as potential risk markers and/or indicators of the state preceding such a tragic act.

关键词： Suicide neuroimmune endocrine neurotransmitters Hormones Cytokines Hypothalamic-pituitary adrenal axis Early life adversity Inflammation Genetic predisposition Psychiatric disorders