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PD-L1 expression associated with better response to EGFR tyrosine kinase inhibitors

Cancer Biology & Medicine 2015年第2期12卷 71-73页

作者： Rafael Rosell ramón palmero Molecular Oncology Research (MORe) Foundation Catalan Institute of Oncology Hospital Germans Trias i Pujol Germans Trias i Pujol Health Sciences Institute and Hospital Campus Can Ruti Instituto Oncológico Dr Rosell Quiron Dexeus University Hospital Pangaea Biotech Thoracic Oncology Unit Department of Medical Oncology Catalan Institute of Oncology L'Hospitalet

Cancer evades host immune surveillance by using immune checkpoints,w hich are inhibitor y pathways cr ucial for maintaining *** cells express multiple inhibitory ligands,and tumor-infiltrating lymphocytes(TIL)express ... 详细信息

关键词：酪氨酸激酶抑制剂 EGFR 细胞毒性T淋巴细胞宿主免疫肿瘤浸润 CTLA-4 程序性死亡抑制途径

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Estimation of the elastic thickness over ancient Mare Moscoviense

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Research in Astronomy and Astrophysics 2019年第12期19卷 318-326页

作者： Zhen Zhong Jian-Guo Yan Teng Zhang Zhi-Yong Xiao Jose Alexis palmero Rodriguez School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430079China Instituto de Astronomiay Ciencias Planetarias de Atacama Universidad de AtacamaCopayapu 485Chile Planetary Science Institute Chinese University of Geosciences(Wuhan)Wuhan 430074China Planetary Science Institute 1700 East Fort Lowell RoadSuite 106TucsonAZ 85719-2395USA

The Moscoviense basin is an atypical lunar impact basin with concentric rings of positive and negative gravity anomalies. This basin can provide insights into the inhomogeneous thermal activities across the farside of the Moon. Based on an updated spherical harmonic thin elastic-shell loading model, we used localized admittance analyses to estimate the elastic thickness as well as other associated selenophysical parameters for the Moscoviense basin. The high precision gravity and topography data employed in our estimation were collected by the Gravity Recovery and Interior Laboratory and the Lunar Orbiter Laser Altimeter missions. Our results indicate that the crust-mantle interface is mainly compensated by the prefilling depth rather than the observed surface topography. The results constrained within two standard deviations yielded a small load ratio(~0.168), a best-fit crustal thickness of 36.2 km, and an optimized crustal density of 3159.5 kg m-3. Such large density approaches the density of olivine-rich mantle materials, implying that the excavation of the Mare Moscoviense occurred during a basin-forming impact. The inversed elastic thickness at Mare Moscoviense was around 18 km, lower than the previous results(~60 km) found over Mare basins on the lunar nearside. These results indicate that extreme thermal activity existed during the Moscoviense basin-forming period such as reheating mechanisms from a double-impact process and mare volcanism.

关键词： Mare Moscoviense localized admittance thin elastic spherical shell elastic thickness

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Stepwise magnetization reversal of geometrically tuned in diameter ni and FeCo bi-segmented nanowire arrays

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nano Research 2019年第7期12卷 1547-1553页

作者： Ester M. palmero Miguel Mendez Silvia Gonzalez Cristina Bran Victor Vega Manuel Vazquez Victor M. Prida Institute of Materials Science of Madrid (ICMM-CSIC) Madrid 28049Spain Department of Physics University of OviedoFederico Garda Lorca 18Oviedo 33007Spain Division of Permanent Magnets and Applications IMDEA NanoscienceMadrid 28049Spain

Magnetization reversal processes of hexagonal dense arrays of bi-segmented ni and Fe50Co50 nanowires consisting of two well defined diameters (45 and 80 nm) have been *** nanowires were grown inside of tailored pores of anodic alumina templates by combined anodization,atomic layer deposition (ALD) and electrodeposition *** experiments have allowed to identify their two-step magnetization reversal process ascribed to the respective segments of different *** is concluded from the differential susceptibility observed in the hysteresis loops,contrary to those for nanowires with homogeneous *** results are also confirmed by the first-order reversal curve (FORC) distribution diagrams,where an elongation parallel to the interaction axis around two coercive field values is obtained,which is correlated to the difference in diameter of the two *** well-defined two-step magnetization reversal process through the nanowire diameter design is thought to be very useful for the advanced control of the remagnetization in arrays of magnetic multidomain systems.

关键词： Bi-segmented nanowires nickel iron cobalt alloy stepwise magnetization reversal first-order reversal curve (FORC)

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Efficient nanostructuring of Isotropic Gas-Atomized MnAl Powder by Rapid Milling(30s)

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Engineering 2020年第2期6卷 173-177页

作者： J.Rial E.M.palmero A.Bollero Division of Permanent Magnets and Applications IMDEA NanoscienceCampus Universidad Autonoma de MadridMadrid 28049Spain

An unprecedentedly short milling time of 30 s was applied to gas-atomized MnAl powder in order to develop permanent magnet properties and,in particular,*** is shown that such a short processing time followed by annealing results in efficient nanostructuring and controlled phase *** defects resulting from the microstrain induced during milling,together with the creation of the bphase during post-annealing,act as pinning centers resulting in an enhanced *** study shows the importance of finding a balance between the formation of the ferromagnetic s-MnAl phase and the bphase in order to establish a compromise between magnetization and coercivity.A coercivity as high as 4.2 kOe(1 Oe=79.6 A·m^-1)was obtained after milling(30 s)and annealing,which is comparable to values previously reported in the literature for milling times exceeding 20 *** reduction of the postannealing temperature by 75℃ for the as-milled powder and a 2.5-fold increase in coercivity,while maintaining practically unchanged the remanence of the annealed gas-atomized material,opens a new path for the synthesis of isotropic MnAl-based powder.

关键词： Permanent magnets(PMs) nanostructuring Phase transformation MnAl Gas atomization Ball milling

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Regional analysis and sustainable development： Application of a synthetic sustainability indicator to Galicia and the European Union

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Chinese Business Review 2009年第1期8卷 1-16页

作者： Federico Martin-palmero Fernando Gonzalez-Laxe Facultad de Ciencias Eeonomicas y Empresariales Universidad de A Coruha A CORUNA 15071 Spain

In general, investigations carried out to date regarding/measuring systems/systems of measurement of sustainable development present two peculiarities： Either they are of a limited practical nature or they do not allow for comparisons between different areas or economies. Global synthetic indicators are an exception to the above; however they have been scarcely developed. This article designs an index of said characteristics, which is subsequently applied to all the countries within the European Union and to the region of Galicia.

关键词： sustainable development regional analysis Spain European Union

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