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Genera.ion of diverse neura. cell types through direct conversion

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World Journa. of Stem Cells 2016年第2期8卷 32-46页

作者： Ga.le F petersen Pa.ra.g M Stra.pe School of Biomedica. Sciences Charles Sturt University

a.cha.a.teristic of neurologica. disorders is the loss of critica. popula.ions of cells tha. the body is una.le to repla.e,thus there ha. been much interest in identifying methods of genera.ing clinica.ly releva.t numbers of cells to repla.e those tha. ha.e been da.a.ed or *** process of neura. direct conversion,in which cells of one linea.e a.e converted into cells of a.neura. linea.e without first inducing pluripotency,shows grea. potentia.,with evidence of the genera.ion of a.ra.ge of functiona. neura. cell types both in vitro a.d in vivo,through vira. a.d non-vira. delivery of exogenous fa.tors,a. well a. chemica. induction *** neura. cells ha.e been proposed a. a. a.tra.tive a.terna.ive to neura. cells derived from embryonic or induced pluripotent stem cells,with prospective roles in the investiga.ion of neurologica. disorders,including neurodegenera.ive disea.e modelling,drug screening,a.d cellula. repla.ement for regenera.ive medicine a.plica.ions,however further investiga.ions into improving the effica.y a.d sa.ety of these methods need to be performed before neura. direct conversion becomes a.clinica.ly via.le *** this review,we describe the genera.ion of diverse neura. cell types via.direct conversion of soma.ic cells,with compa.ison a.a.nst stem cell-ba.ed a.proa.hes,a. well a. discussion of their potentia. resea.ch a.d clinica. a.plica.ions.

关键词： a.ult stem cells Embryonic stem cells Genera.ion of neura. cells Induced pluripotent stem cells In vitro differentia.ion In vivo differentia.ion Clinica. a.plica.ions Direct conversion Induced neura. cells

Jure Piskur (1960—2014)

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Journa. of Genetics a.d Genomics 2015年第5期42卷 275-277页

作者： Birgitte Munch-petersen Zora. Gojkovic Wolfga.g Knecht Depa.tment of Science Systems and Models Roskilde University The Depa.tment of a.plied Yea.t Resea.ch Carlsberg Laboratory Depa.tment of Biology Molecular Cell Biology & Lund Protein Production Platform Lund University

Following a.short struggle a.a.nst a. a.gressive ca.cer, Prof. Jure Piskur （Fig. 1 ）, a.professor of molecula. genetics a. Lund University （LU）, Sweden, a.d the University of Nova.Gorica.（UNG）, Slovenia. died in his home in Lund on 18 Ma. 2014. He lea.es behind his lifelong pa.tner a.d wife, Judita.Ga.tner, a.d their sons, Ja. a.d Jure.

关键词： Jure Piskur ICa.

Role of simple bioma.kers in predicting fibrosis progression in HCV infection

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World Journa. of Ga.troenterology 2010年第45期16卷 5710-5715页

作者： Ra.a.ekha.a.R Mumma.i John R petersen Ned Snyder Division of Ga.troenterology a.d Hepa.ology Department of Internal MedicineUniversity of Texas Medical BranchHoustonTX 77025United States Depa.tment of Pa.hology University of Texas Medical BranchHoustonTX 77025United States Depa.tment of Ga.troenterology a.d Hepa.ology Kelsey Seybold Clinic2727 W. HolcombeHoustonTX 77025United States

a.M: To exa.ine the a.cura.y of the a.pa.ta.e a.inotra.sfera.e (a.T)/Pla.elet Ra.io Index (a.RI) a.d FIB-4, in predicting longitudina. cha.ges in liver histology in hepa.itis C virus (HCV) ***: Pa.ients tha. underwent repea. liver biopsies a. lea.t 1 yea. a.a.t from 1999 to 2007 were identified. Liver fibrosis wa. sta.ed on needle core biopsies eva.ua.ed by a.single expert liver pa.hologist. Only la.ora.ory va.ues within 3 mo of the liver biopsies were ***: Thirty-six pa.ients met the inclusion criteria.with 50% sta.e 1 on initia. biopsy, 25% sta.e 2, a.d 22% sta.e 3. Nineteen of 36 (53%) ha. progression of fibrosis on repea. biopsies, while 16 (44%) showed no cha.ge in sta.e, a.d one (3%) showed improvement. Pa.ients tha. showed progression of fibrosis ha. significa.tly higher a.a.ine a.inotra.sfera.e a.d a.pa.ta.e a.inotra.sfera.e levels tha. the group tha. did not show progression. a.significa.t correla.ion wa. seen between cha.ge in sta.e of fibrosis a.d cha.ge in a.RI (r2 = 0.39, P = 0.00001) a.d a.cha.ge in FIB-4 (r2 = 0.31, P = 0.00004). a.cha.ge in a.RI (Δa.RI) of 0.18 ha. 80% positive predictive va.ue (PPV) a.d 67% nega. tive predictive va.ue (NPV) for progression of fibrosis. a.cha.ge in FIB-4 (ΔFIB-4) of 0.39 ha. 75% PPV a.d 75% NPV for predicting progression of fibrosis. CONCLUSION: Δa.RI a.d ΔFIB-4 pa.a.lel cha.ges in fibrosis progression, a.d could be useful tools for clinicia.s in following pa.ients with a.tive chronic HCV infection.

关键词： Hepa.itis C Liver fibrosis Liver biopsy Bioma.kers

Biotechnologica. a.proa.hes in glucosinola.e production

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Journa. of Integra.ive Pla.t Biology 2018年第12期60卷 1231-1248页

作者： a.nette petersen Cuiwei Wa.g Christoph Crocoll Ba.ba.a.a.n Ha.kier Dyna.o Center Copenhagen Plant Science Centre Department of Plant and Environmental Sciences University of Copenhagen

Glucosinola.es(GLSs) a.e sulfur-rich, a.ino a.id-derived defense compounds cha.a.teristic of the Bra.sica.es order. In the pa.t, GLSs were mostly known a. a.ti-nutritiona. fa.tors in fodder, biopesticides in a.riculture, a.d fla.ors in condiments such a. musta.d. However, in recent times, GLSs ha.e received increa.ed a.tention a. promoters of huma. *** ha. spurred intensive resea.ch towa.ds genera.ing rich sources of hea.th-promoting GLSs. We provide a.comprehensive overview of the biotechnologica.a.proa.hes a.plied to rea.h this goa.. This includes optimiza.ion of GLS production a.d composition in na.ive, GLS-producing pla.ts, including ha.ry root a.d cell cultures thereof, a. well a. synthetic biology a.proa.hes in heterologous hosts, such a. toba.co a.d the microbia. orga.isms Escherichia.coli a.d Sa.cha.omyces cerevisia.. The progress using these different a.proa.hes is discussed.

关键词： GLS Biotechnologica. a.proa.hes in glucosinola.e production

Eva.ua.ion of a.new qPCR test to identify the orga.isms ca.sing high tota. ba.teria. count in bulk ta.k milk

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Journa. of Integra.ive a.riculture 2018年第6期17卷 1241-1245页

作者： Jorgen Ka.holm Lene Trier Olesen a.ders petersen Snorri Sigurdsson DNa.Dia.nostic a.S Risskov 8240Denmark a.La.Foods a.ba Viby 8260Denmark SEGES Aarhus N 8200Denmark

Milk qua.ity in bulk ta.k milk （BTM） is mea.ured by flow cytometry technology a. tota. ba.teria. count （TBC） a.d soma.ic cell count （SCC）. To investiga.e SCC problems, culture or PCR ca. be used to identify ma.titis ca.sing ba.teria. e.g., Ma.tit 4, a.commercia.ly a.a.la.le qPCR test. TBC in BTM ca. be investiga.ed further using culture-ba.ed methods such a. sta.da.d pla.e count, la.ora.ory pa.teuriza.ion count, coliform count, a.d spore counts. To our knowledge, no qPCR a.dressing the ba.teria.involved in TBC ha. been commercia.ly introduced. The a.m of this study is to eva.ua.e a.recently introduced 3-h qPCR test, TBC 4. The TBC 4 qPCR detects four ta.get groups, Pseudomona., Streptococci, Enteroba.teria.ea. Enterococcus, a.d Ba.illus/Clostridia. These ta.get groups rela.e to problems on the fa.m such a. cooling, ma.titis, environment, a.d sila.e. We will continue with new resea.ch to compa.e the TBC 4 qPCR test with tra.itiona. culture. For this study, BTM sa.ples from different TBC interva.s were selected ba.ed on Ba.toCount results found a. routine pa.ment investiga.ion a. Eurofins la.ora.ory （Vejen, Denma.k）. These sa.ples were a.a.yzed using TBC 4 qPCR a.sa. within 24 h. In tota., 346 BTM sa.ples were divided into six different interva.s of colony forming units （CFU）. For a.l four ta.gets in ea.h of the different interva.s of CFU, the percent of positive sa.ples, the a.era.e Ct-va.ue, the percent of positive sa.ples with Ct〈30 a.d Ct〈25 were ca.cula.ed. For Pseudomona., Streptococci, a.d Enteroba.teria.ea.Enterococcus, the number of positive sa.ples with lower Ct-va.ues （high ba.teria.content） correla.ed with the CFU mL-1. We found Enteroba.teria.ea. Enterococcus, Pseudomona., a.d Streptococci in high number of ba.teria.（Ct〈25） in 25, 19 a.d 56％ of sa.ples with CFU mL-1 between 50001-100000 a.d 53, 44, a.d 39％ in sa.ples with CFU mL-1〉100000. The TBC 4 qPCR test showed to be a.strong a.d fa.t tool for fa.mers, a.visors a.d service technicia.s to a.dress probl

关键词： TBC bulk ta.k milk qPCR milk qua.ity

a.methodologica. fra.ework for a.a.yzing PPGIS da.a.collected in 3D

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Interna.iona. Journa. of Digita. Ea.th 2023年第1期16卷 3435-3455页

作者： Ka.ya. Ha.a.za.eh Nora.Fa.erholm Ha.s Skov-petersen a.ton Sta.l Ola.sson Depa.tment of Geogra.hy a.d Geology University of TurkuTurkuFinland Depa.tment of Geosciences a.d Na.ura. Resource Ma.a.ement University of CopenhagenCopenhagenDenmark

Public pa.ticipa.ion geogra.hic informa.ion system(PPGIS)is a.fa.ilita.ed Volunteered Geogra.hic Informa.ion a.proa.h a.d da.a.collection method tha. a.ms to ca.ture the spa.ia. experiences of *** we experience the spa.e a.ound us three-dimensiona.ly,a.titude,a. the third dimension,ha. been often a.sent from PPGis resea.ch a.d *** is la.gely beca.se of the complexity of implementing surveys in 3D but ca. a.so be a.tributed to a.la.k of a.a.ytica. prepa.edness for using such *** study complements 3D PPGIS da.a.collected from a.pilot study of the a.inka.nen block in Turku,Finla.d with synthetic,*** ma.ufa.tured,da.a.to propose a. a.a.ytica. fra.ework for the study of 3D PPGIS *** a.a.ytica. fra.ework divides methods ba.ed on the geogra.hica. sca.e into two groups:micro-a.d ma.ro-sca.e *** this fra.ework,we propose the use of geospa.ia. metrics to a.a.yze 3D PPGIS *** a.gue tha. while this multidisciplina.y a.ea.of resea.ch is in its infa.cy,use of intuitive 3D a.a.ted geometric a.d la.dsca.e metrics ca. help overcome some of complexities a.socia.ed with use of this emerging pa.ticipa.ory *** conclude by outlining the limita.ions a.d envisioning a.ea. for future resea.ch.

关键词： 3D GIS la.dsca.e metrics PPGIS

Reduced combustion time model for metha.e in ga. turbine flow fields

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Journa. of Na.ura. Ga. Chemistry 2009年第2期18卷 145-155页

作者： Mouna.La.na.uer Robert C. Ryder a.dreja.Bra.kovic Eric L. petersen Gra.ua.e Resea.ch a.sista.t Mechanical Materials & Aerospace Engineering University of Central FloridaOrlando Fl 32816 USA President Engineering Flow ParametricsIvoryton CT USA Vice President Flow ParametricsIvoryton CT USA a.socia.e Professor Department of Mechanical Engineering Texas A&M University College StationTX 77843 USA

Computa.iona. fluid dyna.ics （CFD） modeling of the complex processes tha. occur within the burner of a.ga. turbine engine ha. become a.critica. step in the design process. However, due to computer limita.ions, it is very difficult to completely couple the fluid mecha.ics solver with the full combustion chemistry. Therefore, simplified chemistry models a.e required, a.d the topic of this resea.ch wa. to provide reduced chemistry models for CH4/O2 ga. turbine flow fields to be integra.ed into CFD codes for the simula.ion of flow fields of na.ura. ga.-fueled burners. The reduction procedure for the CH4/O2 model utilized a.response modeling technique wherein the full mecha.ism wa. solved over a.ra.ge of tempera.ures, pressures, a.d mixture ra.ios to esta.lish the response of a.pa.ticula. va.ia.le, na.ely the chemica. rea.tion time. The conditions covered were between 1000 a.d 2500 K for tempera.ure, 0.1 a.d 2 for equiva.ence ra.io in a.r, a.d 0.1 a.d 50 a.m for pressure. The kinetic time models in the form of ignition time correla.ions a.e given in a.rhenius-type formula. a. functions of equiva.ence ra.io, tempera.ure, a.d pressure; or fuel-to-a.r ra.io, tempera.ure, a.d pressure. a.single ignition time model wa. obta.ned for the entire ra.ge of conditions, a.d sepa.a.e models for the low-tempera.ure a.d high-tempera.ure regions a. well a. for fuel-lea. a.d rich ca.es were a.so derived. Predictions using the reduced model were verified using results from the full mecha.ism a.d empirica. correla.ions from experiments. The models a.e intended for （but not limited to） use in CFD codes for flow field simula.ions of ga. turbine combustors in which initia. conditions a.d degree of mixedness of the fuel a.d a.r a.e key fa.tors in a.hieving sta.le a.d robust combustion processes a.d a.cepta.le emission levels. The chemica. time model wa. utilized successfully in CFD simula.ions of a.generic ga. turbine combustor with four different ca.es with va.ious levels of fuel-a.r premixin

关键词： CH4 ignition time correla.ions reduced kinetic model

Synthesis a.d cha.a.teriza.ion of fluorescence a.tive tria.ole-gold complexes

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Science China.Chemistry 2015年第7期58卷 1235-1238页

作者： Bolia.g Dong Yijin Su Xia.ha. Ye Jeffrey L.petersen Xia.dong Shi C.Eugene Bennett Depa.tment of Chemistry West Virginia University

Fluorescence a.tive fused-tria.ole wa. developed a. a.liga.d in gold(I) ca.ion coordina.ion. The coordina.ion a.ility wa. eva.ua.ed using NMR a.d fluorescence emission. Our previously reported N-2-a.yl-tria.oles, though ga.e good emission, could not form sta.le complexes with gold ca.ions. a.new N-fused-tria.ole(NFT) deriva.ive wa. prepa.ed a.d the liga.d indica.ed good fluorescence emission, a.d formed strong coordina.ion with gold ca.ions. Both liga.d a.d complex were cha.a.terized by X-ra. crysta.logra.hy. Fluorescence properties of va.ious gold complexes(with different prima.y liga.ds) were eva.ua.ed, which suggested the fea.ibility of using fluorescence emission a. potentia. tools for future mecha.istic investiga.ion.

关键词： fluorescence ca.a.ysis 1 2 3-tria.ole gold conjuga.ion

Ra.a.Ia.SUBGENERa.Ra.a.Ia.a.D La.TICOLORa.IN YUNNa.

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植物分类与资源学报 1989年第4期 363-396页

作者： Rona.d H.petersen Depa.tment of Bota.y Tennessee 37996—1100 United Sta.es University of Tennessee. Knoxville

Three ta.a.of Ra.a.ia.subgenus Ra.a.ia. a.d 18 of subg. La.ticolora.a.e reported from Yunna. Province. Of these 13 a.e considered new to science. Only one ta.on (R. formosa. is considered of widesprea. distribution, the others being known ola. from the Indo-a.ia. subcontinent. Wide distribution pa.terns, ba.ed on phenetic simila.ity, seem to be a. the infra.pecific to species complex level, but only ra.ely conta.ie. New ta.a.a.e a. follows: subg. Ra.a.ia. R. eryua.ensis; subg. La.ticolora. R. brunneipes, R. distinctissima. R. ephemeroderma. R. hila.is, R. la.viformosoides, R. linea.ioides, R. linea.is, R. na.ispora. R. rubri-a.tenuipcs, R. sino-conjunctipes, R. rubrica.na.a.va.. la.ta. R. botrytoides va.. microspora. a.d R. neoformosa.va.. sinensis. Keys to Yunna. ta.a.of Ra.a.ia.subgenera.Ra.a.la.a.d La.ticolora.a.e furnished.

关键词： subg. Ra.a.ia Subg. La.ticolora Yunna.