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Neural Regeneration Research 2024年第11期19卷 2333-2334页

作者： Mingxi Weng ralf Jauch school of Biomedical sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Translational stem Cell Biology Hong Kong Special Administrative RegionChina

Neurodegenerative diseases(NDDs)are a class of disorders characterized by the gradual loss or malfunction of specific cell populations in the nervous system,which can be triggered by genetic or environmental *** a result,patients often experience a decline in mobility,sensation,memory,and cognition,which can ultimately lead to a fatal *** global incidence of NDDs,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,amyotrophic lateral sclerosis(ALs),and multiple sclerosis,is increasing.

关键词： degenerative Huntington sensation

Unraveling the gut-brain axis:the impact of steroid hormones and nutrition on Parkinson's disease

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Neural Regeneration Research 2024年第10期19卷 2219-2228页

作者： Paula Maria Neufeld ralf A.Nettersheim Veronika Matschke Matthias Vorgerd sarah stahlke Carsten Theiss Department of Cytology Institute of AnatomyMedical FacultyRuhr-University BochumBochumGermany Department of Visceral surgery University Hospital BergmannsheilRuhr-University BochumBochumGermany Department of Neurology Heimer Institute for Muscle ResearchUniversity Hospital BergmannsheilRuhr-University BochumBochumGermany

This comprehensive review explores the intricate relationship between nutrition,the gut microbiome,steroid hormones,and Parkinson's disease within the context of the gut-brain *** gut-brain axis plays a pivotal role in neurodegenerative diseases like Parkinson's disease,encompassing diverse components such as the gut microbiota,immune system,metabolism,and neural *** gut microbiome,profoundly influenced by dietary factors,emerges as a key *** during the first 1000 days of life shapes the gut microbiota composition,influencing immune responses and impacting both child development and adult ***-fat,high-sugar diets can disrupt this delicate balance,contributing to inflammation and immune *** nutritional strategies,the Mediterranean diet's anti-inflammatory and antioxidant properties show promise in reducing Parkinson's disease ***-targeted dietary approaches and the ketogenic diet hold the potential in improving brain *** nutrition,emerging research uncovers potential interactions between steroid hormones,nutrition,and Parkinson's ***,with its anti-inflammatory properties and presence in the nervous system,offers a novel option for Parkinson's disease *** ability to enhance neuroprotection within the enteric nervous system presents exciting *** review addresses the hypothesis thatα-synuclein aggregates originate from the gut and may enter the brain via the vagus *** symptoms preceding motor symptoms support this *** gut-brain signaling during gut dysbiosis contributes to inflammation and neurotransmitter imbalances,emphasizing the potential of microbiota-based *** summary,this review uncovers the complex web of interactions between nutrition,the gut microbiome,steroid hormones,and Parkinson's disease within the gut-brain axis *** these connections not only offers novel therapeutic insi

关键词： diet gut-brain axis microbiome neurodegenerative diseases nutrition Parkinson's disease progesterone steroid hormones

The transcription factor HsFA7b controls thermomemory at the shoot apical meristem by regulating ethylene biosynthesis and signaling in Arabidopsis

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Plant Communications 2024年第3期5卷 47-61页

作者： sheeba John Federico Apelt Amit Kumar Ivan FAcosta Dominik Bents Maria Grazia Annunziata Franziska Fichtner Caroline Gutjahr Bernd mueller-Roeber Justyna J.Olas University of Potsdam Institute of Biochemistry and BiologyKarl-Liebknecht-Straße 24-25Haus 2014476 PotsdamGermany Max Planck Institute of Molecular Plant Physiology Am Muehlenberg 114476 PotsdamGermany Laboratory of Molecular Biology Wageningen University6700 AP Wageningenthe Netherlands Center of Plant systems Biology and Biotechnology(CPsBB) 14 St.Knyaz Boris 1 Pokrastitel Str.4023 PlovdivBulgaria Present address:Institute of Plant Biochemistry Heinrich Heine University DusseldorfUniversit€atsstr.140225 DusseldorfGermany Leibniz Institute of Vegetable and Ornamental Crops Theodor-Echtermeyer-Weg 114979 GroßbeerenGermany

The shoot apical meristem(sAM)is responsible for overall shoot growth by generating all aboveground *** research has revealed that the sAM displays an autonomous heat stress(Hs)memory of a previous non-lethal Hs *** the importance of the sAM for plant growth,it is essential to determine how its thermomemory is mechanistically ***,we report that HEAT sHOCK TRAN-sCRIPTION FACTOR A7b(HsFA7b)plays a crucial role in this process in Arabidopsis,as the absence of functional HsFA7b results in the temporal suppression of sAM activity after *** found that HsFA7b directly regulates ethylene response at the sAM by binding to the promoter of the key ethylene signaling gene ETHYLENE-INsENsITIVE 3 to establish ***,we demonstrated that HsFA7b regulates the expression of ETHYLENE OVERPRODUCER 1(ETO1)and ETO1-LIKE 1,both of which encode ethylene biosynthesis repressors,thereby ensuring ethylene homeostasis at the *** together,these results reveal a crucial and tissue-specic role for HsFA7b in thermomemory at the Arabidopsis sAM.

关键词： ethylene response heat stress adaptation shoot apical meristem sAM thermopriming thermomemory

Enterprise applications of semantic technologies for business process management

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Journal of Zhejiang University-science C(Computers and Electronics) 2012年第4期13卷 308-310页

作者： ralf mueller Oracle BPM Product Development

1 Introduction Today’s business process management (BPM)systems have evolved to provide rich and sophisticated tooling and runtime support for subject

关键词：业务流程管理信息技术企业应用程序语义 Web本体语言 PM系统流程模型基础设施

The new kid on the block in insect pest management:sprayable RNAi goes commercial

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science China(Life sciences) 2024年第8期67卷 1766-1768页

作者： Junjie Yan ralf Nauen stuart Reitz Andrei Alyokhin Jiang Zhang David Mota-sanchez Yonggyun Kim subba Reddy Palli silvia I.Rondon Brian A.Nault Juan Luis Jurat-Fuentes Michael s.Crossley William E.snyder Angharad M.R.Gatehouse Myron P.Zalucki Bruce E.Tabashnik Yulin Gao state Key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Bayer AG Crop Science DivisionR&DPest ControlMonheim 40789Germany Department of Crop and soil science Oregon State UniversityOntario 97914USA school of Biology and Ecology University of MaineOrono 04469USA shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China Department of Entomology Michigan State UniversityEast Lansing 48864USA Department of Plant Medicals Andong National UniversityAndong 36729Republic of Korea Department of Entomology University of KentuckyLexington 40503USA Oregon state University Oregon Integrated Pest Management CenterCorvallis 97838USA Department of Entomology Cornell UniversityCornell AgriTechGeneva 14456USA Department of Entomology and Plant Pathology University of TennesseeKnoxville 37996USA Department of Entomology and Wildlife Ecology University of DelawareNewark 19716USA Department of Entomology University of GeorgiaAthensGeorgia 30602USA school of Natural and Environmental sciences Newcastle UniversityNewcastle upon TyneNE17RUUK school of the Environment University of QueenslandBrisbane 4072Australia shandong Engineering Research Center for Environment-Friendly Agricultural Pest Management College of Plant Health and MedicineQingdao Agricultural UniversityQingdao 266109China Department of Entomology University of ArizonaTucson 85721USA National Center of Excellence for Tuber and Root Crop Research Chinese Academy of Agricultural SciencesBeijing 100081China

Insect pest damage to crops is a threat to global food security(Tilman et al.,2011).Climate change,the evolution of insecticide resistance,and the phasing out of insecticides due to environmental and safety concerns exacerbate this *** urgently need safe and effective crop protection tools to sustainably generate yields that meet ever-increasing global demand.

关键词： crops damage pest

Equilibrium segregation to Free surface:Kinet ics and Experiment

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Chinese Physics Letters 1999年第5期16卷 364-366页

作者： CAO Ze-xian ralf mueller WANG En-ge NIE Yu-xin state Key Laboratory for surface Physics Institute of PhysicsChinese Academy of SciencesBeijing 100080 Department of Physics University Kaiserslautern67653 KaiserslauternGermany

Fick's first law is modified with an additional term df(x)/dx to describe the segregation phenomenon,f(x)is a local,analytical function related to the depth profile at *** thus can be determined experimentally by depth profiling *** starting in an initially homogeneous solid is described by an inhomogeneous diffusion equation on the half-infinite *** with and without formation of overlayer suggests different boundary *** solution for the Ansatz f(x)=as exp(-x/d_(s))is in perfect agreement with experimental results on sulphur segregation to the surface of *** from the detailed kinetics,activation energy can be inferred from the surface concentration evolution under different *** sulphur segregation in titanium,E_(act)=718 meV/atom.

关键词： technique. titanium sulphur

Is a Mini-screen for Fetal Alcohol spectrum Disorder Feasible?

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Open Journal of Pediatrics 2024年第4期14卷 767-781页

作者： Tyler mueller Devin Evavold June-Yung Kim Marilyn G. Klug Larry Burd school of Medicine and Health sciences University of North Dakota Grand Forks USA Department of social Work University of North Dakota Grand Forks USA

Background: Fetal Alcohol spectrum Disorders (FAsDs) are a global public health concern with lifelong consequences for affected individuals. Recent prevalence studies suggest FAsD prevalence rates range from 1-5% among school age children. Most people with FAsD are not correctly diagnosed and inadequate screening to identify patients with increased risk may contribute to under-diagnosis. This study developed a 10-item screening tool for FAsD and examined its feasibility. Methods: The sample consisted of 355 children who had been evaluated at an FAsD clinic. Data from the 33-item Alcohol Related Neurodevelopmental Disorder Behavioral Checklist was used to develop a brief FAsD screen by comparing the changes in Cronbach’s alpha for different combinations of items. The validity of the brief scale was then further examined using receiving operating characteristic analyses. Results: The 10-item screen demonstrated acceptable sensitivity, specificity, and accuracy to identify children at high risk for FAsD. The percentage correctly classified was 91.3 and the area under the receiving operating characteristic curve was 0.971. Conclusions: This feasibility study demonstrated that a screen for FAsD consisting of 10 items with yes or no responses can be completed in 3 - 4 minutes. The tool is brief, with a low administration burden and has acceptable epidemiologic performance characteristics including accuracy. Future research should examine the performance of this tool when used in larger, community-based populations where screening for FAsD would be appropriate.

关键词： Fetal Alcohol spectrum Disorders (FAsDs) Children screening Prevalence

Gonadal damage and options for fertility preservation in female and male cancer survivors

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Asian Journal of Andrology 2006年第5期8卷 515-533页

作者： Theodoros Maltaris Heinz Koelbl Rudolf seufert Franklin Kiesewetter Matthias W. Beckmann Andreas.mueller ralf Dittrich Department of Obstetrics and Gynecology Johannes Gutenberg University Mainz D-55124 Germany Division of Andrology Erlangen University Hospital University of Erlangen-Nuremberg Erlangen Germany Department of Obstetrics and Gynecology Erlangen University Hospital University of Erlangen-Nuremberg Erlangen Germany

It is estimated that in 2010, 1 in every 250 adults will be a childhood cancer survivor. Today, oncological surgery, radiotherapy and chemotherapy achieve relatively high rates of remission and long-term survival, yet are often detrimental to fertility. Quality of life is increasingly important to long-term survivors of cancer, and one of the major quality-of-life issues is the ability to produce and raise normal children. Developments in the near future in the emerging field of fertility preservation in cancer survivors promise to be very exciting. This article reviews the published literature, discusses the effects of cancer treatment on fertility and presents the options available today thanks to advances in assisted-reproduction technology for maintaining fertility in male and female patients undergoing this type of treatment. The various diagnostic methods of assessing the fertility potential and the efficacy of in vitro fertilization （IVF） after cancer treatment are also presented.

关键词： reproduction cryopreservation male infertility semen preservation fertility preservation cancer treatment ovarian tissue

Giant mid-IR resonant coupling to molecular vibrations in sub-nm gaps of plasmonic multilayer metafilms

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Light(science & Applications) 2022年第10期11卷 2476-2484页

作者： Rakesh Arul David-Benjamin Grys Rohit Chikkaraddy Niclas s.mueller Angelos Xomalis Ermanno Miele Tijmen Geuser Jeremy J.Baumberg NanoPhotonics Centre Cavendish LaboratoryDepartment of PhysicsJJ Thompson AvenueUniversity of CambridgeCambridge CB30HEUnited Kingdom The Faraday Institution Quad OneHarwell Science and Innovation CampusDidcotUnited Kingdom

Nanomaterials capable of confining light are desirable for enhancing spectroscopies such as Raman scattering,infrared absorption,and nonlinear optical *** superlattices have shown the ability to host collective resonances in the mid-infrared,but require stringent fabrication processes to create well-ordered ***,we demonstrate how short-range-ordered Au nanoparticle multilayers on a mirror,self-assembled by a sub-nm molecular spacer,support collective plasmon-polariton resonances in the visible and infrared,continuously tunable beyond 11 pm by simply varying the nanoparticle size and number of *** resulting molecule-plasmon system approaches vibrational strong coupling,and displays giant Fano dip strengths,sEIRA enhancement factors~106,light-matter coupling strengths g~100 cm-1,Purcell factors~106,and mode volume compression factors~*** collectiive plasmon-polariton mode is highly robust to nanoparticle vacancy disorder and is sustained by the consistent gap size defined by the molecular *** disorder efficiently couples light into the gaps between the multilayers and mirror,enabling Raman and infrared sensing of sub-picolitre sample volumes.

关键词： coupling collective mirror