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Nanofat: A therapeutic paradigm in regenerative medicine

World Journal of Stem Cells 2021年第11期13卷 1733-1746页

作者： Madhan Jeyaraman Sathish Muthu Shilpa sharma Charan Ganta rajni Ranjan Saurabh Kumar Jha Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater Noida 201306Uttar PradeshIndia Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater Noida 201306Uttar PradeshIndia Indian Stem Cell Study Group Lucknow 226010Uttar PradeshIndia Department of Orthopaedics Government Medical College and HospitalDindigul 624001Tamil NaduIndia Department of Pediatric Surgery All India Institute of Medical SciencesNew Delhi 110029New DelhiIndia Department of Stem Cells and Regenerative Medicine Kansas State UniversityManhattanUnited States 10002United States

Adipose tissue is a compact and well-organized tissue containing a heterogeneous cellular population of progenitor cells,including mesenchymal stromal *** to its availability and accessibility,adipose tissue is considered a“stem cell depot.”Adipose tissue products possess anti-inflammatory,anti-fibrotic,antiapoptotic,and immunomodulatory ***,being a compact bundle of stem cells with regenerative and tissue remodeling potential,has potential in translational and regenerative *** the wide range of applicability of its reconstructive and regenerative potential,the applications of nanofat can be used in various *** behaves on the line of adipose tissuederived mesenchymal stromal *** the site of injury,these stromal cells initiate a site-specific reparative response comprised of remodeling of the extracellular matrix,enhanced and sustained angiogenesis,and immune system *** properties of stromal cells provide a platform for the usage of regenerative medicine principles in curbing various *** about nanofat,including various preparation methods,characterization,delivery methods,evidence on practical applications,and ethical concerns are included in this ***,appropriate guidelines and preparation protocols for its optimal use in a wide range of clinical applications have yet to be standardized.

关键词： Adipose tissue Nanofat Stem cells Regenerative medicine Adipose stem cells

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Genetics of severe combined immunodeficiency

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Genes & Diseases 2020年第1期7卷 52-61页

作者： rajni Kumrah Pandiarajan Vignesh Pratap Patra Ankita Singh Gummadi Anjani Poonam Saini Madhubala sharma Anit Kaur Amit Rawat Allergy Immunology Unit Department of PediatricsAdvanced Pediatrics CentrePostgraduate Institute of Medical Education and ResearchChandigarhIndia

Severe Combined Immunodeficiency(SCID)is an inherited group of rare,lifethreatening disorders due to the defect in T cell development and *** manifestations are characterised by recurrent and severe bacterial,viral,and fungal opportunistic infections that start from early infancy *** stem cell transplantation(HSCT)is the treatment of *** pattern of inheritance of SCID may be X-linked or autosomal *** the diagnosis of SCID is usually established by flow cytometry-based tests,genetic diagnosis is often needed for genetic counselling,prognostication,and modification of pre-transplant chemotherapeutic *** review aims to highlight the genetic aspects of SCID.

关键词： Adenosine deaminase Flow cytometry Genetics Newborn screening Severe combined immunodeficiency

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Underpinning the molecular programming attributing heat stress associated thermotoleranee in tea (Camellia sinensis (L.) O. Kuntze)

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Horticulture Research 2021年第1期8卷 1333-1351页

作者： Romit Seth Tony Kipkoech Maritim rajni Parmar Ram Kumar sharma Biotechnology Department CSIR-I nstitute of Himalayan Bioresource Technology(CSIR-IHBT)PalampurHimachal Pradesh 176061India Academy of Scientific and Innovative Research(AcSIR) CSIR-HRDC CampusGhaziabadUttar Pradesh 201002India Teabreeding and genetic improvement division KALRO-Tea Research InstituteBox 82020200 KerichoKenya

The most daunting issue of global climate change is the deleterious impact of extreme temperatures on tea productivity and quality,which has resulted in a quest among researchers and *** current study aims to unravel molecular programming underpinning thermotolerance by characterizing heat tolerance and sensitivity response in 20 tea *** signi fi cantly higher negative in fl uence of heat stress was recorded in a sensitive cultivar with reduced water retention(47%),chlorophyll content(33.79%),oxidation potential(32.48%),and increase in membrane damage(76.4%).Transcriptional pro fi ling of most tolerant and sensitive cultivars identi fi ed 78 differentially expressed unigenes with chaperon domains,including low and high molecular weight heat shock protein(HSP)and heat shock transcription factors(HSFs)involved in heat shock response(HSR).Further,predicted transcriptional interactome network revealed their key role in thermotolerance via well-co-ordinated transcriptional regulation of aquaporins,starch metabolism,chlorophyll biosynthesis,calcium,and ethylene mediated plant signaling *** study identi fi ed the key role of HSPs(CsHSP90)in regulating HSR in tea,wherein,structure-based molecular docking revealed the inhibitory role of geldanamycin(GDA)on CsHSP90 by blocking ATP binding site at N-terminal domain of predicted ***,GDA mediated leaf disc inhibitor assay further af fi rmed enhanced HSR with higher expression of CsHSP17.6,CsHSP70,HSP101,and CsHSFA2 genes in *** the current study,efforts were made to extrapolate a deeper understanding of chaperons mediated regulation of HSR attributing thermotolerance in tea.

关键词： metabolism programming stress

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Medication adherence and quality of life among type-2 diabetes mellitus patients in India

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World Journal of Diabetes 2021年第10期12卷 1740-1749页

作者： Rakhi Mishra Suresh K sharma rajni Verma Priyanka Kangra Preeti Dahiya Preeti Kumari Priya Sahu Priyanka Bhakar Reena Kumawat Ravinder Kaur Ravinder Kaur Ravi Kant College of Nursing All India Institute of Medical SciencesUttarakhand 249203RishikeshIndia Department of Medicine All India Institute of Medical SciencesUttarakhand 249203RishikeshIndia

BACKGROUND Diabetes mellitus(DM)is a progressively increasing metabolic disorder and a significant public health burden that demands immediate global ***,there is a paucity of data about adherence to antidiabetic drugs among patients with type-2(T2)DM in Uttarakhand,*** research reported that more than 50%of patients do not adhere to the correct administration and appropriate medicine *** has been reported that patients with chronic diseases who adhere to treatment may experience improvement in quality of life(QoL)and vice *** To assess the adherence to antidiabetic medication and QoL among patients with *** This cross-sectional descriptive study was conducted at a tertiary care hospital in Uttarakhand,*** Medication Adherence Rating Scale and World Health Organization QoL-BREF scale were used to assess medication adherence and *** Two hundred seventy-seven patients suffering from T2DM participated in the *** mean age was 50.80(±10.6)years,155(56%)had a poor adherence level and 122(44%)had a good adherence level to antidiabetic *** adjusting for sociodemographic factors,multiple linear regression analysis found patients who were adherent to antidiabetic medications had significantly higher mean overall perception of QoL and overall perception of health,with beta scores of 0.36 and 0.34,respectively(both P=0.000)points compared with nonadherent *** There was an association between medication adherence and QoL in patients with ***,there is a need to plan awareness and counseling programs followed by regular follow-up to motivate patient adherence to recommended treatment and lifestyle regimens.

关键词： Medication adherence Quality of life Diabetes mellitus Tertiary care hospital India

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