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Efficacy of stromal vascular fraction for knee osteoarthritis:A prospective,single-centre,non-randomized study with 2 years follow-up

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World Journal of Orthopedics 2024年第5期15卷 457-468页

作者： Madhan Jeyaraman Naveen Jeyaraman Tarun Jayakumar Swaminathan Ramasubramanian rajni Ranjan Saurabh Kumar Jha Ashim Gupta Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennaiTamil Nadu 600077India Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater NoidaUttar Pradesh 201310India Department of Orthopaedics and Regenerative Medicine South Texas Orthopaedic Research InstituteLaredoTX 78045United States Department of Orthopaedics KIMS-Sunshine HospitalHyderabadTelangana 500032India Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennaiTamil Nadu 600002India Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh 201306India Department of Zoology Kalindi CollegeUniversity of DelhiNew Delhi 110008India Department of Orthopaedics and Regenerative Medicine Regenerative OrthopaedicsNoida 201301Uttar PradeshIndia Department of Orthopaedics and Regenerative Medicine Future BiologicsLawrencevilleGA 30043United States Department of Orthopaedics and Regenerative Medicine BioIntegrateLawrencevilleGA 30043United States

BACKGROUND Current osteoarthritis(OA)treatments focus on symptom relief without addressing the underlying disease *** regenerative medicine,current treatments have *** regenerative medicine,more research is needed for intra-articular stromal vascular fraction(SVF)injections in OA,including dosage optimization,long-term efficacy,safety,comparisons with other treatments,and mechanism *** To compare the efficacy of intra-articular SVF with corticosteroid(ICS)injections in patients with primary knee *** The study included 50 patients with Kellgren-Lawrence grades II and III *** were randomly assigned(1:1)to receive either a single intra-articular SVF injection(group A)or a single intra-articular ICS(triamcinolone)(group B)*** were followed up at 1,3,6,12,and 24 *** analog score(VAS)and International Knee Documentation Committee(IKDC)scores were administered before the procedure and at all *** safety of SVF in terms of adverse and severe adverse events was *** analysis was performed with SPSS Version 26.0,IBM Corp,Chicago,IL,United *** Both groups had similar demographics and baseline clinical ***-up showed minor patient loss,resulting in 23 and 24 in groups A and B *** A experienced a notable reduction in pain,with VAS scores decreasing from 7.7 to 2.4 over 24 months,compared to a minor reduction from 7.8 to 6.2 in Group *** difference in pain reduction in group A was statistically significant from the third month ***,Group A showed significant improvements in knee functionality,with IKDC scores rising from 33.4 to 83.10,whereas Group B saw a modest increase from 36.7 to *** improvement in Group A was statistically significant from 6 months and maintained through 24 *** Our study demonstrated that intra-articular administration of SVF can lead to reduced pain and improved knee function in pa

关键词： Knee osteoarthritis Adipose tissue Stromal vascular fraction Regenerative medicine Orthobiologics

Increased alcohol consumption during the COVID-19 pandemic:A cross-sectional study

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World Journal of Clinical Cases 2024年第18期12卷 3410-3416页

作者： rajni Rathore Shahid Bakhsh Rangrej Victoria Carvalho Department of Pharmacology and Therapeutics Saint James School of MedicineArnos Vale VC0280Saint Vincent and the Grenadines Department of Anatomy and Research Saint James School of MedicineArnos Vale VC0280Saint Vincent and the Grenadines Medical School Basic Sciences Saint James School of MedicineArnos Vale VC0280Saint Vincent and the Grenadines

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has significantly impacted health,mental well-being,and societal functioning,particularly for individuals with psychiatric conditions and substance use *** evidence highlights a concerning increase in alcohol consumption during the pandemic,with a study spanning 2015-2020 indicating heightened usage,especially among young and middle-aged adults,for relaxation and tension ***,addressing challenges exacerbated by the pandemic,another study underscored persistent barriers to healthcare access,resulting in increased alcohol and tobacco use rates and limited healthcare *** findings shed light on the unique vulnerabilities exposed by the pandemic,emphasizing the need to investigate further its impact on alcohol consumption in diverse non-urban American *** To investigate the impact of the COVID-19 pandemic on alcohol abuse using socioeconomic and medical parameters in diverse non-urban community in *** Based on a cross-sectional analysis of 416 participants the United States in 2021,the study utilized The Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition criteria to categorize alcohol consumption *** aged 21 years and above were surveyed through an online platform due to COVID-19 *** survey was conducted from January 14 to January 31,2022,recruiting participants via social media and ensuring *** consent was secured,emphasizing the voluntary nature of participation,and participants could only take the survey *** Out of 416 survey respondents,396 met eligibility criteria,with 62.9%reporting increased alcohol consumption during ***(68.8%)and ages 21-29 years(34.6%)*** alcohol consumption decreased by 2.8%(P=0.237),moderate by 21.4%(P<0.001),and heavy increased by 14.9%(P<0.001).Alcohol abuse rose by 6.5%(P=0.0439),with a 7%increase in self-identified alcohol abuser

关键词： Alcoholism 2019 Novel coronavirus SARS-CoV-2 COVID-19 Mental health issue

Hindi translation and validation of the English version of the gastrointestinal symptom rating scale questionnaire:An observational study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第5期15卷 33-39页

作者： Neha Jindal Anuraag Jena Krishan Kumar Bijaya K Padhi rajni Sharma Vaneet Jearth Usha Dutta Vishal Sharma Department of Gastroenterology Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India Department of Psychiatry Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India Department of Community Medicine and School of Public Health Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India Advanced Pediatric Centre Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India

BACKGROUND The gastrointestinal symptom rating scale(GSRS)is a questionnaire in English language which is designed to assess the clinical symptoms in patients with irritable bowel syndrome(IBS)and peptic ulcer *** validated scale has questions on around 15 items and has been validated in patients with dyspepsia and *** To translate and validate the English version of the GSRS questionnaire to the Hindi *** The purpose of the present work was to create a Hindi version of this questionnaire for use in the Indian *** process involved various steps as per the World Health Organization methodology including initial forward translation,backward translation,and assessment by an expert *** pilot testing was followed by testing in healthy and diseased *** The Hindi translation was pilot tested in 20 individuals and further validated in healthy controls(n=30,15 females)and diseased individuals(n=72,27 females).The diseased group included patients with functional dyspepsia and ***'s alpha for internal consistency on the final translated GSRS questionnaire was 0.715 which is considered *** questions significantly differentiated the diseased population from the healthy population(P value<0.05)in the translated Hindi version of the *** The translated Hindi GSRS can be used to evaluate gastrointestinal function in clinical trials and community surveys in Hindi speaking populations.

关键词： Irritable bowel syndrome Gut health Dyspepsia Symptoms Pain Constipation Diarrhoea

Boundary Element Modeling of Multiconnected Ocean Basin in Visakhapatnam Port Under the Resonance Conditions

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China Ocean Engineering 2021年第5期35卷 662-675页

作者： Prashant KUMAR Prachi PRIYA rajni Department of Applied Sciences National Institute of Technology DelhiDelhi 110040India Jindal Global Business School O P Jindal Global UniversitySonipatHaryana 131001India

A mathematical model has been developed to analyze the influence of extreme water waves over multiconnected regions in Visakhapatnam Port,India by considering an average water depth in each multiconnected *** addition,partial reflection of incident waves on coastal boundary is also *** domain of interest is divided mainly into two regions,i.e.,open sea region and harbor region namely as Region-I and Region-II,***,Region-II is divided into multiple connected *** 2-D boundary element method(BEM)including the Chebyshev point discretization is utilized to solve the Helmholtz equation in each region separately to determine the wave *** numerical convergence is performed to obtain the optimum numerical accuracy and the validation of the current numerical approach is also conducted by comparing the simulation results with existing *** four key spots based on the moored ship locations in Visakhapatnam Port are identified to perform the numerical *** wave amplification at these locations is estimated for monochromatic incident waves,considering approximate water depth and different reflection coefficients on the wall of port under the resonance *** addition,wave field analysis inside the Visakhapatnam Port is also conducted to understand resonance *** current numerical model provides an efficient tool to analyze the amplification on any realistic ports or harbors.

关键词： boundary element method amplification factor Helmholtz equation reflection coefficient Visakhapatnam Port

A Modified Proximity Approach in the Fusion of Heavy Ions

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Chinese Physics Letters 2010年第11期27卷 43-46页

作者： Ishwar Dutt rajni Bansal Department of Physics Panjab University Chandigarh-160014 India

By using a suitable set of the surface energy coefficient, nuclear radius, and universal function, the original proximity potential 1977 is modified. The overestimate of the data by 4% reported in the literature is significantly reduced. Our modified proximity potential reproduces the experimental data nicely compared to its older versions.

关键词： Nuclear physics

Mathematical Modeling of Moored Ship Motion in Arbitrary Harbor utilizing the Porous Breakwater

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China Ocean Engineering 2023年第5期37卷 738-752页

作者： Prachi Priya Prashant Kumar Gulshan rajni Government Model Sanskriti Senior Secondary School Ganaur Sonipat 131101India Department of Applied Sciences(Mathematics) National Institute of TechnologyDelhi 110036India JindalGobal Business School O.P.Jindal Global UniversitySonepat 131001India

The motion of the moored ship in the harbor is a classical hydrodynamics problem that still faces many challenges in naval operations,such as cargo transfer and ship pairings between a big transport ship and some small ships.A mathematical model is presented based on the Laplace equation utilizing the porous breakwater to investigate the moored ship motion in a partially absorbing/reflecting *** motion of the moored ship is described with the hydrodynamic forces along the rotational motion(roll,pitch,and yaw)and translational motion(surge,sway,and heave).The efficiency of the numerical method is verified by comparing it with the analytical study of Yu and Chwang(1994)for the porous breakwater,and the moored ship motion is compared with the theoretical and experimental data obtained by Yoo(1998)and Takagi et al.(1993).Further,the current numerical scheme is implemented on the realistic Visakhapatnam Fishing port,India,in order to analyze the hydrodynamic forces on moored ship motion under resonance *** model incorporates some essential strategies such as adding a porous breakwater and utilizing the wave absorber to reduce the port’s *** has been observed that these tactics have a significant impact on the resonance inside the port for safe maritime ***,the current numerical model provides an efficient tool to reduce the resonance within the arbitrarily shaped ports for secure anchoring.

关键词： boundary element method Laplace equation porous breakwater partially reflecting/absorbing harbor wall moored ship motion

Optimal Eighth Order Convergent Iteration Scheme Based on Lagrange Interpolation

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Acta Mathematicae Applicatae Sinica 2017年第4期33卷 1093-1102页

作者： rajni SHARMA Ashu BAHL Department of Applied Sciences D.A.V. Institute of Engineering and Technology Kabir Nagar Jalandhar 144008 India Research Scholar I.K. Gujral Punjab Technical University Jalandhar-Kapurthala Highway Kapurthala-144601 Punjab India Department of Mathematics D.A.V. College Jalandhar 144008 India

In this paper, based on fourth order Ostrowski method, we derive an optimal eighth order iteration scheme for obtaining simple roots of nonlinear equations using Lagrange interpolation and suitable weight functions. The scheme requires three evaluations of the function and one evaluation of the first derivative per iteration. Numerical examples are included to confirm the theoretical results and to show the competitive performance of the proposed iteration scheme.

关键词： nonlinear equations Ostrowski method Lagrange interpolation order of convergence efficiencyindex

A new lignan rhamnoside from Bauhinia retusa seed pods(Caesalpiniaceae)

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Chinese Chemical Letters 2011年第9期22卷 1081-1083页

作者： Sushma Semwal rajni Kant Sharma Department of Chemistry HNB Garhwal Central University SrinagarUttarakhandIndia Department of Chemistry University of Cape TownCape TownRondebosch 7701South Africa

A new lignan rhamnoside identified as 2,6-di（4＇,5＇-dihydroxyphenyl）-3,7-dioxabicyclo[3.3.0]octane-1-hydroxy-5-O-rhamnopyranoside （1） has been isolated from the ethanolic extract of seed pods of Bauhinia retusa. ... 详细信息

关键词： Bauhinia retusa Caesalpiniaceae Lignan rhamnoside

Renal gluconeogenesis in insulin resistance:A culprit for hyperglycemia in diabetes

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World Journal of Diabetes 2021年第5期12卷 556-568页

作者： rajni Sharma Swasti Tiwari Department of Molecular Medicine and Biotechnology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014India

Renal gluconeogenesis is one of the major pathways for endogenous glucose *** in this process may contribute to hyperglycemia in cases with insulin resistance and *** reviewed pertinent studies to elucidate the role of renal gluconeogenesis regulation in insulin resistance and diabetes.A consensus on the suppressive effect of insulin on kidney gluconeogenesis has started to build ***-resistant models exhibit reduced insulin receptor(IR)expression and/or post-receptor signaling in their kidney *** IR expression or post-receptor signaling can cause impairment in insulin’s action on kidneys,which may increase renal gluconeogenesis in the state of insulin *** is now established that the kidney contributes up to 20%of all glucose production via gluconeogenesis in the post-absorptive ***,the rate of renal glucose release excessively increases in *** rise in renal glucose release in diabetes may contribute to fasting hyperglycemia and increased postprandial glucose *** glucose release by the kidneys and renal expression of the gluconeogenic-enzyme in diabetic rodents and humans further point towards the significance of renal ***,the available literature suggests that impairment in renal gluconeogenesis in an insulinresistant state may contribute to hyperglycemia in type 2 diabetes.

关键词： Renal gluconeogenesis Insulin-resistance Insulin Insulin receptor signaling Diabetes Gluconeogenic enzymes