检索结果-南通市图书馆

Chlorogenic acid may be a potent inhibitor of dimeric SARS-CoV-2 main protease 3CLpro: an in silico study

Traditional Medicine Research 2021年第2期6卷 135-148页

作者： rajkumar sanjay patil Nayeem A.Khatib Vishal Shivalingappa patil Shailendra sanjay Suryawanshi Department of Pharmacology and Toxicology KLE College of PharmacyBelagaviKLE Academy of Higher Education and ResearchJNMC CampusNehru NagarBelagavi 590010KarnatakaIndia Department of Pharmaceutical Chemistry KLE College of PharmacyBelagaviKLE Academy of Higher Education and ResearchJNMC CampusNehru NagarBelagavi 590010KarnatakaIndia

Background:Since the emergence of coronavirus disease 2019 to date,there is no available approved drug or definitive treatment for coronavirus disease 2019 viral infection,and the identification of novel hits against therapeutic targets has become a global *** purpurea is a traditional herb utilized to treat cough,fever,sore throat,respiratory tract infection,and so on as an immune *** this study,in silico molecular docking approach was used to screen phytocompounds from *** against severe acute respiratory syndrome coronavirus 2 main protease 3C-like protease(3CLpro)and severe acute respiratory syndrome coronavirus main peptidase(96%sequence similarity)to blunt the viral gene expression and viral ***:Initially,we screened phytocompounds for their druggability and ADMET ***,x-ray crystallographic structures of main proteases 3CLpro and main peptidase having Protein Data Bank ID 6LU7 and 2GTB were used as protein targets for the identification of potential drug *** performed docking using AutoDock Vina by PyRx 0.8 *** Discovery Studio Visualizer v2019 was used to analyze ligand-protein *** probable protein targets of the selected compound were predicted by BindingDB(P≥0.7).STRING and Kyoto Encyclopedia of Genes and Genomes pathways are utilized to identify the molecular pathways modulated by the predicted targets(FDR≤0.05),and the network interaction between compounds and protein pathways was constructed by Cytoscape ***:Among all the compounds,chlorogenic acid showed druggable characteristics and scored the lowest binding energy with main protease and main peptidase via interacting with active site 1 domain amino acid ***,chlorogenic acid interacted with Phe140 main protease 3CLpro,which is potentially involved in the *** analysis identified chlorogenic acid to modulate insulin resistance,necroptosis,interleukin-17,tumor nec

关键词： Molecular docking Echinacea purpurea Chlorogenic acid COVID-19 Main protease 3CLpro Network pharmacology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Case of Large Anterior Meningocele Associated with Uterine Didelphys

引用

Open Journal of Modern Neurosurgery 2024年第2期14卷 104-107页

作者： Joseph Maalouly Matt Wilson sanjay Adusumilli Vijidha rajkumar Shanu Gambhir Department of Neurosurgery Norwest Private Hospital Bella Vista Australia Department of Obstetrics and Gynecology Norwest Private Hospital Bella Vista Australia Department of General Surgery Norwest Private Hospital Bella Vista Australia

We report a 27-year-old female who presented with abdominal distension, saddle anesthesia, and lower back pain. CT and MRI of the abdomen/spine were performed which showed a large anterior sacral meningocele occupying most of the pelvic and abdominal cavity and displacement of their respective contents. Anterior approach was chosen, uterine didelphys was identified and mobilized, meningocele identified and gentle drainage with subsequent resection of the cyst wall and watertight closure was achieved. Subsequent MRI demonstrated resolution of most the sacral meningocele. Patient symptoms improved and are doing well.

关键词： Sacral Agenesis Curarino Triad Large Meningocele

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inverse modelling of aquifer parameters in basaltic rock with the help of pumping test method using MODFLOW software

引用

Geoscience Frontiers 2017年第6期8卷 1385-1395页

作者： Kanak Moharir Chaitanya Pande sanjay patil Sant Gadge Baba Amravati University AmravatiIndia Maharashtra Remote Sensing Application Center PuneIndia

The origin and movement of groundwater are the fundamental questions that address both the temporal and spatial aspects of ground water run and water supply related issues in hydrological *** groundwater flows through an aquifer,its composition and temperature may variation dependent on the aquifer condition through which it ***,hydrologic investigations can also provide useful information about the subsurface geology of a *** because such studies investigate processes that follow under the Earth's shallow,obtaining the information necessary to answer these questions is not continuously ***,which discharge groundwater table directly,afford to study subsurface hydrogeological *** present study of estimation of aquifer factors such as transmissivity(T)and storativity(S)are vital for the evaluation of groundwater *** are several methods to estimate the accurate aquifer parameters(*** analysis,pumping test,etc.).In initial days,these parameters are projected either by means of in-situ test or execution test on aquifer well samples carried in the *** simultaneous information on the hydraulic behavior of the well(borehole)that provides on this method,the reservoir and the reservoir boundaries,are important for efficient aquifer and well data management and *** most common in-situ test is pumping test performed on wells,which involves the measurement of the fall and increase of groundwater level with respect to *** alteration in groundwater level(drawdown/recovery)is caused due to pumping of water from the ***(1935)was first to propose method to evaluate aquifer parameters from the pumping test on a bore well in a confined *** is essential to know the transmissivity(T=Kb,where b is the aquifer thickness;pumping flow rate,Q=TW(dh/dl)flow through an aquifer)and storativity(confined aquifer:S=bS_s,unconfined:S=S_y),for the characterization of the aquifer parameters in an unkn

关键词： Pumping test Hantush method GPS MODFLOW Inverse modelling Hydraulic parameters

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dual-tree complex wavelet transform and super-resolution based video inpainting application to object removal and error concealment

引用

CAAI Transactions on Intelligence Technology 2020年第4期5卷 314-319页

作者： Gajanan Tudavekar sanjay R.patil Santosh S.Saraf Department of Electronics&Communication Engineering Angadi Institute of Technology and ManagementBelagaviKarnatakaIndia Visvesvaraya Technological University BelagaviKarnatakaIndia Department of Electronics&Telecommunication Engineering Marathwada Institute of TechnologyAurangabadMaharashtraIndia Department of Electronics&Communication Engineering KLS Gogte Institute of TechnologyBelagaviKarnatakaIndia

Video inpainting is a technique that fills in the missing regions or gaps in a video by using its known *** existing video inpainting algorithms are computationally expensive and introduce seam in the target region that arises due to variation in brightness or contrast of the *** overcome these drawbacks,the authors propose a novel two-stage *** the first step,sub-bands of wavelets of a low-resolution image are obtained using the dualtree complex wavelet *** algorithm and auto-regression technique are then applied to these subbands to inpaint the missing *** fuzzy logic-based histogram equalisation is used to further enhance the image by preserving the image brightness and improve the local *** the second step,the image is enhanced using super-resolution *** process of down-sampling,inpainting and subsequently enhancing the video using the super-resolution technique reduces the video inpainting *** framework is tested on video sequences by comparing and analysing the structural similarity index matrix,peak-signal-to-noise ratio,visual information fidelity in pixel domain and execution time with the state-of-the-art *** experimental analysis gives visually pleasing results for object removal and error concealment.

关键词： resolution video image

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Case of Large Anterior Meningocele Associated with Uterine Didelphys

引用

Open Journal of Modern Neurosurgery（现代神经外科学进展） 2024年第2期 104页

作者： Joseph Maalouly Matt Wilson sanjay Adusumilli Vijidha rajkumar Shanu Gambhir

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Potential of herbal constituents as new natural leads against helminthiasis: A neglected tropical disease

引用

Asian Pacific Journal of Tropical Medicine 2019年第7期12卷 291-299页

作者： Kiran D.patil Shashikant B.Bagade sanjay R.Sharma Ketan V.Hatware NMIMS School of Pharmacy and Technology Management

The WHO reports that billions of people and animals in tropical and subtropical regions are affected by helminthiasis as neglected tropical disease. It is predominant in underdeveloped areas;nevertheless, the increase in the number of travelers and migrants has made this infection more common. The current mass drug treatment produces severe side effects and many strains of helminths are resistant to them. None of the chemotherapeutic drugs meets the ideal requirements of anthelmintics, such as broad spectrum of activity, single dose cure, free from side effect and cost-effectiveness. Today, many researchers are screening the traditional herbal system in search of the anthelmintic herbal constituents which overcome all the problems of synthetic drugs. Several researchers proclaim anthelmintic activity of herbal medicines by using different experimental models. The present review demonstrates natural product drug discovery, outlining potential of herbal constituents from natural sources as natural leads against helminthiasis.

关键词： Neglected tropical diseases Herbal constituents Helminthiasis Herbal anthelmintics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dual inhibition of COVID-19 spike glycoprotein and main protease 3CLpro by Withanone from Withania somnifera

引用

Chinese Herbal Medicines 2021年第3期13卷 359-369页

作者： Vishal Shivalingappa patil Vrushabh B.Hupparage Ajay P.Malgi sanjay H.Deshpande Sathgowda A.patil Shamanand P.Mallapur Department of Pharmacology and Toxicology KLE College of PharmacyKLE Academy of Higher Education and Research(KAHER)Belagavi 590010India Regional Centre for Biotechnology NCR-Biotech Science ClusterFaridabad 121001India

Objective:To identify the safe and effective natural inhibitors of spike glycoprotein and main protease 3CLpro using potential natural antiviral compounds which are studied under various animal models and viral cell ***:First,compounds were retrieved from the Pub Chem database and predicted for their druggability using the Mol Soft web server,and compounds having drug-like property were predicted for major adverse drug reactions like cardiotoxicity,hepatotoxicity,arrhythmia,myocardial infarction,and nephrotoxicity using *** of nontoxic antiviral compounds with spike glycoprotein and main protease 3CLpro was performed using Auto Dock vina by PyRx 0.8 *** stability of compoundprotein interactions was checked by molecular dynamic(MD)simulation using Schrodinger Desmond ***:Based on the druggable and nontoxic profile,nine compounds were *** them,Withanone from Withania somnifera showed the highest binding affinity and best fit at active sites 1 of spike glycoprotein(glycosylation site)and main protease 3CLpro via interacting with active site amino acid residues before and after MD simulation at 50 ***,which may reduce the glycosylation of SARS-CoV-2 via interacting with Asn343 and inhibit viral ***:The current study reports Withanone as a non-toxic antiviral against SARS-CoV-2 and serve as a potential lead hit for further experimental validation.

关键词： antiviral COVID-19 docking dynamics main protease 3CLpro SARS-CoV-2 spike glycoprotein Withanone Withania somnifera(Linn.)Dunal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of skeletal, dental and soft tissue changes in young adults with Class II malocclusion, treated either by camouflage, fixed functional appliance or orthognathic surgery—A prospective study on Indian subjects

引用

Open Journal of Stomatology 2012年第4期2卷 373-382页

作者： Anjana Shetty Anand patil sanjay Ganeshkar Department of Orthodontics and Dentofacial Orthopaedics AECS Maaruthi Dental College Banglore India Department of Orthodontics and Dentofacial Orthopaedics SDM College of Dental Sciences Dharwad India

Introduction: Borderline Class II malocclusion due to deficient mandible can be treated either by orthodontic camouflage, fixed functional appliances or by orthodontics followed by surgical mandibular advancement. Methodology: A prospective study was designed on young adults with Class II malocclusion on account of a deficient mandible. A total of 45 subjects were divided into three groups of 15 individuals each. The patients were treated either by camouflage, fixed functional appliances or by orthognathic surgery. Pre and post treatment cephalograms were used to assess the skeletal, dental and soft tissue changes. Pre and post treatment profile photographs were assessed on a Visual Analogue Scale (VAS) by orthodontists, oral surgeons and laypersons. Results: Each group achieved a reduction in facial convexity, but the results obtained from the surgical group were more pronounced than the camouflage and the fixed functional group. Conclusion: The reduction in convexity in the camouflage group was by retracting the upper anteriors, which increases the nasolabial angle. In the fixed functional appliance a combination of skeletal and dentoalveolar changes can be observed. However the most appropriate reduction in profile convexity can be obtained by combined orthodontic and surgical treatment of malocclusion.

关键词： Class II Malocclulsion Camouflage Fixed Function Appliance Orthognathic Surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Graphene-wrapped Ag3PO4/LaCO3OH heterostructures for water purification under visible light

引用

Journal of Energy Chemistry 2016年第5期25卷 845-853页

作者： Santosh S.patil Mukund G.Mali Animesh Roy Mohaseen S.Tamboli Virendrakumar G.Deonikar Deepak R.patil Milind V.Kulkarni Salem S.Al-Deyab Sam S.Yoon sanjay S.Kolekar Bharat B.Kale Centre for Materials for Electronics Technology(C-MET) Departnent of Electronics and Information Technology(DeitY)Govt.of IndiaPuneIndia Analytical Chemistry and Material Science Laboratory Department of ChemitryShivaji UniversityKolhapurMS India Solar Cell■Aerosol Science Laboratory School of Mech.EngKorea UniversitySeoulSouth Korea and School of Chemical SciencesSolapur UniversitySolapurMSIndia Petrochemical Research Chair Department of ChemistryKing Saud UniversityRiyadhSaudi Arabia

We demonstrated a unique synthesis approach of graphene（GR）-wrapped AgPO/LaCOOH（APO/LCO）heterostructures by an in-situ wet chemical method. FESEM analysis reveals the formation of rhombic dodecahedrons of APO decorated with LCO and later wrapped with GR flakes. Optical studies shows two absorption edges corresponding to the band gap energies of APO（2.41 eV） and LCO（4.1 eV）. Considering the absorption edge of the heterostructures in the visible region, the photocatalytic activities of photocatalysts containing different APO/LCO mass ratios were evaluated by the degradation of MB. GR-decorated composite with 20% LCO（APO/LCO20/GR） exhibited the highest photocatalytic activity for MB degradation, with a rate constant, k of 0.541 min. The photocatalytic activity of APO/LCO20/GR more greatly enhanced than those of the individual constituents（APO, LCO, APO/LCO20）. The enhanced photocatalytic activity of the heterostructure can be attributed to the co-catalytic effect of LCO as well as intriguing physicochemical properties of GR. To understand the enhanced photocatalytic activity of the heterostructures the photocatalytic reaction mechanism is proposed in detail. The recyclability of the APO/LCO/GR composite photocatalyst is further evaluated by reusing the catalyst in replicate photocatalytic experiments which shows consistent photocatalytic activity thereby confirms the stability and reusability of heterostructure photocatalyst.

关键词： Ag3PO4 LaCO3OH Graphene Heterostructures Photocatalytic MB degradation Co-catalyst

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aloin attenuates chronic constriction injury-induced neuropathic pain in rats by inhibiting inflammatory cytokines and oxidative stress

引用

Asian Pacific Journal of Tropical Biomedicine 2021年第5期11卷 205-213页

作者： Aarti S.Kale Avinash R.Wadkar Umesh B.Mahajan Lalit A.Birari Sateesh Belemkar Sameer N.Goyal Shreesh Ojha sanjay J.Surana Chandragouda R.patil Kalpesh R.patil Department of Pharmacology R.C.Patel Institute of Pharmaceutical Education and ResearchShirpur-425405Dist.DhuleMaharashtraIndia School of Pharmacy&Technology Management SVKM's NMIMSMPTPShirpur-425405Dist-DhuleMaharashtraIndia Shri Vile Parle Kelavani Mandal's Institute of Pharmacy Dhule-424001MaharashtraIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityP.O.Box 17666Al AinAbu DhabiUAE Department of Pharmacognosy R.C.Patel Institute of Pharmaceutical Education and ResearchShirpur-425405Dist.DhuleMaharashtraIndia

Objective:To investigate the effect of aloin against chronic constriction injury(CCI)-induced neuropathic pain in ***:Rats were randomly divided into 7 groups:GroupⅠ(normal control),GroupⅡ(sham-operated),GroupⅢ(CCI control)and GroupⅣ,Ⅴ,Ⅵ,andⅦ,which underwent CCI surgery and then were administered with aloin(5 mg/kg,p.o.;25 mg/kg,p.o.;125 mg/kg,p.o.)and gabapentin(50 mg/kg,p.o.),respectively for 14 *** neuropathy was induced by silk ligatures(4-0)loosely placed around the sciatic *** thresholds against mechanical stimuli(Von-Frey filaments)and thermal stimuli(12℃and 40℃)were measured at midplantar paw region ipsilateral to the compressed nerve on day-3,7,11,and *** concentration of cytokines including tumor necrosis factor-α(TNF-α),interleukin-6,and interleukin-1βwas estimated at *** day 14,motor nerve conduction velocity was determined under urethane anesthesia(1.25 g/kg).Oxidative stress parameters(malondiadehyde,glutathione,catalase,and superoxide dismutase)were estimated in sciatic nerve homogenates at day *** nerve samples were processed for histological ***:Aloin significantly reduced CCI-induced mechanical and thermal *** also improved motor nerve conduction velocity and decreased oxidative stress in nerve *** addition,it decreased pro-inflammatory cytokine levels and restored the histoarchitecture of compressed sciatic ***:Aloin mitigates CCI-induced neuropathic pain in rats by inhibiting oxidative stress and pro-inflammatory cytokines in the afflicted sciatic nerve.

关键词： Aloin Chronic constriction injury Antioxidant Neuropathic pain

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：