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In-silico and in-vitro evaluation of docetaxel and berberine as potential p53 modulating apoptotic inducers in oral squamous cell carcinoma

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Asian Pacific Journal of Tropical Biomedicine 2022年第12期12卷 530-540页

作者： Smrutipragnya Samal rajesh kumar Meher Debasmita Dubey Showkat Ahmad Mir Binata Nayak Mahesh Chandra Sahu Pradeep kumar Naik Goutam Rath Santosh kumar Swain Department of Otorhinolaryngology and Head and Neck Surgery IMS and SUM HospitalSiksha‘O’Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyotiviharBurlaSambalpurOdishaIndia Medical Research Laboratory IMS and SUM HospitalSiksha‘O’Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia School of Life Sciences Sambalpur UnivesityJyotiviharBurlaSambalpurOdishaIndia ICMR-Regional Medical Research Centre ChandrasekharpurBhubaneswar-751023India School of Pharmaceutical Sciences Siksha‘O’Anusandhan Deemed to be UniversityBhubaneswar-751030India

Objective:To investigate the interaction of p53 with docetaxel and berberine and their anticancer activities against oral squamous cell ***:The interaction between p53 with docetaxel and berberine was investigated and their mechanisms of action against oral squamous cell carcinoma were *** studies were performed to determine any toxic impact of the drugs on the vital organs of tested ***:In silico results revealed the molecular interaction of docetaxel and berberine with p53 and the molecules were found to be potential p53 *** and berberine inhibited the proliferation of cancer cells in a concentration-dependent *** cytometry analysis revealed that docetaxel and berberine at IC50 concentrations upregulated the expression of p53 in oral squamous cell carcinoma cells,thus triggering apoptotic cell *** addition,no toxicity was observed in the liver and kidney tissues of mice after docetaxel and berberine ***:Docetaxel and berberine significantly suppressed the proliferation of oral cancer cells by activating p53 expression and causing apoptotic cell *** compounds can be potential agents for the treatment of oral cancer,with little to no toxicity at the tissue level.

关键词： Docetaxel Berberine PC-3 OVCAR-3 OSCC SCC-29B p53 Anticancer Apoptosis

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Resilience Building and Collaborative Governance for Climate Change Adaptation in Response to a New State of More Frequent and Intense Extreme Weather Events

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International Journal of Disaster Risk Science 2023年第1期14卷 162-169页

作者： Huiling Ouyang Xu Tang Renhe Zhang Alexander Baklanov Guy Brasseur rajesh kumar Qunli Han Yong Luo Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghai200438China Fudan Development Institute Fudan UniversityShanghai200433China Integrated Research on Disaster Risk(IRDR)International Centre of Excellence(ICoE)on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health Fudan UniversityShanghai200438China Science and Innovation Department World Meteorological Organization(WMO)CH1211GenevaSwitzerland Max Planck Institute for Meteorology 20146HamburgGermany Research Applications Laboratory National Center for Atmospheric ResearchBoulderCO80301USA Integrated Research on Disaster Risk(IRDR)−International Programme Office(IPO) Beijing100094China Ministry of Education Key Laboratory for Earth System Modeling and Department of Earth System ScienceTsinghua UniversityBeijing100084China

The weather conditions of the summer of 2022 were very unusual,particularly in Eastern Asia,Europe,and North *** devasting impact of climate change has come to our attention,with much hotter and drier conditions,and with more frequent and intense flooding *** extreme events have reached a dangerous level,increasingly threatening human *** interconnected risks caused by these extreme disaster events are triggering a chain effect,forcing us to respond to these crises through changes in our living environment,which affect the atmosphere,the biosphere,the economy including the availability of energy,our cities,and our global ***,we have to confront the abnormal consequences of untypical,rapid changes of extreme events and fast switches between extreme states,such as from severe drought to devastating *** this new situation,it is crucial to improve the adaptation capacity of our societies in order to reduce the risks associated with climate change,and to develop smarter strategies for climate ***-quality development must be science-based,balanced,safe,sustainable,and climate-resilient,supported by the collaborative governance of climate mitigation and *** article provides some recommendations and suggestions for resilience building and collaborative governance with respect to climate adaptation in response to a new planetary state that is characterized by more frequent and severe extreme weather events.

关键词： Climate change adaptation Collaborative governance Extreme weather events Resilience building

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Spontaneous closure of stoma

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Gastroenterology Report 2016年第4期4卷 325-327,I0003页

作者： Narendra Pandit Harjeet Singh Hemanth kumar rajesh Gupta G.R.Verma Division of Surgical Gastroenterology Department of General Surgery Post Graduate Institute of Medical Education and Research(PGIMER)ChandigarhIndia

Intestinal loop stoma is a common surgical procedure performed for various benign and malignant abdominal problems,but it rarely undergoes spontaneous closure,without surgical *** male patients presented to our emergency surgical department with acute abdominal *** of them was diagnosed as having rectosigmoid perforation and underwent diversion sigmoid loop colostomy after primary closure of the *** other was a known case of carcinoma of the rectum who had already undergone low anterior resection with covering loop ileostomy;the patient underwent second loop ileostomy,this time for complicated intestinal *** our surprise,both the loop colostomy and ileostomy closed spontaneously at 8 weeks and 6 weeks,respectively,without any *** stoma closure is a rare and interesting *** exact etiology for spontaneous closure remains unknown,but it may be hypothesized to result from slow retraction of the stoma,added to the concept of a tendency towards spontaneous closure of enterocutaneous fistula.

关键词： ileostomy colostomy spontaneous closure of stoma

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ηmesons in hot magnetized nuclear matter

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Chinese Physics C 2022年第2期46卷 160-177页

作者： rajesh kumar Arvind kumar Department of Physics Dr.B R Ambedkar National Institute of Technology JalandharJalandhar-144011PunjabIndia

ηN interactions are investigated in hot magnetized asymmetric nuclear matter using the chiral SU(3)model and chiral perturbation theory(ChPT).In the chiral modcl,thc in-medium properties of η-mesons are calcu-lated using medium modified scalar densities under the influence of an extermal magnetic ***,in a com-bined chiral model and ChPT approach,off-shell contributions of the ηN interactions are evaluated from the ChPTeffective ηN Lagrangian,and the in-medium effect of scalar densities are incorporated from the chiral SU(3)*** find that the magnetic field has a significant effect on the in-medium mass and optical potential of η mesons,andwe observe a deeper mass-shift in the combined chiral model and ChPT approach than in the solo chiral SU(3)*** both approaches,no additional mass-shift is observed due to the uncharged nature of η mesons in the presenceof a magnetic field.

关键词： hadron physics ηinteractions in-medium mesons

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Effects of E2 and El-E2 Interference on Coulomb Dissociation of 19C

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Chinese Physics Letters 2007年第3期24卷 656-659页

作者： rajesh Kharab Pardeep Singh Ravinder kumar Department of Physics Kurukshetra University Kurukshetra Hr.-136 119 India

We investigate the effects of higher order multipole transitions, in particular electric quadrupole （E2） and El-E2 interference, on the Coulomb dissociation of 19 C within the framework of the first order eikonal approximation. The sensitivity of the total Coulomb breakup cross section and the longitudinal momentum distribution of the core fragment to these effects are checked. The breakup occurs predominately through the dipole transition and the contribution of E2 transition to the total cross section is found to be within the range from 1 to 3% of that of El. It is further observed that the El-E2 interference term contributes nothing to the integrated cross section. On the other hand, the longitudinal momentum distribution is observed to be insensitive to the E2 transition while the El-E2 interference introduces a small asymmetry in its shape.

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Is prophylactic placement of drains necessary after subtotal gastrectomy?

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World Journal of Gastroenterology 2007年第27期13卷 3738-3741页

作者： Manoj kumarl Seung Bong Yangl Vijay kumar Jaiswall Jay N Shahl Manish Shreshthal rajesh Gongal Department of Surgery Patan Hospital Kathmandu Nepal

AIM： To determine the evidence-based values of prophylactic drainage in gastric cancer surgery. METHODS： One hundred and eight patients, who underwent subtotal gastrectomy with D1 or D2 lymph node dissection for gastric cancer between January 2001 and December 2005, were divided into drain group or no-drain group. Surgical outcome and post-operative complications within four weeks were compared between the two groups. RESULTS： No significant differences were observed between the drain group and no-drain group in terms of operating time （171 ± 42 rain vs 156 ± 39 rain）, number of post-operative days until passage of flatus （3.7 ± 0.5 d vs 3.5 ± 1.0 d）, number of post-operative days until initiation of soft diet （4.9±0.7 d vs 4.8±0.8 d）, length of post-operative hospital stay （9.3±2.2 d vs 8.4±2.4 d）, mortality rate （5.4% vs 3.8%）, and overall postoperative complication rate （21.4% vs 19.2%）. CONCLUSION： Prophylactic drainage placement is not necessary afer subtotal gastrectomy for gastric cancer since it does not offer additional benefits for the patients.

关键词： Prophylactic drainage Subtotal gastrectomy Gastric cancer Post-operative complications Operative outcome

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latrogenic aortic pseudoaneurysm following anterior tho- racic spine surgery masquerading as chronic infection

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Chinese Journal of Traumatology 2013年第6期16卷 368-370页

作者： Vijay Goni A jay Bahl Nirmal Raj Gopinathan Vibhu Krishnan rajesh kumar Department of Orthopaedics Postgraduate Institute ofMedical Research and Education Chandigarh India

Late vascular complications involving aorta are rare but devastating adversities following anterior thoracic spine operations are *** current article describes our experience with one such patient who had an iatrogenic pseudoaneurysm of the thoracic aorta,mimicking *** patient was treated successfully following concomitant efforts by multidisciplinary experts with *** wish to highlight upon the significance of recognizing the possible sinister consequences of a dangerously prominent spinal implant and the role of a suspicious surgeon in identifying these menacing complications at the right time.

关键词： Fractures, bone Aorta, thoracic Aneurysm, false latrogenic disease

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Inguinoscrotal region as an unusual site of extra-pancreatic collections in infected pancreatic necrosis

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Gastroenterology Report 2016年第3期4卷 246-250,I0003页

作者： Saurabh Kalia Rahul Gupta Sunil DShenvi Hemanth kumar rajesh Gupta Mandeep Kang Surinder Singh Rana Deepak kumar Bhasin Rajinder Singh Surgical Gastroenterology Division Department of General SurgeryPostgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Radiology Postgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarhIndia

Severe acute pancreatitis often leads to pancreatic and peripancreatic collections but,rarely,it can lead to collections at sites remote from the *** male patients presented with abdominal pain and inguinoscrotal *** were initially misdiagnosed with obstructed inguinal hernia,epididymo-orchitis and hydrocele,***,their diagnosis of acute pancreatitis was revealed on laparotomy in one patient and on computed tomography(CT)in the remaining two *** these cases had extensive peripancreatic necrosis and paracolic collections tracking along the psoas muscle,downwards towards the *** collections were initially managed by percutaneous drainage and saline irrigation as a part of the‘step-up’*** of these patients required open necrosectomy,while all required incision and drainage of inguinoscrotal *** the patients were discharged in satisfactory *** swelling is unusual as a first presentation of acute pancreatitis.A high index of suspicion,with careful study of patient’s history and examination along with CT,may provide an accurate *** drainage may be required to control sepsis and also provide an egress route for intra-abdominal collections.

关键词： acute pancreatitis inguinoscrotal collections step-up approach necrosectomy

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An Assessment of Yarsagumba(Ophiocordyceps sinensis) Collection in Dhorpatan Hunting Reserve, Nepal

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Journal of Mountain Science 2014年第2期11卷 555-562页

作者： Barna Bahadur THAPA Saroj PANTHI rajesh kumar RAI Uttam Babu SHRESTHA Achyut ARYAL Sabina SHRESTHA Bhushan SHRESTHA Department of National Parks and Wildlife Conservation Babar Mahal Dhorpatan Hunting Reserve Baglung Station Green Governance Nepal Department of Biology University of Massachusetts Institute of Natural and Mathematical Sciences Massey University Graduate School of Biotechnology Institute of Life Sciences and Resources Kyung Hee University Green Energy Mission/Nepal Ghatte Kulo Anam Nagar Mushroom Research Division National Institute of Horticultural and Herbal Science Rural Development Administration

Yarsagumba(Ophiocordyceps sinensis), an endemic species to the Himalayas and Tibetan Plateau, is one of the most valuable medicinal mushrooms in the world. In Nepal, it is distributed largely in isolated patches of alpine grasslands of 3,000-5,000 m elevation. Although it is reported from 27 northernmost districts of Nepal, the local distribution pattern of this species is largely ***, the collection system and local management regime of this species are not well documented. We conducted a field survey at Dhorpatan Hunting Reserve(DHR) among the different stakeholders in January-June 2012 to assess collection sites, patterns and trends and to understand the management regime. We estimated that about 75 kg of Yarsagumba is collected every year from DHR and the amount has been declining since 2008. To manage the resource, locals have initiated regulating the collection by issuing permits, taxing to the collectors, and monitoring the activities of harvesters with the help of park authorities. The revenue generated at local level from the permits has been used for community developmental activities.

关键词： Chinese caterpillar fungus Medicinal fungus Himalayan gold Conservation Yartsagunbu

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An unusual cause of simultaneous common bile and pancreatic duct dilation

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Gastroenterology Report 2015年第3期3卷 258-261页

作者： Puneet Chhabra Surinder Singh Rana Vishal Sharma Ravi Sharma rajesh Gupta Deepak kumar Bhasin Department of Gastroenterology Postgraduate Institute of Medical Education and Research(PGIMER)ChandigarhIndia Department of Surgery Postgraduate Institute of Medical Education and Research(PGIMER)ChandigarhIndia

Simultaneous dilation of both the common bile duct and the pancreatic duct(double-duct sign)is usually because of ampullary or pancreatic *** we report an unusual cause of double-duct dilation;we describe the case of a 49-year-old female who developed afferent loop syndrome after pylorus-preserving pancreaticoduodenectomy:crosssectional imaging of the abdomen revealed a double-duct sign.

关键词： afferent loop syndrome pylorus preserving pancreaticoduodenectomy

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