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Dye-sensitized photo-oxidation of disulfiram

Chinese Journal of Chemistry 1995年第5期13卷 464-467页

作者： CHOBISA C.S.BHARDWAJ rajesh punjabi Pinki B.AMETA Suresh C. Department of Chemistry College of Science Sukhadia University Udaipur 313001 (Raj.) IndiaDepartment of Chemistry College of Science Sukhadia University Udaipur 313001 (Raj.) IndiaDepartment of Chemistry College of Science Sukhadia University Udaipur 313001 (Raj.) IndiaDepartment of Chemistry College of Science Sukhadia University Udaipur 313001 (Raj.) IndiaDepartment of Chemistry College of Science Sukhadia University Udaipur 313001 (Raj.) India

Dye-sensitized photo-oxidation of disulfiram has been carried out under various reaction conditions including change in solvents and sensitizers. The product has been isolated and characterized by its physical, chemical and spectral data. To confirm the participation of singlet-oxygen in the reaction, the experiment has also been carried out in the presence of various singlet oxygen scavengers.

关键词： Dye-sensitization photo-oxidation disulfiram

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Peripheral cemento-ossifying fibroma: A case report with review of literature

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World Journal of Clinical Cases 2013年第3期1卷 128-133页

作者： Amit Kumar Mishra Rahul Maru Shrikant Vishnuprasad Dhodapkar Gagan Jaiswal rajesh Kumar Heena punjabi Sri Aurobindo Institute of Dentistry and Post Graduate Institute Indore 452018India

Peripheral cemento-ossifying fibroma(PCOF) is a rare osteogenic neoplasm that ordinarily presents as an epulis-like growth. This is of a reactive rather than neoplastic nature and its pathogenesis is uncertain. PCOF predominantly affects adolescent and young adults with greatest prevalence around 28 years. We report here a rare clinical case of PCOF of the mandible, 1 cm mesiodistally and 1.5 cm occluso-gingivally in diameter, which caused difficulty in eating and speech, in a 42-year-old female patient. She was asymptomatic for 1 year and on follow-up for 6 mo post surgically showed gingival health and normal radioopacity of bone without any recurrence. Clinical, radiographic and histological characteristics are discussed and recommendations regarding differential diagnosis, treatment and follow up are provided. The controversial varied nomenclature and possible etiopathogenesis of PCOF are emphasized.

关键词： Peripheral cemento-ossifying fibroma Gingivectomy Granuloma

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Gastroprotective effect of Acacia nilotica young seedless pod extract:Role of polyphenolic constituents

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Asian Pacific Journal of Tropical Medicine 2012年第7期5卷 523-528页

作者： Vijay Kumar Bansal rajesh Kumar Goel Department of Pharmaceutical Sciences NIMS UniversityJaipurIndia Department of Pharmaceutical Sciences and Drug Research Punjabi University PatialaIndia

Objective:To systematically evaluate antiulcer potential of Acacia nilotica in different ulcer models in ***:Different extracts[ethanolie,50%hydroethanolic(50:50),70% hydroethanolic(70:30) and aqueous]of young seedless pods were examined in pylorus ligation induced gastric ulcers in *** parameters like,volume of gastric acid secretion,pH,free acidity,total acidity,ulcer index,mucin content and antioxidant studies were determined and were compared between extract treated,standard and vehicle control following ulcer induction. The most active extract was also evaluated in swimming stress induced and NSAID induced gastric ***:Among different extracts of young seedless pods only hydroethanolic extracts showed significant antiulcer activity in pyloric ligation induced *** more the 70%hydroethanolic extract showed better protection as compared to 50%hydroethanolic *** 70%hydroethanolic extract also showed significant mucoprotection in swimming stress induced and nonsteroidal antiinflammatory drugs induced gastric ***: The results of present study concluded that the hydroethanolic extract of young seedless pods of Acacia nilotica has antiulcer activity in pylorus ligation,swimming stress and NSAID induced rat ulcer *** extract containing more amount of phenolic components show high antiulcer activity,indicating the phenolic component of the extract to be responsible for the activity of the extracts.

关键词： Peptic ulcer Acacia nilotica Ulcer index Tannins Flavonoids

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Pharmacokinetic, pharmacodynamic, and neurochemical investigations of lamotrigine-pentylenetetrazole kindled mice to ascertain it as a reliable model for clinical drug-resistant epilepsy

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Animal Models and Experimental Medicine 2020年第3期3卷 245-255页

作者： Sandeep Kumar rajesh K.Goel Department of Pharmaceutical Sciences&Drug Research Punjabi UniversityPatialaPunjabIndia

Background:Pentylenetetrazole kindling has long been used for the screening of investigational antiseizure *** presence of lamotrigine,at a very low dose,does not hamper kindling in mice;rather it modifies this epileptogenesis process into drug-resistant *** lamotrigine-pentylenetetrazole kindled mice show resistance to lamotrigine,phenytoin,and *** may also be possible that other licensed antiseizure drugs,like the mentioned drugs,remain ineffective in this model;therefore,this was the subject of this ***:Swiss albino mice were kindled with pentylenetetrazole for 35 days in the presence of either methylcellulose vehicle or lamotrigine(subtherapeutic dose,ie,5 mg/kg).Vehicle vs lamotrigine-kindled mice were compared in terms of(a)resistance/response toward nine antiseizure drugs applied as monotherapies and two drug combinations;(b)lamotrigine bioavailability in blood and brain;(c)blood-brain barrier integrity;and(d)amino acids and monoamines in the cerebral cortex and ***:Lamotrigine vs vehicle-kindled mice are similar(or not significantly different P>.05 from each other)in terms of(a)response toward drug combinations;(b)lamotrigine bioavailability;and(c)blood-brain barrier integrity except for,significantly(P<.05)reduced taurine and increased glutamate in the cerebral cortex and *** from these,lamotrigine-kindled mice show significant(P<.05)resistant to lamotrigine(15 mg/kg),levetiracetam(40 mg/kg);carbamazepine(40 mg/kg),zonisamide(100 mg/kg),gabapentin(224 mg/kg),pregabalin(30 mg/kg),phenytoin(35 mg/kg),and topiramate(300 mg/kg).Conclusion:Lamotrigine-pentylenetetrazole kindling takes longer to develop(~5 weeks)in comparison to lamotrigine-amygdale(~4 weeks)and lamotriginecorneal(~2 weeks)kindling ***,drug screening through this model may yield superior drugs with novel antiseizure mechanisms.

关键词： animal models drug-resistant epilepsy kindling lamotrigine refractory epilepsy

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