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Common polymorphisms of protein tyrosine phosphate non-receptor type 2 gene are not associated with risk of Crohn’s disease in Indian

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World Journal of Gastrointestinal Pathophysiology 2022年第4期13卷 114-123页

作者： Kaushik Chatterjee Amit kumar Dutta Ashish goel Rekha Aaron Vijayalekshmi Balakrishnan Ajith Thomas Anoop John Rajeeb Jaleel Deepu David Reuben Thomas Kurien SD Chowdhury Ebby George Simon AJ Joseph Prasanna Premkumar Anna B Pulimood Department of Gastrointestinal Sciences Christian Medical College and HospitalVellore 632004Tamil NaduIndia Department of Gastroenterology Christian Medical CollegeVellore 632004Tamil NaduIndia Departments of Biostatistics Christian Medical CollegeVellore 632004Tamil NaduIndia

BACKGROUND Multiple genetic risk factors for Crohn’s disease(CD)have been ***,these observations are not consistent across different *** protein tyrosine phosphate non-receptor type 2(PTPN2)gene plays a role in various aspects of host defense including epithelial barrier function,autophagy,and innate and adaptive immune *** common polymorphisms in the PTPN2 gene(rs2542151 and rs7234029)have been associated with risk of CD in Western *** To evaluate the association of PTPN2 gene polymorphisms with risk of CD in Indian *** We conducted a prospective case-control *** with CD were recruited,and their clinical and investigation details were *** were patients without organic gastrointestinal disease or other comorbid *** common polymorphisms in the PTPN2 gene(rs2542151 and rs7234029)were *** was extracted from peripheral blood samples of cases and controls and target DNA was amplified using specific sets of *** amplified fragments were digested with restriction enzymes and the presence of polymorphism was detected by restriction fragment length *** frequency of alleles was *** frequencies of genotypes and alleles were compared between cases and controls to look for significant *** A total of 108 patients with CD(mean age 37.5±12.7 years,females 42.6%)and 100 controls(mean age 39.9±13.5 years,females 37%)were *** the single nucleotide polymorphism(SNP)rs7234029,the overall frequency of G variant genotype(AG or GG)was noted to be significantly lower in the cases compared to controls(35.2%vs 50%,P=0.05).For the SNP rs2542151,the overall frequency of G variant genotype(GT or GG)was noted to be similar in cases compared to controls(43.6%vs 47%,P=0.73).There were no significant differences in minor allele(G)frequency for both polymorphisms between the cases and *** the SNPs had no significant association with a

关键词： PTPN2 gene Crohn’s disease Genetic polymorphism Case-control study Asia Risk factor

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A Comparative Study on Processing of High Alumina Hematite Iron Ore by Gravity, Magnetic and Flotation Methods

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材料科学与工程（中英文A版） 2013年第5期3卷 349-354页

作者： rajendra kumar Rath Sunati Mohanty Bibhuranjan Nayak Ratnakar Singh Kalyan kumar Bhattacharyya Mineral Processing Division CSIR-National Metallurgical Laboratory Council of Scientific and Industrial Research Burma MinesJamshedpur 831007 India

The low grade iron ore sample contains both lumps and fines. It is mostly hematitic iron ore and considerable amount of goethitic/limonitic material is also present in it. The major impurities present were quartz and clay. It is observed that the iron bearing phases are poorly liberated above 300 μm and the liberation improves below 300 μm. More than 80% liberation is achieved below 106 μm. Based on the liberation data, the feed for the different beneficiation methods was prepared by stage crushed the ROM followed by grinding passing to 106 μm and the ground material (-106 μm) was deslimed. The underflow was subjected to various beneficiation techniques such as tabling, enhanced gravity separator (EGS), wet high intensity magnetic separation (WHIMS) and flotation and the results are discussed. All the methods studied could be able to produce pellet grade concentrate with iron content of 64.5%, however, a marginal higher yield was observed for WHIMS (81%).

关键词：重力分离器浮选方法赤铁矿氧化铝低品位铁矿石磁力地面材料选矿方法

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Expression of multidrug resistance proteins in retinoblastoma

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International Journal of Ophthalmology(English edition) 2017年第11期10卷 1655-1661页

作者： Swati Shukla Arpna Srivastava Sunil kumar Usha Singh Sandeep Goswami Bhavna Chawla Mandeep Singh Bajaj Seema Kashyap Jasbir Kaur Department of Ocular Biochemistry Dr. Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences New Delhi 110029 India Oculoplasty & Pediatric Opthalmology Services Dr. Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences New Delhi 110029 India Department of Ocular Pathology Dr. Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences New Delhi 110029 India

AIM： To elucidate the mechanism of multidrug resistance in retinoblastoma, and to acquire more insights into in vivo drug ***： Three anticancer drug resistant Y79 human RB cells were generated against vincristine, etoposide or carboplatin, which are used for conventional chemotherapy in RB. Primary cultures from enucleated eyes after chemotherapy（PCNC） were also prepared. Their chemosensitivity to chemotherapeutic agents（vincristine, etoposide and carboplatin） were measured using MTT assay. Western blot analysis was performed to evaluate the expression of p53, Bcl-2 and various multidrug resistant proteins in retinoblastoma ***： Following exposure to chemotherapeutic drugs, PCNC showed less sensitivity to drugs. No significant changes observed in the p53 expression, whereas Bcl-2 expression was found to be increased in the drug resistant cells as well as in PCNC. Increased expression of P-glycoprotein（P-gp） was observed in drug resistant Y79 cells; however there was no significant change in the expression of P-gp found between primary cultures of primarily enucleated eyes and PCNC. Multidrug resistance protein 1（Mrp-1） expression was found to be elevated in the drug resistant Y79 cells as well as in PCNC. No significant change in the expression of lung resistance associatedprotein（Lrp） was observed in the drug resistant Y79 cells as well as in ***： Our results suggest that multidrug resistant proteins are intrinsically present in retinoblastoma which causes treatment failure in managing retinoblastoma with chemotherapy.

关键词： retinoblastoma chemotherapy multidrug resistance multidrug resistance associated proteins

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印度某医疗中心机械性眼外伤患者受伤情况分析（英文）

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国际眼科杂志 2017年第12期17卷 2207-2211页

作者： Neha Chauhan Rajeev Tuli Rattan kumar Sharma Dinesh kumar dr.rajendra prasad 政府医学院眼科印度176304 dr.rajendra prasad政府医学院社区医学部印度176304

目的:研究农村转诊中心到访以病人机械性眼损伤模式。方法:本研究在*** Prasad Government Medical College(RPGMC),Kangra(Himachal Pradesh)眼科进行。研究从2013-01-01/2013-12-31,周期12mo,包括数据收集、整理、描述、分析和解释,然后进行为期1mo的随访。前瞻性研究,包括200例机械性眼损伤的患者,所有患者都接受了问卷调查,并进行详细的眼部检查。根据国际眼损伤类型分为开放性眼球损伤和闭合性眼部损伤。受损的眼睑、泪腺以及颅神经麻痹视为独立存在,通过MSExcel 2007表格使用Epiinfo7软件进行数据分析。结果:在研究期间,共接收门诊患者21710例,其中200例为机械性眼损伤,占门诊总人数的0.921%。患者年龄为1~80(平均33.12±20.48)岁。151(75.5%)例男性,49(24.5%)例女性患者,男女比例为3:1。200例受试者中,眼部损伤情况分别为:家中(100眼)、运动场所(29眼)、职业损伤(29眼)、道路交通事故(38眼)、暴力冲突(10眼)、学校(3眼)、宗教场所踩踏事故(1眼)。就诊时视力达到6/12的有47%,<6/12~6/36有13.5%,<6/36~1/60有6%,<1/60~光感有22%,无光感的4%。7.5%患者视力无法通过国际标准视力表评估。大多数患者为闭合性眼部损伤(54.5%),涉及眼睑、泪腺(23%),开放性眼部损伤为19.5%,3%累及颅神经。结论:眼部机械性损伤是造成单眼失明的常见病因,具有可预防性。

关键词：眼部损伤眼睑和泪腺穿孔撕裂

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Effect of Pest Exclusion Net(PEN)on the Sustainable Production of Late Season Broad Leaf Mustard(BLM)in Chitwan,Nepal

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Journal of Agricultural Science and Technology(A) 2018年第5期8卷 315-322页

作者： Ram Chandra Neupane Arjun kumar Shrestha rajendra Regmi Kim Fooyontphanich Ananta Raj Devkota Faculty of Agriculture Agriculture and Forestry UniversityChitwan 44209Nepal Asia Innovative Farmers Activity(AIFA)Project WINROCK InternationalBangkok 10330Thailand

Broad leaf mustard(BLM)(Brassica juncea ***,Brassicaceae)is one of the most widely consumed vegetable crops in *** production of crop in open field is constrained by major pests like mustard aphid and flea *** study was aimed to determine the effects of pest exclusion net(PEN)on pest-infestation and yield of BLM cultivar“Khumal Broad Leaf”.The experiment was carried out in randomized complete block design(RCBD)with five treatments and four *** treatments included control(no mulch+no net+no pesticide spray),black plastic mulch only,reflective plastic mulch only,black plastic mulch+no net+pesticide spray,and PEN+black plastic mulch+no pesticide *** were analyzed with RSTAT software package and means were separated by Duncan’s multiple range test(DMRT)at 5%level of *** result revealed that crop under PEN had highest plant height(38.99 cm),lowest number of aphid(0-0.86 per plant),flea beetle(0-1.07 per plant)and highest total marketable yield(77.50 ton/ha)while control had lowest plant height(20.06 cm),highest number of aphid(maximum 2.49 per plant),flea beetle(maximum 2.00 per plant)and lowest total marketable yield(13.75 ton/ha).Economic analysis revealed highest benefit-cost ratio in PEN(9.90).This study indicates that the use of PEN protect BLM against aphid and flea beetle,increases yield and can be considered as a viable technology for BLM production by smallholder growers of Nepal.

关键词： Broad leaf mustard(BLM) pest exclusion net(PEN) mustard aphid flea beetle

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印度Ispat CSP工厂生产优质热轧卷

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钢铁 2004年第Z1期39卷 393-400页

作者： Fritz-Peter Pleschiutschnigg Vilas Vishnu Jamnis Sukhdev Raj Talwar Atul kumar Misra Ratna Prasad V. Atluri R. B. Singh Prem Shankar rajendra K. Verma Rajesh K. Goyal Vidiya P. Mishra Bidyapati Deepu B. Peter Meierling Joseph Pleschiutschnig United Steel Center Operations SIP&HSM Operations Steel Melt Shop Operations Caster Operations Process Quality Rolling Mill Operations 　　　　 Ispat Industries Ltd Ispat Industries Ltd

　　1998年,印度Ispat公司开始投产CSP生产线(图1).这个生产线原计划年产300万t热轧卷,年产210万t高炉提供铁水.Midren装置年产160万吨海绵铁.……

关键词：印度工厂生产热轧卷生产线海绵铁装置投产铁水高炉

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Developments of Rill Networks: An Experimental Plot Scale Study

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Journal of Water Resource and Protection 2013年第2期5卷 133-141页

作者： Pravat kumar Shit Gouri Sankar Bhunia Ramkrishna Maiti Department of Geography & Environment Management Vidyasagar University Medinipur India Senior Research Fellow (ICMR) Rajendra Memorial Research Institutes of Medical Sciences (ICMR) Bihar India

Enumerating the relative proportions of soil losses due to rill erosion processes during monsoon and post-monsoon season is a significant factor in predicting total soil losses and sediment transport and deposition. Present study evaluated the rill network with simulated experiment of treatments on varying slope and rainfall intensity to find out the rill erosion processes and sediment discharge in relation to slope and rainfall intensity. Results showed a significant relationship between the rainfall intensity and sediment yield (r = 0.75). Our results illustrated that due to increase in rainfall intensity represent the development of efficient rill network while, no rill was found with a slope of 20° and a rainfall intensity of 60 mm·h-1. The highest rill length was observed in plot E with 20° slope and 120 mm·h-1 rainfall intensity at 360 minutes. Positive and strong correlation (R2 = 0.734, P 0.001) was observed between the cumulative rainfall intensity and sediment discharge. A longitudinal profile was delineated and showed that the depth and numbers of depressions amplified with time and were more prominent for escalating rainfall intensity for its steeper slopes. Information derived from the study could be applied to estimate longer-term erosion stirring over larger areas possessing parallel landforms.

关键词： Rill Network Slope Gradient Rainfall Simulation Sediment Yield

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Assessment of School Infrastructure at Primary and Upper Primary Level: A Geospatial Analysis

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Journal of Geographic Information System 2012年第5期4卷 412-424页

作者： Gouri Sankar Bhunia Pravat kumar Shit Soumen Dubai Department of Geography & Environment Management Vidyasagar University Medinipur India Office of the Sarva-Siksha-Mission (SSM) Paschim Medinipur India rajendra Memorial Research Institutes of Medical Sciences (ICMR) Bihar India

With the introduction of powerful and high-speed personal computers, proficient techniques for infrastructure development and management have advanced, of which Geoinformatics technology is of great significance. An attempt has been made for broad mapping and analysis of existing infrastructures in the context of planning scheme in Paschim Medinipur district, and to delineate the development zones of educational infrastructure facilities. The thematic layers considered in this study are infrastructure accessibility, type and condition of classroom and number of classroom allocated for the educational system at primary and upper primary level. Moran’s I statistics was used to estimate the spatial distribution of elementary infrastructure across the district. All these themes and their individual features were then assigned weights according to their relative importance in educational development and corresponding normalized weights were obtained based on the Saaty’s analytical hierarchy process. The thematic layers were finally integrated in GIS software based on multi-criteria approach to yield educational development infrastructure index. Moran’s I statistics shows girl’s toilet, electric and boundary wall facility within the district are clustered in pattern at primary level. At the upper primary level, only electric and computer facilities shows the clustered distribution across the district. However, four different zones have been delineated, namely ‘very good’, ‘good’, ‘moderate’ and ‘poor’. The block covered by very good elementary educational infrastructure facility is Daspur –I and Dantan –II at primary level and Keshiary block at upper primary level in Paschim Medinipur district. Finally, it is concluded that the Geoinformatics technology is very efficient and useful for the identification of infrastructure development.

关键词： Educational Infrastructure Spatial Auto-Correlation Saaty’s Analytical Hierarchy Process Multi-Criteria Approach

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Assessment of Factors Affecting Ephemeral Gully Development in Badland Topography: A Case Study at Garbheta Badland (Pashchim Medinipur,

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International Journal of Geosciences 2013年第2期4卷 461-470页

作者： Pravat kumar Shit Gouri Sankar Bhunia Ramkrishna Maiti Department of Geography & Environment Management Vidyasagar University Medinipur India rajendra Memorial Research Institutes of Medical Sciences (ICMR) Patna Bihar India

Gully erosion in the Paschim Medinipur district of West Bengal, Indiahas been an issue of anxiety, formed by the amputation of soil from narrow channels through the accretion of surface runoff. Here, we attempted to investigate the erosion variability of gully in a micro catchment area, and also scrutinized the gully cross-sectional areas as distinct components of gully volumes. Twelve gullies were randomly selected in different slopes. To determine the geometric growth of the gully dimensions and soil loss, the initial length of gully, the width of the gully and depth of respective gullies was monitored in different seasons. Univariate analysis was conducted to measure the association between gully head retreat and vegetation coverage, slope, rainfall volume and runoff contributing area. We found strong and significant relation between the slope of gully head and linear retreat in the pre monsoon (p 0.008) and post monsoon (p 0.024) season respectively. Conversely, rainfall volume and gully head retreat showed a strong relationship in the pre monsoon (r = 0.80), monsoon (r = 0.66) and post-monsoon period (r = 0.94);while meager relationship was observed with rainfall intensity (r = 0.06). Results also illustrated that the overall retreat of gully head had very strong and positive relationship with the runoff contributing area (r = 0.89, p 0.001), and maximum gully erosion was observed in the monsoon period (55.67%). These results indicate that slope, rainfall and runoff contributing area have a strong positive influence on gully erosion in Paschim Medinipur district, since the initiation of the gully.

关键词： Gully Erosion Gully Heads Rainfall Runoff Contributing Area Sediment Yield

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灾难教育与管理为学生，教师和灾害管理人员所著

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国外科技新书评介 2015年第3期 8-8页

作者： rajendra kumar Bhandari 李亚宁不详中国科学院自动化研究所

灾害造成巨大的经济、人员损失，全球应共同努力，开发、采用新技术，以提高危险和灾害的预测水平。本书通过地震、海啸、火山爆发、山体滑坡、飓风、龙卷风、洪水、火灾和暴风雪灾害的经典案例，介绍了在灾害管理中科学和技术发展的价... 详细信息

灾害造成巨大的经济、人员损失，全球应共同努力，开发、采用新技术，以提高危险和灾害的预测水平。本书通过地震、海啸、火山爆发、山体滑坡、飓风、龙卷风、洪水、火灾和暴风雪灾害的经典案例，介绍了在灾害管理中科学和技术发展的价值，在灾害管理、公众反应以及备灾预警方面给予人们正确的引导与教育。通过科学探究、战略规划、能力建设、敏捷思考、积极协同的预防行动和快速反应，表达了对无灾害世界的美好憧憬。

关键词：灾害管理管理人员教育学生灾难教师科学探究快速反应

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