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Chinese Chemical Letters 2016年第2期27卷 287-294页

作者： Zahid Zaheer Firoz A.Kalam Khan Jaiprakash N.Sangshetti rajendra H.patil Dr.Rafiq Zakaria Campus Y.B.Chavan College of PharmacyAurangabad 431001MSIndia Department of Biotechnology Savitribai Phule Pune UniversityPune 411007MSIndia

A series of novel 3-substituted-4-hydroxycoumarin derivatives 6（a-1） were synthesized in high yield using one-pot three component coupling reaction catalyzed by ceric ammonium nitrate. These compounds were evaluated for antileishmanial activity against Leishmania donovani promastigotes and antioxidant activity（DPPH-radical scavenging activity）. Two compounds, 6h（IC50= 9.90 μmol/L） and 6i（IC50= 6.90 μmol/L） displayed potent antileishmanial activity when compared with standard antileishmanial agents pentamidine（IC50= 16.15 μmol/L） and miltefosine（IC50= 12.50 μmol/L）. Three compounds, 6c（IC50= 10.79 μmol/L）, 6h（IC50= 10.60 μmol/L）, and 6i（IC50= 10.73 μmol/L） showed significant antioxidant activity favorably with the antioxidant standards butylated hydroxy toluene（IC50= 16.47 μmol/L） and ascorbic acid（IC50= 12.69 μmol/L）. A molecular docking study of compounds 6（a-1） suggested a possible mode of binding with the Adenine phosphoribosyltransferase enzyme of ***. ADME properties were predicted in silico and support the potential of 6（a-1） to show favorable drug-like properties.

关键词： 4-Hydroxycoumarin Ceric ammonium nitrate Antileishmanial activity Antioxidant activity Molecular docking study ADME properties

Recent Advances in Nano‑Enabled Seed Treatment Strategies for Sustainable Agriculture:Challenges,Risk Assessment,and Future Perspectives

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Nano-Micro Letters 2023年第4期15卷 153-189页

作者： Amruta Shelar Shivraj Hariram Nile Ajay Vikram Singh Dirk Rothenstein Joachim Bill Jianbo Xiao Manohar Chaskar Guoyin Kai rajendra patil Department of Technology Savitribai Phule Pune UniversityPuneMaharashtra 411007India Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health School of Pharmaceutical ScienceJinhua AcademyZhejiang Chinese Medical UniversityHangzhou 310053ZhejiangPeople’s Republic of China Department of Chemical and Product Safety German Federal Institute for Risk Assessment(BfR)Max‑Dohrn‑Strasse10589 BerlinGermany Institute for Materials Science University of Stuttgart70569 StuttgartGermany International Research Center for Food Nutrition and Safety Jiangsu UniversityZhenjiang 212013People’s Republic of China Faculty of Science and Technology Savitribai Phule Pune UniversityPuneMaharashtra 411007India Department of Biotechnology Savitribai Phule Pune UniversityPuneMaharashtra 411007India

Agro seeds are vulnerable to environmental stressors,adversely affecting seed vigor,crop growth,and crop *** agrochemical-based seed treatments enhance seed germination,but they can also cause damage to the environment;therefore,sustainable technologies such as nano-based agrochemicals are urgently *** can reduce the dose-dependent toxicity of seed treatment,thereby improving seed viability and ensuring the controlled release of nanoagrochemical active ingredients However,the applications of nanoagrochemicals to plants in the field raise concerns about nanomaterial safety,exposure levels,and toxicological implications to the environment and human *** the present comprehensive review,the development,scope,challenges,and risk assessments of nanoagrochemicals on seed treatment are ***,the implementation obstacles for nanoagrochemicals use in seed treatments,their commercialization potential,and the need for policy regulations to assess possible risks are also *** on our knowledge,this is the first time that we have presented legendary literature to readers in order to help them gain a deeper understanding of upcoming nanotechnologies that may enable the development of future generation seed treatment agrochemical formulations,their scope,and potential risks associated with seed treatment.

关键词： Agro seeds Environmental seed stressors Nanoagrochemicals Toxicological implications Risk regulations

ZnO/CdS Nanocomposite: An Anti-Microbial and Anti-Biofilm Agent

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Advances in Microbiology 2020年第4期10卷 166-179页

作者： Haribhau Gholap Akash Gholap rajendra patil Department of Physics Fergusson College Pune India College of Pharmacy Mula Education Society Sonai Ahmednagar India Department of Biotechnology Savitribai Phule Pune University Pune India

Microbial infectious are becoming a global threat, which is a reason for rise in mortality of human beings. One of the reasons for this mortality has been the drug resistance in microbes. The drug resistance poses a major challenge for effective control of microbial infections, and this threat has prompted us to search for alternative strategy to control the microbial infections. Recently, nanomaterials have emerged as an alternative to conventional platforms because they combine multiple mechanisms of action into one platform due to the distinctive properties of nanosized materials. In the present research we have attempted to synthesize ZnO/CdS nanocomposite for its application as an antimicrobial agent. We have characterized the synthesized nanocomposites by X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV-Vis), photoluminescence spectroscopy (PL), field emission scanning electron microscopy (FESEM) and high-resolution transmission electron microscopy (HRTEM). The nanocomposites have exhibited good antibacterial property against Gram positive and Gram-negative organisms by virtue of the generation of reactive oxygen species (ROS) inside the cells, as reflected by ruptured appearances in the FESEM micrographs. Apart from antimicrobial activity, it also inhibited biofilm formations in Pseudomonas aeruginosa, a causative organism in lung infection and burn associated infections.

关键词： ZnO/CdS Antimicrobial Biofilm Pseudomonas Bacillus Escherichia

Phenazine Methosulphate Modulating the Expression of Genes Involved in Yeast to Hyphal Form Signal Transduction in <i>Candida albicans</i>

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Advances in Microbiology 2017年第11期7卷 707-718页

作者： Ashwini Khanderao Jadhav Priyanka Jangid rajendra patil Wasudev Gade Kiran Kharat Sankunny Mohan Karuppayil School of Life Sciences SRTM University Nanded India Department of Biotechnology Savitribai Phule Pune Univesity Pune India Department of Biotechnology Deogiri College Aurangabad India

Candida albicans has ability to switch from yeast to hyphal form which is an important virulence factor. The objective of the research is to study the effect of Phenazine Methosulphate (PMS) on virulence factors and to study expression profile in yeast to hyphal form transition in C. albicans. Phenazine Methosulphate (PMS) acted as an inhibitor of yeast to hyphal form transition, adhesion and biofilm formation in C. albicans. RTPCR study demonstrated that PMS Modulate the expression of genes involved in Ras1-cAMP-Efg1 and Cek1-MAPK signal transduction pathways. Cell cycle of C. albicans was arrested at S phase on treatment of PMS. Hyphal suppressor genes like Tup1, Mig1 and Nrg1 were upregulated by PMS. Based on our data on expression of genes during yeast to hyphal form transition in presence and absence of PMS, we hypothesize that inhibition of hyphal formation may be due to the overexpression of negative regulators of hyphal growth. Targeting of hyphal specific genes involved in these pathways may be a promising strategy for anti-candida drug development.

关键词： Phenazine Methosulphate Candida albicans Y-H Form Transition Biofilm Tup1 Mig1 and Nrg1

Semiconductor metal oxide compounds based gas sensors： A literature review

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Frontiers of Materials Science 2015年第1期9卷 14-37页

作者： Sunil Jagannath patil Arun Vithal patil Chandrakant Govindrao DIGHAVKAR Kashinath Shravan THAKARE Ratan Yadav BORASE Sachin Jayaram NANDRE Nishad Gopal DESHPANDE rajendra Ramdas AHIRE Department of Physics S. G. Patil Arts Science & Commerce College Sakri-424304 Dist. Dhule India Department of Physics L. V. H. College Panchavati Nashik-422003 India Thin and Thick film Laboratory M. S. G. College Malegaon Camp Malegaon-423105 Dist. Nashik India Department of Physics Uttamrao Patil College Dahivel Dist-Dhule India Department of Physics Shivaji University Kolhapur-416004 India

This paper gives a statistical view about important contributions and advances on semiconductor metal oxide （SMO） compounds based gas sensors developed to detect the air pollutants such as liquefied petroleum gas （LPG）, H2S, NH3, CO2, acetone, ethanol, other volatile compounds and hazardous gases. Moreover, it is revealed that the alloy/composite made up of SMO gas sensors show better gas response than their counterpart single component gas sensors, i.e., they are found to enhance the 4S characteristics namely speed, sensitivity, selectivity and stability. Improvement of such types of sensors used for detection of various air pollutants, which are reported in last two decades, is highlighted herein.

关键词： gas sensor semiconductor metal oxide (SMO) sensitivity air pollutant gas response

Antinociceptive activity of Ricinus communis ***

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Asian Pacific Journal of Tropical Biomedicine 2011年第2期1卷 139-141页

作者： Dnyaneshwar J Taur Maruti G Waghmare rajendra S Bandal Ravindra Y patil Department of Pharmacognosy SVPM's College of Pharmacy Department of Pharmaceutical Chemistry SVPM's College of Pharmacy Department of Pharmacognosy PDEA's Shankarrao Ursal College of Pharmaceutical Sciences and Research Center

Objective:To evaluate the antinociceptive activity of the methanol extract of Ricinus communis leaves(MRCL).Methods:Antinociceptive activity was evaluated using acetic acid induced writhing test,formalin induced paw licking and tail immersion method in mice at doses of 100,125 and 130 mg/kg ***:The results indicated that MRCL exhibited considerable antinociceptive activity against three classical models of pain in *** phytochemical analysis suggested the presence of saponin,steroids and ***:It can be concluded that MRCL possesses antinociceptive potential that may be due to saponin,steroids and alkaloids in it.

关键词： Ricinus communis Analgesic Antinociceptive Writhing Formalin

Distereoselective one-pot synthesis of pyrimidopyrimidines using sulfated tin oxide as a reusable catalyst:An extension of Biginelli-type reaction

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Chinese Chemical Letters 2013年第12期24卷 1070-1074页

作者： Rupali L.Magar Prashant B.Thorat Pratima B.Thorat Vinod V.Thorat Bhagawan R.patil rajendra P.Pawar Department of Chemistry Deogiri College Department of Chemistry Dnyanopasak College Department of Chemistry Sharda Mahavidyalaya

The Biginelli-type compounds 4,5,8a-triarylhexahydropyrimido[4,5-d]pyrimidine-2,7（1H,3H）-diones were synthesized by a one-pot three-component reaction using sulfated tin oxide as a reusable catalyst. This method has the advantages of high yields, short reaction time, simple starting materials and reusability of catalyst for several times.

关键词： Biginelli-type reaction Multicomponent reactions Pyrimido[4 5-d]pyrimidine Sulfated tin oxide Reusable catalyst

Novel one-pot synthesis of 4H-chromene derivatives using amino functionalized silica gel catalyst

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Chinese Chemical Letters 2014年第3期25卷 455-458页

作者： Vijaykumar M.Joshi Rupali L.Magar Prashant B.Throat Sunil U.Tekale Bhagavan R.patil Mangal P.Kale rajendra P.Pawar Department of Chemistry Karmveer Ramraoji Aher ArtsScience and Commerce College Department of Chemistry Deogiri College Department of Chemistry Dnyanopasak College Department of Chemistry Sharda Mahavidyalaya

A simple, efficient, and environmentally benign method for the synthesis of 4H-chromene derivatives was developed using well ordered and recoverable amino functionalized silica gel as a base catalyst. The 4H-chromene derivatives were obtained in short time and excellent yield （87%-96%） by three component reaction of aldehydes, malononitrile and cyclic 1,3-diketones in water at 70 ℃.

关键词： Aldehydes4H-ChromenesAmino functionalized silica gel

Surgical route and pathological risk factors in early cervical cancer-Node Zero(SURPEC-N0)

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 42-53页

作者： T S Shylasree Stuti Gupta Akshay patil Pooja Singh Amita Maheshwari Santosh Menon Supriya Chopra Lavanya Gurram Palak Popat Umesh Mahantshetty rajendra Kerkar Department of Gynaecology Oncology Tata Memorial HospitalHomi Bhabha National InstituteMumbai 400012India Consultant Gynaecological Oncologist Department of Gynaecological OncologyAberdeen Royal InfirmaryForesterhill Aberdeen AB252ZNUK Department of Biostatistics Tata Memorial HospitalHomi Bhabha National InstituteMumbai 400012India Department of Pathology Gynaecology Oncology Disease Management GroupTata Memorial HospitalHomi Bhabha National InstituteMumbai 400012India Department of Radiation Oncology Gynaecology Oncology Disease Management GroupTata Memorial HospitalHomi Bhabha National InstituteMumbai 400012India Department of Radiology Gynaecology Oncology Disease Management GroupTata Memorial HospitalHomi Bhabha National InstituteMumbai 400012India

Aim:The aim of this study is to compare disease-free survival(DFS)and overall survival(OS)in patients with stage I cervical cancer(≤4cms,lymph node-negative)undergoing open radical hysterectomy(ORH)*** invasive radical hysterectomy(MIRH).Methods:All patients undergoing radical hysterectomy between January 2012-December 2018 from the largest tertiary referral cancer centre were included.A 1:1 propensity matching was done based on four independent prognostic factors to compare DFS and OS with the route of ***:One hundred and ninety-nine patients were included during the study *** median age of the cohort was 50 *** median follow-up of patients was 47 *** 1:1 propensity matching,a total of 174 patients were analysed for DFS and OS in ORH(n=87)and MIRH(n=87)*** measure was used in two-thirds of the patients during ***-nine patients(16.7%)had *** the matched cohort(n=174),the DFS at 36 and 60 months was 84.8%(78.1%-89.6%)and 81%(73.4%-86.6%)respectively and the OS was 96.5%(91.7%-98.5%)and 95.6%(90.3%-98%)*** was no statistically significant difference in DFS or OS between ORH and ***:The present study showed no difference in oncological outcomes in MIRH compared to *** audits on patient characteristics such as screening/vaccination history along with surgical technique/load and matching for crucial risk factors should be factored in future studies to eliminate the possible methodological errors.

关键词： Cancer cervix radical hysterectomy route of surgery oncological outcomes

First contact investigations and compliance to treatment in patients with uveitis

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1820-1826页

作者： Anuja patil Sanjeev Gupta Pradeep Venkatesh Mousumi Banerjee Vinod Kumar Rohan Chawla Shorya Vardhan Azad Atul Kumar Dr.rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical SciencesNew Delhi 110029India

AIM:To ascertain the pattern of investigations at first contact in uveitic patients and evaluate compliance to ***:An observational study comprised of 201 uveitic patients presenting for the first time to our centre from January 2019 to June *** information regarding systemic investigations undertaken by specialists at the time of first contact and the cost of these investigations were reviewed on the first visit to our *** with the treatment was determined and reasons behind non-compliance were evaluated on the first follow-up in patients who had no improvement in clinical signs and ***:The mean age of the study group was 35.35±14.1y and gender composition was 59.7%males and 40.3%*** uveitis was observed in 45.3%of patients,intermediate uveitis in 31.8%of patients,posterior uveitis in 14.9%of patients and panuveitis in 8.0%of *** with a systemic disease was evident in 17.9%of *** compared with standard guidelines and uveitis patterns,systemic investigations were identified to be relevant only in 38.3%of ***-compliance to treatment was documented in 22.4%of *** reasons for non-compliance were inadequate counselling by the treating physician about treatment in 26.7%of patients and a busy schedule at work/school in 22.2%of ***:Significant number of investigations performed at first contact is found to be contrary to standard guidelines and are not contributory to the *** a quarter of patients in this study are found to be non-compliant with the *** is more challenging to achieve in school-going children and working *** availability of comprehensive,periodically updated,evidence-based guidelines on the role of investigations and the use of trained counsellors may help to channelize proper evaluation and improve compliance to treatment,respectively,in patients with uveitis.

关键词： uveitis compliance investigations first contact