检索结果-南通市图书馆

Phytochemical profile and biological activity of Juglans regia

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2016年第5期14卷 359-373页

作者： Nisha Panth Keshav Raj Paudel rajendra karki College of Pharmacy and Natural Medicine Research Institute Mokpo National University Department of Oriental Medicine Resource Mokpo National University

Juglans regia Linn. （Juglandaceae）, popularly known as English or Persian walnut, is a valuable medicinal plant with a potency to cure various diseases in traditional medicine, Since ancient time, different local ethnic groups have used various part of J. regia for a wide array of ailments including helminthiasis, diarrhea, sinusitis, stomach ache, arthritis, asthma, eczema, scrofula, skin disorders, diabetes mellitus, anorexia, thyroid dysfunction, cancer and infectious diseases. Biological activities of J. regia have been reported in several peer review journals and scientific attention is increasing. The present review attempts to provide comprehensive information on plant description, ethnobotanical use, toxicity, phytochemical profile, pharmacology, clinical studies and current research prospective of the J. regia. Currently, there is an immense interest on isolation/identification of active constituents from walnut and screening those active compounds for pharmacological activities. In addition, researchers are performing clinical trials as well as screening various solvent extracts or fractions of J. regia in several animal diseases models to identify promising therapeutic benefits. In the present work, we review the latest information based on published scientific investigations of J. regia.

关键词： plant extracts Juglans regia medicine, traditional phytochemicals pharmacology

Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第7期18卷 1798-1808页

作者： Sarang Tartey Prajwal Gurung rajendra karki Amanda Burton Paul Hertzog Thirumala-Devi Kanneganti Department of Immunology St.Jude Children’s Research HospitalMemphisTN38105USA Inflammation Program University of IowaIowa CityIA52241USA Centre for Innate Immunity&Infectious Diseases Hudson Institute of Medical ResearchDepartment of Molecular and Translational SciencesMonash UniversityClaytonVictoria3168Australia

The SHP-1 protein encoded by the Ptpn6 gene has been extensively studied in hematopoietic cells in the context of inflammation.A point mutation in this gene(Ptpn6spin)causes spontaneous inflammation in mice,which has a striking similarity to neutrophilic dermatoses in *** findings highlighted the role of signaling adapters and kinases in promoting inflammation in Ptpn6spin mice;however,the underlying transcriptional regulation is poorly ***,we report that SYK is important for driving neutrophil infiltration and initiating wound healing responses in Ptpn6spin ***,we found that deletion of the transcription factor Ets2 in myeloid cells ameliorates cutaneous inflammatory disease in Ptpn6spin mice through transcriptional regulation of its target inflammatory ***,Ets-2 drives IL-1α-mediated inflammatory signaling in neutrophils of Ptpn6spin ***,in addition to its well-known role in driving inflammation in cancer,Ets-2 plays a major role in regulating IL-1α-driven Ptpn6spin-mediated neutrophilic dermatoses.

关键词： Autoinflammation ETS-2 IL-1α Neutrophilic dermatoses PTPN6 SHP-1

Extract of buckwheat sprouts scavenges oxidation and inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated macrophages (RAW264.7)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2013年第4期11卷 246-252页

作者： rajendra karki Cheol-Ho Park Dong-Wook Kim Department of Oriental Medicine Resources Mokpo National University Division of Pharmacology and Toxicology School of Pharmacy University of Missouri-Kansas City Department of Bio-Health Technology Kangwon National University

OBJECTIVE： Buckwheat has been considered as a potential source of nutraceutical components on the world market of probiotic foodstuffs. The purpose of this study was to evaluate the effects of tartary buckwheat （Fagopyrum tataricum） sprouts on oxidation and pro-inflammatory mediators. METHODS： The anti-oxidant effects of buckwheat extract （BWE） and rutin were evaluated by using 1,1-diphenyl-2-picrylhydrazyl （DPPH）-and nitric oxide （NO）-scavenging activities, serum peroxidation and chelating assays. Lipopolysaccharide （LPS）-stimulated RAW264.7 cells were used to evaluate anti-inflammatory activities of buckwheat and rutin. NO production in LPS- stimulated RAW264.7 cells was determined by using Griess reagent. The expressions of inducible nitric oxide synthase （iNOS）, cyclooxygenase-2 （COX-2）, nuclear factor-kappa B （NF-κB） p65 subunit in cytosolic and nuclear portions were determined by Western blot analysis. Also, the production of inflammatory cytokines interleukin-6 （IL-6） and tumor necrosis factor-α （TNF-α） was determined by enzyme-linked immunosorbent assay. RESULTS： Inhibitory concentration 50 values for DPPH- and NO-scavenging activities of BWE were 24.97 and 72.54 μg/mL respectively. BWE inhibited serum oxidation and possessed chelating activity. Furthermore, BWE inhibited IL-6 and TNF-a production in LPS-stimulated RAW264.7 cells. Also, BWE inhibited iNOS and COX-2 expression and NF-KB p65 translocation. CONCLUSION： Buckwheat sprouts possessed strong antioxidant activity and inhibited production of pro-inflammatory mediators in the applied model systems. Thus, buckwheat can be suggested to be beneficial in inflammatory diseases by inhibiting the free radicals and inflammatory mediators.

关键词： Fagopyrum plant extracts oxidation nitric oxide synthase type II cyclooxygenase 2

Foeniculum vulgare *** lipopolysaccharide-induced microglia activation and ameliorates neuroinflammation-mediated behavioral deficits in mice

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 28-39页

作者： Sushruta Koppula Ramesh Alluri Spandana rajendra Kopalli College of Biomedical and Health Sciences Konkuk UniversityChungju-SiChungcheongbuk Do27478Republic of Korea Cognitive Science Research Initiative Lab Department of PharmacologyVishnu Institute of Pharmaceutical Education and ResearchNarsapurTelangana502313India Department of Bioscience and Biotechnology Sejong UniversityGwangjin-guSeoul 05006Republic of Korea

Objective:To investigate the effect of Foeniculum vulgare extract against lipopolysaccharide(LPS)-induced microglial activation in vitro as well as cognitive behavioral deficits in ***:LPS-activated BV-2 cell viability was measured using MTT assay and reactive oxygen species(ROS)was studied using DCF-DA *** antioxidative enzymes and pro-inflammatory mediators were analyzed using respective ELISA kits and Western *** in vivo testing,LPS(1 mg/kg,i.p.)was given daily for five days in male Swiss albino mice to produce chronic *** and behavioral tests were performed using open-field,passive avoidance,and rotarod experiments in LPS-induced ***:Foeniculum vulgare extract(25,50 and 100μg/mL)significantly attenuated the LPS-activated increase in nitric oxide(NO),ROS,cyclooxygenase-2,inducible NO synthase,IL-6,and TNF-alpha(P<0.05).Moreover,LPS-induced oxidative stress and reduced antioxidative enzyme levels were significantly improved by Foeniculum vulgare extract(P<0.05).The extract also regulated the NF-κB/MAPK signaling in BV-2 *** an in vivo study,Foeniculum vulgare extract(50,100,and 200 mg/kg)markedly mitigated the LPS-induced cognitive and locomotor impairments in *** fingerprinting analysis showed distinctive peaks with rutin,kaempferol-3-O-glucoside,and anethole as identifiable ***:Foeniculum vulgare extract can ameliorate LPS-stimulated neuroinflammatory responses in BV-2 microglial cells and improve cognitive and locomotor performance in LPS-administered mice.

关键词： Foeniculum vulgare Microglia Lipopolysaccharide Antioxidant Neuroinflammation MAPK signaling Cognition

Nanozyme‑Engineered Hydrogels for Anti‑Inflammation and Skin Regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第6期16卷 127-179页

作者： Amal George Kurian rajendra K.Singh Varsha Sagar Jung‑Hwan Lee Hae‑Won Kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science&BK21 NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Department of Biomaterials Science School of DentistryDankook UniversityCheonan 31116Republic of Korea UCL Eastman‑Korea Dental Medicine Innovation Centre Dankook UniversityCheonan 31116Republic of Korea Cell and Matter Institute Dankook UniversityCheonan 31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan 31116Republic of Korea

Inflammatory skin disorders can cause chronic scarring and functional impairments,posing a significant burden on patients and the healthcare *** therapies,such as corticosteroids and nonsteroidal anti-inflammatory drugs,are limited in efficacy and associated with adverse ***,nanozyme(NZ)-based hydrogels have shown great promise in addressing these ***-based hydrogels possess unique therapeutic abilities by combining the therapeutic benefits of redox nanomaterials with enzymatic activity and the water-retaining capacity of *** multifaceted therapeutic effects of these hydrogels include scavenging reactive oxygen species and other inflammatory mediators modulating immune responses toward a pro-regenerative environment and enhancing regenerative potential by triggering cell migration and *** review highlights the current state of the art in NZ-engineered hydrogels(NZ@hydrogels)for anti-inflammatory and skin regeneration *** also discusses the underlying chemo-mechano-biological mechanisms behind their ***,the challenges and future directions in this ground,particularly their clinical translation,are *** insights provided in this review can aid in the design and engineering of novel NZ-based hydrogels,offering new possibilities for targeted and personalized skin-care therapies.

关键词： Nanozymes Hydrogels ROS scavenging Anti-inflammation Skin regeneration

Impact factors and pathways of halonitromethanes formation from aspartic acid during LED-UV_(265)/chlorine disinfection

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2024年第1期18卷 129-144页

作者： Liangwen Zhu Tao Wang Qian Tang Qing Wang Lin Deng Jun Hu Chaoqun Tan rajendra Prasad Singh Key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education School of Civil EngineeringSoutheast UniversityNanjing 211189China College of Environment Zhejiang University of TechnologyHangzhou 310014China

Light emitting diode (LED-UV)/chlorine disinfection can replace UV/chlorine disinfection in wastewater treatment plants and water supply plants. Halonitromethanes (HNMs) are a class of novel nitrogenous disinfection by-products, which are characterized by higher cytotoxicity and genotoxicity than regulated disinfection by-products. Herein, the impact factors and pathways of HNMs formation from aspartic acid (ASP) were investigated during LED-UV_(265)/chlorine disinfection. The results showed that three types of chlorinated-HNMs (Cl-HNMs) were found during LED-UV265/chlorine disinfection, and their concentrations increased first and then declined as the reaction progressed. Cl-HNMs yields increased with increasing LED-UV_(265) intensity, free chlorine dosage, and ASP concentration, which declined with increasing pH (6.0–8.0). Meantime, the important impact of the coexisting ions contained in water matrices on HNMs formation from ASP was observed during LED-UV_(265)/chlorine disinfection. It was found that copper ions (Cu^(2+)) promoted Cl-HNMs formation. Furthermore, when bromide (Br–) appeared during LED-UV265/chlorine disinfection, nine types of HNMs were detected simultaneously. Moreover, Br– not only converted Cl-HNMs toward brominated (chlorinated)-HNMs and brominated-HNMs but also showed a marked effect on HNMs concentrations and species. Subsequently, the possible pathways of HNMs formation from ASP were proposed during LED-UV_(265)/chlorine disinfection. At last, it was proved that the formation trends of HNMs obtained in the real waters were similar to those in simulated waters. This work elaborated on the influence factors and pathways of HNMs formation, which is conducive to controlling the HNMs produced during LED-UV_(265)/chlorine disinfection.

关键词： LED-UV265 chlorine HNMs Aspartic acid Bromide Copper ions

Advanced Computing for Cardiovascular Disease Prediction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Statistics 2024年第3期14卷 228-242页

作者： Santosh Gaire Poshan Belbase Amrit Kafle rajendra Bhandari Vitreous State Laboratory The Catholic University of America Washington DC USA Department of Physics The Catholic University of America Washington DC USA

Developing a predictive model for detecting cardiovascular diseases (CVDs) is crucial due to its high global fatality rate. With the advancements in artificial intelligence, the availability of large-scale data, and increased access to computational capability, it is feasible to create robust models that can detect CVDs with high precision. This study aims to provide a promising method for early diagnosis by employing various machine learning and deep learning techniques, including logistic regression, decision trees, random forest classifier, extreme gradient boosting (XGBoost), and a sequential model from Keras. Our evaluation identifies the random forest classifier as the most effective model, achieving an accuracy of 0.91, surpassing other machine learning and deep learning approaches. Close behind are XGBoost (accuracy: 0.90), decision tree (accuracy: 0.86), and logistic regression (accuracy: 0.70). Additionally, our deep learning sequential model demonstrates promising classification performance, with an accuracy of 0.80 and a loss of 0.425 on the validation set. These findings underscore the potential of machine learning and deep learning methodologies in advancing cardiovascular disease prediction and management strategies.

关键词： Machine Learning Deep Learning Classification Performance Matrix Accuracy

Surface-functionalized hole-selective monolayer for high efficiency single-junction wide-bandgap and monolithic tandem perovskite solar cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第1期88卷 317-326,I0008页

作者： Devthade Vidyasagar Yeonghun Yun Jae Yu Cho Hyemin Lee Kyung Won Kim Yong Tae Kim Sung Woong Yang Jina Jung Won Chang Choi Seonu Kim rajendra Kumar Gunasekaran Seok Beom Kang Kwang Heo Dong Hoe Kim Jaeyeong Heo Sangwook Lee School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials Science and Engineering and Optoelectronics Convergence Research CenterChonnam National UniversityGwangju 61186Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea

Carbazole moiety-based 2PACz([2-(9H-carbazol-9-yl)ethyl]phosphonic acid)self-assembled monolayers(SAMs)are excellent hole-selective contact(HSC)materials with abilities to excel the charge-transferdynamics of perovskite solar cells(PSCs).Herein,we report a facile but powerful method to functionalize the surface of 2PACz-SAM,by which reproducible,highly stable,high-efficiency wide-bandgap PSCs can be *** 2PACz surface treatment with various donor number solvents improves assembly of 2PACz-SAM and leave residual surface-bound solvent molecules on 2PACz-SAM,which increases perovskite grain size,retards halide segregation,and accelerates hole *** surface functionalization achieves a high power conversion efficiency(PCE)of 17.62%for a single-junction wide-bandgap(~1.77 e V)*** also demonstrate a monolithic all-perovskite tandem solar cell using surfaceengineered HSC,showing high PCE of 24.66%with large open-circuit voltage of 2.008 V and high fillfactor of 81.45%.Our results suggest this simple approach can further improve the tandem device,when coupled with a high-performance narrow-bandgap sub-cell.

关键词： Perovskite solar cells 2PACz Monolithic tandem solar cells Wide bandgap

Direct-Seeded Rice: Genetic Improvement of Game-Changing Traits for Better Adaption

在线全文

学校读者我要写书评

暂无评论

Rice science 2024年第4期31卷 417-433页

作者： Priyanka NEGI Jagadish RANE rajendra Sadashiv WAGH Tukaram Jayaram BHOR Dipti Digambar GODSE Priyanka JADHAV C.ANILKUMAR Dasari SREEKANTH K.SAMMI REDDY Sharad Ramrao GADAKH K.M.BORAIH C.B.HARISHA P.S.BASAVARAJ Indian Council of Agricultural Research(ICAR)-National Institute of Abiotic Stress Management Baramati 413115India Mahatma Phule Krishi Vidyapeeth Rahuri 413722India ICAR-Central Institute for Arid Horticulture Bikaner 334006India ICAR-National Rice Research Institute Cuttack 753006India ICAR-Directorate of Weed Research Jabalpur 482004India Dr.Panjabrao Deshmukh Krishi Vidyapeeth Akola 444104India

The sustainability of rice production continues to be a subject of uncertainty and inquiry attributed to shifts in climatic conditions. In light of the impending climate change crisis and the high labor and water costs accompanying it, direct-seeded rice(DSR) is unquestionably one of the most practical solutions. Despite its resource and climate-friendly advantages, early maturing rice faces weed competitiveness and seedling establishment challenges. Resolving these issues is crucial for promoting its wider adoption among farmers, presenting it as a more effective sustainable rice cultivation method globally. Diverse traditional and contemporary breeding methods are employed to mitigate the limitations of the DSR approach, leveraging advanced techniques such as speed breeding and genome editing. Focusing on key traits like mesocotyl length elongation, early seedling vigor, root system architecture, and weed competitiveness holds promise for transformative improvements in DSR adaptation at a broader scale within farming communities. This review aims to summarize how these features contribute to increased crop production in DSR conditions and explore the research efforts focusing on enhancing DSR adaptation through these traits. Emphasizing the pivotal role of these game-changing traits in DSR adaptation, our analysis sheds light on their potential transformative impact and offers valuable insights for advancing DSR practices.

关键词： climate change direct-seeded rice aerobic rice early vigor trait