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Immunotherapy in type 1 d.abetes:Novel pathway to the future ahead

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World.Journal of d.abetes 2024年第10期15卷 2022-2035页

作者： Sayantan Ray rajan Palui d.partment of End.crinology All India Institute of Medical SciencesBhubaneswar 751019India d.partment of End.crinology The Mission HospitalDurgapur 713212India

Since the d.scovery of insulin over 100 years ago,the focus of research in the management of type 1 d.abetes(T1d.has centered.around.glycemic control and.management of complications rather than the prevention of autoimmune d.struc-tion of pancreaticβ***,in recent years,there has been significant ad.ancement in immune-targeted.pharmacotherapy to halt the natural progres-sion of *** immune-targeted.intervention aims to alter the und.rlying pa-thogenesis of T1d.by targeting d.fferent aspects of the immune *** im-munotherapy can either antagonize the immune med.ators like T cells,B cells or cytokines(antibod.-based.therapy),or reind.ce self-tolerance to pancreaticβcells(antigen-based.therapy)or stem-cell ***,the US Food.and.d.ug Ad.inistration approved.the first immunotherapy teplizumab to be used.only in stage 2 of ***,the wind.w of opportunity to practically implement this approved.molecule in the selected.target population is *** this Ed.to-rial,we briefly d.scuss the various promising recent d.velopments in the field.of immunotherapy research in ***,further stud.es of these newer thera-peutic agents are need.d.to explore their true potential for prevention or cure of T1d.

关键词： Type 1 d.abetes Immunotherapy Teplizumab Antigen based.therapy Stem cell immunotherapy

Mod.lling of strain ind.ced.magnetic anisotropy in Au ad.itive FePt thin films

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Progress in Natural Science:Materials International 2019年第5期29卷 517-524页

作者： rajan Goyal S.Lamba S.Annapoorni d.partment of Physics and.Astrophysics University of Delhi School of Sciences Indira Gandhi National Open University

L10ord.ring at low temperature and.controlled.grain size are prerequisites for the fabrication of magnetic record.ng med.a. This can be achieved.by several method. such as ad.ition, und.r layer or over layer of third.element in FePt. In the present work, the kinetics of L10 ord.ring in the presence of immiscible element Au is investigated.by varying the Au concentration at d.fferent annealing temperatures. The structural analysis shows that the Au ad.itive not only promotes the ord.ring at low temperature but also supports the textured.growth along(001) plane. The magnetic measurements supported.by theoretical simulations using Monte Carlo pred.cts that the enhancement in coercivity attributed.to ind.ced.strain anisotropy and.weakening of inter-granular exchange coupling may be d.e to presence of Au at grain bound.ries.

关键词： Anisotropy Monte Carlo FePt

Effect of firing cond.tions ＆ release height on terminal performance of submunitions and.cond.tions for optimum height of release

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d.fence Technology（防务技术） 2017年第3期13卷 200-205页

作者： L.K.Gite A.Anand.raj R.S.d.od.ar d.K.Joshi K.M.rajan Armament Research d.velopment Establishment (ARd.) Defence Research Development Organization Ministry of Defence Government of India

Submunitions should.exhibit optimum terminal performance at target end.when released.from certain pre-d.termined.height. Selection of an optimum height of release of the submunitions d.pend. on the terminal parameters like forward.throw, remaining velocity, impact angle and.flight time. In this paper,the effects of initial firing cond.tions and.height of release on terminal performance of submunitions d.scussed.in d.tail. For d.fferent height of release, the relation between range and.forward.throw is also established.& valid.ted.for a number of firing altitud. and.rocket configurations.

关键词：最佳高度终端子弹性能射击剩余速度飞行时间冲击角

Physical,Mechanical,and.Tribological Attributes of Stir-Cast AZ91/SiC_p Composite

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Acta Metallurgica Sinica(English Letters) 2014年第2期27卷 295-305页

作者： K.K.Ajith Kumar Abhilash Viswanath T.P.d.rajan U.T.S.Pillai B.C.Pai Material Science and.Technology d.vision CSIR-National Institute for Interdisciplinary Science and Technology

In the present investigation, composites with silicon carbid. particle （SiCp） as reinforcement and.AZ91 magnesium alloy as matrix have been synthesized.using liquid.metal stir-casting technique with optimized.processing cond.tions. The composites with good.particle d.stribution in the matrix, and.better grain refinement and.good.interfacial bond.ng between the matrix and.reinforcement have been obtained. The effect of SiCp content on the physical, mechanical, and.tribological properties of Mg-based.metal matrix composite （MMC） is stud.ed.with respect to particle d.stribution, grain refinement, and.particle/matrix interfacial reactions. The electrical cond.ctivity, coefficient of thermal expansion, microas well as macro-hard.ess, tensile and.compressive properties, and.the fracture behavior of the composites along with d.y slid.ng wear of the composites have been evaluated.and.compared.with the base alloy.

关键词： Composite AZ91d.alloy Casting alloy Mechanical properties Wear

Growth and.Characterization of Organic NLO Crystal:β-Naphthol

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Journal of Materials Science & Technology 2011年第3期27卷 271-274页

作者： S.Janarthanan R.Sugaraj Samuel S.Selvakumar Y.C.rajan d.Jayaraman S.Pand. d.partment of Physics Presidency College d.partment of Chemistry Presidency College d.partment of Physics L.N.Govt.College d.partment of Material Science Engineering National Chiao Tung University

Single crystals of β-Naphthol （/3N）, an organic nonlinear optical （NLO） material was successfully grown by temperature lowering method.using chloroform as solvent. The initial compound.was purified.by repeated.recrystallization process. As-grown crystals were characterized.by single crystal X-ray d.ffraction （XRd. stud.es to ascertain that βN crystal crystallized.in the monoclinic system with a noncemtrosymmetric space group. Vibrational frequencies of various functional groups in the crystals were d.rived.from Fourier transform infrared.（FTIR） spectroscopy and.proton nuclear magnetic resonance （NMR） spectrum. Optical characterization was d.ne using UV-Visible near-infrared.（NIR） spectroscopy. The thermal behaviour of the material was stud.ed.by thermo gravimetric and.d.fferential thermal plots. Scanning electron microscopy （SEM） stud. was carried.out on the surface of the grown crystals to investigate the nature of d.fects in the crystal surface and.the NLO property of the crystal was tested.by Nd.YAG laser as a source.

关键词： Crystal growth Fourier transform infrared.(FTIR) spectroscopy Nonlinear optical crystal Scanning electron microscopy (SEM)

Introd.ction to structural analysis & d.sign /

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Introduction to structural analysis & design /

A Non-Intrusive Stochastic Phase-Field.for Fatigue Fracture in Brittle Materials with Uncertainty in Geometry and.Material Properties

2001年

作者： rajan Subramaniam d.

来源：畅想之星图书光盘版（南... 评论

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Computer Mod.ling in Engineering & Sciences 2024年第11期141卷 997-1032页

作者： rajan Aravind.Sund.rarajan Natarajan Krishnankutty Jayakumar Ratna Kumar Annabattula d.partment of Mechanical Engineering Indian Institute of Technology MadrasChennai600036India Vikram Sarabhai Space Centre Thiruvananthapuram695022India

Und.rstand.ng the probabilistic nature of brittle materials d.e to inherent d.spersions in their mechanical properties is important to assess their reliability and.safety for sensitive engineering *** is all the more important when elements composed.of brittle materials are exposed.to d.namic environments,resulting in catastrophic fatigue *** authors propose the application of a non-intrusive polynomial chaos expansion method.for probabilistic stud.es on brittle materials und.rgoing fatigue fracture when geometrical parameters and.material properties are rand.m ind.pend.nt *** the probabilistic nature of fatigue fracture in brittle materials is crucial for ensuring the reliability and.safety of engineering structures subjected.to cyclic *** growth is mod.lled.using a phase-field.approach within a finite element *** mod.lling fatigue,fracture resistance is progressively d.grad.d.by mod.fying the regularised.free energy functional using a fatigue d.grad.tion *** of cycles to failure is treated.as the d.pend.nt variable of interest and.is estimated.within acceptable limits d.e to the rand.mness in ind.pend.nt *** 2d.benchmark problems are solved.to d.monstrate the ability of this approach to pred.ct the d.pend.nt variable responses with significantly fewer simulations than the Monte Carlo *** proposed.approach can accurately pred.ct results typically obtained.through 105 or more runs in Monte Carlo simulations with a red.ction of up to three ord.rs of magnitud. in required.*** ind.pend.nt rand.m variables’sensitivity to the system response is d.termined.using Sobol’*** proposed.approach has low computational overhead.and.can be useful for computationally intensive problems requiring rapid.d.cision-making in sensitive applications like aerospace,nuclear and.biomed.cal *** technique d.es not require reformulating existing finite element cod. and.can

关键词： Phase-field fatigue fracture polynomial chaos expansion material uncertainty rand.m variables non-intrusive stochastic technique

Review of MXenes as a component in smart textiles and.an ad.orbent for textile wastewater remed.ation

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Chinese Chemical Letters 2024年第2期35卷 208-222页

作者： Kaniz Farhana Kumaran Kad.rgama Abu Shad.te Faisal Mahamud. rajan Jose d.partment of Apparel Engineering Bangladesh University of TextilesDhaka 1208Bangladesh Faculty of Mechanical and.Automotive Engineering Technology Universiti Malaysia Pahang26600 PekanPahangMalaysia Center of Automotive Engineering Universiti Malaysia PahangMalaysia College of Engineering Universiti Malaysia Pahang26300 GambangPahangMalaysia Faculty of Ind.strial Sciences & Technology Universiti Malaysia Pahang26300 KuantanMalaysia Center of Intelligent Materials Universiti Malaysia Pahang26300 KuantanMalaysia

Two-d.mensional(2d.MXenes have emerged.as an archetypical layered.material combining the properties of an organic-inorganic hybrid.offering materials sustainability for a range of *** surface functional groups and.the associated.chemical properties'tailorability through functionalizing MXenes with other materials as well as hyd.ophilicity and.high cond.ctivity enable them to be the best successor for various applications in textile ind.stries,especially in the ad.ancement of smart textiles and.remed.ation of textile ***-based.textile composite performs superb smartness in high-performance wearables as well as in the red.ction of textile d.es from *** article critically reviews the significance of MXenes in two sectors of the textile ***,we review the improvement of textile raw materials such as fiber,yarn,and.fabric by using MXene as electrod.s in supercapacitors,pressure ***,we review ad.ancements in the removal of d.es from textile wastewater utilizing MXene as an absorbent by the ad.orption ***-based.textiles d.monstrated.superior strength through the strong bond.ng between MXene and.textile structures as well as the treatment of ad.orbate by ad.orbent(MXene in the ad.orption process).We id.ntify critical gaps for further research to enable their real-life applications.

关键词： Textile fibers Ind.strial wastewater treatment MAX phases Hybrid.electrod.s Ad.orption

Self-lubricating bid.rectional carbon fiber reinforced.smart aluminum composites by squeeze infiltration process

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Journal of Materials Science & Technology 2019年第11期35卷 2559-2569页

作者： K.M.Sree Manu L.Ajay Raag T.P.d.rajan B.C.Pai Vijay Petley Shweta Namd.o Verma CSIR-National Institute for Interd.sciplinary Science and.Technology TrivandrumIndia Gas Turbine Research Establishment(GTRE) BangaloreIndia

Self-lubrication is one of the smart material properties required.for prod.cing components with enhanced.wear resistance and.low coefficient of ***(Bd.satin weave polyacrylonitrile(PAN)based.carbon fiber(Cf)fabric preform was successfully infiltrated.with Al 6061 alloy by squeeze infiltration *** infiltrated.composite shows uniform d.stribution of carbon fibers in the matrix with the elimination of porosities,fiber d.mage and.close control on the formation of d.leterious aluminum carbid.(Al4C3)***/Al composite exhibits remarkable wear resistance compared.to unreinforced.alloy d.e to the formation of self-lubricating tribolayer on the pin surface,which intercepts the contact of matrix metal to counter *** Bd.carbon fiber enhanced.the hard.ess and.compressive strength of the composite by restraining the plastic flow behavior of *** resolution transmission electron microscopy shows the presence of Al2O3 and.MgAl2O4 spinel,confirmed.by Ed. and.SAd.pattern,at the composite *** composite shows a lower d.nsity of 2.16 g/cm^3 which is a major ad.vantage for weight red.ction compared.to the monolithic alloy(2.7 g/cm^3).

关键词： Metal matrix composites Squeeze infiltration Aluminum Carbon fiber fabric Tribology Microstructure