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Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing

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World Journal of Gastroenterology 2015年第7期21卷 2011-2029页

作者： rajagopal n aravalli neil C Talbot Clifford J Steer Department of Radiology University of Minnesota Medical School Minneapolis Beltsville Agricultural Research Center US Department of Agriculture Departments of Medicine and Genetics Cell Biology and Development University of Minnesota

AIM:To identify the genes induced and regulated by the MYC protein in generating tumors from liver stem ***:In this study,we have used an immortal porcine liver stem cell line,PICM-19,to study the role of c-MYC in ***-19 cells were converted into cancer cells(PICM-19-CSCs)by overexpressing human *** identify MYC-driven differential gene expression,transcriptome sequencing was carried out by RnA sequencing,and genes identified by this method were validated using real-time *** vivo tumorigenicity studies were then conducted by injecting PICM-19-CSCs into the flanks of immunodeficient ***:Our results showed that MYC-overexpressing PICM-19 stem cells formed tumors in immunodeficient mice demonstrating that a single oncogene was sufficient to convert them into cancer cells(PICM-19-CSCs).By using comparative bioinformatics analyses,we have determined that>1000 genes were differentially expressed between PICM-19 and *** ontology analysis further showed that the MYCinduced,altered gene expression was primarily associated with various cellular processes,such as metabolism,cell adhesion,growth and proliferation,cell cycle,inflammation and ***,six genes expressed by PICM-19 cells(CDO1,C22orf39,DKK2,EnPEP,GPX6,SRPX2)were completely silenced after MYC-induction in PICM-19-CSCs,suggesting that the absence of these genes may be critical for ***:MYC-driven genes may serve as promising candidates for the development of hepatocellular carcinoma therapeutics that would not have deleterious effects on other cell types in the liver.

关键词： Hepatocellular carcinoma MYC Stem cells Gene expre

The Correlation Coefficient of Hesitancy Fuzzy Graphs in Decision Making

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Computer Systems Science & Engineering 2023年第7期46卷 579-596页

作者： n.rajagopal Reddy S.Sharief Basha School of Advanced Sciences Vellore Institute of TechnologyVellore632014TamilnaduIndia

The hesitancy fuzzy graphs(HFGs),an extension of fuzzy graphs,are useful tools for dealing with ambiguity and uncertainty in issues involving decision-making(DM).This research implements a correlation coefficient measure(CCM)to assess the strength of the association between HFGs in this article since CCMs have a high capacity to process and interpret *** CCM that is proposed between the HFGs has better qualities than the existing *** lowers restrictions on the hesitant fuzzy elements’length and may be used to establish whether the HFGs are connected negatively or ***,a CCMbased attribute DM approach is built into a hesitant fuzzy *** article suggests the use of weighted correlation coefficient measures(WCCMs)using the CCM concept to quantify the correlation between two *** decisionmaking problems of hesitancy fuzzy preference relations(HFPRs)are *** research proposes a new technique for assessing the relative weights of experts based on the uncertainty of HFPRs and the correlation coefficient degree of each *** paper determines the ranking order of all alternatives and the best one by using the CCMs between each option and the ideal *** the meantime,the appropriate example is given to demonstrate the viability of the new strategies.

关键词： Hesitancy fuzzy graph correlation coefficient measures energy hesitancy fuzzy preference relationships decision making

A Limited Area Model for Monsoon Prediction

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Advances in Atmospheric Sciences 1990年第1期7卷 111-126页

作者： S.S.Singh S.S Vaidya E.n.rajagopal Indian Instituteof Tropical Meteorology Pune-411005 IndiaIndian Instituteof Tropical Meteorology Pune-411005 IndiaIndian Instituteof Tropical Meteorology Pune-411005 India

A six level regional primitive equation model has been formulated and tested for monsoon prediction. The model uses dynamic normal mode initialization scheme for obtaining initial balance. The physical processes included are: the large scale condensation, the Kuo type of cumulus convection, the surface friction, the sensible heat supply and evaporation over the sea. The actual smooth orography is included. The model has been integrated for 48 hrs using input of 7 July and 8 August 1979 when the domain of integration was dominated by an intense monsoon depression. In order to investigate the model simulation of formative stage of the depression, the model was also integrated using input of 4 July ***, the envelope orography has been constructed and included in the model for investigating its effects on the monsoon prediction. Results of the model forecast are presented and discussed.

关键词： GMT mode

Optical and Microstructural Characterisations of Pulsed rf Magnetron Sputtered Alumina Thin Film

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Journal of Materials Science & Technology 2013年第10期29卷 929-936页

作者： I.neelakanta Reddy V.rajagopal Reddy n.Sridhara S.Basavaraja A.K.Sharma Arjun Dey Thermal Systems Group ISRO Satellite CentreVimanapura Post Department of Physics Sri Venkateswara University Bruker India nanotechnology Laboratory Jawaharlal Nehru Centre for Advanced Scientifc Research (JNCASR)

Alumina thin films were deposited on fused quartz and SS304 substrate by pulsed rf magnetron sputtering with both direct and reactive methods. The films were characterised by energy dispersive X-ray spectroscopy, X-ray diffraction, scanning electron microscopy, field emission scanning electron microscopy and atomic force microscopy to reveal the microstructure, surface morphology and topography of thin films. Transmittance and reflectance of alumina thin film were evaluated after deposition on the quartz substrate. Transmittance of the quartz remains almost un-altered when alumina was deposited by the reactive sputtering. A marginal decrease of ~4% in the transmittance of quartz was, however, observed after deposition of alumina by direct sputtering. Infrared emittance of the substrate also remains almost constant after deposition of thin alumina film. Further, as-deposited alumina on SS304 obtained by both direct and reactive sputtering process was amorphous in nature. However, after annealing crystalline peaks were observed.

关键词： Alumina Thin film rf magnetron sputtering Microstructure Transmittance Reflectance Infrared emissivity

The Laplacian Energy of Hesitancy Fuzzy Graphs in Decision-Making Problems

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Computer Systems Science & Engineering 2023年第3期44卷 2637-2653页

作者： n.rajagopal Reddy Mohammad Zubair Khan S.Sharief Basha Abdulrahman Alahmadi Ahmed H.Alahmadi Chiranji Lal Chowdhary School of Advanced Sciences Vellore Institute of TechnologyVellore632014TamilnaduIndia Department of Computer Science and Information Taibah UniversityMedinaSaudi Arabia Department of Mathematics School of Advanced SciencesVellore Institute of TechnologyVellore632014TamilnaduIndia School of Information Technology and Engineering Vellore Institute of TechnologyVellore632014TamilnaduIndia

Decision-making(DM)is a process in which several persons concur-rently engage,examine the problems,evaluate potential alternatives,and select an appropriate option to the *** for determining order preference by similarity to the ideal solution(TOPSIS)is an established DM *** objective of this report happens to broaden the approach of TOPSIS to solve the DM issues designed with Hesitancy fuzzy data,in which evaluation evidence given by the experts on possible solutions is presents as Hesitancy fuzzy decision matrices,each of which is defined by Hesitancy fuzzy ***:we represent analytical results,such as designing a satellite communication network and assessing reservoir operation methods,to demonstrate that our suggested thoughts may be used in ***:We studied a new testing method for the arti-ficial communication system to give proof of the future construction of satellite earth *** aim to identify the best one from the different testing *** are alsofinding the best operation schemes in the *** this article,we present the concepts of Laplacian energy(LE)in Hesitancy fuzzy graphs(HFGs),the weight function of LE of HFGs,and the TOPSIS method technique is used to produce the hesitancy fuzzy weighted-average(HFWA).Also,consider practical examples to illustrate the applicability of thefinest design of satellite communication systems and also evaluation of reservoir schemes.

关键词： Hesitancy fuzzy graphs(HFGs) laplacian energy satellite communication system reservoir operation schemes decision-making

Local sum uncertainty relations for angular momentum operators of bipartite permutation symmetric systems

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Chinese Physics B 2022年第6期31卷 163-169页

作者： I Reena H S Karthik J Prabhu Tej Sudha A R Usha Devi A K rajagopal Department of Physics JnanabharathiBangalore UniversityBangalore-560056India 2 International Centre for Theory of Quantum Technologies University of GdanskGdansk80-308Poland Department of Physics Ramaiah University of Applied SciencesBangalore-560054India Department of Physics Kuvempu UniversityShankaraghattaShimoga-577451India Inspire Institute Inc. AlexandriaVirginia22303USA

We show that violation of the variance based local sum uncertainty relation(LSUR)for angular momentum operators of a bipartite system,proposed by Hofmann and Takeuchi[***.A 68032103(2003)],reflects entanglement in the equal bipartitions of an n-qubit symmetric state with even *** establish the one-to-one connection with the violation of LSUR with negativity of covariance matrix[***.A 364203(2007)]of the two-qubit reduced system of a permutation symmetric n-qubit state.

关键词： sum uncertainty relations permutation symmetry rotational invariance

Schottky barrier parameters and structural properties of rapidly annealed Zr Schottky electrode on p-type Gan

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Journal of Semiconductors 2017年第6期38卷 44-51页

作者： V.rajagopal Reddy B.Asha Chel-Jong Choi Department of Physics Sri Venkateswara University School of Semiconductor and Chemical Engineering Semiconductor Physics Research Center (SPRC)Chonbuk National University

The Schottky barrier junction parameters and structural properties of Zr/p-Gan Schottky diode are explored at various annealing *** analysis showed that the barrier height（BH）of the Zr/pGa n Schottky diode increases with annealing at 400°C（0.92 eV（I–V）/1.09 e V（C–V））compared to the asdeposited one（0.83 eV（I–V）/0.93 eV（C–V））.However,the BH decreases after annealing at 500°***,at different annealing temperatures,the series resistance and BH are assessed by Cheung’s functions and their values ***,the interface state density（nSS/of the diode decreases after annealing at 400°C and then somewhat rises upon annealing at 500°*** reveals that the maximum BH is obtained at 400°C,and thus the optimum annealing temperature is 400°C for the *** XPS and XRD analysis revealed that the increase in BH may be attributed to the creation of Zr–n phases with increasing annealing up to 400°*** BH reduces for the diode annealed at 500°C,which may be due to the formation of Ga–Zr phases at the *** AFM measurements reveal that the overall surface roughness of the Zr film is quite smooth during rapid annealing process.

关键词： zirconium Schottky contacts p-type Gan electrical characteristics energy distribution curves X-ray photoelectron spectroscopy X-ray diffraction

Volumetric and Viscometric Studies of 4-Aminobutyric Acid in Aqueous Solutions of Salbutamol Sulphate at 308.15, 313.15 and 318.15K

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Chinese Journal of Chemical Engineering 2009年第5期17卷 796-804页

作者： K. rajagopal S.S. Jayabalakrishnan Departrnent of Physics Government College ofEngg Tirunelveli-627007 Tamil Nadu India Department of Physics P.S.R. Engg. College Sivakasi Tamil Nadu India

Density （ρ） and viscosity （η） measurements were carried out for 4-aminobutyric acid in 0.0041,0.0125 and 0.0207 mol·L-1 aqueous salbutamol sulphate at T=308.15,313.15 and *** measured values of density and viscosity were used to estimate some important parameters such as apparent molar volume Vφ,limiting apparent molar volume Vφ0,transfer volume △Vφ0,hydration number Hn,second derivative of infinite dilution of partial molar volume with temperature 2Vφ0/T2,viscosity B-coefficients,variation of B with temperature dB/dT,free energy of activation per mole of solvent △μ10＊ and solute △μ20＊,activation entropy △S20＊ and activation enthalpy △H20＊ of the amino *** parameters have been interpreted in terms of solute-solute and solute-solvent interactions and structure making/breaking ability of solutes in the given solution.

关键词： density standard partial molar volume hydration ntnZnber relative viscosity B-coefficient activation parameters

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上位效应对遗传算法可靠性的影响（英文）

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2019年第2期20卷 109-116页

作者： Sajad JAFARI Tomasz KAPITAnIAK Karthikeyan rajagopal Viet-Thanh PHAM Fawaz E.ALSAADI Biomedical Engineering Department Amirkabir University of Technology Division of Dynamics Lodz University of Technology Center for nonlinear Dynamics Defence University6020 BishoftuEthiopia Modeling Evolutionary Algorithms Simulation and Artificial Intelligence Faculty of Electrical&Electronics EngineeringTon Duc Thang University Department of Information Technology Faculty of Computing and ITKing Abdulaziz University

目的:探讨遗传算法的局限性和实用性,并分析基于相互作用产生的上位效应对遗传算法可靠性的影响。创新点:1.指出遗传算法缺陷的根源;2.基于测试样本函数定义目标函数,以判断遗传算法的适用性。方法:1.基于非上位效应函数(表1)和上位效... 详细信息

目的:探讨遗传算法的局限性和实用性,并分析基于相互作用产生的上位效应对遗传算法可靠性的影响。创新点:1.指出遗传算法缺陷的根源;2.基于测试样本函数定义目标函数,以判断遗传算法的适用性。方法:1.基于非上位效应函数(表1)和上位效应函数(表2),以及非上位效应函数F4和上位效应函数F6的结构图来验证遗传算法可靠性;2.通过计算样本函数(公式(1))和遗传算法流程(图3)表达遗传算法的工作原理。3.利用克洛弗函数(公式(2))和计算不同结构角下的函数分布(图4),进一步判断匹配度(表3)和计算效率(表4);定义新的目标函数(公式(9))和一组新的变量(公式(10))来实现变量相关性解离。结论:1.对当前遗传算法存在的不足给出了独到见解,并认为正定性的假设并非可以保证遗传算法实际的有效性和优化性。2.定义成本代价函数用以判断遗传算法可靠性,并分别考虑上位性和非上位性效应两种情形。当成本代价函数在非上位性效应下时,遗传算法是有效的;否则,可以把n维函数降级为n个一维函数,从而采用更简单的算法来判断。基于一些通用的基准,进一步设计三类样本函数来证实以上判断,且这些样本函数适合于上位性效应情形和非上位效应情形。3.遗传算法的瓶颈在于主算子和相干匹配性;可以通过破坏某些结构来实现变量关系的解离,从而抑制相干匹配性对遗传算法的影响。希望相关读者在处理实际优化问题时能验证作者关于上位效应的定性结论,并给出更可靠的方法来表征这种效应。

关键词：上位性效应遗传算法相干匹配性叠加性优化成本代价函数