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Evolutionary consequences of deception： Complexity and informational content of colony signature are favored by social parasitism

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Current Zoology 2014年第1期60卷 137-148页

作者： Maria Cristina LORENZI Laura AZZANI anne-Genevieve BAGNRRES Department of Life Sciences and Systems Biology University of Turin via Accademia Albertina 13 10123 Torino Italy I.R.B.I. - UMR CNRS 7261 - Universit6 de Tours Facult6 des Sciences Parc Grandmont 37200 Tours France

Nestmate recognition codes show remarkable chemical complexity, involving multiple biochemical pathways. This complexity provides the opportunity to evaluate the ecological and social conditions that favor the evolution of complex signaling. We investigated how the chemical signatures of three populations of the social paper wasp Polistes biglumis differed in terms of concentration of hydrocarbons, proportions of branched hydrocarbons and overall variation. We tested whether the variation in chemical signatures among populations could be explained by the prevalence of social parasites or whether this was just an effect of local abiotic conditions which influenced the composition of the hydrocarbon cuticular layer. We studied the chemical signa- ture in three populations in which obligate social parasites differed in the selection pressures they imposed on host populations. Within each population, we restricted our analyses to non-parasitized hosts, to avoid potential short-term effects of parasite pres- ence on the host chemical signatures. We found that host colonies in parasitized populations had more diverse profiles than the parasite-free population. Moreover, the overall concentration of hydrocarbons and the relative proportion of branched hydrocar- bons were larger in the parasitized populations, relative to the non-parasitized one. This is to our knowledge the first evidence in favour of the hypothesis that different traits in the host chemical signatures as a whole undergo evolutionary changes resulting from directional or balancing selection imposed by social parasites. We conclude that obligate social parasites act as ＇engines of diversity＇ on host chemical signatures and operate in favor of a geographic mosaic of diverging communication codes

关键词： Polistes Brood parasitism Cipher Nestmate recognition Hydrocarbons Geographic mosaic Crozier's paradox

How Properties that Distinguish Solids from Fluids and Constraints of Spherical Geometry Suppress Lower Mantle Convection

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Journal of Earth Science 2018年第1期29卷 1-20页

作者： anne M. Hofmeister Everett M. Criss Department of Earth and Planetary Sciences Washington University St. Louis MO 63130 USA Panasonic Avionics Corporation Lake Forest CA 92630 USA

The large magnitude of the dimensionless Rayleigh number （Ra-10^8） for Earth＇s -3 000 km thick mantle is considered evidence of whole mantle convection. However, the current formulation assumes behavior characteristic of gases and liquids and also assumes Cartesian geometry. Issues arising from neglecting physical properties unique to solids and ignoring the spherical shapes for planets include：（1） Planet radius must be incorporated into Ra, in addition to layer thickness, to conserve mass during radial displacements. （2） The vastly different rates for heat and mass diffusion in solids, which result from their decoupled transport mechanisms, promote stability. （3） Unlike liquids, sub- stantial stress is needed to deform solids, which independently promotes stability. （4） High interior compression stabilizes the mantle in additional minor ways. Therefore, representing conditions for convection in solid, self-gravitating spheroids, requires modifying formulae developed for bottom- heated fluids near ambient conditions under an invariant gravitational field. To derive stability criteria appropriate to solid spheres, we use dimensional analysis, and consider the effects of geometry, force competition, and microscopic behavior. We show that internal heating has been improperly ac- counted for in the Ra. We conclude that the lower mantle is stable for two independent reasons： heat diffusion far outpaces mass diffusion （creep） and yield strength of solids at high pressure exceeds the effective deviatoric stress. We discuss the role of partial melt in lubricating plate motion, and explain why the Ra is not applicable to the multi-component upper mantle. When conduction is insufficient to transport heat in the Earth, melt production and ascent are expected, not convection of solid rock.

关键词： plasticity diffusion mantle convection stability criteria dimensional analysis geometry.

How virtual reality can help visualise and assess geohazards

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International Journal of Digital Earth 2019年第2期12卷 173-189页

作者： Hans-Balder Havenith Philippe Cerfontaine anne-Sophie Mreyen Georisk and Environment Department of GeologyUniversity of LiegeLiègeBelgium

Geohazard research requires extensive spatiotemporal understanding based on an adequate multi-scale representation of modelling *** most commonly applied representation basis for collected data is still the one of a 2D plane,typically a *** maps of spatial data can be visualised and processed by using Geographic Information *** is far less common to use 3D geomodels for the analysis and visualisation of spatial *** the visualisation of both spatial and temporal hazard components,there are no standardised *** claim that a full geohazard assessment is only possible inside a new type of geoscientific and technological environment that is at the same time multi-dimensional,spatiotemporal,integrated,fully interactive(tele-)immersive,and *** and subsurface processes are interacting at various scales that are difficult to be overviewed at *** Reality(VR)technology could provide an attractive solution to overcome the multi-dimensional and spatiotemporal *** review of geoscientific applications using VR technology developed by multiple teams around the world shows that some solutions have already been developed many years ago,but widespread use was not *** is clearly changing now and soon we will see if VR can contribute to a better understanding of geo-processes.

关键词： 4D geospace spatiotemporal analysis virtual environments immersive visualisation collaboration

Evaluation of the Heat,Entropy,and Rotational Changes Produced by Gravitational Segregation during Core Formation

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Journal of Earth Science 2015年第1期26卷 124-133页

作者： anne M.Hofmeister Robert E.Criss Department of Earth and Planetary Sciences Washington University

Core formation by gravitational segregation allegedly released sufficient interior heat to melt the Earth. Analysis of the energetics, which compare gravitational potential energy （Ug） of a fictitious, homogeneous reference state to Earth＇s current layered configuration, needs updating to correct errors and omissions, and to accommodate recent findings：（1） An erroneous positive sign was used for Ug while maintaining the reference value of 0 at infinity, which results in an incorrect sign fur AUg, which is crucial in determining whether a process is endothermic or exothermic. （2） The value of Ug for Earth＇s initial state is uncertain. （3） Recent meteorite evidence indicates that core formation began before the Earth was full-sized, which severely limits AUg. （4） Inhomogeneous accretion additionally reduced AUg. （5） The potentially large effect of differential rotation between the core and the mantle was not accounted for. （6） Entropy changes associated with creating order were neglected. Accordingly, we revise values of Ug, evaluate uncertainties, and show that AUg was converted substantially to eonfigurational energy （TAS）. These considerations limit the large sources of primordial heat to impacts and radioactivity. Although these processes may play a role in core formation, their energies are independent of gravitational segregation, which produces order and rotational energy, not internal heat. Instead, gravitational segregation promotes planetary cooling mainly because it segregates lithophilic radioactive elements upward, increasing surface heat flux while shortening the distance over which radiogenic heat diffuses outwards.

关键词： core formation primordial heat configurational energy thermodynamics rotational energy.

Integrate Omics Data and Molecular Dynamics Simulations toward Better Understanding of Human 14-3-3 Interactomes and Better Drugs for Cancer Therapy

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Journal of Genetics and Genomics 2015年第10期42卷 531-547页

作者： Jo anne J.Babula Jing-Yuan Liu Department of Pharmacology and Toxicology Indiana University School of Medicine Department of Computer and Information Science Indiana University Purdue University Indianapolis

The 14-3-3 protein family is among the most extensively studied, yet still largely mysterious protein families in mammals to date. As they are well recognized for their roles in apoptosis, cell cycle regulation, and proliferation in healthy cells, aberrant 14-3-3 expression has unsurprisingly emerged as instrumentalin the development of many cancers and in prognosis. Interestingly, while the seven known 14-3-3 isoforms in humans have many similar functions across cell types, evidence of isoform-specific functions and localization has been observed in both healthy and diseased cells The strikingly high similarity among 14-3-3 isoforms has made it difficult to delineate isoform-specific functions and for isoform-specific targeting. Here, we review our knowledge of 14-3-3 interactome（s） generated by high- throughput techniques, bioinformatics, structural genomics and chemical genornics and point out that integrating the information with molecular dynamics （MD） simulations may bring us new opportunity to the design of isoform-specific inhibitors, which can not only be used as powerful research tools for delineating distinct interactomes of individual 14-3-3 isoforms, but also can serve as potential new anti-cancer drugs that selectively target aberrant 14-3-3 isoform.

关键词： Interactome Chemical genomics Structural genomics Molecular dynamics simulation

Ependymal cells and multiple sclerosis: proposing a relationship

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Neural Regeneration Research 2020年第2期15卷 263-264页

作者： Dale Hatrock Nina Caporicci-nucci Jo anne Stratton The Montreal Neurological Institute McGill UniversityMontrealCanada Integrated Program in Neuroscience McGill UniversityMontrealCanada

Multiple sclerosis (MS) currently affects ~2.5 million people worldwide. MS is typically diagnosed in young adults and is usually not fatal, meaning people live long lives with MS. Affected individuals usually suffer from progressive physical and/or cognitive disability, often including fatigue (89.6%), depression (53.9%), memory loss (49.0%), motor or sensory dysfunction (76.4%, 70.4%) and urinary incontinence (50.8%).

关键词： multiple sclerosis relationship dysfunction

Identification of Arabidopsis MYB56 as a Nove Substrate for CRL3BPM E3 Ligases

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Molecular Plant 2015年第2期8卷 242-250页

作者： Liyuan Chen anne Bernhardt JooHyun Lee Hanjo Hellmann School of Biological Sciences Washington State University Abelson 435 Pullman WA 99164-4236 USA Present address: Plant Gene Expression Center UC Berkeley Albany CA 94710 USA present address: Robert Koch Institut 13353 Berlin Germany

Controlled stability of proteins is a highly efficient mechanism to direct diverse processes in living cells. A key regulatory system for protein stability is given by the ubiquitin proteasome pathway, which uses E3 ligases to mark specific proteins for degradation. In this work, MYB56 is identified as a novel target of a CULLIN3 （CUL3）-based E3 ligase. Its stability depends on the presence of MATH-BTB/POZ （BPM） proteins, which function as substrate adaptors to the E3 ligase. Genetic studies have indicated that MYB56 is a negative regulator of flowering, while BPMs positively affect this developmental program. The interaction between BPMs and MYB56 occurs at the promoter of FLOWERING LOCUS T （FT）, a key regulator in initiating flowering in Arabidopsis, and results in instability of MYB56. Overall the work establishes MYB transcription factors as substrates of BPM proteins, and provides novel information on components that participate in controlling flowering time in plants.

关键词： CUL3 BPM MYB transcription factor E3 ligase flowering

Preliminary studies on occurrence of monensin antibiotic in Bosque River Watershed

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Journal of Environmental Sciences 2013年第2期25卷 268-273页

作者： Sudarshan Kurwadkar Victoria Sicking Barry Lambert anne McFarland Forrest Mitchell Environmental Engineering Department of Engineering and PhysicsBox T-0390Tarleton State UniversityStephenvilleTX 76402USA Environmental Engineering Program Department of Engineering and PhysicsTarleton State UniversityStephenvilleTX 76402USA Department of Animal Sciences Box T-0070Tarleton State UniversityStephenvilleTX 76402USA Texas Institute for Applied Environmental Research Box T-0410Tarleton State UniversityStephenvilleTX 76402USA Texas A&M AgriLife Research 1229 N.US Hwy 281StephenvilleTX 76401USA

Water quality impact due to excessive nutrients has been extensively studied. In recent years, however, micro-pollutants such as pharmaceuticals and hormonal products used in animal agriculture have added an additional impact to overall water quality. Pharmaceuticals used in the poultry, swine, beef, and dairy industries have been detected in various environmental matrices such as, soil, groundwater and surface water. In this study, 26 surface water samples were collected throughout the Bosque River Watershed （BRW） with samples representing a range of land use conditions and locations of major dairy operations. Samples were analyzed using commercially available Enzyme-Linked Immunosorbent Assay test. Of the 26 samples, three samples consistently tested positive for monensin antibiotic with concentration ranging from 0.30 to 3.41 μg/L. These three samples were collected from sites that received varying amount of agriculture wastes （11.7% to 31.3%） and located downstream from sites associated with moderate levels of animal agriculture. The preliminary results suggest that there is a potential for monensin occurrence in the BRW, although initial findings indicate only very low levels.

关键词： ELISA ionophore monensin antibiotic dairy waste emerging pollutants pharmaceuticals

Representation of Specific Diagnosis for Low Back Pain Using the 11^(th) Revision of International Classification of Diseases and Related Health Problems: Perspectives of Conventional Medicine and Traditional Medicine

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World Journal of Traditional Chinese Medicine 2021年第2期7卷 234-239页

作者： anne Chang Hong Zhao UF Central Administration Medical History and Culture HeritageKarolinska InstituteSolnaSweden Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijingChina

Background:The 11th revision of the International Classification of Diseases and Related Health Problems(ICD-11)was released on June 18,2018,by the World Health Organization and will come into effect on January 1,*** from the chapters on the classification of diseases in the conventional medicine(CM),a new chapter,traditional medicine(TM)conditions–Module 1,was *** back pain(LBP)is one of the common reasons for the physician *** classification codes for LBP in the ICD-11 are vital to documenting accurate clinical ***:The qualitative case study method was *** secondary use data for 100 patients were randomly selected using the ICD-11 online interface to find the classification codes for both the CM section and the TM Conditions–Module 1(TM1)section for LBP ***:Of the 27 codes obtained from the CM section,six codes were not relevant to LBP,whereas the other 21 codes represented diagnoses of LBP and its related diseases or *** the TM1 section,six codes for different patterns and disorders represented the diagnoses for LBP from the TM ***:This study indicates that specific diagnoses of LBP can be represented by the combination of CM classification codes and TM1 classification codes in the ICD-11;the CM codes represent specific and accurate clinical diagnoses for LBP,whereas the TM1 codes add more accuracy to the diagnoses of different patterns from the TM perspective.

关键词： 11^(th)revision of the International Classification of Diseases and Related Health Problems revision low back pain traditional medicine conditions-module 1