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Rapid metabolic fingerprinting with the aid of chemometric models to identify authenticity of natural medicines: Turmeric, Ocimum, and Withania somnifera study

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Journal of Pharmaceutical Analysis 2023年第9期13卷 1041-1057页

作者： Samreen Khan Abhishek kumar Rai Anjali Singh Saudan Singh Basant kumar Dubey raj Kishori Lal Arvind Singh Negi Nicholas Birse Prabodh kumar Trivedi Christopher T.Elliott Ratnasekhar Ch Metabolomics Lab Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Crop Production&Protection Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Academy of Council of Scientific and Industrial Research(ACSIR) Ghaziabad201002India Department of Biotechnology Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Genetics and Plant Breeding Department Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Phytochemistry Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India School of Biological Sciences Queen's UniversityBelfastBT95DLUK

Herbal medicines are popular natural medicines that have been used for *** use of alternative medicines continues to expand rapidly across the *** World Health Organization suggests that quality assessment of natural medicines is essential for any therapeutic or health care applications,as their therapeutic potential varies between different geographic origins,plant species,and *** of herbal medicines based on a limited number of secondary metabolites is not an ideal *** quality should be considered based on a complete metabolic profile,as their pharmacological activity is not due to a few specific secondary metabolites but rather a larger group of bioactive compounds.A holistic and integrative approach using rapid and nondestructive analytical strategies for the screening of herbal medicines is required for robust *** this study,a rapid and effective quality assessment system for geographical traceability,species,and variety-specific authenticity of the widely used natural medicines turmeric,Ocimum,and Withania somnifera was investigated using Fourier transform near-infrared(FT-NIR)spectroscopy-based metabolic *** different geographical origins of turmeric,five different Ocimum species,and three different varieties of roots and leaves of Withania somnifera were studied with the aid of machine learning *** good discrimination(R^(2)>0.98,Q^(2)>0.97,and accuracy=1.0)with sensitivity and specificity of 100%was achieved using this metabolic fingerprinting *** study demonstrated that FT-NIR-based rapid metabolic fingerprinting can be used as a robust analytical method to authenticate several important medicinal herbs.

关键词： Rapid metabolic fingerprinting Natural medicines FT-NIR Chemometric models

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The Curation of Genetic Variants: Difficulties and Possible Solutions

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Genomics, Proteomics & Bioinformatics 2012年第6期10卷 317-325页

作者： Kapil raj Pandey Narendra Maden Barsha Poudel Sailendra Pradhananga Amit kumar Sharma Deerwalk Services Department of Microbiology Bangalore University Central Department of Microbiology Tribhuvan University Department of Bioinformatics Wageningen University Department of Biotechnology Kathmandu University

The curation of genetic variants from biomedical articles is required for various clinical and research purposes. Nowadays, establishment of variant databases that include overall information about variants is becoming quite popular. These databases have immense utility, serving as a user-friendly information storehouse of variants for information seekers. While manual curation is the gold standard method for curation of variants, it can turn out to be time-consuming on a large scale thus necessitating the need for automation. Curation of variants described in biomedical literature may not be straightforward mainly due to various nomenclature and expression issues. Though current trends in paper writing on variants is inclined to the standard nomenclature such that variants can easily be retrieved, we have a massive store of variants in the literature that are present as non-standard names and the online search engines that are pre- dominantly used may not be capable of finding them. For effective curation of variants, knowledge about the overall process of curation, nature and types of difficulties in curation, and ways to tackle the difficulties during the task are crucial. Only by effective curation, can variants be correctly interpreted. This paper presents the process and difficulties of curation of genetic variants with possible solutions and suggestions from our work experience in the field including literature support. The paper also highlights aspects of interpretation of genetic variants and the importance of writing papers on variants following standard and retrievable methods.

关键词： Difficulties in curation Automated curation Manual curation Interpretation of variants

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On the Design of Circular Fractal Antenna with U-Shape Slot in CPW-Feed

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Wireless Engineering and Technology 2010年第2期1卷 81-87页

作者： raj kumar 不详

A new ultawideband circular fractal antenna with notched-band characteristics is presented. A notched-band characteristic is achieved by employing a U-shape slot in 50 Ω feed lines. The ultra-wideband impedance matching and compact size have been obtained by using CPW-feed technique and the fractal concept. The measured result of proposed fractal antenna exhibits the ultra wideband characteristics from 3.0 to 18.0 GHz at VSWR 2:1 except notched-band frequency. The proposed antenna has been analyzed theoretically and experimentally with respect to design parameters. The measured radiation pattern of fractal antenna is nearly omnidirectional in azimuth plane throughout the operating frequency. This antenna is useful for UBW communication system.

关键词： Monopole Antenna Wideband Antenna Resonant Frequency Fractal Antennas Multib Antenna

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AVirtual Cloud Storage Architecture for Enhanced Data Security

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Computer Systems Science & Engineering 2023年第2期44卷 1735-1747页

作者： M.Antony Joans kumar C.Christopher Columbus E.Ben George T.Ajith Bosco raj Department of Information Technology St.Xavier’s Catholic College of EngineeringNagercoil629003Tamil NaduIndia Department of Computer Science Engineering PSN College of Engineering and TechnologyTirunelveli627152India Department of Computer Science Engineering University of Technology and Applied SciencesMuscat112Oman Department of Electronics and Communications Engineering PSN College of Engineering and TechnologyTirunelveli627152India

The sensitive data stored in the public cloud by privileged users,such as corporate companies and government agencies are highly vulnerable in the hands of cloud providers and *** proposed Virtual Cloud Storage Archi-tecture is primarily concerned with data integrity and conﬁdentiality,as well as *** provide conﬁdentiality and availability,theﬁle to be stored in cloud storage should be encrypted using an auto-generated key and then encoded into distinct *** the encoded chunks ensured theﬁle integrity,and a newly proposed Circular Shift Chunk Allocation technique was used to determine the order of chunk ***ﬁle could be retrieved by performing the opera-tions in *** the regenerating code,the model could regenerate the missing and corrupted chunks from the *** proposed architecture adds an extra layer of security while maintaining a reasonable response time and sto-rage *** results analysis show that the proposed model has been tested with storage space and response time for storage and *** VCSA model consumes 1.5x(150%)storage *** was found that total storage required for the VCSA model is very low when compared with 2x Replication and completely satisﬁes the CIA *** response time VCSA model was tested with different sizedﬁles starting from 2 to 16 *** response time for storing and retrieving a 2 MBﬁle is 4.96 and 3.77 s respectively,and for a 16 MBﬁle,the response times are 11.06 s for storage and 5.6 s for retrieval.

关键词： Erasure code regenerating code cryptography virtual cloud storage architecture circular shift chunk allocation algorithm

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Infanticide:A Concept

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Journal of Forensic Science and Medicine 2017年第1期3卷 42-46页

作者： Arneet Arora Jayanthi Yadav Sanjay kumar Yadav Hans raj Singh Department of Forensic Medicine and Toxicology All India Institute of Medical Sciences Deparment of Forensic Medicine and Toxicology Gandhi Medical College National Law Institute University BhopalMadhya PradeshIndia

Infanticide is killing of a child<12 months of age by a mother who has not fully recovered from the effects of pregnancy,giving birth and lactation,and suffers some degree of mental ***,in India,infanticide means unlawful destruction of a newly bom child and is regarded as murder in law and is punishable under section 302 completely neglecting postpartum psychiatric state of mothers5 *** studies have indicated a high incidence of postpartum depression in mother of developing as well as developed *** lack of awareness in medical fraternity,legal experts,and society leads to miscarriage of *** this article,we have compared legal status of infanticide in various countries vis-a-vis India and thus tried to arrive at a more humane and pragmatic approach in cases of infanticide keeping in mind the psychological state of mother,gender inequality,weak public health infrastructure,and the prevalent practice of homicide of unwanted/female child.A psychiatric or medical assessment model of mother by panel of experts in case of infanticide should be *** and awareness of postpartum psychiatric illness among medical professionals,legal persons,and society is an important aspect.

关键词： Compos mentis infanticide postpartum depression puerperium

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Considerations for gluten free foods-pearl and finger millet processing and market demand

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Grain & Oil Science and Technology 2023年第2期6卷 59-70页

作者： Manivannan Selladurai Manoj kumar Pulivarthi Anu Suprabha raj Mehreen Iftikhar P.V.Vara Prasad Kaliramesh Siliveru Kansas State University Department of Grain Science and IndustryManhattan 66506KansasUSA Kansas State University Department of AgronomyManhattan 66506KansasUSA

The market demand for gluten free foods is increasing due to frequent incidences of celiac disease and increasing awareness on consumption of gluten free *** have become the major constituent of diet as they are gluten-free and also excellent sources of micro and macro nutrients such as vitamins,minerals,dietary fibers and phenolic *** various millets,the finger millet and the pearl millet are the two most important and common millet varieties grown ***,they are regarded as the staple foods of the poor and vulnerable populations,development of new products and improvements in their nutritional quality will aid in the general health of these *** of millets and production of variable gluten-free ready-to-eat and nutritional supplements has increased their market value in the recent ***,processing can also help in shelf-life extension of the millets with nutritional enrichment,expanding its markets to non-traditional millet *** this context,the present review is aimed to focus on the current processing methods to develop products from the two millet varieties that are gluten free and outline their nutritional benefits.

关键词： Pearl millet Finger millet Nutritional value Processing Market value

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Genome-Wide Analysis of von Willebrand Factor A Gene Family in Rice for Its Role in Imparting Biotic Stress Resistance with Emphasis on Rice Blast Disease

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Rice science 2022年第4期29卷 375-384页

作者： Suhas Gorakh KARKUTE Vishesh kumar Mohd TASLEEM Dwijesh Chandra MISHRA Krishna kumar CHATURVEDI Anil RAI Amitha Mithra SEVANTHI Kishor GAIKWAD Tilak raj SHARMA Amolkumar U.SOLANKE Indian Council of Agricultural Research(ICAR)-National Institute for Plant Biotechnology New Delhi 110012India ICAR-Indian Agricultural Statistics Research Institute New Delhi 110012India ICAR-Division of Crop Science New Delhi 110001India

von Willebrand factor A(vWA)genes are well characterized in humans except for few BONZAI genes,but the vWA genes are least explored in *** the novelty and vital role of vWA genes,this study aimed at characterization of vWA superfamily in *** genome was found to have 40 vWA genes distributed across all the 12 chromosomes,and 20 of the 40 vWA genes were unique while the remaining shared large fragment similarities with each other,indicating gene *** addition to vWA domain,vWA proteins possess other different motifs or domains,such as ubiquitin interacting motif in protein degradation pathway,and RING finger in protein-protein *** analysis of vWA genes in available expression data suggested that they probably function in biotic and abiotic stress responses including hormonal response and *** frequency of transposon elements in the entire 3K rice germplasm was negligible except for 9 vWA genes,indicating the importance of these genes in *** and functional diversities showed that the vWA genes in a blast-resistant rice variety Tetep had huge variations compared to blast-susceptible rice varieties HP2216 and ***-PCR analysis of vWA genes in Magnaporthe oryzae infected rice tissues indicated OsvWA9,OsvWA36,OsvWA37 and OsvWA18 as the optimal candidate genes for disease *** is the first attempt to characterize vWA gene family in plant species.

关键词： von Willebrand factor A biotic stress abiotic stress rice blast disease Magnaporthe oryzae

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A Distributed Model for Real-Time Flood Forecasting in the Godavari Basin Using Space Inputs

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International Journal of Disaster Risk Science 2011年第3期2卷 31-40页

作者： Korada Hari Venkata Durga Rao Vala Venkateshwar Rao Vinay kumar Dadhwal Gandarbha Behera Jaswant raj Sharma National Remote Sensing Centre Indian Space Research Organization (ISRO) Hyderabad 500 625 India

Hydrological modelling of large river catchments has become a challenging task for water resources engineers due to its complexity in collecting and handling of both spatial and non-spatial data such as rainfall,gauge-discharge data,and topographic and hydraulic *** this article,a flood forecast model is developed for the Godavari Basin,India through a distributed modelling approach using space *** approach includes rainfall runoff modelling,hydrodynamic flow routing,calibration,and validation of the model with field discharge *** study basin is divided into 128 subbasins to improve the model *** and hydraulic parameters of each subbasin and channel are computed using the land use/land cover grid that is derived from the Indian Remote Sensing Satellite(IRS–P6) AWi FS sensor data(56 m resolution),Shuttled Radar Topographic Mission(SRTM) Digital Elevation Model(DEM),and the soil textural *** model is calibrated using the field hydrometeorological data of 2000 and validated with the data of *** model was tested during the 2010 floods with real-time 3-hour interval hydrometeorological and daily evapotranspiration *** in estimating the peak flood discharge and lag time was found to be very *** forecast lead time is increased by 12 hours compared to conventional methods of forecasting.

关键词： flood rainfall meteorological

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Nurses and nursing students’knowledge regarding blood transfusion:A comparative cross-sectional study

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Journal of Integrative Nursing 2022年第3期4卷 137-144页

作者： Rakhi GAUR Shiv kumar MUDGAL Neha SUYAL Suresh kumar SHARMA rajat AGARWAL Ritu raj Chaturvedi JITENDER College of Nursing AIIMSDeogharJharkhandIndia Government Nursing College HaldwaniUttarakhandIndia College of Nursing AIIMSJodhpurRajasthanIndia Department of CTVS AIIMSDeogharJharkhandIndia Department of Medicine AIIMSDeogharJharkhandIndia Department of Neurosurgery AIIMSRishikeshUttarakhandIndia

Objective:The objective of this study is to measure and compare the knowledge of nursing students and nurses on blood transfusion in an Indian *** and Methods:The present comparative,cross-sectional study enrolled 296 nurses and 177 nursing students through a purposive sampling from a medical university hospital and different nursing *** data were collected in the month of June and July of year 2021,using a self-structured *** questionnaire had two sections:Section-I contained demographic data(8 items for nurses and 5 for students)and section-II included 26 items that assessed nurses’and nursing students’knowledge on blood ***:Findings indicated that nurses and nursing students had insufficient knowledge about blood ***,however,had significantly greater total blood transfusion knowledge scores than nursing students(16.51±3.85 vs.12.10±3.28;P<0.001).The marital status(adjusted odds ratio[AOR]=0.456,95%confidence interval[CI]0.244,0.853;P=0.037),educational level(AOR=5.072,95%CI 1.982,9.634(P=0.003);AOR=6.540,95%CI 2.54,16.871;P=0.001)and work experience(AOR=0.216,95%CI 0.067,0.702[P=0.037];AOR=0.331,95%CI 0.135,0.811;P=0.013)were the significant predictors of the level of knowledge among *** attendance in any educational programme on blood transfusion(AOR=0.225,95%CI:0.062,0.818;P=0.041)was a significant predictor of the level of knowledge among nursing ***:Nurses and nursing students have unsatisfactory knowledge on blood transfusion;emphasizing the critical need for immediate and successful teaching activities in this area.

关键词： Blood transfusion comparative knowledge nurses nursing students

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A Generalization of the Cayley-Hamilton Theorem

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Advances in Pure Mathematics 2013年第1期3卷 109-115页

作者： raj kumar Kanwar Department of Mathematics and Statistics Himachal Pradesh University Shimla India

It is proposed to generalize the concept of the famous classical Cayley-Hamilton theorem for square matrices wherein for any square matrix A, the det (A-xI) is replaced by det f(x) for arbitrary polynomial matrix f(x).

关键词： Polynomial Matrix Square Matrix Non-Singular Matrix Adjoint of a Matrix Leading Coefficient Matrix

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