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Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice

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Cellular & Molecular Immunology 2019年第1期16卷 65-74页

作者： Vanessa Lamontain Tobias Schmid Dorothea Weber-Steffens David Zeller Zsuzsa Jenei-Lanzl Harald Wajant rainer H Straub Daniela N Männel Institute of Immunology University of Regensburg93042 RegensburgGermany Laboratory of Experimental Rheumatology and Neuroendocrine Immunology Department of Internal MedicineUniversity Hospital Regensburg93042 RegensburgGermany Division of Molecular Internal Medicine Department of Internal Medicine IIUniversity Hospital Würzburg97070 WürzburgGermany

Tumor necrosis factor(TNF)and its receptors TNF receptor type 1(TNFR1)and type 2(TNFR2)have a central role in chronic inflammatory *** TNFR1 mainly confers inflammation,activation of TNFR2 elicits not only pro-inflammatory but also anti-inflammatory *** this study,we wanted to investigate the anti-inflammatory therapeutic potential of selective activation of TNFR2 in mice with established collageninduced *** with established arthritis induced by immunization with bovine collagen type II were treated with six injections of the TNFR2-specific agonist TNCscTNF80,given every second *** days after treatment cessation,the cell compositions of bone marrow,spleen and lymph nodes were *** were visually scored until day 30 after the start of therapy and the degree of joint inflammation was determined by *** with TNCscTNF80 increased arthritis-induced *** effect was seen on the infiltration rate of inflammatory immature myeloid cells and on the reduction of lymphoid cells in secondary lymphoid *** treatment,frequency of regulatory T(Treg)cells in the CD4+T-cell population was increased in both spleen and inguinal lymph *** addition,the expression of TNFR2 on Treg cells was *** clinical score started to improve 1 week after cessation treatment and remained lower 30 days after initiation of *** histological score also revealed amelioration of joint inflammation in TNCscTNF80-treated versus control *** of TNFR2 might provide a suitable therapeutic strategy in autoimmune arthritis by increasing the numbers of regulatory cell types,in particular Treg cells,and by attenuation of arthritis.

关键词： collagen type II-induced arthritis regulatory T cells TNF TNF receptor type 2 TNFR2-specific agonist TNCscTNF80

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贵州桐梓奥陶系十字铺组疑源类

微体古生物学报 2000年第1期17卷 30-38,117页

作者：李军王怿 rainer Brocke 中国科学院南京地质古生物研究所南京210008 Forschungsinstitut Senckenberg

贵州桐梓红花园 Llanvirn期十字铺组产出保存良好的疑源类 ,可以和国内、外同期疑源类组合进行对比。十字铺组疑源类的丰富和多样性表明其沉积环境应为正常浅海相。Arbusculidi-um,Coryphidium和 Striatotheca等典型分子的出现 ,表明 Ll... 详细信息

贵州桐梓红花园 Llanvirn期十字铺组产出保存良好的疑源类 ,可以和国内、外同期疑源类组合进行对比。十字铺组疑源类的丰富和多样性表明其沉积环境应为正常浅海相。Arbusculidi-um,Coryphidium和 Striatotheca等典型分子的出现 ,表明 Llanvirn期扬子地台属于环冈瓦纳疑源类生物地理区。

关键词：疑源类 Llanvirn期十字铺组奥陶系正常浅海相

Mechano-Stimulation Triggers Turgor Changes Associated with Trap Closure in the Darwin Plant Dionaea muscipula

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Molecular Plant 2014年第4期7卷 744-746页

作者： María Escalante-Pérez Sonke Scherzer khaled A.S. Al-Rasheid Christoph Dottinger Erwin Neher rainer Hedrich Department for Membrane Biophysics Max-Planck-Institute for Biophysical ChemistryD-37077 GottingenGermany

The Darwin plant, also known as the Venus flytrap, Dionaea muscipula, has fascinated people since Darwin＇s time. The plant lives in nutrient-poor habitats but has been able to overcome the limitations of its surroundings by evolving a carnivorous lifestyle, particularly by modifying its leaves into active traps to catch animals. When flies, ants, or other small animals touch mechano-sensitive hairs protruding from the inner surface of the bi-lobed trap, it shuts within a fraction of a second.

关键词： VENUS'S flytrap TURGOR

Numerical Simulation of Fluid Flow Inside a Molten Liquid Metal Droplet Located in an Electromagnetic Induction Generated by Two Different Inducting Currents

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Journal of Iron and Steel Research International 2012年第S1期19卷 127-130页

作者： Alimata DIARRA Annie GAGNOUD Jacqueline ETAY Andreas STEIN rainer WUNDERLICH SIMaP-EPM CNRS-INPG-UJF Phelma-Campus BP75 38402 St Martin d'Heres cedexFrance EADS Astrium Department TEB 2288039 FriedrichshafenGermany Institute of Micro and Nanomaterials Ulm University Albert-Einstein-Allee 4789081 UlmGermany

Electromagnetic levitation of electrically conductive droplets by alternating magnetic fields is Sa technique used to measure the physical properties of liquid metallic alloys such as surface tension,viscosity,heat *** can be conducted in microgravity,to reduce electromagnetic stirring and shaping of the *** inductor of the EML is composed of a single inductor which two types of voltage are *** type of electrical installation generates a field to center the metallic droplet and another field to heat and excite *** use a commercial code join to a homemade code to compute flows generated by inducting voltages recorded in the sounding rocket TEXUS-EML-2(Feb2008).In this flight,two samples(Cu75Co25 at%and A168,5Ni31,5 at%)of 8 mm diameter have been processed.

关键词： electromagnetic levitation superposed inducting currents microgravity electromagnetic stirring

Analysis of Cartilage Creep Recovery Using a Highly Dynamic Closed-loop Test System

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Journal of Bionic Engineering 2018年第6期15卷 1057-1066页

作者： Josef Stolberg-Stolberg Peter Foehr Iris Pflieger Lara kuntz Constantin von Deimling Andreas Obermeier Peter M. Prodinger Christian U. Grosse rainer Burgkart Department of Orthopaedics and Sports Orthopaedics Klinikum rechts der Isar Technical University of Munich Munich 81675 Germany Department of Trauma Hand and Reconstructive Surgery University Hospital Muenster Albert-Schweitzer-Campus 1 Muenster 48149 Germany Chair of Non-destructive Testing Technical University of Munieh Munich 81245 Germany Department of Trauma Surgery Trauma Center Murnau Murnau 82418 Germany

The aim of this study was to analyze cartilage creep and creep recovery after static and cyclic loading. Up to now technical limitations have hindered the measurement of creep recovery. For this reason, we developed a closed loop micro creep and creep-recovery indentation test system with active force control. Bovine osteochondral explants were tested under static （110 kPa） and cyclic （100 cycles, 350 kPa/35 kPa, 1 Hz） loading conditions and subsequently creep recovery was measured. The cartilage thickness was determined using needle indentation. For static loading, the creep and creep-recovery rates were significantly different during the first 60 seconds （p 〈 0.05）. Cyclic loading was assessed for the medial and lateral patella and resulted in a physiological patellar cartilage strain of 7.7% ± 2.6% and 8.2% ± 2.7%, respectively. We recorded a creep recovery of 97.8% ±2.1% for the medial and 98.3% ± 2.4% for the lateral patella. The advantage of this study over earlier in vitro studies is that we recorded creep-recovery profiles with an actively controlled setup. This allowed us to analyze creep recovery immediately after removing the creep load, in contrast to MRI-based in vivo studies. In future, the presented method will enable us to quantify spatial variations within articular joints.

关键词： articular cartilage indentation creep recovery arthritis regenerative tissue

Seismic signature of the collision between the east Tibetan escape flow and the Sichuan Basin

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Seismic signature of the collision between the east Tibetan ...

Persistent effect of nurse-led education on self-care behavior and disease knowledge in heart failure patients

中国科学院地质与地球物理研究所第十届(2010年度)学术年会

作者： rainer.kind Deutsches GeoForschungsZentrum GFZ Telegrafenberg14473 PotsdamGermany Freie Universitat Berlin Germany

GPS displacement vectors show that the crust in east Tibet is being squeezed in an easterly direction by the northward motion of the Indian plate,and the Sichuan Basin is resisting this stream and redirecting it mainly towards *** Longmen Shan,containing the steepest rise to the high plateau anywhere in Tibet, results from the strong interaction between the east Tibetan escape flow and the rigid Yangtze block (Sichuan Basin),but the kinematics and dynamics of this interaction are still the subject of some *** herein present results from a dense passive-source seismic profile from the Sichuan Basin into eastern Tibet in order to study the deep structure of this collision *** P and S receiver function images we observe a sudden rise of the Lithosphere-Asthenosphere Boundary(LAB) from 120 to 150 km beneath the Sichuan Basin and from 70 to 80 km beneath eastern *** contrast,the depth of the crust-mantle boundary (Moho) increases from 36 to 40 km beneath the Sichuan Basin and from 55 to 60 km beneath eastern Tibet. The 410km discontinuity is depressed below eastern Tibet by about 30 km,although the 660 remains at nearly the same depth throughout the *** these observations,we conclude that the mode of collision that occurs between Tibet and the Sichuan Basin is very different to that found between India and *** southern Tibet,we observe in essence the subduction of the Indian plate,which penetrates northwards for several hundred kilometers under central *** very thin mantle part of the lithosphere beneath eastern Tibet may indicate delamination or removal of the bottom of the lithosphere by hot asthenospheric escape *** process leads to the exceptionally steep topography at the eastern Tibetan margin as a result of gravitational *** view is supported by the very unusual depression of the 410 km discontinuity beneath eastern Tibet,which could be caused by the dynamics of the sub-vertical downward asthenospheric f

关键词： east Tibetan escape flow Sichuan Basin receiver function imaging mantle transition zone

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International Journal of Nursing Sciences 2021年第2期8卷 161-167,I0002页

作者： Astrid Huesken rainer Hoffmann Sofien Ayed Department of Cardiology Angiology and Sleep MedicineBonifatius Hospital LingenLingenGermany

Purpose:The guidelines on the management of patients with heart failure support intensive patient education on *** present study aimed to evaluate the short-term and long-term impacts of a structured education provided by a qualified heart failure nurse on patients'self-care behavior and disease ***:One hundred fifty patients(66±12 years)hospitalized for heart failure participated in a structured one-hour educational session by a heart failure *** completed a questionnaire comprising 15 questions(nine questions from the European Heart Failure Self-Care Behavior Scale[EHFScB-9]and six on the patients'disease knowledge)one day before and one day and six months after the educational *** responses for each question ranged from 1(complete agreement)to 5(complete disagreement).Results:After the educational session,the total EHFScB-9 score improved from 24.31±6.98 to 14.94±6.22,and the disease knowledge score improved from 18.03±5.44 to 10.74±4.30(both Pknowledge on the cause of patients'heart failure(-1.53±1.43).At 6-month follow-up,EHFScB-9 score was 17.33±7.23 and knowledge score was 12.34±5.30(both Pknowledge with a persistent effect at 6-month *** are no patient characteristics which preclude the implementation of an educational session.

关键词： Heart failure knowledge Patient education Self care

The fate of ^(15)N-labeled nitrogen inputs to pot cultured beech seedlings

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Journal of Forestry Research 2009年第4期20卷 314-322,I0005页

作者： Ali Bagherzadeh rainer Brumme Friedrich Beese Department of Agriculture Islamic Azad University-Mashhad Branch Institute of Soil Science and Forest Nutrition Georg-August University of Goettingen

The partitioning of nitrogen deposition among forest soil （including forest floor）, leachate and above- and belowground biomass of pot cultured beech seedlings in comparison to non-cultured treatments were investigated by adding 1.92 g.m^-2 ^15N tracer in throughfall for two successive growing seasons at a greenhouse experiment. Ammonium and nitrate depositions were simulated on four treatments （cultured and non-cultured） and each treatment was labeled with either ^15N-NH4^＋ or ^15N-NO3^-. Total recovery rates of the applied ^15N in the whole system accounted for 74.9% to 67.3% after ^15N-NH4^＋ and 85.3% to 88.1% after ^15N-NO3^-in cultured and non-cultured treatments, respectively. The main sink for both ^15N tracers was the forest soil （including forest floor）, where 34.6% to 33.7% of ^15N-NH4^＋ and 13.1% to 9.0% of ^15N-NO3^-were found in cultured and non-cultured treatments, respectively, suggesting strong immobilization of both N forms by hetero- trophic microorganisms. Nitrogen immobilization by microorganisms in the forest soil （including forest floor） was three times higher when ^15N-NH4^＋ was applied compared to ^15N-NO3^-. The preferential heterotrophic use of ammonium resulted in a two times higher retention of deposited ^15N-NH4^＋ in the forest soil as compared to plants. In contrast, nitrate immobilization in the forest soil was lower compared to plants, although statistically it was not significantly different. In total the immobilization of ammonium in the plant-soil system was about 60% higher than nitrate, indicating the importance of the N-forms deposition for retention in forest ecosystems.

关键词： ^15N tracer nitrogen retention and recovery beech seedling forest soil immobilization nitrogen budget

Mass spectrometric profiling of phosphorylated serine／threonine residues and（patho）physiological relevance of selected residues in insulin signal transduction and type 2 Diabetes mellitus

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Mass spectrometric profiling of phosphorylated serine／threo...