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HCV-specific cytokine induction in monocytes of patients with different outcomes of hepatitis C

World Journal of Gastroenterology 2002年第3期8卷 562-566页

作者： rainer p.woitas Uwe petersen Dirk Moshage Hans H.Brackmann Bertfried Matz Tilman Sauerbruch Ulrich Spengler Department of Intemal Medicine I University of Bonn53105 BonnGermany Institute of Experimental Hematology University of Bonn53105 BonnGermany Institute of Medical Microbiology and Immunology University of Bonn53105 BonnGermany

AIM:Cytokine release by macrophages critically determines the type of immune response to an ***,we studied hepatitis C virus(HCV)-specific induction of interleukins-1β,-10,-12(IL-1β,IL-10,IL-12),and tumor necrosis factor-α(TNF-α)in monocytes. METHODS:Intracallular cytokine expression was studied by flow cytometry in 23 patients with chronic hepatitis C,14 anti-HCV seropositives without viremia and 11 controls after stimulation of peripheral blood mononuclear calls with recombinant core,NS3,NS4,NSSa and NSSb proteins. RESULTS:patients with HCV viremia revealed greater spontaneous expression of IL-1β,TNF-α,and IL-10. Furthermore,greater than twofold higher IL-10 expression was induced by the HCV antigens in chronic hepatitis C than in the other two groups(ppreferentially. CONCLUSION:In chronic hepatitis C antigen-specific cytokine induction in monocytes is apparently shifted towards predominant IL-10 induction-not counterbalanced by antiviral type 1 *** may contribute to persistent viral replication.

关键词： Adult Cytokines Female Hepacivirus Hepatitis C, Chronic Humans In Vitro Interleukin-1 Interleukin-10 Interleukin-12 Male Middle Aged Monocytes Research Support, Non-U.S. Gov't Tumor Necrosis Factor-alpha Viremia

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Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study

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World Journal of Gastroenterology 2005年第48期11卷 7631-7638页

作者： Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon peled Tilman Sauerbruch Ulrich Spengler rainer p.woitas Department of Internal Medicine 1 Institute of Experimental Hematology Institute of Medical Microbiology and Immunology TIB MOLBIOL Synthesis Laboratory Goldyne Savad Institute of Gene Therapy

AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV ***: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time pCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES ***: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,p = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, p = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% p = 0.002;1.7%; p = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy ***: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection.

关键词： RANTES polymorphism HIV/HCV-coinfectJon HCV

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