检索结果-南通市图书馆

Conditional Generative Adversarial Networks for modelling fuel sprays

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

能源与人工智能(英文) 2023年第2期12卷 62-75页

作者： Cihan Ates Farhad Karwan Max Okraschevski rainer koch Hans-Jörg Bauer Karlsruhe Institute of Technology(KIT) Institute of Thermal TurbomachineryGermany Karlsruhe Institute of Technology(KIT) Machine Intelligence in Energy SystemsGermany

In this study, the probabilistic, data driven nature of the generative adversarial neural networks (GANs)was utilized to conduct virtual spray simulations for conditions relevant to aero engine combustors. Themodel consists of two sub-modules: (i) an autoencoder converting the variable length droplet trajectories intofixed length, lower dimensional representations and (ii) a Wasserstein GAN that learns to mimic the latentrepresentations of the evaporating droplets along their lifetime. The GAN module was also conditioned withthe injection location and the diameters of the droplets to increase the generalizability of the whole *** training data was provided from highly resolved 3D, transient Eulerian–Lagrangian, large eddy simulationsconducted with OpenFOAM. Neural network models were created and trained within the open source machinelearning framework of PyTorch. Predictive capabilities of the proposed method was discussed with respect tospray statistics and evaporation dynamics. Results show that conditioned GAN models offer a great potentialas low order model approximations with high computational efficiency. Nonetheless, the capabilities of theautoencoder module to preserve local dependencies should be improved to realize this potential. For the currentcase study, the custom model architecture was capable of conducting the simulation in the order of secondsafter a day of training, which had taken one week on HPC with the conventional CFD approach for the samenumber of droplets (200,000 trajectories).

关键词： Generative Adversarial Networks Generative learning Fuel injection Aero engines Multivariate time series

Level of education and mortality after radical prostatectomy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2017年第2期19卷 173-177页

作者： Michael Froehner rainer koch Stefan Propping Dorothea Liebeheim Matthias Hfibler Gustavo B Baretton Oliver W Hakenberg Manfred P Wirth Department of Urology University Hospital 'Carl Gustav Carus' Technische Universit~t Dresden Fetscherstrasse 74 D-01307 Dresden Germany Department of Medical Statistics and Biometry University Hospital 'Carl Gustav Carus' Technische Universitat Dresden Fetscherstrasse 74 D-01307 Dresden Germany Department of Anesthesiology University Hospital 'Carl Gustav Carus' Technische Universitat Dresden Fetscherstrasse 74 D-01307 Dresden Germany Department of Pathology University Hospital 'Carl Gustav Carus' Technische Universitat Dresden Fetscherstrasse 74 D-01307 Dresden Germany Department of Urology University of Rostock Ernst-Heydemann-Strasse 6 D-18055 Rostock Germany

Estimating the risk of competing mortality is of importance in men with early prostate cancer to choose the most appropriate way of management and to avoid over- or under-treatment. In this study, we investigated the impact of the level of education in this context. The study sample consisted of 2630 patients with complete data on level of education （college, university degree, master craftsmen, comparable profession, or others）, histopathological tumor stage （organ confined or extracapsular）, lymph node status （negative or positive）, and prostatectomy specimen Gleason score （〈7, 7, or 8-10） who underwent radical prostatectomy between 1992 and 2007. Overall, prostate cancer-specific, competing, and second cancer-related mortalities were study endpoints. Cox proportional hazard models for competing risks were used to study combined effects of the variables on these endpoints. A higher level of education was independently associated with decreased overall mortality after radical prostatectomy （hazard ratio [HR]： 0.75, 95% confidence interval [95% CI]： 0.62-0.91, P = 0.0037）. The mortality difference was attributable to decreased second cancer mortality （HR： 0.59, 95% Ch 0.40-0.85, P = 0.0052） and noncancer mortality （HR： 0.73, 95% Ch 0.55-0.98, P = 0.0345） but not to differences in prostate cancer-specific mortality （HR： 1.16, 95% Ch 0.79-1.69, P = 0.4536 in the full model）. In conclusion, the level of education might serve as an independent prognostic parameter supplementary to age, comorbidity, and smoking status to estimate the risk of competing mortality and to choose optimal treatment for men with early prostate cancer who are candidates for radical prostatectomy.

关键词： comorbidity competing risk analysis level of education life expectancy mortality proportional hazards model prostate cancer radical prostatectomy smoking socioeconomic status

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

全球化学品管理战略:机遇和风险

产业与环境 2005年第2期27卷 7-8页

作者： rainer koch 方晨怡（译） Chairman of the Techical Affairs Group of the International Council of Chemical Associations （ICCA） Bayer AG Governmental and Product Affairs Gebaeude 9115 D-51368 Leverkusen Germany 不详

由以往和化学品安全相关的国际活动发展而来的国际化学品管理战略(SAICM)得到了联合国环境署(UNEP)理事会的支持.全球化学品行业认为SAICM应该被作为实现世界可持续发展首脑会议议定目标的路线图.全球在化学品安全使用问题上的不断进步... 详细信息

由以往和化学品安全相关的国际活动发展而来的国际化学品管理战略(SAICM)得到了联合国环境署(UNEP)理事会的支持.全球化学品行业认为SAICM应该被作为实现世界可持续发展首脑会议议定目标的路线图.全球在化学品安全使用问题上的不断进步将要求生产者、销售者、使用者、政府和其他利益相关方在生产链各有关环节责任分担的基础上采取共同协调的行动.从这个意义上说,制定一个全球战略提供了通过建立新的伙伴关系来实现化学品安全的机会.但是,如果SAICM成为国家、地区和国际层面附加的更严格的调控手段的基础,则其可能达不到期望的影响.

关键词：化学工业化学品管理安全管理法规体系发展战略

A New Kind of Atomic Force Microscopy Scan Control Enabled by Artificial Intelligence:Concept for Achieving Tip and Sample Safety Through Asymmetric Control

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nanomanufacturing and Metrology 2024年第2期7卷 50-59页

作者： Johannes Degenhardt Mohammed Wassim Bounaim Nan Deng rainer Tutsch Gaoliang Dai Physikalisch-Technische Bundesanstalt Bundesallee 10038116 BrunswickGermany Institut Für Prozessmess-und Sensortechnik Technische Universität Ilmenau EhrenbergstraBe 2998693 IlmenauGermany Institute of Production Metrology TU Braunschweig SchleinitzstraBe 2038106 BrunswickGermany

This paper introduces a paradigm shift in atomic force microscope(AFM)scan control,leveraging an artificial intelligence(AI)-based *** contrast to conventional control methods,which either show a limited performance,such as proportional integral differential(PID)control,or which purely focus on mathematical optimality as classical optimal control approaches,our proposed AI approach redefines the objective of control for achieving practical *** presented AI controller minimizes the root-mean-square control deviations in routine scans by a factor of about 4 compared to PID control in the presented setup and also showcases a distinctive asymmetric response in complex situations,prioritizing the safety of the AFM tip and sample instead of the lowest possible control *** development and testing of the AI control concept are performed on simulated AFM scans,demonstrating its huge potential.

关键词： Atomic force microscopy Artificial intelligence Deep reinforcement learning Optimal control

Predicting potential invasion risks of Leucaena leucocephala(Lam.)de Wit in the arid area of Saudi Arabia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Arid Land 2024年第7期16卷 983-999页

作者： Haq S MARIFATUL Darwish MOHAMMED Waheed MUHAMMAD Kumar MANOJ Siddiqui H MANZER Bussmann W rainer Department of Ethnobotany Institute of BotanyIlia State UniversityTbilisi 0162Georgia The Centre of Excellence on Sustainable Land Management(CoE-SLM) Indian Council of Forestry Research and EducationDehradun 248006India Department of Botany and Microbiology College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Botany State Museum for Natural HistoryKarlsruhe 76133Germany

The presence of invasive plant species poses a substantial ecological impact,thus comprehensive evaluation of their potential range and risk under the influence of climate change is *** study uses maximum entropy(MaxEnt)modeling to forecast the likelihood of Leucaena leucocephala(Lam.)de Wit invasion in Saudi Arabia under present and future climate change *** the MaxEnt modeling,we integrated climatic and soil data to predict habitat suitability for the invasive *** conducted a detailed analysis of the distribution patterns of the species,using climate variables and ecological *** focused on the important influence of temperature seasonality,temperature annual range,and precipitation *** distribution modeling used robust measures of area under the curve(AUC)and receiver-operator characteristic(ROC)curves,to map the invasion extent,which has a high level of accuracy in identifying appropriate *** complex interaction that influenced the invasion of *** was highlighted by the environmental parameters using Jackknife ***,the actual geographic area where *** was found in Saudi Arabia was considerably smaller than the theoretical maximum range,suggesting that it had the capacity to expand *** MaxEnt model exhibited excellent prediction accuracy and produced reliable results based on the data from the ROC *** and temperature were the primary factors influencing the potential distribution of ***,an estimated area of 216,342 km^(2)in Saudi Arabia was at a high probability of invasion by *** investigated the potential for increased invasion hazards in the future due to climate change scenarios(Shared Socioeconomic Pathways(SSPs)245 and 585).The analysis of key climatic variables,including temperature seasonality and annual range,along with soil properties such as clay composition and nitrogen content,unveiled their substanti

关键词： area under the curve invasive species invasion risks climate change MaxEnt model

Translocator protein and neurodegeneration: insights from Alzheimer’s disease

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1090-1091页

作者： Arpit Kumar Pradhan rainer Rupprecht Gerhard Rammes Klinik für Anaesthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Graduate School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany Department of Psychiatry and Psychotherapy University RegensburgRegensburgGermany

The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce *** main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.

关键词： cholesterol organs

COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stroke(COTTIS):a pilot study

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2024年第3期9卷 258-267页

作者： Jürgen Bardutzky rainer Kollmar Forat Al-Rawi Johann Lambeck Mohammad Fazel Christian Taschner Wolf-Dirk Niesen Department of Neurology and Neurophysiology Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburgGermany Neurology and Neurointensive Care Darmstadt HospitalDarmstadtGermany BrainCool AB LundSweden Department of Neuroradiology Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburgGermany

Background To evaluate the feasibility and safety of a fast initiation of cooling to a target temperature of 35℃by means of transnasal cooling in patients with anterior circulation large vessel occlusion(LVO)undergoing endovascular thrombectomy(EVT).Methods Patients with an LVO onset of<24hour who had an indication for EVT were included in the *** cooling(RhinoChill)was initiated immediately after the patient was intubated for EVT and continued until an oesophageal target temperature of 35℃was *** was maintained with surface cooling for 6-hour postrecanalisation,followed by active rewarming(+0.2℃/hour).The primary outcome was defined as the time required to reach 35℃,while secondary outcomes comprised clinical,radiological and safety *** Twenty-two patients(median age,77 years)were included in the study(14 received additional thrombolysis,4 additional stenting of the proximal internal carotid artery).The median time intervals were 309min for last-seen-normal-to-groin,58min for door-to-cooling-initiation,65min for door-to-groin and 123min for *** target temperature of 35℃was reached within 30min(range 13–78min),corresponding to a cooling rate of 2.6℃/*** recanalisation,86%of the patients had a body temperature of≤35℃.The median National Institutes of Health Stroke Scale at admission was 15 and improved to 2 by day 7,and 68%of patients had a good outcome(modified Rankin Scale 0–2)at 3 *** complications included asymptomatic bradycardia(32%),pneumonia(18%)and asymptomatic haemorrhagic transformation(18%).Conclusion The combined application of hypothermia and thrombectomy was found to be feasible in sedated and ventilated *** events were comparable to those previously described for EVT in the absence of *** effect of this procedure will next be evaluated in the randomised COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stro

关键词： maintained continued initiated

Small mammal community composition impacts bank vole (Clethrionomys glareolus) population dynamics and associated seroprevalence of Puumala orthohantavirus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2024年第1期19卷 52-65页

作者： Felicitas Maria BUJNOCH Daniela REIL Stephan DREWES Ulrike MROSENFELD rainer G.ULRICH Jens JACOB Christian IMHOLT Julius Kühn-Institute Federal Research Centre for Cultivated PlantsInstitute for Epidemiology and Pathogen DiagnosticsRodent ResearchMünsterGermany University of Münster Institute for Evolution and BiodiversityMünsterGermany Friedrich-Loeffler-Institut Federal Research Institute for Animal HealthInstitute of Novel and Emerging Infectious DiseasesGreifswald-Insel RiemsGermany

Rodents are important reservoirs for zoonotic pathogens that cause diseases in *** is hypoth-esized to be closely related to pathogen prevalence through multiple direct and indirect *** example,the presence of non-host species can reduce contact rates of the main reservoir host and thus reduce the risk of transmission(“dilution effect”).In addition,an overlap in ecological niches between two species could lead to increased interspecific competition,potentially limiting host densities and reducing density-dependent pathogen transmission *** this study,we investigated the relative impact of population-level regulation of direct and indirect drivers of the prevalence of Puumala orthohantavirus(PUUV)in bank voles(Clethrionomys glareolus)during years with high *** compiled data on small mammal community composition from four regions in Germany between 2010 and *** equation modeling revealed a strong seasonality in PUUV control mechanisms in bank *** abundance of shrews tended to have a negative relationship with host abundance,and host abundance positively influenced PUUV seroprevalence,while at the same time increasing the abundance of competing non-hosts like the wood mouse(Apodemus sylvaticus)and the yellow-neckedfield mouse(Apodemusflavicollis)were associated with reduced PUUV seroprevalence in the *** results indicate that for PUUV in bank voles,dilution is associated with increased interspecific *** pressures leading to the decline of Apodemus *** a specific habitat could lead to the amplification of mechanisms promoting PUUV transmission within the host populations.

关键词： bank vole biodiversity Puumala orthohantavirus small mammals

Perspective: Dimensions of Environment and Health in Arctic Communities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Environment & Health 2024年第1期2卷 3-10页

作者： rainer Lohmann Bonita Beatty Jessica Graybill Elena Grigorieva Ketil Lenert Hansen Anu Soikkeli Graduate School of Oceanography University of Rhode IslandNarragansettRhode Island 02882United States College of Arts and Sciences University of SaskatchewanSaskatoonSaskatchewan S7N 5A2Canada Jessica Graybill−Colgate UniversityHamiltonNew York 13346United States Geographisches Institut Humboldt UniversitätBerlin 10099Germany Regional Centre for Child Youth Mental Health and Child Welfare North(RKBU Nord)UiT The Arctic University of NorwayTromsø9037Norway Oulu School of Architecture University of OuluOulu 90014Finland

In the Arctic,environment and health are linked in myriad ways.A key emphasis has been on numerous long-lived contaminants in traditional foods,particularly marine mammals,and their well-documented impacts on human,animal and environmental health(“One health approach”).More recent concerns for Indigenous communities focus on the(side)effects of the switch to a modern,processed diet,which is accompanied by a loss of tradition and emerging health ***,the availability of traditional foods is increasingly threatened by the impacts of climate change,which also causes the emergence and spread of new and old diseases,such as *** change,including thawing permafrost and new forest fire regimes,threatens the built environment and *** particular,well-built,planned,and healthy housing is urgently needed,given that much time is spent *** care,particularly for remote and Indigenous communities,is sparse,and often ignores traditional knowledge and local *** communities in the Arctic continue to suffer from marginalization,resource colonization/extraction,and the impacts of *** examples of the green energy transition,such as in Norway,continue a pattern of ignoring Indigenous rights and ***,the connection between environment and health in the Arctic is multifaceted and complex,and investigations and solutions ought to embrace an interdisciplinary and holistic approach toward improving Environmental and Human Health in the region.

关键词： Climate change Indigenous Infrastructure Permafrost Housing Health care Well-being Green transition