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Trends in mortality among the geriatric population undergoing Surgical aortic valve replacement (SAVR) and potential racial disparities: a 20-year perspective via the National (Nationwide) Inpatient Sample

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Journal of Geriatric Cardiology 2024年第7期21卷 716-722页

作者： Nomesh Kumar Kamleshun Ramphul FNU Bawna Nitish Behary Paray Mansimran Si-ngh Dulay Jasninder Singh Dhaliwal Shruti Aggarwal Sebastian Mactaggart Suma Sri Chennapragada Shaheen Sombans Renuka Verma Hemamalini Sakthivel raheel ahmed Department of Internal Medicine Detroit Medical Center Sinai Grace-Wayne State UniversityMichiganUSA In-dependent Researcher TrioletMauritius Independent researcher Farmington HillsMichiganUSA Royal Devon University Healthcare NHS Foundation Trust ExeterUnited Kingdom Royal Brompton Hospital part of Guy’s and St.Thomas’NHS Foundation TrustLondonUnited Kingdom Department of Internal Medicine University of Cali-forniaRiversideUSA Independent Researcher New DelhiIndia Northumbria Hospitals NHS Foundation Trust NewcastleUnited Kingdom Department of Internal Medicine Louisiana State UniversityShreveportUSA Sha-heen Sombans Independent ResearcherHyderabadIndia Department of Internal Medicine Kirk Kerkorian School of Medicine at UNLVLas VegasUSA One Brooklyn Health System/Interfaith Medical Ctr Program BrooklynNYUSA

ed data from the National(Nationwide)Inpatient Sample over a 20-year period from 2001 to 2020 using specific ICD-9 and ICD-10 *** included patients aged≥60 and≤80 years with races recorded as White,African American,or Hispanic at the time of their hospitalization for *** analyzed and reported the baseline characteristics,risk-adjusted in-mortality,and complications stratified by *** Results Of 420,181 patients studied,90.0%identified as White,4.0%as African American and 6.0%as *** a de-crease in overall in-hospital mortality rates from 3.8%between 2001-2005 to 1.8%between 2016-2020,African Americans had higher odds of all-cause in-hospital deaths compared to Whites(aOR=1.390,P<0.001).Additionally,they were more likely to experi-ence cardiogenic shock(aOR=1.241,P<0.001)and acute kidney injury(aOR=1.314,P<0.001)as well as more likely to require organ support such as IABP use(aOR=1.336,P<0.001)or invasive mechanical ventilation(aOR=1.342,P<0.001).Interestingly,Americans were less likely to report events of acute ischemic stroke compared to Whites(aOR=0.852,P<0.001).African Conclusions Despite a reassuring reduction in overall in-hospital mortality rates of geriatric patients undergoing SAVR for aor-tic stenosis,racial disparities in health outcomes remain pervasive with minorities more likely to report higher in-hospital mor-bidity and mortality.

关键词： mortality likely spite

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An Open IoT Framework Based on Microservices Architecture

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China Communications 2017年第2期14卷 154-162页

作者： Long Sun Yan Li raheel ahmed Memon College of Computer Science Sichuan University Chengdu 610064 China College of manufacturing Science and Engineering Sichuan University Chengdu 610064 China School of Computer Science University of Engineering Science and Technology Chengdu 610064 China Department of Computer Science Sukkur Institute of Business Administration Sukkur Sindh Pakistan

With the continuous development and evolvement of Internet of Things(Io T), monolithic application becomes much larger in scale and even more complex in structure. This leads to poor scalability, extensibility and maintainability. In response to those challenges, microservice architecture has been introduced in the field of Io T application, due to its flexibility, lightweight and loose coupling. However, the existing Io T framework of microservice mainly focus on a specific domain, therefore, this greatly limits its application. In this paper, we propose a general microservice system framework for the Io T application, which is a better scalable, extendable and maintainable architecture. We introduce its system design and related microservices, and emphasize on core service and device communication from service layer to physical layer. It has better capacity to support interoperability and accommodate heterogeneous objects. In addition, this framework can easily achieve more application integration such as automation, intelligence, Geo service and Big Data.

关键词： Internet of things IoT micro service software architecture

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Cloud-based ***-based IoT:a comparative survey and way forward

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Frontiers of Information Technology & Electronic Engineering 2020年第4期21卷 563-586页

作者： raheel ahmed MEMON Jian Ping LI Junaid ahmed Muhammad Irshad NAZEER Muhammad ISMAIL Khursheed ALI School of Computer Science and Technology University of Electronic Science and Technology of ChinaChengdu 610031China Department of Computer Science Sukkur IBA UniversitySukkur 65200Pakistan School of Automation University of Electronic Science and Technology of ChinaChengdu 610031China

The Internet of Things(IoT)has been evolving for more than a *** advancements have increased its popularity,but concerns and risks related to IoT are growing considerably along with the increased number of connected *** 2013,a new cryptography-based infrastructure called blockchain emerged with the potential to replace the existing cloud-based infrastructure of IoT through *** this article,we provide a taxonomy of the challenges in the current IoT infrastructure,and a literature survey with a taxonomy of the issues to expect in the future of the IoT after adopting blockchain as an *** two architectures are compared based on their strengths and *** a brief survey of ongoing key research activities in blockchain is presented,which will have considerable impact on overcoming the challenges encountered in the applicability of blockchain in ***,considering the challenges and issues in both infrastructures and the latest research activities,we propose a high-level hybrid IoT approach that uses the cloud,edge/fog,and blockchain together to avoid the limitations of each infrastructure.

关键词： Internet of Things(IoT) Cloud Blockchain Data center Taxonomy

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Malakoplakia: Rare Disorder with No Significant Racial Prevalence

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Open Journal of Pathology 2023年第3期13卷 146-152页

作者： Rong Chen raheel ahmed Cristina Magi-Galluzzi Chirag R. Patel Sameer Al Diffalha Department of Pathology University of Alabama at Birmingham (UAB) Birmingham Alabama USA Department of Pathology Mayo Clinic Hospital Phoenix Arizona USA

Introduction: Malakoplakia is a rare acquired granulomatous inflammatory condition. Microscopically it is characterized by sheets of histiocytes with abundant eosinophilic granular cytoplasm (known as von Hansemann cells) with intracytoplasmic rounded concentric basophilic inclusions (Michelis-Guttmann bodies). We reviewed all cases of malakoplakia diagnosed at our institution in the past 15 years, including clinical, macroscopic, and microscopic features as well as treatment and prognosis. Methods: Gross and microscopic features of cases diagnosed as malakoplakia from 2005 to 2019 at our institution were reviewed. Clinical history, including sites of involvement, clinical presentation, imaging, past medical history, treatment, follow-up and prognosis, as well as demographic characteristics were obtained. Results: Eighteen surgical pathology cases of malakoplakia were identified. Most cases occurred in female (14/18, 77.8%) and all in adults (median age 48.5 years;range 31 - 87). Half of the patients were Caucasian, 44% African American and 6% were reported as “other” race. One third (6/18) of patients presented with a mass-like lesion on imaging or endoscopic studies. As to site of lesion, 61.1% (11/18) involved GU tract, 27.8% (5/18) gastrointestinal (GI) tract, 5.6% (1/18) liver, and 5.6% (1/18) vagina. 38.9% of patients (7/18) had antibiotics treatment upon diagnosis. Conclusion: Malakoplakia is a rare disorder occurring in a wide age range, more commonly in females, with no significant racial prevalence. While the GU and GI tracts are the most common sites, other anatomic locations can be involved. Accurate diagnosis and appropriate treatment are important to avoid recurrence.

关键词： Malakoplakia Von Hansemann Cells Michelis-Guttmann Bodies

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Framework for fault-tolerant speed tracking control of gasoline engines using the first principle-based engine model

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Journal of Control and Decision 2023年第4期10卷 560-571页

作者： raheel Anjum ahmed Yar Ghulam Murtaza Qadeer ahmed Aamer I.Bhatti Controls and Signal Processing Research Group(CASPR) Capital University of Science and TechnologyIslamabadPakistan Department of Mechanical Engineering College of E&MENational University of Sciences and TechnologyIslamabadPakistan Center for Automotive Research The Ohio State UniversityColumbusOHUSA Department of Electrical Engineering Capital University of Science and TechnologyIslamabadPakistan

Optimal engine torque management,a fundamental objective,depends predominantly on engine speed tracking *** ensures to attain desired speed profile in the presence of uncertainties,disturbances and *** the other hand,certain requirements such as emissions control,fuel efficiency and drivability are degraded in case of poorspeed ***,constraints on engine speed tracking performance are even more stringent for hybrid power-train architecture as crankshaft speed and engine torque are the basic variables for coordinated *** tracking is also considered essential for gearshift control ofthe automatic *** this research work,a framework for fault-tolerant speed tracking of the gasoline engine is proposed using the First Principle-based Engine Model(FPEM).A high-fidelity direct relationship between fuel injection input and engine speed is derived by the transformation of *** is induced in the fuel injection subsystem to generate the torque *** the proposed framework,a second-order sliding mode-based control technique is applied to track desired speed profile by mitigating the faultsin the fuel injection *** data acquired from the engine test rig is used to demonstrate the offline validity and fault tolerance capabilities of the proposed framework in MATLAB/Simulink.

关键词： Engine speed tracking fault-tolerant control gasoline engines sliding mode control

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Liver transplantation during global COVID-19 pandemic

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World Journal of Clinical Cases 2021年第23期9卷 6608-6623页

作者： Mostafa Alfishawy Nso Nso Mahmoud Nassar Jonathan Ariyaratnam Sakil Bhuiyan raheel S Siddiqui Matthew Li Howard Chung Amira Al Balakosy ahmed Alqassieh Tibor Fülöp Vincent Rizzo ahmed Daoud Karim M Soliman Infectious Diseases Infectious Diseases Consultants and Academic Researchers of Egypt IDCARECairo 0000Egypt Department of Medicine Icahn School of Medicine at Mount Sinai(NYC Health and Hospitals:Queens)New YorkNY 11373United States Clinical pharmacy department Icahn School of Medicine at Mount Sinai(NYC Health and Hospitals:Queens)New YorkNY 11373United States Tropical Medicine Department Ain Shams UniversityCairo 11517Egypt Department of Surgery Medical University of South CarolinaCharlestonSC 29425United States Department of Medicine Medical University of South CarolinaCharlestonSC 29425United States Department of Medicine Kasr Alainy Medical SchoolCairo UniversityCairo 11562Egypt

The coronavirus disease 2019(COVID-19)caused by severe acute respiratory disease respiratory syndrome coronavirus-2 has significantly impacted the health care systems *** transplantation(LT)has faced an unequivocal challenge during this unprecedented *** targeted review aims to cover most of the clinical issues,challenges and concerns about LT during the COVID-19 pandemic and discuss the most updated literature on this rapidly emerging subject.

关键词： COVID-19 Calcineurin inhibitors Cytokine Distributive justice End-stage liver disease Immunosuppression Liver transplantation Mortality

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Novel mutations in PDE6A and CDHR1 cause retinitis pigmentosa in Pakistani families

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1843-1851页

作者： Muhammad Dawood Siying Lin Taj Ud Din Irfan Ullah Shah Niamat Khan Abid Jan Muhammad Marwan Komal Sultan Maha Nowshid raheel Tahir Asif Naveed ahmed Muhammad Yasin Emma LBaple Andrew HCrosby Shamim Saleha Department of Biotechnology and Genetic Engineering Kohat University of Science and Technology(KUST)Kohat 26000Khyber PakhtunkhwaPakistan Medical Research RILD Wellcome Wolfson Centre(Level 4)Royal Devon and Exeter NHS Foundation TrustExeterDevon EX25DWUK Department of Ophthalmology KMU Institute of Medical Sciences(KIMS)Kohat 26000Khyber PakhtunkhwaPakistan

AIM:To investigate the genetic basis of autosomal recessive retinitis pigmentosa(arRP)in two consanguineous/endogamous Pakistani ***:Whole exome sequencing(WES)was performed on genomic DNA samples of patients with arRP to identify disease causing *** sequencing was performed to confirm familial segregation of identified mutations,and potential pathogenicity was determined by predictions of the mutations’***:A novel homozygous frameshift mutation[NM_000440.2:c.1054delG,p.(Gln352Argfs*4);Chr5:g.149286886del(GRCh37)]in the PDE6A gene in an endogamous family and a novel homozygous splice site mutation[NM_033100.3:c.1168-1G>A,Chr10:g.85968484G>A(GRCh37)]in the CDHR1 gene in a consanguineous family were *** PDE6A variant p.(Gln352Argfs*4)was predicted to be deleterious or pathogenic,whilst the CDHR1 variant c.1168-1G>A was predicted to result in potential alteration of ***:This study expands the spectrum of genetic variants for arRP in Pakistani families.

关键词： autosomal recessive retinitis pigmentosa PDE6A CDHR1 variants Pakistani families

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Current systematic reviews and meta-analyses of COVID-19

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World Journal of Virology 2021年第4期10卷 182-208页

作者： Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo Department of Internal Medicine Icahn School of Medicine at Mount Sinai/NYC H&H QueensNew YorkNY 11432United States Department of Infectious Diseases Infectious Diseases Consultants and Academic Researchers of Egypt(IDCARE)Cairo 11221Outside of the USEgypt Department of Medicine Division of NephrologyUniversity of Tennessee Health Science CenterKnoxville CityTN 38103United States Department of Medical St.George's UniversityWest Indies 38901Grenada Department of Internal Medicine Faculty of MedicineCairo UniversityCairo 11221Egypt Department of Oncology Broomfiled HospitalMid and South Essex NHS Foundation TrustESSEXChelmsford 12422United Kingdom Department of Critical Care Unit Icahn School of Medicine at Mount Sinai/NYC H&H QueensNew YorkNY 11432United States

BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million *** the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of *** To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be *** We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS *** included studies were extracted from Embase,Medline,and Cochrane *** publication timeframe of included studies ranged between January 01,2020,to October 30,*** that were published in languages other than English were not considered for this systematic *** finalized full-text articles are freely accessible in the public *** Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 *** inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 *** screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and ***,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stro

关键词： Systematic review Meta-analyses COVID-19 Review Coronavirinae

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