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Efficacy and safety of over-the-scope clip: Including complications after endoscopic submucosal dissection

World Journal of Gastroenterology 2013年第18期19卷 2752-2760页

作者： Noriko Nishiyama Hirohito Mori Hideki Kobara Kazi rafiq Shintarou Fujihara Mitsuyoshi Kobayashi Makoto Oryu Tsutomu Masaki Department of Gastroenterology and Neurology Faculty of Medicine Kagawa University Kagawa 761-0796 Japan Department of Pharmacology Faculty of Medicine Kagawa University Kagawa 761-0796 Japan

AIM: To retrospectively review the results of over-thescope clip (OTSC) use in our hospital and to examine the feasibility of using the OTSC to treat perforations after endoscopic submucosal dissection (ESD). METHODS: We enrolled 23 patients who presented with gastrointestinal (GI) bleeding, fistulae and perforations and were treated with OTSCs (Ovesco Endoscopy GmbH, Tuebingen, Germany) between November 2011 and September 2012. Maximum lesion size was defined as lesion diameter. The number of OTSCs to be used per patient was not decided until the lesion was completely closed. We used a twin grasper (Ovesco Endoscopy GmbH, Tuebingen, Germany) as a grasping device for all the patients. A 9 mm OTSC was chosen for use in the esophagus and colon, and a 10 mm device was used for the stomach, duodenum and rectum. The overall success rate and complications were evaluated, with a particular emphasis on patients who had undergone ESD due to adenocarcinoma. In technical successful cases we included not only complete closing by using OTSCs, but also partial closing where complete closure with OTSCs is almost difficult. In overall clinical successful cases we included only complete closing by using only OTSCs perfectly. All the OTSCs were placed by 2 experienced endoscopists. The sites closed after ESD included not only the perforation site but also all defective ulcers ***: A total of 23 patients [mean age 77 years (range 64-98 years)] underwent OTSC placement during the study period. The indications for OTSC placement were GI bleeding (n = 9), perforation (n = 10), fistula (n = 4) and the prevention of post-ESD duodenal artificial ulcer perforation (n = 1). One patient had a perforation caused by a glycerin enema, after which a fistula formed. Lesion closure using the OTSC alone was successful in 19 out of 23 patients, and overall success rate was 82.6%. A large lesion size (greater than 20 mm) and a delayed diagnosis (more than 1 wk) were the major contributing fac

关键词： Over-the-scope clip Gastrointestinal bleed-ing Endoscopic submucosal dissection complications Gastrointestinal fistulae Gastrointestinal perforation

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Meta-analysis of dragon's blood resin extract as radio-protective agent

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Journal of Coastal Life Medicine 2017年第9期5卷 409-416页

作者： Subaika Mahmood Toseef Fatima Hina Zulfaqar Romana Saher Muhammad rafiq Abdul Rehman Rongji Dai Muhammad Ashfaq Murtaza Hasan Department of Biochemistry&Biotechnology(Baghdad-ul-Jadeed Campus) the Islamia University of BahawalpurBahawalpur63100Pakistan School of life Sciences Beijing Institute of TechnologyBeijing100081People’s Republic of China

In health sciences, much efforts had been made in past years to explore the radio-protective agents from natural resources due to rapid exposure of radiations to environment such as space traveling, radiotherapy and largely growing telecommunication industry. It becomes crucial to find natural sources for radio-protection. In correspondence, dragon's blood (DB) is a traditional Chinese medicinal plant that possesses great medicinal values due to the presence of several phenolic compounds. For a long time, DB has been used in treatment of blood stasis, inflammation, oxidative stress, immune suppression and tumors, but recently it has been extensively used as radio-protective agent. There is no comprehensive review on radio-protective characterization of DB resin extract in literature. In our review, an attempt has been made to highlight unique and inherent radio-protection in liver, brain, kidney, lung, spleen and cerebrum. This review will help people in exploring the radioactive protectants from natural resources.

关键词： Dragon's blood Bioreduction Radioprotection Oxidative stress Immune suppression

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Simple Quantitation of Flucytosine in Low Volume Serum Samples and Evaluation of Common Endogenous Interferences by HPLC-UV

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American Journal of Analytical Chemistry 2022年第9期13卷 289-299页

作者： Abdul rafiq Khan Ali Alothaim Waleed Tamimi Majid Alshaibani Souad Marwan Al Enazi Syed Muhammad Saad Khalid Mohammed Khan Department of Pathology and Laboratory Medicine King Abdulaziz Medical City Riyadh KSA Department of Chemistry University of Karachi Karachi Pakistan H. E. J. Research Institute of Chemistry International Center for Chemical and Biological Sciences University of Karachi Karachi Pakistan

5-Fluorocytosine (5-FC) is used for the treatment of several infections. It is extremely important to monitor blood level concentration for maximum activity to avoid its side effects. A simple, faster, and more accurate analytical method is developed and validated using high-performance liquid chromatography with UV detection in a very low-volume serum sample. Exactly 50 μL of serum was precipitated with 5% trichloroacetic acid. After mixing and centrifugation, 20 μL of supernatant was injected into the HPLC column. Detection was performed at 280 nm. The method is very specific and free from interfering substances due to different drugs and their different circulating metabolites. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.50 μg/L and 1.0 μg/L, respectively. The method was linear in the range of 5 - 150 μg/L in the serum sample. In method comparison, the correlation coefficient r2 was 0.999 and the percentage recovery was 90% - 105% on four levels of the quality control samples. Within run and between run precision was found to be less than 2.2% at four different concentrations (5, 25, 50, and 100 μg/L). A simple, faster, and more accurate HPLC-UV method is developed which is very useful for monitoring 5-FC concentration in low volume serum samples without evaporation step and ion exchange chromatography within minutes.

关键词： 5-Fluorocytosine Serum Sample HPLC-UV Method Quantification Validation

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Colorectal cancer screening use among insured adults: Is out-of-pocket cost a barrier to routine screening?

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2018年第4期9卷 31-38页

作者： Abhilash Perisetti Hafiz Khan Nayana E George Rachana Yendala Aamrin rafiq Summre Blakely Drew Rasmussen Nathan Villalpando Hemant Goyal Department of Gastroenterology University of Arkansas for Medical Sciences Department of Public Health Texas Tech University Health Sciences Department of Internal Medicine University of Arkansas Medical Sciences Department of Hematology and Oncology Texas Tech University Health Sciences Department of Biological Sciences Texas Tech University School of Medicine Texas Tech University Health Sciences Center Department of Internal Medicine Mercer University School of Medicine

AIM To describe the characteristics of adults who needed to see a doctor in the past year but could not due to the extra cost and assess the impact of limited financial resources on the receipt of routine fecal occult blood test, sigmoidoscopy, or colonoscopy for colon cancer screening among insured patients. METHODS Data obtained from the 2012 Behavioral Risk Factor Surveillance System included 215436 insured adults age 50-75 years. We computed frequencies, adjusted odds ratios(a ORs), and 95%CIs using SAS v9.3 software. RESULTS Nine percent of the study population needed to see a doctor in the past year but could not because of cost. The numbers were significantly higher among those aged 50-64(P < 0.0001), Non-Hispanic Whites(P < 0.0001), and those with a primary care physician(P < 0.0001) among other factors. Adjusting for possible confounders, a ORs for not seeing the doctor in the past year because of cost were: stool occult blood test within last year a OR = 0.88; 95%CI: 0.76-1.02, sigmoidoscopy within last year a OR = 0.72; 95%CI: 0.48-1.07, colonoscopy within the last year a OR = 0.91; 95%CI: 0.81-1.02. CONCLUSION We found that the limited financial resources within the past 12 mo were significantly associated with colorectal cancer(CRC) non-screening. Patients with risk factors identified in this study should adhere to CRC guidelines and should receive financial help if needed.

关键词： Fecal occult blood Healthcare delivery Sigmoidoscopy Colorectal cancer Screening Access to care Behavioral Risk Factor Surveillance System

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Impella心脏轴流泵与心源性休克救治研究进展

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中华实用诊断与治疗杂志 2019年第9期33卷 833-837页

作者：高传玉 rafiq Ahmed BHAT 张静张健河南省人民医院心脏中心郑州大学人民医院心内科华中阜外医院河南省冠心病防治重点实验室河南省心血管流行病学研究中心郑州大学华中阜外医院郑州450003 中国医学科学院阜外医院心力衰竭中心北京100037

心源性休克的常见原因包括急性心肌梗死、心肌病、心包疾病、心肌炎、开胸手术,其主要表现为心输出量下降、平均动脉压下降、终末靶器官灌注不足,休克进入死亡瀑布。尽管介入、溶栓技术取得很大进步,但ST段抬高型心肌梗死合并心源性休... 详细信息

心源性休克的常见原因包括急性心肌梗死、心肌病、心包疾病、心肌炎、开胸手术,其主要表现为心输出量下降、平均动脉压下降、终末靶器官灌注不足,休克进入死亡瀑布。尽管介入、溶栓技术取得很大进步,但ST段抬高型心肌梗死合并心源性休克患者住院病死率仍高达50%以上。Impella是心脏血流动力学辅助装置轴流泵,可稳定心源性休克患者血流动力学,减轻左心室负荷,增加器官的有效灌注,促进患者康复。本文就目前治疗心源性休克面临的挑战及Impella心脏轴流泵在心源性休克救治中作用的研究进展作一综述。

关键词：心源性休克机械循环支持 Impella心脏轴流泵临床预后

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Radical excision of Barrett's esophagus and complete recovery of normal squamous epithelium

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World Journal of Gastroenterology 2013年第31期19卷 5195-5198页

作者： Hirohito Mori Hideki Kobara Kazi rafiq Noriko Nishiyama Shintaro Fujihara Maki Ayagi Tatsuo Yachida Kiyohito Kato Tsutomu Masaki Department of Gastroenterology and Neurology Kagawa University Kagawa 761-0793 Japan Department of Pharmacology Kagawa UniversityKagawa 761-0793 Japan

To treat Barrett's esophagus(BE),radiofrequency ablation or cryotherapy are effective treatments for eradicating BE with dysplasia and intestinal metaplasia,and reduce the rates of Barrett's esophageal adenocarcinoma(BAC).However,patients with BE and dysplasia or early cancer who achieved complete eradication of intestinal metaplasia,BE recurred in 5% within a year,requiring expensive endoscopic *** performed endoscopic submucosal dissection as complete radically curable treatment procedure for BE with dysplasia,intestinal metaplasia and BAC.

关键词： Barrett’s esophagus Radiofrequency ablation Cryotherapy Endoscopic submucosal dissection Radically curable treatment

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经皮机械循环辅助装置——Impella研究进展

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中华心力衰竭和心肌病杂志（中英文） 2020年第3期4卷 217-221页

作者：高传玉张静 rafiq Ahmed Bhat 张健郑州大学华中阜外医院河南省人民医院心脏中心郑州451464 中国医学科学院阜外医院心力衰竭中心心力衰竭重症监护病区北京100037

越来越多的研究证据表明,机械循环辅助(MCS)可以对循环系统提供有效辅助,纠正血流动力学紊乱状态,改善器官组织灌注,提高患者的生存率,其临床应用逐渐增多。Impella作为经皮MCS装置的一种,目前已经被美国食品及药品管理局(FDA)批准用于... 详细信息

越来越多的研究证据表明,机械循环辅助(MCS)可以对循环系统提供有效辅助,纠正血流动力学紊乱状态,改善器官组织灌注,提高患者的生存率,其临床应用逐渐增多。Impella作为经皮MCS装置的一种,目前已经被美国食品及药品管理局(FDA)批准用于心原性休克(CS)或者选择性和紧急高危经皮冠状动脉介入治疗(PCI)或保护性PCI患者。因此,本文将从Impella的作用原理、Impella在CS患者中应用、Impella在高危PCI患者中应用及Impella指南推荐意见和批准适应证说明等几个方面介绍Impella临床应用的研究进展。

关键词：机械循环辅助心原性休克高危复杂介入指征患者 Impella 预后

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Effect of FFD-410 (HiOwna-Jr.), a Balanced Herbal Nutritional Supplement on Biochemical, Hematological, Immunological and Cognitive Parameters of Wistar Rats

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Food and Nutrition Sciences 2013年第6期4卷 660-667页

作者： Suryakanth Dattatraya Anturlikar Mohamed rafiq Gollapalle Laksminarayanashastry Viswanatha Mohammed Azeemuddin Agadi Hiremath Thippeswamy Uday Kumar Veeranna Kanni Pralhad Sadashiv Patki Department of Pharmacology R&D Center The Himalaya Drug Company Bangalore India Department of Pharmacology R&D Center The Himalaya Drug Company Bangalore India.

Present study was aimed to evaluate the effect HiOwna-Jr. (FFD-410) on vital biochemical, hematological, immunological and cognitive functions in rats;also in vitro antioxidant studies were carried out to evaluate the antioxidant capacity of FFD-410. Animals of respective groups were treatment with FFD-410 for 90 days and blood samples were collected for the estimation of biochemical, hematological parameters and serum immunoglobulin levels;haemoagglutination assay was carried out using Sheep Red blood cells (SRBC’s). In addition, effect of FFD-410 on cognition and memory was evaluated by modified elevated plus maze test. Apart from in vivo studies, in vitro studies such as DPPH radical scavenging assay, reducing power assay and ORAC assays were carried out to evaluate the free radical scavenging and antioxidant activity of FFD-410. Pretreatment with FFD-410 for 90 days did not bring about any change in serum biochemical and hematological parameters and relative organ weights etc., which could account for its wide safety margin at tested dose levels (2.5 and 5.0 g/kg, p.o.). However, FFD-410 showed potent immunostimulant activity by elevating the serum immunoglobulins and haemoagglutination titer values, also the pretreatment with FFD-410 showed dose dependent improvement in short-term cognition and memory in elevated plus maze test. Furthermore, in vitro antioxidant studies FFD-410 exhibited significant and dose dependent free radical scavenging and antioxidant activity as assessed by DPPH (IC50 value of 1162.6 μg/ml), reducing power and ORAC assays (Trolox equivalence/g of 76.1). These findings suggest that, FFD-410 possess very good antioxidant, cognition improving and potent immunostimulant properties. Also, there was no significant change in the serum biochemical and hematological parameters and relative organ weights were observed after 90 days treatment with FFD-410, which could account for its wide safety of margin at tested dose levels (2.5 and5.0 g/kg. p.o

关键词： HiOwna-Jr. Herbal Nutritional Supplement Antioxidants ORAC Assay Hematology Immunomodulator Cognition Improvement

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Molecular Targets of Curcumin and Future Therapeutic Role in Leukemia

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Journal of Biosciences and Medicines 2018年第4期6卷 33-50页

作者： Sabika rafiq Muhammad Hassan Raza Mehwish Younas Fariha Naeem Romisha Adeeb Javed Iqbal Pervez Anwar Umara Sajid Hafiza Muniba Manzoor Department of Biotechnology University of Gujrat Sialkot Subcampus Sialkot Pakistan Department of Biotechnology & Bioinformatics International Islamic University Islamabad Pakistan Department of Biotechnology University of Health Sciences Lahore Lahore Pakistan

Leukemia is a most prevalent type of cancer around the globe. Due to major side effects of Chemotherapy and radiotherapy, scientists worked to explore the alternative source to treat leukemia. An alternative source for the treatment of leukemia existed in the form of curcumin, a natural phenolic compound extracted from curcuma longa plant. It exhibited anticancer properties reducing the tumor load via apoptosis and cell cycle arrested in various cancer cell lines and controlled tumor proliferation by blocking tumor inducing gene such as FLT3, Akt gene, ROS and NF-κB inhibition. At molecular level, curcumin plays a key therapeutic role in protection of normal cells by up regulation of NRF-2 that induces production of cellular antioxidants. It regulates various signaling pathways including NF-KB, JAK/STAT, PI3K/AKT and JNK pathways, thereby affecting cancer initiation, progression, and metastasis. This review described the potential of curcumin for treatment of leukemia;it affects different signaling cascades and their regulation. This study provides a preclinical foundation for future usage of curcumin in the treatment of cancer.

关键词： Curcumin Antioxidant Signaling Pathways Apoptosis Therapeutic Potential Leukemic Load

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Global observation of urban expansion and land-cover dynamics usingsatellite big-data

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Science Bulletin 2021年第4期66卷 297-300页

作者： Wenhui Kuang Guoming Du Dengsheng Lu Yinyin Dou Xiaoyong Lid Shu Zhang Wenfeng Chi Jinwei Dong Guangsheng Chen Zherui Yin Tao Pan rafiq Hamd Yali Hou Chunyang Chen Han Li Chen Miao Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China School of Public Administration and Law Northeast Agricultural UniversityHarbin 150030China School of Geographical Sciences Fujian Normal UniversityFuzhou 350007China University of Chinese Academy of Sciences Beijing J00049China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China School of Resources and Environmental Economics Inner Mongolia University of Finance and EconomicsHohhot 010017China School of Environmental&Resource Sciences Zhejiang Agriculture and Forestry UniversityHangzhou 311300China Xinjiang Institute of Ecology and Geography Chinese Academy of SciencesUrumqi 830011China Royal Meteorological Institute of Belgium Brussels 1180Belgium National Remote Sensing Center of China Beijing 100036China

Humans deeply influence the urbanizing of earth’s surface system in an exacerbating manner across space and time[1].Around the globe,urban land-use/cover changes reflect the intensities of human activities and land s... 详细信息

关键词： dominated expansion dynamics

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