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Investigating the therapeutic efficacy of psilocybin in advanced cancer patients: A comprehensive review and meta-analysis

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World Journal of Clinical Oncology 2024年第7期15卷 908-919页

作者： Husam Bader Husam Farraj Joud Maghnam Yazan abu Omar Department of Internal Medicine University of MichiganAnn ArborMI 48109United States Department of Internal Medicine University of New MexicoAlbuquerqueNM 87106United States Faculty of Medicine AL-Balqa Applied UniversityAl-Salt 19110Jordan

BACKGROUND Psilocybin,a naturally occurring psychedelic compound found in certain species of mushrooms,is known for its effects on anxiety and *** has recently gained increasing interest for its potential therapeutic effects,particularly in patients with advanced *** systematic review and meta-analysis aim to evaluate the effects of psilocybin on adult patients with advanced *** To investigate the therapeutic effect of psilocybin in patients with advanced *** A comprehensive search of electronic databases was conducted in PubMed,Cochrane Central Register of Controlled Trials,and Google Scholar for articles published up to February *** reference lists of the included studies were also searched to retrieve possible additional *** A total of 7 studies met the inclusion criteria for the systematic review,comprising 132 *** results revealed significant improvements in quality of life,pain control,and anxiety relief following psilocybin-assisted therapy,specifically results on anxiety *** effect sizes indicated statistically significant reductions in symptoms of anxiety at both 4 to 4.5 months[35.15(95%CI:32.28-38.01)]and 6 to 6.5 months[33.06(95%CI:28.73-37.40)].Post-administration compared to baseline assessments(P<0.05).Additionally,patients reported sustained improvements in psychological well-being and existential distress fo-llowing psilocybin *** The findings provided compelling evidence for the potential benefits of psilocybin-assisted therapy in improving quality of life,pain control,and anxiety relief in patients with advanced cancer.

关键词： Quality of life Advanced cancer Psilocybin Systemic review Meta analysis

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Quality of life and psychological distress in end-stage renal disease patients undergoing hemodialysis and transplantation

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World Journal of Nephrology 2024年第3期13卷 34-40页

作者： Emad A Shdaifat Firas T abu-Sneineh Abdallah M Ibrahim Community Nursing Department Imam Abdulrahman Bin Faisal UniversityDammam 1982Saudi Arabia Department of Fundamental Nursing Imam Abdulrahman Bin Faisal UniversityDammam 1982Saudi Arabia

BACKGROUND Among diverse profound impacts on patients’quality of life(QoL),end-stage renal disease(ESRD)frequently results in increased levels of depression,anxiety,and *** replacement therapies such as hemodialysis(HD)and transplantation(TX)are intended to enhance QoL,although their ability to alleviate psychological distress remains *** research posits the existence of a significant correlation between negative emotional states and QoL among ESRD patients,with varying effects observed in HD and TX *** To examine the relationship between QoL and negative emotional states(depression,anxiety,and stress)and predicted QoL in various end-stage renal replacement therapy patients with *** This cross-sectional study included HD or TX patients in the Eastern Region of Saudi *** 36-item Short Form Survey and Depression Anxiety Stress Scale(DASS)was used for data collection,and correlation and regression analyses were *** The HD and TX transplantation groups showed statistically significant inverse relationships between QoL and DASS *** patients with high anxiety levels and less education scored low on the physical component summary(PCS).In addition,the results of the mental component summary(MCS)were associated with reduced *** with older transplant patients,TX patients’PCS scores were lower,and depression,stress,and negative working conditions were highly correlated with MCS *** The findings of this study revealed notable connections between well-being and mental turmoil experienced by individuals undergoing HD and *** PCS of HD patients is affected by heightened levels of anxiety and lower educational attainment,while the MCS of transplant patients is influenced by advancing age and elevated stress *** insights will contribute to a more comprehensive understanding of patient support.

关键词： Anxiety Depression End-stage renal disease Hemodialysis Patient Reported Outcome Measures Psychological distress Quality of life Renal replacement therapy outcomes Saudi Arabia Stress

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Detailed Analyses of Nymphea Seeds Consumed in the Senegal River Valley

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Food and Nutrition Sciences 2024年第8期15卷 695-700页

作者： Nicolas Cyrille Ayessou Michel bakar Diop Fatou Kiné Gueye César Bassène Mame Samba Mbaye Centre dEtudes sur la Scurit Alimentaire et les Molcules Fonctionnelles (CESAM-RESCIF) Universit Cheikh Anta DIOP Dakar Sngal Unit de formation et de Recherche des Sciences Agronomiques de lAquaculture et des Technologies Alimentaires Universit Gaston Berger Saint-Louis Sngal Laboratoire de Botanique-Biodiversit Biologie Vgtale Universit Cheikh Anta Diop Dakar Senegal

Physicochemical investigations were performed on seeds of Nymphea lotus and N. micrantha consumed in the Senegal River valley. They revealed a composition similar to that of cereals. In order to estimate their intrinsic quality, the determination of their amino acid, fatty acid and monosaccharids profiles was done. The results indicate that monosaccharides are represented specifically by saccharose (7%) and glucose (0.67%);a predominance of stearic acid and linoleic acid as unsaturated acids (24.86%);arachidic and palmitic acids as the only saturated acid found (11.12%);a good ratio of unsaturated/saturated acid (2.23);a lack of oleic acid, linoleic, palmitoleic, myristic, caprylic acids;a poor-quality index protein due to low quantity amino acids. Nevertheless, all essential amino acids are present in the seeds. The Nymphea sp grains consumed by the populations around the Senegal River valley offer an interesting nutritional quality linked to fatty acids and carbohydrates.

关键词： Nymphea Seeds Composition

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Nutritional management guidelines for pancreatitis-a commentary

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 873-874页

作者： Chinenye R.Dike Maisam abu-El-Haija Department of Pediatrics Division of GastroenterologyHepatologyand NutritionUniversity of Alabama at BirminghamBirminghamALUSA Department of Pediatrics College of MedicineUniversity of CincinnatiCincinnatiOHUSA Division of Gastroenterology Hepatologyand NutritionCincinnati Children’s Hospital Medical CenterCincinnatiOHUSA

The recent ESPEN practical guideline on clinical nutrition in acute pancreatitis(AP)and chronic pancreatitis(CP)is a very useful resource for directing clinical management of AP and CP(1).Screening for nutritional risks and proactive management of different nutritional aspects is an integral step in the care of patients with *** the catabolic state,inflammatory state,the effect of diet on pain,the exocrine and endocrine derangements that accompany pancreatitis cases;studying evidence based nutritional modalities becomes *** guidelines included all the recommendations of the ESPEN guideline on clinical nutrition for pancreatitis that were published in 2020(2),but also included summaries,flowcharts and diagrams of the recommendations.A total of 48 statements are included in the guidelines,with level of evidence and the grade assessment.

关键词： Acute pancreatitis(AP) diet management

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National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

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World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： Faisal Saud Dar Zaigham Abbas Irfan Ahmed Muhammad Atique Usman Iqbal Aujla Muhammad Azeemuddin Zeba Aziz abu bakar Hafeez Bhatti Tariq Ali Bangash Amna Subhan Butt Osama Tariq Butt Abdul Wahab Dogar Javed Iqbal Farooqi Faisal Hanif Jahanzaib Haider Siraj Haider Syed Mujahid Hassan Adnan Abdul Jabbar Aman Nawaz Khan Muhammad Shoaib Khan Muhammad Yasir Khan Amer Latif Nasir Hassan Luck Ahmad Karim Malik Kamran Rashid Sohail Rashid Mohammad Salih Abdullah Saeed Amjad Salamat Ghias-un-Nabi Tayyab Aasim Yusuf Haseeb Haider Zia Ammara Naveed Department of Hepatopancreatic Biliary Surgery&Liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and Liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan University of Aberdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic Biliary Surgery&Liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic Biliary Surgery&Liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatobiliary&Liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army Liver Transplant Unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan Rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the *** Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this *** effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required before *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for *** only curative treatment is the surgical resection of the biliary tree based on the Bismuth-Corlette *** patients with unresectable hCCA can be considered for liver *** chemotherapy should be offered to patients with a high risk of *** use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary *** with acute cholangitis can be drained with endoscopic or percutaneous biliary *** chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA.

关键词： Hilar cholangiocarcinoma Bismuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative biliary drainage Portal vein embolisation Surgical resection Hepatectomy

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Multi-Scale Network with Integrated Attention Unit for Crowd Counting

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Computers, Materials & Continua 2022年第11期73卷 3879-3903页

作者： Adel Hafeezallah Ahlam Al-Dhamari Syed Abd Rahman abu-bakar Department of Electrical Engineering Taibah UniversityMadinahSaudi Arabia Department of Electronics and Computer Engineering School of Electrical EngineeringFaculty of EngineeringUniversiti Teknologi Malaysia81310JohorMalaysia Department of Computer Engineering Hodeidah UniversityHodeidahYemen

Estimating the crowd count and density of highly dense scenes witnessed in Muslim gatherings at religious sites in Makkah and Madinah is critical for developing control strategies and organizing such a large ***,since the crowd images in this case can range from low density to high density,detection-based approaches are hard to apply for crowd ***,deep learning-based regression has become the prominent approach for crowd counting problems,where a density-map is estimated,and its integral is further computed to acquire the final count *** this paper,we put forward a novel multi-scale network(named 2U-Net)for crowd counting in sparse and dense *** proposed framework,which employs the U-Net architecture,is straightforward to implement,computationally efficient,and has single-step *** layers are used to retrieve the pooling layers’erased information and learn hierarchically pixelwise spatial *** helps in obtaining feature values,retaining spatial locations,and maximizing data integrity to avoid data *** addition,a modified attention unit is introduced and integrated into the proposed 2UNet model to focus on specific crowd *** proposed model concentrates on balancing the number of model parameters,model size,computational cost,and counting accuracy compared with other works,which may involve acquiring one criterion at the expense of other *** on five challenging datasets for density estimation and crowd counting have shown that the proposed model is very effective and outperforms comparable mainstream ***,it counts very well in both sparse and congested crowd *** 2U-Net model has the lowest MAE in both parts(Part A and Part B)of the ShanghaiTech,UCSD,and Mall benchmarks,with 63.3,7.4,1.5,and 1.6,***,it obtains the lowest MSE in the ShanghaiTech-Part B,UCSD,and Mall benchmarks with 12.0,1.9,and 2.1,respectively.

关键词： Computer vision crowd analysis crowd counting U-Net max-pooling index unpooling attention units

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Study the Structural, Electronic, Optical Properties of CZTS Compound after Doping Ba at Zn Site and Si at Sn Site Using Density Functional Theory (DFT)

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Materials Sciences and Applications 2024年第9期15卷 305-319页

作者： Fatema Najrin Rabeya bakar Sarna Sayedul Hasan Shariful Islam Budrun Neher Md. Mahbubur Rahman Bhuiyan Farid Ahmed Department of Physics Jahangirnagar University Bangladesh Department of Physics Sunamganj Science and Technology University Santiganj Bangladesh

The structural, electronic, and optical properties of Cu2Zn1−xBaxSn1−ySiyS4 compounds have been calculated using GGA-PBE function within the framework of Density Functional Theory (DFT). In the present work, lattice parameters remained the same, that is tetragonal crystal structure for 0% and 100% doping concentration. The electronic band gap of Cu2Zn1−xBaxSn1−ySiyS4 compounds has been gradually increased for continuous increment of doping concentration where the highest electronic band gap is 1.117 eV for Cu2BaSiS4 structure. Moreover, the band gap changes from direct to indirect band gap with the increase of doping concentration in the parent compound. The absorption coefficient has been found to be high (> 104 cm−1) in UV-region for all the doping concentration which makes the studied compound as a potential candidate of absorber layer in the UV detector. The theoretical study of the effect of double doping in the CZTS compound is very interesting for improving the quality of it and it would be a reference for the theoretical and experimental researchers.

关键词： Photovoltaics Absorber Layer Density Functional Theory (DFT) Band Gap Solar Cell

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Effect of Exchange-Correlation Functional on the Structural, Mechanical, and Optoelectronic Properties of Orthorhombic RbSrBr3 Perovskite

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Materials Sciences and Applications 2024年第6期15卷 137-154页

作者： Fatema Najrin Rabeya bakar Sarna Md. Alamin Sarker Budrun Neher Md. Mahbubur Rahman Bhuiyan Farid Ahmed Department of Physics Jahangirnagar University Dhaka Bangladesh Department of Electrical and Electronics Engineering Green University of Bangladesh Purbachal American City Kanchan Rupganj Narayanganj-1461 Dhaka Bangladesh

In the present study, the effect of the exchange-correlation functional on the structural, mechanical, and optoelectronic properties of orthorhombic RbSrBr3 perovskite has been investigated using various functionals in Density Functional Theory (DFT) with the CASTEP code. The optimized lattice parameters are quite similar for all the functionals. The electronic properties have shown that RbSrBr3 perovskite is a wide direct band gap compound with a band gap energy ranging from 4.296 eV to 4.494 eV for all the functionals. The mechanical parameters like elastic constants, Young’s modulus, Shear modulus, Poisson’s ratio, Pugh’s ratio, and an anisotropic factor reveal that the RbSrBr3 perovskite has ductile behavior and an anisotropic nature which signifies the mechanical stability of the compound. The Debye temperature might withstand lattice vibration heat. High absorption coefficient (>104 cm−1), high optical conductivity, and very low reflectivity have been found in the RbSrBr3 perovskite for all functions. The computed findings on the RbSrBr3 perovskite suggested that the presented studied material is potentially applicable for photodetector and optoelectronic devices.

关键词： Density Functional Theory Mechanical Properties Photodetector Ductility Anisotropic Factor

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Toxicity evaluation of ZnO and TiO_2 nanomaterials in hydroponic red bean(Vigna angularis) plant:Physiology, biochemistry and kinetic transport

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Journal of Environmental Sciences 2018年第10期30卷 140-152页

作者： Shanaz Jahan Yatimah Binti Alias Ahmad Farid Bin abu bakar Ismail Bin Yusoff Department of Geology Environmental and Earth Sciences Faculty of Science University of Malaya Department of Chemistry Faculty of Science University of Malaya University Malaya Centre for Ionic Liquids (UMCi L) University of Malaya

The toxicity and kinetic uptake potential of zinc oxide（Zn O） and titanium dioxide（TiO2）nanomaterials into the red bean（Vigna angularis） plant were investigated. The results obtained revealed that Zn O, due to its high dissolution and strong binding capacity, readily accumulated in the root tissues and significantly inhibited the physiological activity of the plant. However, TiO2 had a positive effect on plant physiology, resulting in promoted growth. The results of biochemical experiments implied that Zn O, through the generation of oxidative stress, significantly reduced the chlorophyll content, carotenoids and activity of stress-controlling enzymes. On the contrary, no negative biochemical impact was observed in plants treated with TiO2. For the kinetic uptake and transport study, we designed two exposure systems in which Zn O and TiO2 were exposed to red bean seedlings individually or in a mixture approach. The results showed that in single metal oxide treatments, the uptake and transport increased with increasing exposure period from one week to three ***, in the metal oxide co-exposure treatment, due to complexation and competition among the particles, the uptake and transport were remarkably decreased. This suggested that the kinetic transport pattern of the metal oxide mixtures varied compared to those of its individual constituents.

关键词： Metal oxides Physiological impacts Biochemical impacts Uptake kinetics Translocation Growth inhibition

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Fireworks Optimization with Deep Learning-Based Arabic Handwritten Characters RecognitionModel

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Computer Systems Science & Engineering 2024年第5期48卷 1387-1403页

作者： Abdelwahed Motwakel Badriyya B.Al-onazi Jaber S.Alzahrani Ayman Yafoz Mahmoud Othman abu Sarwar Zamani Ishfaq Yaseen Amgad Atta Abdelmageed Department of Computer and Self Development Prince Sattam bin Abdulaziz UniversityAlKharj16278Saudi Arabia Department of Language Preparation Arabic Language Teaching InstitutePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Industrial Engineering College of Engineering at AlqunfudahUmm Al-Qura UniversityMakkah24211Saudi Arabia Department of Information Systems Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Computer Science Faculty of Computers and Information TechnologyFuture University in EgyptNew Cairo11835Egypt

Handwritten character recognition becomes one of the challenging research *** studies were presented for recognizing letters of various *** availability of Arabic handwritten characters databases was *** a quarter of a billion people worldwide write and speak *** historical books and files indicate a vital data set for many Arab nationswritten in ***,Arabic handwritten character recognition(AHCR)has grabbed the attention and has become a difficult topic for pattern recognition and computer vision(CV).Therefore,this study develops fireworks optimizationwith the deep learning-based AHCR(FWODL-AHCR)*** intention of the FWODL-AHCR technique is to recognize the distinct handwritten characters in the Arabic *** initially pre-processes the handwritten images to improve their quality of ***,the RetinaNet-based deep convolutional neural network is applied as a feature extractor to produce feature ***,the deep echo state network(DESN)model is utilized to classify handwritten ***,the FWO algorithm is exploited as a hyperparameter tuning strategy to boost recognition *** simulations in series were performed to exhibit the enhanced performance of the FWODL-AHCR *** comparison study portrayed the supremacy of the FWODL-AHCR technique over other approaches,with 99.91%and 98.94%on Hijja and AHCD datasets,respectively.

关键词： Arabic language handwritten character recognition deep learning classification parameter tuning

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