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Health 2015年第13期7卷 1782-1787页

作者： Ana rafaela Dantas dos Santos Ana Mayara Gomes de Sousa Fernanda Diniz de Sá Adriana Gomes Magalhaes Fábia Barbosa de Andrade Higo Luiz Amorim Belo Maia Faculty of Health Sciences of Trairi(FACISA) Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil

This article is about a report of the experiment of PRO/PET-Saúde students in the anti-HIV tests implementation in the town of Santa Cruz-RN. The goal is to report the importance and discuss the aspects of the moment experienced above inside the basic health unit in the town of Santa Cruz-RN. The experience occurred in the months from February to March 2014 and they were conducted within 8 hours per week. This way, it is observed that the period lived made possible great reflection about the making of the examination in the pre-natal appointment routines, cataloguing challenges which come up during their adequacy within the services. Lastly, the action developed aimed for the aggregation of an active learning process in the search for a critical sense in the experienced practice, allowing and prioritizing the basic health unit as a scope of reference and counter-reference in the public health service, increasing concrete answers and the needs of the population, guaranteeing an adequate service delivery and strengthening the SUS more and more. The insertion of students through the PRO/PET-Saúde-Rede Cegonha enables a reorientation of professional formation, from the integration between service and teaching.

关键词： Pregnant Student Teaching-Service HIV Tests Vertical Transmissions

Just in Time Education: Educational Technology for Professional’s Health

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Open Journal of Nursing 2022年第5期12卷 349-362页

作者： Monica Motta Lino Jean Carlos Müller Da Silva Bizarro† Eloisa Cesa Zuanazzi† Luiza Sheyla Evenni Porfírio Will Castro† Felipa rafaela Amadigi Thaise Torres Sophia Da Fonseca Rangel Interdisciplinary Laboratory of Educational Technologies in Health Department of Nursing Federal University of Santa Catarina Florianópolis Brazil

Objective: Verify if the educational technology based on Just in Time Education is relevant to Permanent Health Education in Workers’ Health. Method: This study is exploratory and descriptive qualitative research. Were performed semi-structured interviews were carried out with the worker’s health team of a large company from the South of Brazil region. The collected data were carried out in 2021, between January and May, through the virtual environment, with eight participants from the Work Health Team of Eletrosul, located in Florianópolis, who agreed to participate in the research by signing the Free and Informed Consent Term, in accordance with the data saturation criterion. The research was approved by the Ethics Committee (n. 4079133) and the data were submitted to Bardin for thematic content analysis. Result: The results are presented from three categories: 1) Expansion and inclusion in Permanent Education needs;2) Tools adopted in educational processes;3) Just in Time Education: educational technology for workers’ health. Conclusion: The active methodology Just in Time Education helps the processes of Permanent Education in Health, which moved from a face-to-face model to e-learning and required the knowledge renewal in the technology area to maintain efficient communication. This methodology allows quick and accurate access to information from a reliable, adequate, and up-to-date source, causing a positive impact on the qualified and problem-solving work process, in line with the needs of the employer and the company. Therefore, Just in Time Education can provide standardization, organization, and informational and operational quality necessary in this context, in addition to serving as an indicator and data generator (management tool).

关键词： Permanent Health Education Educational Technology Worker’s Health Active Methodology Qualitative Research

Pinetonina<sup>TM</sup>, an Intranasally Administered Essential Oil Preparation, Is Effective in Decrease of Cortisol Levels and on the Glutamate Release Modulation

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Neuroscience & Medicine 2018年第3期9卷 135-149页

作者： Maira Jardim Fernando Amaral Valeria Maria de Souza Antunes Fernando Rodrigues Mariana Soares Alves de Souza Fernanda Rossi Siqueto Luiza Melanie Silva rafaela Alves Bertolino Victor Cavalaro Carlos Rocha Oliveira Institute of Osmology and Essential Oils Camanducaia Brazil Group of Fitocomplexes and Cellular Signaling School of Health Science Anhembi Morumbi University S&#227 o Paulo Brazil University of Anhembi Morumbi S&#227 o Paulo Brazil Institute of Osmology and Essential Oils Minas Gerais Brazil and Group of Fitocomplexes and Cellular Signaling School of Health Science Anhembi Morumbi University S&#227 o Paulo Brazil

Background: Most anxiety complaints are treated with pharmacological measures involving barbiturates and benzodiazepines, in which they may end up causing tolerance and pharmacological dependence. Integrative approaches such as aromatherapy are used in addition to medications to improve sleep quality and reduce anxiety. Thus, PinetoninTM, a phytocomplex obtained from a blend of essential oils aims to aid in the symptoms of stress and anxiety. Methods: The cytotoxicity of PinetoninTM was evaluated MTT assay using fibroblasts and astrocytes showed reduction in the cell viability only at high concentrations. Evaluation of intracellular calcium and determination of residual glutamate in the supernatant of astrocyte cultures showed agonist action of dihydroxyphenylglycine (DHPG) increasing linearly the concentration of intracellular calcium and the glutamate levels in the supernatants of the cultures. On the other hand, cultures of astrocytes treated with PinetoninTM showed residual glutamate levels in the supernatants reducing proportionally, as well as, intracellular calcium reduction. The determination of salivary cortisol showed a significant reduction in salivary cortisol levels in the group that received PinetoninTM. The evaluation of the electroencephalogram in patients treated with PinetoninTM had a significant increase (P Results: A reduction in dose-dependent cell viability was observed when compared to cultures of PinetoninTM treated fibroblasts with control culture. When PinetoninTM and linole are administered in astrocytic cells, there was a reduction of the intracellular concentration of Ca2+ against a control group treated with DHPG agonist. The evaluation of salivary cortisol demonstrated a reduction when the patient group was treated with PinetoninTM by purchasing the results against the group of patients treated with saline. Reinforcing the relaxed state of that group, alpha waves have been increased and reductions in beta waves. Conclusion: The results

关键词： Pinetonin Anxiety Cortisol Astrocites Glutamate

废墟中的“博物馆”——圣保罗Casa Rex办公室

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现代装饰 2013年第11期 48-57页

作者： Femando Forte Loureno Gimenes Rodngo Marcondes Ferraz rafaela Netto 谢作标 FGMF Arqutetos

Casa Rex工作室将一栋始建于20世纪40年代，位于圣保罗帕坎布的住宅大楼选择作为新办公楼的新址。这栋大楼在过去的几十年曾历经数次粗劣的改造，本身的建筑特色几乎完全被掩盖。CasaREX是巴西当地一家知名的工作室，此次希望FGMFArquit... 详细信息

Casa Rex工作室将一栋始建于20世纪40年代，位于圣保罗帕坎布的住宅大楼选择作为新办公楼的新址。这栋大楼在过去的几十年曾历经数次粗劣的改造，本身的建筑特色几乎完全被掩盖。CasaREX是巴西当地一家知名的工作室，此次希望FGMFArquitetos能将新办公地点改造成个性化十足的实体空间，以此希望重新找回因工作室的迅速扩张而失去的个性。

关键词： Casa 博物馆办公室废墟工作室建筑特色实体空间个性化

Labor Pain through the Eyes of Brazilian Women and Delivery Nurses

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Open Journal of Nursing 2018年第1期8卷 78-92页

作者： rafaela Feitosa Coutinho Taiane da Silva Alves Alecssandra de Fátima Silva Viduedo Rejane Antonello Griboski Casandra G. R. M. P. de Leon Juliana Machado Schardosim School of Ceilandia University of Brasília Brasília Brazil Maternity Hospital Brasília Brasília Brazil The Undergraduate Program in Nursing School of Ceilandia University of Brasília Brasília Brazil

Objective: Understanding the perception of women who have recently given birth in a Brazilian hospital regarding labor pain and nursing involvement in the labor process. Methodology: exploratory, descriptive and qualitative study carried out in a Maternity part of the supplementary health system in the Federal District (DF). Data were collected between May and July 2015 through interviews using a semi-structured questionnaire. The sample consisted of 16 mothers and data analysis followed Bardin methodology in three phases. Results: The pain experienced during labor is surrounded by feelings and expectations. Both positive and negative feelings experienced by mothers were identified in the interviews and unanimous opinion was the fact that the second stage is the most painful period as continuous pain is experienced. Some of the participants compared pain with strong menstrual cramps, renal colic and back pain;others, said labor pain was the strongest ever experienced. The immediate contact with the newborn was referred to as a reward for coping with breast pain and suffering. Other factors such as the importance of follow-up, support and coping with the pain and care provided by health staff were also highlighted. Conclusion: empowerment of the mother and family through knowledge is considered an important tool to fight pain and cope with the birth process in a positive and physiological way, which in the long run promotes a cultural change in the population regarding the importance of vaginal birth.

关键词： Labor Pain Supplementary Health Birth Humanization Obstetrical Nursing Nursing Care

Essential Oils from Mentha viridis(L).*** Mentha pulegium L.:Cytogenotoxic Effects on Human Cells

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American Journal of Plant Sciences 2017年第6期8卷 1423-1437页

作者： Lucilene Fernandes Silva Maria das Gracas Cardoso Paulo Sérgio Castilho Preté Maria Luisa Teixeira David Lee Nelson Maísa Lamounier Magalhaes Vanuzia Rodrigues Fernandes Ferreira rafaela Vieira Souza Luana Isac Soares Silvana Marcussi Departamento de Química Universidade Federal de LavrasCampus UniversitárioLavrasMinas GeraisBrasil Departamento de Química Universidade Federal dos Vales do Jequitinhonha e MucuriCampus UniversitárioDiamantinaMinas GeraisBrasil Departamento de Ciência dos Alimentos Universidade Federal de LavrasCampus UniversitárioLavrasMinas GeraisBrasil

The essential oils from Mentha viridis (L). L. and Mentha pulegium L. were studied to assess their inhibitory potential on phospholipase from snake venoms and to determine their cytogenotoxic action on human cells. These essential oils were able to inhibit the breakdown of phospholipids induced by venoms of snakes of the Bothrops genus. Both oils presented hemolytic activity, although the Mentha viridis (L). L. oil induced hemolysis only at the highest concentrations (14.6 and 29 μL·mL-1). The essential oil from M. viridis induced 3.9;8.6 and 16.2 times greater damage to human leukocyte DNA than that observed with the positive control (100 μg·μL-1 doxorubicin) at concentrations of 0.25;0.5 and 1.0 μL·mL-1, respectively. A similar effect was observed for the oil from M. pulegium (2.1, 2.5 and 15.8 times greater damage). The results extend the characterization of these essential oils and demonstrate their potential use in industries.

关键词： Essential Oils Mentha viridis(L).L. Mentha pulegium L. Hemolysis Comet Assay

Occurrence of Antimicrobials in River Water Samples from Rural Region of the State of Rio de Janeiro, Brazil

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Journal of Environmental Protection 2016年第2期7卷 230-241页

作者： Mychelle Alves Monteiro Bernardete Ferraz Spisso Julia Rodrigues Martins Pastor dos Santos rafaela Pinto da Costa Rosana Gomes Ferreira Mararlene Ulberg Pereira Talita da Silva Miranda Bárbara Rodrigues Geraldino de Andrade Luiz Antonio d’Avila Chemistry School/Federal University of Rio de Janeiro (EQ/UFRJ) Rio de Janeiro Brazil National Institute for Quality Control in Health/Oswaldo Cruz Foundation (INCQS/FIOCRUZ) Rio de Janeiro Brazil University Centre of Barra Mansa (UBM) Barra Mansa Brazil National of Institute of Cancer (INCA) Rio de Janeiro Brazil

The occurrence of antimicrobials in the aquatic environment and drinking water has raised the question of their impact on the environment and public health. Animal production is one of the most expressive activities of Brazilian agribusiness. In order to ensure the productivity and competitiveness of the sector, the use of drugs for therapeutic and prophylactic purposes is a common practice. Due to the continuous release of antimicrobials into the environment, the aim of this study was to compare the frequency of detection of tetracyclines and sulfonamides in surface water collected from rural areas in Lidice District of Rio Claro, in the State of Rio de Janeiro, Brazil. An investigative study was conducted with 24 river water samples analyzed by high-performance liquid chromatography coupled to tandem mass spectrometry and the aim of this study was to determine residues of sulfonamides and tetracyclines based on the USEPA method 1694. The results indicated the presence of sulfamethoxazole and oxytetracycline concentrations at the ng·L-1 level. The applied method showed overall good performance with recoveries above 57%, method detection limits ≤ 7.17 ng·L-1, method quantification limits ≤ 23.90 ng·L-1 and good linearity.

关键词： Antimicrobial LC-MS/MS Surface Water Sulfonamides Tetracyclines

Oncolytic virus therapy in cancer: A current review

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World Journal of Virology 2021年第5期10卷 229-255页

作者： Jonathan Santos Apolonio Vinicius Lima de Souza Goncalves Maria Luisa Cordeiro Santos Marcel Silva Luz Joao Victor Silva Souza Samuel Luca Rocha Pinheiro Wedja rafaela de Souza Matheus Sande Loureiro Fabricio Freire de Melo Universidade Federal da Bahia Instituto Multidisciplinar em SaudeVitoria da Conquista 45029-094BahiaBrazil Universidade Estadual do Sudoeste da Bahia Campus Vitoria da ConquistaVitoria da Conquista 45083-900BahiaBrazil

In view of the advancement in the understanding about the most diverse types of cancer and consequently a relentless search for a cure and increased survival rates of cancer patients,finding a therapy that is able to combat the mechanism of aggression of this disease is extremely ***,oncolytic viruses(OVs)have demonstrated great benefits in the treatment of cancer because it mediates antitumor effects in several *** can be used to infect cancer cells,especially over normal cells,to present tumor-associated antigens,to activate“danger signals”that generate a less immune-tolerant tumor microenvironment,and to serve transduction vehicles for expression of inflammatory and immunomodulatory *** success of therapies using OVs was initially demonstrated by the use of the genetically modified herpes virus,talimogene laherparepvec,for the treatment of *** this time,several OVs are being studied as a potential treatment for cancer in clinical ***,it is necessary to be aware of the safety and possible adverse effects of this therapy;after all,an effective treatment for cancer should promote regression,attack the tumor,and in the meantime induce minimal systemic *** this manuscript,we will present a current review of the mechanism of action of OVs,main clinical uses,updates,and future perspectives on this treatment.

关键词： Oncolytic viruses Antitumor response Tumor lysis Tumor cells Mechanism Therapy

Sensitivity of a Rapid Mix Test with Combined Synthetic Antigens Derived from Mycobacterium Leprae PGL-1 for Diagnosis and Surveillance of Leprosy

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Open Journal of Immunology 2020年第1期10卷 1-9页

作者： Maria do Perpétuo Socorro Amador Silvestre Maxwell Furtado de Lima Antonio G.P.Pereira Aline Rodrigues Bernardo rafaela Lopes Diniz Pedro Paulo Ferreira Ribeiro Edimílson Domingos da Silva Luana Nepomuceno Gondim Costa Lima Instituto Evandro Chagas Rodovia BR-316km 07AnanindeuaParáBrasil Programa de Desenvolvimento Tecnologico de reativos para diagnostico GPRED-Bio Manguinhos-FioCruzRio de JaneiroBrasil

Introduction: In the Americas, Brazil contributes 91.63% of the total cases and the state of Pará still has high endemia for leprosy. Objective: To analyze the performance of a rapid test for the diagnosis and epidemiological surveillance of leprosy in endemic areas. Methods: The sample consisted of 70 MB multibacillary leprosy (MB) patients, 63 paucibacillary (PB) patients, and 80 intradomiciliary consanguineous contacts (ICSCO) of patients. A rapid test with a 15-minute reading was applied using two prototypes: prototype 1, double test with trisaccharide antigen (NT-P-BSA) at 1a. line (83.2 ng/test) and disaccharide antigen (ND-O-BSA) at 2a. (83.2 ng/test), both with a flow of 0.08 μL/mm with a 10 μC membrane, anti-IgM conjugate with a flow of 0.040 μL/mm and a Tris-Triton and prototype 2 runner buffer with MIX antigen (trisaccharide + disaccharide) in the same concentrations and conditions of prototype 1. Results: The comparison of the MIX test positivity rate and the disaccharide or trisaccharide doublet test across all samples was statistically significant, demonstrating that the MIX test had higher seropositivity rates compared to the ND-O-BSA or NT-P-BSA. It was demonstrated that the MIX test showed a good performance, with 25.39% of the PB patients negative for the disaccharide and trisaccharide duplet test, but positive for MIX. Conclusions: These data suggest the potential for further optimizing the performance by adding other synthetic antigens to the MIX antigens.

关键词： Leprosy Diagnosis Rapid Test

Phytochemical bioprospecting, antioxidant, antimicrobial and cytotoxicity activities of saline extract from Tithonia diversifolia(Hemsl) *** leaves

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Asian Pacific Journal of Tropical Biomedicine 2018年第5期8卷 245-253页

作者： Bruno Rafael Barboza Bárbara rafaela da Silva Barros Bárbara de Azevedo Ramos Maiara Celine de Moura Thiago Henrique Napoleao Maria Tereza dos Santos Correia Luana Cassandra Breitenbach Barroso Coelho Iranildo José da Cruz Filho Ana Maria Souto Maior Túlio Diego da Silva Leylianne de Cássia Rodrigues Nerys Edson Renan Barros de Santana Cláudia Sampaio de Andrade Lima Virgínia Maria Barros de Lorena Cristiane Moutinho Lagos de Melo Department of Antibiotics Biosciences Centre Federal University of Pernambuco Department of Biochemistry Biosciences Centre Federal University of Pernambuco Center for Strategic Techmologies of the Northeast Department of Biophysics Biosciences Centre Federal University of Pernambuco Aggeu Magalhaes Institute IAM/FIOCRUZ

Objective:To evaluate antimicrobial and antioxidant properties of saline extract from Tithonia diversifolia leaves by phytochemical bioprospecting,and investigate its safety against animal ***:The saline extract was prepared,with NaCl(0.15 M),by constant stirring of the dried and pulverized leaves,followed by volume reduction by *** extract was phytochemical characterized using ultra-performance liquid chromatography,and total phenol and flavonoid analysis also was *** antioxidant capacity was determined through DPPH*radical,the antimicrobial property was evaluated against standard bacteria and fungi,and the viability assays were performed against mice ***:Fifteen compounds were identified belonging to two main classes terpenoids and *** extract showed 22.185 mg GAE/g of total phenolic compounds and 3.220 mg QE/g of ***,extract showed higher antioxidant ability similar to butylated hydroxytoluene a standard molecule[(3.042±0.019)mg AAE/g and(4.12±0.10)mg AAE/g to saline extract and butylated hydroxytoluene,respectively].The antimicrobial assays demonstrated that the extract had a significant antifungal potential against Candida species and could be used with safety against mice splenocytes,in concentrations lower than 50μg/mL,promoting higher proliferation in these ***:Saline extract from Tithonia diversifolia leaves presents potential antioxidant,antifungal properties and induces immunostimulation in mice splenocytes.

关键词： Tithonia diversifolia Extract Antioxidant Antifungal properties Immunostimulation