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In silico prospective analysis of the medicinal plants activity on the CagA oncoprotein from Helicobacter pylori

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World Journal of Clinical Oncology 2024年第5期15卷 653-663页

作者： rafaela Viana Vieira Gabrielle Caroline Peiter Fabrício Freire de Melo Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Universidade Federal do Paraná Campus ToledoToledo 85919-899Brazil Universidade Tecnológica Federal do Paraná Campus ToledoParaná85902-490Brazil Universidade Federal da Bahia Instituto Multidisciplinar em Saúde-Campus Anísio TeixeiraVitória da Conquista 45029-094Brazil Universidade Federal do Paraná-Setor Palotina Programa de Pós-graduação em BiotecnologiaPalotina 85950-000Brazil

BACKGROUND Colonization with Helicobacter pylori(***)has a strong correlation with gastric cancer,and the virulence factor CagA is implicated in *** have been conducted using medicinal plants with the aim of eliminating the pathogen;however,the possibility of blocking ***-induced cell differentiation to prevent the onset and/or progression of tumors has not been *** type of study is expensive and time-consuming,requiring in vitro and/or in vivo tests,which can be solved using ***,prospective computational analyses were conducted to assess the feasibility of interaction between phenolic compounds from medicinal plants and the CagA *** To perform a computational prospecting of the interactions between phenolic compounds from medicinal plants and the CagA oncoprotein of *** In this in silico study,the structures of the phenolic compounds(ligands)kaempferol,myricetin,quercetin,ponciretin(flavonoids),and chlorogenic acid(phenolic acid)were selected from the PubChem *** phenolic compounds were chosen based on previous studies that suggested medicinal plants as non-drug treatments to eliminate *** *** three-dimensional structure model of the CagA oncoprotein of ***(receptor)was obtained through molecular modeling using computational tools from the I-Tasser platform,employing the threading *** primary sequence of CagA was sourced from GenBank(BAK52797.1).A screening was conducted to identify binding sites in the structure of the CagA oncoprotein that could potentially interact with the ligands,utilizing the GRaSP online *** the ligands and receptor were prepared for molecular docking using AutoDock Tools 4(ADT)software,and the simulations were carried out using a combination of ADT and AutoDock Vina v.1.2.0 *** sets of simulations were performed:One involving the central region of CagA with phenolic compounds,and another involvi

关键词： CagA oncoprotein Phenolic compounds Helicobacter pylori In silico analyses Medicinal plants Prospective analysis

Transarterial embolization is an acceptable bridging therapy to hepatocellular carcinoma prior to liver transplantation

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World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-Silva Leandro A Scaffaro Mauricio Farenzena Lucas Prediger rafaela K Silva Flávia Heinz Feier Tomaz J M Grezzana-Filho Pablo D Rodrigues Alexandre de Araujo Mario Reis Alvares-da-Silva Roberta C Marchiori Cleber Rosito Pinto Kruel Marcio Fernandes Chedid Department of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive malignant neoplasm that requires liver transplantation(LT).Despite patients with HCC being prioritized by most organ allocation systems worldwide,they still have to wait for long *** therapies(LRTs)are employed as bridging therapies in patients with HCC awaiting *** largely used in the past,transarterial embolization(TAE)has been replaced by transarterial chemoembolization(TACE).However,the superiority of TACE over TAE has not been consistently shown in the *** To compare the outcomes of TACE and TAE in patients with HCC awaiting *** All consecutive patients with HCC awaiting LT between 2011 and 2020 at a single center were *** patients underwent LRT with either TACE or *** patients also underwent percutaneous ethanol injection(PEI),concom-itantly or in different treatment *** choice of LRT for each HCC nodule was determined by a multidisciplinary *** primary outcome was waitlist dropout due to tumor progression,and the secondary outcome was the occurrence of adverse *** the subset of patients who underwent LT,complete pathological response and post-transplant recurrence-free survival were also *** Twelve(18.5%)patients in the TACE group(only TACE and TACE+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tumor progression(P log-rank test=0.29).Adverse events occurred in 8(12.3%)and 2(5.3%)patients in the TACE and TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TACE group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Among these patients,complete pathological response was detected in 7(14.6%)and 9(31%)patients in the TACE and TAE groups,respectively(P=0.145).Post-LT,HCC recurred in 9(18.8%)and 4(13.8%)patients in the TACE and TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was simila

关键词： Hepatocellular carcinoma Transarterial embolization Transarterial chemoembolization Liver transplantation Locoregional therapy Bridging

Ontogenetic niche specialization of the spider crab Libinia ferreirae associated with the medusa Lychnorhiza lucerna

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Current Zoology 2022年第5期68卷 549-559页

作者： Geslaine rafaela Lemos Gonçalves Milena Regina Wolf Mariana Antunes Felipe Wanderley Amorim Maria Lucia Negreiros-Fransozo Antonio Leão Castilho Group of Studies on Crustacean Biology Ecology and Culture-NEBECCBiosciences InstituteSão Paulo State UniversityBotucatuSP 18618-689Brazil and Laboratory of Pollination Ecology and Interactions-LEPI Biosciences InstituteSão Paulo State UniversityBotucatuSP 18618-689Brazil

Symbiotic relationships in marine environments are not fixed and can change throughout the animal’s *** study investigated the ontogeny of symbiosis of the spider crab Libinia ferreirae with the host medusa Lychnorhiza *** described the type of relationship,the temporal correlation among species,and food *** than 50%of the sampled crabs were symbionts,most in early life *** highest number of crabs found in a single medusa was *** was observed throughout most of the year but was more evident in warm *** crab has many benefits in this relationship with a *** is the use of food resources captured by the medusa,primarily *** the crab steals the medusa’s food,it is a kleptoparasitic *** is a niche partition between symbiont and the free-living crabs as they occupy different habitats and use nonoverlapping food *** research reported that symbiosis first developed during the crab’s last larval phase(megalopa)when crab and medusa are in the same *** of the crab’s behavior shows that symbiosis occurs when the crab can grab to the medusa when the host touches the sea *** crab also took advantage of water currents,releasing itself from the substrate and then drifting toward the *** symbiotic relationship that crabs have with the medusa provides then with a nursery,food resources,shelter,dispersion,and decreased competition with free-living adult crabs,all essential for the crab’s survival.

关键词： behavior development kleptoparasitism megalopa niche segregation

Near-infrared leaf reflectance modeling of Annona emarginata seedlings for early detection of variations in nitrogen concentration

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Journal of Forestry Research 2023年第1期34卷 269-282页

作者： rafaela Lancas Gomes Marília Caixeta Sousa Felipe Girotto Campos Carmen Sílvia Fernandes Boaro José Raimundo de Souza Passos Gisela Ferreira Bioestatistic Plant BiologyParasitology and Zoology DepartmentBioscience Institute(IBB)Universidade Estadual Paulista(UNESP)BotucatuSao PauloBrazil

Nitrogen(N)monitoring is essential in nurseries to ensure the production of high-quality *** spectroscopy(NIRS)is an instantaneous,nondestructive method to monitor *** data such as NIRS can also provide the basis for developing a new vegetation spectral index(VSI).Here,we evaluated whether NIRS combined with statistical modeling can accurately detect early variations in N concentration in leaves of young plants of Annona emargiaata and developed a new VSI for this *** were grown in a hydroponics system with 0,2.75,5.5or 11 mM N for 45 *** we measured gas exchange,chlorophylla fluorescence,and pigments in leaves;analyzed complete leaf nutrients,and recorded spectral data for leaves at 966 to 1685 nm using *** a statistical learning approach,the dimensionality of the spectral data was reduced,then models were generated using two classes(N deficiency,N)or four classes(0,2.75,5.5,11 mM N).The best combination of techniques for dimensionality reduction and classification,respectively,was stepwise regression(PROC STEPDISC)and linear discriminant *** was possible to detect N deficiency in seedlings leaves with 100%precision,and the four N concentrations with93.55%accuracy before photosynthetic damage to the plant ***,NIRS combined with statistical modeling of multidimensional data is effective for detecting N variations in seedlings leaves of ***.

关键词： Mineral nutrition of plants Near-infrared spectroscopy Spectral vegetation index Digital signature Statistical learning Fluorescence of chlorophylla

Valorization of the agro-industrial by-products of bacupari(Garcinia brasiliensis(Mart.))through production of flour with bioactive properties

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Food Bioscience 2022年第1期45卷 377-385页

作者： Anely Maciel de Melo rafaela Cristina Turola Barbi Bruno Patrício Costa Mˆonica Ikeda Danielle Carpine Rosemary Hoffmann Ribani Food Engineering Graduate Program Federal University of ParanaDepartment of Chemical Engineering81531-990CuritibaPRBrazil

Brazil has a wide variety of fruits that remain insufficiently *** encourage the use of one such fruit,the bacupari((Garcinia brasiliensis(Mart.)),the current study produced flours from its by-products(the peel and seed)at two maturation stages and subsequently evaluated their proximate composition,physical,antioxidant,bioactive,microstructural and thermal *** results revealed that the flours have a high in fiber content(>15%)and are a potential source of protein(>5%).Seed flour has an energy value similar to that of wheat flour and other conventional *** flour micrographs indicate the presence of starch,a fact confirmed by viscosity *** flours contain phenolic compounds and exhibit antioxidant activity,especially the unripe peel *** the compounds identified by chromatography,those present in the greatest concentrations were quinine(≅111μg/g),p-coumaric acid(≅25μg/g),m-coumaric acid(≅15μg/g),and formononetin(≅21μg/g),all of which are known to have several human health *** flour crystallinity diminished as the fruit *** flour exhibited similar thermal transitions but less thermal stability than seed *** summary,this study revealed that flours produced from the peel and seeds of bacupari,which are generated in large quantities as agro-industrial by-products,can be used as alternative ingredients in various sectors of the food industry.

关键词： Antioxidant activity Bacupari fruit Seed Peel Phenolic compounds

Phenolic profile and biological potential of Endopleura uchi extracts

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Asian Pacific Journal of Tropical Medicine 2015年第11期8卷 870-878页

作者： Luis R.Silva rafaela Teixeira CICS-UBI-Centro de Investigacao em Ciencias da Saude.Universidale da Beira Interior Av.Infante D.Henrique.6201-506.Corilha.Portugal Instituto Politecnico de Castelo Branco Escola Superior de Saude Dr Lopes DiasArenido do EmpresarioCampus da Talagueira6000-767Castelo BrancaPortugal LEPABE Departamento de Engenharia QuimicaFaculdade de Engenharia.Universidade do PortoRua Dr.Roberto Friass/n4200-465 PortoPortugal REQUIMTE/Laboratorio de Farmacognosia Departamento de QuimicaFaculdade de FarmaciaUniversidade do Porto.Rua de Jorge Viterbo Ferreira228.4050-313 PortoPortugal

Objective:To improve the knowledge on the metabolite composition of Endopleura uchi bark,concerning phenolic compounds,and to evaluate some of its biological capacities for further possible exploitation in food and pharmaceutical industries associated to their healthpromoting ***:Two different extracts(infusion and hydroethanolic) were studied concerning phenolic composition and biological ***:Five compounds were determined by HPLC-DAD,being bergenin the major *** general way,infusion presents a greater richness in these *** antioxidant,***,α-glucosidase and antibacterial activity were checked by in vitro assays.A dose-dependent response was noticed against DPPH,superoxide and nitric oxide radicals,acetylcholinesterase,butyrylcholinesterase and against α-glucosidase inhibitory *** capacity of both extracts was investigated against Gram-positive and Gramnegative bacteria,being more effective against the first *** concentrations of infusion extract tested here revealed that is non-toxic for intestinal(Caco-2) cells ***:The results suggest that the extracts of Endopleura uchi may be interesting for incorporating in pharmaceutical preparations for human health,since it can suppress hyperglycaemia and inhibit cholinesteases,and or as food additive due to its antiradical and antibacterial activities.

关键词： Endopleura uchi Bark Phenolic compounds Anti-diabe

Distinguishing the Regional Atmospheric Controls on Precipitation Isotopic Variability in the Central-Southeast Portion of Brazil

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Advances in Atmospheric Sciences 2022年第10期39卷 1693-1708,I0018-I0020页

作者： Vinícius dos SANTOS Peter MARSHALL FLEMING Luís HENRIQUE MANCINI Stela DALVA SANTOS COTA Graziele Beatriz de LIMA rafaela RODRIGUES GOMES Roberto Eduardo KIRCHHEIM Ricardo SANCHÉZ-MURILLO Didier GASTMANS São Paulo State University(UNESP) Environmental Studies Center.Av.24ABased1515-Bela Vista13.506-900Rio Claro(SP)Brazil Center for the Development of the Nuclear Technology(CDTN-CNEN) Av.Presidente Antônio Carlos6.627Campus da UFMG-Pampulha31270-90Belo Horizonte(MG)Brazil Universidade de Brasília-UnB Instituto de GeociênciasLaboratório de Isótopos Estáveis.Campus"Darcy Ribeiro"Asa Norte70.910-900Brasília(DF)Brasil Hydrology and Territorial Management Directory(DHT) The Geological Survey of Brazil(CPRM-SGB)São Paulo(SP)Brazil University of Texas at Arlington Earth and Environmental Sciences Department500 Yates StreetArlingtonTexas76019USA Stable Isotopes Research Group and Water Resources Management Laboratory Universidad NacionalHerediaCosta Rica

Precipitation isotope ratios(O and H)record the history of water phase transitions and fractionation processes during moisture transport and rainfall ***,we evaluated the isotopic composition of precipitation over the central-southeastern region of Brazil at different *** isotopic compositions were associated with classical effects(rainfall amount,seasonality,and continentality),demonstrating the importance of vapor recirculation processes and different regional atmospheric systems(South American Convergence Zone-SACZ and Cold Fronts-CF).While moisture recycling and regional atmospheric processes may also be observed on a daily timescale,classical effects such as the amount effect were not strongly correlated(δ^(18)O-precipitation rate r≤-0.37).Daily variability revealed specific climatic features,such asδ^(18)O depleted values(~-6‰to-8‰)during the wet season were associated with strong convective activity and large moisture *** isotopic analysis revealed the role of different moisture sources and transport *** ratios combined with d-excess explain how atmospheric recirculation processes interact with convective activity during rainfall formation *** findings provide a new understanding of rainfall sampling timescales and highlight the importance of water isotopes to decipher key hydrometeorological processes in a complex spatial and temporal context in central-southeastern Brazil.

关键词： precipitation stable water isotopes d-excess moisture source and transport southern Atlantic Ocean and Amazon

Behavior of materials for earth and rockfill dams:Perspective from unsaturated soil mechanics

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Frontiers of Structural and Civil Engineering 2010年第1期4卷 1-39页

作者： Eduardo E.ALONSO rafaela CARDOSO Universidad Politécnica de Cataluña BarcelonaSpain Instituto Superior Técnico LisbonPortugal

The basis of the design of earth and rockfill dams is focused on ensuring the stability of the structure under a set of conditions expected to occur during its *** mechanical and hydraulic conditions must be considered since pore pressures develop during construction,after impoundment and in *** instability phenomena caused by transient flow and internal erosion must be *** prediction of the hydromechanical behavior of traditional and non-traditional materials used in the construction of dams is therefore *** materials used for dam’s construction cover a wide range from clayey materials to *** a broad sense they are compacted materials and therefore unsaturated materials.A summary of the current level of knowledge on the behavior of traditional materials used in the construction of dams is presented in the *** compacted materials(with a significant clay fraction),rockfill and compacted soft rocks are studied with more *** latter are non-traditional *** are analysed because their use,as well as the use of mixtures of soil and rock,is becoming more necessary for sustainability reasons.

关键词： dams unsaturated soil mechanics suction rockfill clayey soil mixture

Mercury in aquatic fauna contamination:A systematic review on its dynamics and potential health risks

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Journal of Environmental Sciences 2019年第10期31卷 205-218页

作者： Paloma de Almeida Rodrigues rafaela Gomes Ferrari Luciano Neves dos Santos Carlos Adam Conte Junior Molecular and Analytical Laboratory Center Department of Food TechnologyFaculty of VeterinaryUniversidade Federal FluminenseNiteróiBrazil Chemistry Institute Food Science ProgramUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil National Institute of Health Quality Control Fundacaeo Oswaldo CruzRio de JaneiroBrazil Laboratory of Theoretical and Applied Ichthyology Department of Ecology and Marine ResourcesUniversidade Federal do Estado do Rio de JaneiroRio de JaneiroBrazil

Mercury is an important pollutant,released into aquatic ecosystems both naturally and by anthropogenic *** element is transferred to aquatic organisms in different ways,causing potential health *** addition,mercury can be accumulated by humans,especially through the consumption of contaminated *** systematic review aims to present mercury pathways,the major routes through which this element reaches the aquatic environment and its transformations until becoming available to living animals,leading to bioaccumulation and biomagnification *** key biotic and abiotic factors affecting such processes,the impact of mercury on animal and human health and the issue of seafood consumption as a source of chronic mercury contamination are also addressed.A total of 101 articles were retrieved from a standardized search on three databases(PubMed,Emabse,and Web of Science),in addition to 28 other studies not found on these databases but considered fundamental to this review(totaling 129 articles).Both biotic and abiotic factors display fundamental importance in mediating mercurial dynamics,i.e.,muscle tropism,and salinity,***,mercurial contamination in aquatic environments affects animal health,especially the risk of extinction species and also on human health,with methylmercury the main mercury species responsible for acute and chronic symptomatology.

关键词： Mercury levels Seafood Methylmercury Public health Aquatic environment