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The Administration of Ocoxin Increases the Quality of life of Patients with Advanced Epithelial or Metastatic Ovarian Cancer Undergoing Neoadjuvant Chemotherapy

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Journal of Cancer Therapy 2022年第9期13卷 561-584页

作者： Karen lópez Miguel Daniel Ricardo Martínez Ávila lliset Álvarez Pérez Gisselle Martínez Rabasa Alejandro linchenat lambert Roberto Esperón Noa lisandra Heredia Manzano Margarita De Quesada Amigó rafael I. Reyes Velázquez Danay Corrales Otero Ramon Ropero Toirac Idelmis Curbelo Heredia Mircea Betancourt Cabeza Tania A. Agrelo Ramos Rosa María Muñoz Reyes Juan Jesús lence Anta Rosalía Fuentes Sosa Karelia Silvera Candó Kirenia Silva Rodríguez Zaida lastre Sosa Mayte Robaina García Eduardo Sanz David Marquez Department of Medical Oncology INOR La Habana Cuba Department of Gynaeco-Oncology INOR La Habana Cuba Department of Anatomical Pathology INOR La Habana Cuba Department of Imaging INOR La Habana Cuba Clinical Research Section INOR La Habana Cuba Department of Onco-Psychology INOR La Habana Cuba Clinical laboratory Department INOR La Habana Cuba Clinical Trials Pharmacy Department INOR La Habana Cuba Department of Biostatistics CENCEC La Habana Cuba Scientific Department CATALYSIS Madrid Spain

Background: 70% of ovarian cancer cases are diagnosed at an advanced stage (III or IV) of the disease and, in turn, with a high prevalence of peritoneal carcinosis and ascites, which leads to progressive malnutrition in patients, with the consequent deterioration of their general condition. There is a very important relationship between nutritional status, quality of life, survival, and the ability to tolerate multidisciplinary treatment of peritoneal carcinosis. Methods: A phase II, open-label, single-center, non-randomised clinical trial was conducted that included 36 patients with advanced disease who were administered the nutritional supplement Ocoxin, 30 ml twice a day, beginning one week before chemotherapy (CT) based on carboplatin/paclitaxel, of which they receive three cycles with neoadjuvant intent. Ocoxin treatment was continued during chemotherapy and for three weeks after completion of the last cycle, as well as during any periods for which this treatment was discontinued due to toxicity. The effect of Ocoxin on the quality of life was assessed through the QlQ C30 and QlQ OV28 questionnaires from the start of treatment until the end of the follow-up period. In addition, the Karnofsky Index and nutritional parameters were assessed. Results: There were no significant differences between adverse events versus baseline values, except in leukocytes, lymphocytes, neutrophils, AlT, and AST. There was no deterioration of the Qol scales, except for those related to the effects of chemotherapy and alopecia. Conclusions: Ocoxin as an adjuvant to chemotherapy appears to improve better tolerance to chemotherapy, showed a good safety profile, and improved quality of life. For further information on Ocoxin neoadjuvant therapy benefits, a phase III clinical trial will be needed.

关键词： Chemotherapy Radiotherapy Ovarian Cancer Oncology Quality of life Ad-juvant Therapy Supportive Care

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Hypoglycemic Therapy in Chronic Hepatic Disease literature Review

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Open Journal of Endocrine and Metabolic Diseases 2020年第10期10卷 137-146页

作者： Pedro luis Imbeth-Acosta Nehomar Pájaro-Galvis Víctor leal-Martinez Jorge Rico-Fontalvo Rodrigo Daza-Arnedo Orlando Castañeda-lópez María Cardona-Blanco Karen Mercado-Anillo José lucas-Daza Christian Perez-Calvo Jhonatan Hernández-Meza Álvaro Barraza-Pombo Marianela Florez-Ortega Jorge Hoyos-Fortich Isabella Uparella-Gulfo Blas de lezo Clinic Cartagena Bolívar Colombia Faculty of Health Sciences University of Sinú Cartagena Bolívar Colombia New Bocagrande Hospital Cartagena Bolívar Colombia Colombian Association of Nephrology Medellín Colombia Colombian Association of Nephrology Cartagena Colombia Endocrinos SAS Cartagena Colombia Renal Unit B. Braun Medellín Antioquia Colombia University of Cartagena Cartagena Bolívar Colombia Colombian Association of Nephrology Ibagué Colombia Caribbean University Hospital Cartagena Colombia University of Sinu Cartagena Colombia Epidemiologist Blas de Lezo Clinic Cartagena Colombia Naval Hospital Cartagena Colombia rafael Nuñ ez University Cartagena Colombia

Chronic liver disease (ClD) refers to a structural and functional change of the liver, which modifies the pharmacokinetics of multiple drugs, including hypoglycemic agents. This alteration depends on the severity deg... 详细信息

le="text-align:justify;"> Chronic liver disease (CLD) refers to a structural and functional change of the liver, which modifies the pharmacokinetics of multiple drugs, including hypoglycemic agents. This alteration depends on the severity degree of the liver disease, clinical characteristics of the patient, and comorbidities presence such as kidney disease and drug biochemistry. Insulin is considered a safe therapeutic strategy in patients with CLD, however, for many oral hypoglycemic agents, its use and dose adjustment will depend on the Child-Pugh score, based on the risk of hypoglycemia in this type of patient.

关键词： Cirrhosis Hypoglycemic Agents Pharmacokinetics (MeSH)

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