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The Administration of Ocoxin Increases the Quality of Life of patients with Advanced Epithelial or Metastatic Ovarian Cancer Undergoing Neoadjuvant Chemotherapy

World Journal of Cardiovascular Diseases（心血管病） 2012年第4期

作者： José Luis Aceves Abel Archundia Araceli páez rafael Vilchis Elvira Varela Emma Rodriguez Guillermo Diaz Lourdes Flores-Luna Martha Alvarado Manuel Lopez H. Luis Felipe Monta？o Felipe Masso

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Journal of Cancer Therapy 2022年第9期13卷 561-584页

作者： Karen López Miguel Daniel Ricardo Martínez Ávila Lliset Álvarez pérez Gisselle Martínez Rabasa Alejandro Linchenat Lambert Roberto Esperón Noa Lisandra Heredia Manzano Margarita De Quesada Amigó rafael I. Reyes Velázquez Danay Corrales Otero Ramon Ropero Toirac Idelmis Curbelo Heredia Mircea Betancourt Cabeza Tania A. Agrelo Ramos Rosa María Muñoz Reyes Juan Jesús Lence Anta Rosalía Fuentes Sosa Karelia Silvera Candó Kirenia Silva Rodríguez Zaida Lastre Sosa Mayte Robaina García Eduardo Sanz David Marquez Department of Medical Oncology INOR La Habana Cuba Department of Gynaeco-Oncology INOR La Habana Cuba Department of Anatomical pathology INOR La Habana Cuba Department of Imaging INOR La Habana Cuba Clinical Research Section INOR La Habana Cuba Department of Onco-psychology INOR La Habana Cuba Clinical Laboratory Department INOR La Habana Cuba Clinical Trials pharmacy Department INOR La Habana Cuba Department of Biostatistics CENCEC La Habana Cuba Scientific Department CATALYSIS Madrid Spain

Background: 70% of ovarian cancer cases are diagnosed at an advanced stage (III or IV) of the disease and, in turn, with a high prevalence of peritoneal carcinosis and ascites, which leads to progressive malnutrition in patients, with the consequent deterioration of their general condition. There is a very important relationship between nutritional status, quality of life, survival, and the ability to tolerate multidisciplinary treatment of peritoneal carcinosis. Methods: A phase II, open-label, single-center, non-randomised clinical trial was conducted that included 36 patients with advanced disease who were administered the nutritional supplement Ocoxin, 30 ml twice a day, beginning one week before chemotherapy (CT) based on carboplatin/paclitaxel, of which they receive three cycles with neoadjuvant intent. Ocoxin treatment was continued during chemotherapy and for three weeks after completion of the last cycle, as well as during any periods for which this treatment was discontinued due to toxicity. The effect of Ocoxin on the quality of life was assessed through the QLQ C30 and QLQ OV28 questionnaires from the start of treatment until the end of the follow-up period. In addition, the Karnofsky Index and nutritional parameters were assessed. Results: There were no significant differences between adverse events versus baseline values, except in leukocytes, lymphocytes, neutrophils, ALT, and AST. There was no deterioration of the QoL scales, except for those related to the effects of chemotherapy and alopecia. Conclusions: Ocoxin as an adjuvant to chemotherapy appears to improve better tolerance to chemotherapy, showed a good safety profile, and improved quality of life. For further information on Ocoxin neoadjuvant therapy benefits, a phase III clinical trial will be needed.

关键词： Chemotherapy Radiotherapy Ovarian Cancer Oncology Quality of Life Ad-juvant Therapy Supportive Care

Evaluation of Differential Item Functioning of the Center of Epidemiological Scale Depression Revisited for Gender in Mexican Adolescents

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psychology Research 2013年第4期3卷 232-241页

作者： Jesus rafael Osomo Mungula Herminia Beatriz Segura Celis Ochoa Alma Gloria Vallejo Casarin patricia Andrade palos Universidad Veracruzana Veracruz Mexico Universidad Nacional Autenoma de Mexico Mexico Mexico

The literature on depression reports great differences between women and men, presenting women higher rates of depression, few researchers have questioned if the instruments used to evaluate depression can affect these gender differences. This study aimed at the determination of the DIF (differential item functioning) of the CES-D-R (Center of Epidemiological Scale Depression Revisited), taking into account the gender variable. A sample of 1,636 adolescents whose mean was 13.3 years, standard deviation 1.0 participated in this research. The analysis was calculated using DIF MH (Mantel-Haenszel) method and detected 13 items with DIF of the total of 35 items with significant presence of DIF. Six items were identified with DIF in high execution, five of those favor women. These results suggest a revision of the CES-D-R in terms of gender.

关键词：性别差异流行病学抑郁症青少年墨西哥评价研究人员项目运作

Complex Regulation of prolyl-4-Hydroxylases Impacts Root Hair Expansion

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Molecular plant 2015年第5期8卷 734-746页

作者： Silvia M. Velasauez Martiniano M. Ricardi Christian peter poulsen Ai Oikawa Adiphol Dilokpimol Adnan Halim Silvina Mangano Silvina paola Denita Juarez Eliana Marzol Juan D. Salgado Salter Javier Gloazzo Dorosz Cecilia Borassi Svenning Rune Moller rafael Buono Yukiko Ohsawa Ken Matsuoka Marisa S. Otegui Henrik V. Scheller Naomi Geshi Bent Larsen petersen Norberto D. lusem Jose M. Estevez Instituto de Fisiologfa Biologia Molecular y Neurociencias (IFIBYNE-CONICET) Facultad de Ciencias Exactas y Naturales Universidad de Buenos AiresBuenos Aires C1428EGA Argentina VKR Research Centre Department of Plant and Environmental Sciences University of Copenhagen DK-1871 Frededksberg C Denmark Joint BioEnergy Institute Feedstocks Division Lawrence Berkeley National Laboratory 5885 Hollis Street Emeryville CA 94608 USA Copenhagen Center for Glycomios Department of Cellular and Molecular Faculty of Health and Medical Sciences University of CopenhagenDK-2200 Copenhagen N Denmark Department of Botany University of Wisconsin Madison WI 53706 USA RIKEN plant Science Center Tsurumi-ku Yokohama 230-0045 Japan Laboratory of plant Nutrition Faculty of Agriculture Kyushu University Hakozaki 6-10-1 Higashi-ku Fukuoka 812-8581 Japan Departamento de Fisiologia Biologia Molecular y Celular Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Buenos Aires C1428EGAArgentina These authors contributed equally to the article. present address: Fungal physiology CBS-KNAW Fungal Biodiversity Center Uppsalalaan 8 Utrecht 3584 CT The Netherlands present address: The Danish Stem Cell Center The Panum Institute Blegdamsvej 3B DK-2200 Copenhagen Denmark

Root hairs are single cells that develop by tip growth, a process shared with pollen tubes, axons, and fungal hyphae. However, structural plant cell walls impose constraints to accomplish tip growth. In addition to polysaccharides, plant cell walls are composed of hydroxyproline-rich glycoproteins （HRGps）, which include several groups of O-glycoproteins, including extensins （EXTs）. proline hydroxylation, an early post-translational modification （pTM） of HRGps catalyzed by prolyl 4-hydroxylases （p4Hs）, defines their subsequent O-glycosylation sites. In this work, our genetic analyses prove that p4H5, and to a lesser extent p4H2 and p4H13, are pivotal for root hair tip growth. Second, we demonstrate that p4H5 has in vitro preferred specificity for EXT substrates rather than for other HRGps. Third, by p4H promoter and protein swapping approaches, we show that p4H2 and p4H13 have interchangeable functions but cannot replace p4H5. These three p4Hs are shown to be targeted to the secretory pathway, where p4H5 forms dimers with p4H2 and p4H13. Finally, we explore the impact of deficient proline hydroxylation on the cell wall architec- ture. Taken together, our results support a model in which correct peptidyl-proline hydroxylation on EXTs, and possibly in other HRGps, is required for proper cell wall self-assembly and hence root hair elongation in Arabidopsis thaliana.

关键词： enzymology cell expansion cell walls protein targeting proline hydroxylation root hairs

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适用于合成燃料生产的气化基础，过程和应用

国外科技新书评介 2016年第1期 14-14页

作者： rafael Luque 陈宏刚不详华北电力大学

气化是以非燃烧的方式把含碳原料转化为合成气，所得产品合成气本身既可做燃料使用，也可以进一步加工制取合成燃料。气化技术是比直接燃烧效率更高的清洁利用能源的手段。本书对气化科学和工程以及通过多种原料的气化制取合成燃料的技... 详细信息

气化是以非燃烧的方式把含碳原料转化为合成气，所得产品合成气本身既可做燃料使用，也可以进一步加工制取合成燃料。气化技术是比直接燃烧效率更高的清洁利用能源的手段。本书对气化科学和工程以及通过多种原料的气化制取合成燃料的技术做了全面总结和评述。

关键词：气化技术燃料生产合成气基础应用合成燃料燃烧效率利用能源

D2/H2与5A分子筛在低温下(<77 K)相互作用的热力学、动力学及选择性研究

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D2/H2与5A分子筛在低温下(<77 K)相互作用的热力学、动力学及选择...

The Impulsivity and Drinking Motives as predictor of the Alcohol Consumption in College Students

第二届中国氚科学与技术学术交流会

作者：熊仁金 Xicohténcatl rafael Balderas Zhang Linda 李佩龙姚勇桑革宋江锋陈长安唐涛罗德礼 Hirscher Michael 四川省氢同位素工程技术研究中心 Max planck Institute for Intelligent Systems

氢同位素(D和T)在聚变能源、元素示踪、反应堆及医疗健康领域都有广泛应用,而氢同位素分离是其有效利用的重要环节。现在常用的氢同位素分离方法有低温精馏法(CD)、热扩散法、洗提色谱法、热置换色谱法,以及由此而发展起来的有效钯柱色... 详细信息

氢同位素(D和T)在聚变能源、元素示踪、反应堆及医疗健康领域都有广泛应用,而氢同位素分离是其有效利用的重要环节。现在常用的氢同位素分离方法有低温精馏法(CD)、热扩散法、洗提色谱法、热置换色谱法,以及由此而发展起来的有效钯柱色谱法、热循环吸附法(TCAp)等。但这些方法存在的缺陷是成本高、效率低,如低温精馏法需要20～24 K的低温,且其D/H2分离因子约为1.6。分子筛由于其特有的孔结构、低价、良好的热及辐照稳定性在氢同位素分离领域得到越来越多的关注。本文系统研究了D/H与5A分子筛在低温下(<77 K)相互作用的热力学、动力学及D/H2选择性。由30～77K范围等温吸附曲线获得了D及H2在不同温度和压力下的吸附量及其D和H2的吸附差异,同时获得不同吸附量下D及H的吸附热力学焓变(?Had)。动力学研究表明H2在不同的温度、压力及气体组成条件下吸脱附动力学均快于D。采用热脱附谱(TDS)研究了不同条件下的D/H2选择性,结果表明在加载压力50mbar及时间60min的条件下,D/H2选择性在30,35,40,50及60K分别为8.83,6.42,4.98,3.96及4.04,这是首次实验研究5A分子筛在低于77 K条件下对氢同位素气体的选择性。

关键词：氢同位素分离分子筛热脱附谱

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psychology Research 2014年第1期4卷 40-47页

作者： Diana Betancourt Ocampo Sahid rafael Garcia Campos Jazmin Garcia Zarate Laura Alejandra Corona Guevara Alejandro Gonzalez-Gonzfilez Universidad Anahuac Mexico Norte Huixquilucan Mexico Universidad Nacional Autonoma de Moxico Mexico City Mexico

The main objective of this research is to determine the effect of the impulsivity as well as the causes of drinking alcohol in college. We selected a non-probabilistic sample of 36 students of a private college, 47.1% were male and 52.9 female, with an age range of 17-27 years and a mean of 20.66 years. To measure the alcohol consumption, we used an adapted version of the Drinking Motives Questionnaire, which consists of three dimensions: coping reasons, social reasons and conformity reasons. Impulsivity was evaluated with the adapted versions of the plutchik scale consisting of 15 items in Likert scale with four response options ranging from never to always. These results showed that 93.6% of the participants reported the consumption of alcohol sometime in their lives. As for the effect of the causes for drinking and the impulsivity of the consumption in college students, the results showed that the three dimensions to drink explained 39% of the variance in the alcohol consumption among young people, however, impulsivity did not enter as a predictor variable.

关键词：食用酒精消费预测大学生饮酒民办高校消费量原因非概率

Three-Dimensional Conformal and Intensity Modulated Dynamic Radiotherapy in Juvenile Nasopharyngeal Angiofibroma

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Transcranial Direct Current Stimulation Combined with peripheral Neuromuscular Stimulation Improves Quality of Life, Fatigue, and pain in a patient with Rheumatoid Arthritis and Refractory Radicular pain Related to Spinal Stenosis

International Journal of Otolaryngology and Head & Neck Surgery（耳鼻喉） 2023年第4期

作者： María Fátima Chilaca Rosas David rafael Salazar Calderon Manuel Tadeo Contreras Aguilar Carlos Eduardo Barrios Merino Melissa García Lezama Benjamín Conde Castro Shelley Astrid Martínez Torres Katia Hernández Salgado rafael Medrano Guzmán

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Open Journal of Rheumatology and Autoimmune Diseases（风湿病与自身免疫疾病期刊） 2023年第1期

作者： rafael Giovani Missé Lucas De Macedo Dos Santos Clarice Tanaka Abrahão Fontes Baptista Samuel Katsuyuki Shinjo

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家庭住宅法国拉马蒂埃尔

世界建筑导报 2018年第2期33卷 88-89页

作者： nader tehrani dan gallagher katie faulkner tim wong craig chapple john houser ellee lee kevin lee parke macdowell ryan murphy jonathan palazzolo caitlin scott joana rafael rawan alsane 不详 AIA RA

几个世纪以来，不同的地理环境一直都采用这类封闭的庭院形式--每一次都根据当地气候、风俗习惯和建筑实践进行改造。作为一种在建筑物内捕捉户外景观的手段，庭院由建筑内部结构决定。流畅的庭院不但提供内外部隐私保护，而且也不断地... 详细信息

几个世纪以来，不同的地理环境一直都采用这类封闭的庭院形式--每一次都根据当地气候、风俗习惯和建筑实践进行改造。作为一种在建筑物内捕捉户外景观的手段，庭院由建筑内部结构决定。流畅的庭院不但提供内外部隐私保护，而且也不断地向外延伸，积极融入周边景观。该住宅遵守严格的分区指导方针，同时通过在屋顶上扩建自然植物区系与景观融合。坐落在橄榄树林、松树和葡萄园内．该住宅充分利用坡地，从而获得可持续的拓展和种植系统。从概念上讲．人们可以把庭院建筑看作是一个框架：

关键词：家庭住宅庭院建筑拉马法国建筑实践地理环境风俗习惯内部结构