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NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling

Cellular & Molecular Immunology 2021年第4期18卷 1045-1057页

作者： Xabier Unamuno Javier Gomez-Ambrosi Beatriz Ramirez Amaia Rodriguez Sara Becerril Victor Valenti rafael moncada Camilo Silva Javier Salvador Gema Fruhbeck Victoria Catalan Metabolic Research Laboratory Clfnica Universidad de NavarraPamplonaSpain CIBER Fisiopatologfa de la Obesidad y Nutricion(CIBEROBN) Instituto de Salud Carlos ⅢPamplonaSpain Obesity and Adipobiology Group Instituto de Investigaci6n Sanitaria de Navarra(IdiSNA)PamplonaSpain Department of Surgery Clinica Universidad de NavarraPamplonaSpain Department of Anesthesia Clinica Universidad de NavarraPamplonaSpain Department of Endocrinology&Nutrition Clfnica Universidad de NavarraPamplonaSpain

The NLRP3-IL-1β pathway plays an important role in adipose tissue(AT)-induced inflammation and the development of obesityassociated *** aimed to determine the impact of NLRP3 on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and extracellular matrix(ECM)*** obtained from 98 subjects were used in a case-control *** expression of different components of the inflammasome as well as their main effectors and inflammation-and ECM remodeling-related genes were *** impact of blocking NLRP3 using siRNA in lipopolysaccharide(LPS)-mediated inflammation and ECM remodeling signaling pathways was *** demonstrated that obesity(P<0.01),obesity-associated T2D(P<0.01)and NAFLD(P<0.05)increased the expression of different com ponents of the inflammasome as well as the expression and release of IL-1β and IL-18 in *** also found that obese patients with T2D exhibited increased(P<0.05)hepatic gene expression levels of NLRP3,IL1B and *** showed that NLRP3,but not NLRP1,is regulated by inflammation and hypoxia in visceral *** revealed that the inhibition of NLRP3 in human visceral adipocytes significantly blocked(P<0.01)LPS-induced inflammation by downregulating the mRNA levels of CCL2,IL1B,IL6,IL8,S100A8,S100A9,TLR4 and TNF as well as inhibiting(P<0.01)the secretion of IL1-β into the culture ***,blocking NLRP3 attenuated(P<0.01)the LPS-induced expression of important molecules involved in AT fibrosis(COL1A1,COL4A3,COL6A3 and MMP2).These novel findings provide evidence that blocking the expression of NLRP3 reduces AT inflammation with significant fibrosis attenuation.

关键词： NLRP3 Inflammasone Inflammation Obesity Type 2 diabetes Nonalcoholic fatty liver disease

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FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes

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Cellular & Molecular Immunology 2021年第10期18卷 2457-2459页

作者： Gema Frühbeck Victoria Catalán Víctor Valentí rafael moncada Javier Gómez-Ambrosi Sara Becerril Camilo Silva Piero Portincasa Javier Escalada Amaia Rodríguez Metabolic Research Laboratory Clínica Universidad de NavarraPamplonaSpain CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN) Instituto de Salud Carlos IIIMadridSpain Obesity and Adipobiology Group Instituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain Department of Endocrinology and Nutrition Clínica Universidad de NavarraPamplonaSpain Department of Surgery Clínica Universidad de NavarraPamplonaSpain Department of Anesthesia Clínica Universidad de NavarraPamplonaSpain Department of Biomedical Sciences and Human Oncology Clinica Medica“A.Murri”University of Bari Medical SchoolPoliclinico HospitalBariItaly.

A sedentary lifestyle and obesity are important risk factors for severe COVID-19 complications and death[1,2].Excessive adipose tissue(AT)might contribute to more extensive viral spread with increased shedding,immune activation,and cytokine amplification[3].Several factors secreted by contracting muscle,termed myokines,mediate the beneficial effects of exercise in a wide range of diseases,including obesity[4].Thus,we conducted a study to explore the potential role of myokines of the fibronectin type III domain-containing family,FNDC4 and FNDC5,in mechanisms underlying the increased susceptibility to COVID-19 complications in obesity.

关键词： FNDC5 obesity FND

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Differences in seed dormancy and germination in amphicarpic legumes:manifold bet-hedging in space and time

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Journal of Plant Ecology 2021年第4期14卷 662-672页

作者： Ricardo Sanchez-Martin Jose Maria Gomez Pierre-Olivier Cheptou rafael Rubio de Casas Departamento Ecologia Vegetal Centro de Investigaciones sobre Desertificacion(CIDE-CSIC-UV-GV)Carretera de Moncada-Naquera Km 4546113 MoncadaValenciaSpain Departamento de Ecologia Funcional y Evolutiva Estacion Experimental de Zonas AridasEEZA-CSICCtra.de Sacramento s/nLa Cañada de San Urbano04120 AlmeriaSpain Centre d’Ecologie Fonctionnelle et Evolutive(CEFE) CEFE UMR 5175CNRSUniversite de MontpellierUniversite Paul-Valery7 MontpellierEPHE1919 route de Mende34293 Montpellier Cedex 05France Departamento de Ecologia Universidad de GranadaAvda.de Fuentenueva s/n18071 GranadaSpain

Aims Dispersal through space or time via dormancy is one of the primary processes whereby organisms can influence the environment they *** plants,strong evolutionary correlations are expected between the two kinds of dispersal because both are performed by the seeds and play comparable adaptive *** this paper,we investigated these evolutionary correlations using amphicarpic plants,which simultaneously produce aerial seeds with high spatial dispersal propensity and subterranean seeds that do not *** We investigated the variation in dormancy and germination in aerial and subterranean seeds of two amphicarpic legumes(Vicia amphicarpa *** Lathyrus amphicarpos L.)and two closely related homocarpic taxa(Vicia sativa *** Lathyrus cicera L.)by estimating germination percentages following different combinations of dormancy breaking treatments(*** after-ripening,cold stratification and physical scarification).Important Findings Our results showed complex interactions between spatial and temporal *** after dispersal,aerial seeds were more dormant than their subterranean counterparts,but this trend reversed with after-ripening,as seeds developed physical *** of homocarpic plants germinated at higher percentages than those of their amphicarpic congeners and lost dormancy homogeneously with ***,amphicarpic seeds exhibited varied dormancy strategies modulated by both physiological and physical *** are expected to increase variation in emergence timing,providing multiple levels of diversifying *** strategy might be adaptive under highly unpredictable conditions by enabling plants to rely on historically favorable sites in good seasons without preventing spatial and temporal migration.

关键词： amphicarpy dormancy/colonization trade-off amphicarpic legumes environmental heterogeneity seed dormancy and germination Mediterranean environments

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