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i.testi.al mi.robi.ta i. health and di.ease: Role of bi.i.obacteri. i. gut homeostasi.

World Journal of Gastroenterology 2014年第41期20卷 15163-15176页

作者： rafael Tojo Adolfo Suárez Marta G Clemente Clara G de los reyes-Gavi.án Abelardo Margolles Mi.uel Guei.onde Patri.i. Ruas-Madi.do Gastroenterology Department Hospital de Cabue?es Gastroenterology Department Hospital Universitario Central de Asturias (HUCA) Respi.atory Department Hospital Universitario Central de Asturias (HUCA) Department of Mi.robi.logy and Bi.chemi.try of Dai.y Products Instituto de Productos Lácteos de Asturias-Consejo Superior de Investigaciones Científicas (IPLA-CSIC)

The pool of mi.robes i.habi.i.g our body i. known as “mi.robi.ta” and thei. collecti.e genomes as “mi.robi.me”. The colon i. the most densely populated organ i. the human body, although other parts, such as the ski., vagi.al mucosa, or respi.atory tract, also harbour speci.i. mi.robi.ta. Thi. mi.robi.l communi.y regulates some i.portant metaboli. and physi.logi.al functi.ns of the host, and dri.es the maturati.n of the i.mune system i. early li.e, contri.uti.g to i.s homeostasi. duri.g li.e. Alterati.ns of the i.testi.al mi.robi.ta can occur by changes i. composi.i.n (dysbi.si.), functi.n, or mi.robi.ta-host i.teracti.ns and they can be di.ectly correlated wi.h several di.eases. The only di.ease i. whi.h a clear causal role of a dysbi.ti. mi.robi.ta has been demonstrated i. the case of Clostri.i.m di.fi.i.e i.fecti.ns. Nonetheless, alterati.ns i. composi.i.n and functi.n of the mi.robi.ta have been associ.ted wi.h several gastroi.testi.al di.eases (i.flammatory bowel di.ease, colorectal cancer, or i.ri.able bowel syndrome), as well as extra-i.testi.al pathologi.s, such as those affecti.g the li.er, or the respi.atory tract (e.g., allergy, bronchi.l asthma, and cysti. fi.rosi.), among others. Speci.s of Bi.i.obacteri.m genus are the normal i.habi.ants of a healthy human gut and alterati.ns i. number and composi.i.n of thei. populati.ns i. one of the most frequent features present i. these di.eases. The use of probi.ti.s, i.cludi.g bi.i.obacteri. strai.s, i. preventi.e medi.i.e to mai.tai. a healthy i.testi.al functi.n i. well documented. Probi.ti.s are also proposed as therapeuti. agents for gastroi.testi.al di.orders and other pathologi.s. The World Gastroenterology Organi.ati.n recently publi.hed potenti.l cli.i.al appli.ati.ns for several probi.ti. formulati.ns, i. whi.h speci.s of lactobaci.li.are predomi.ant. Thi. revi.w i. focused on probi.ti. preparati.ns contai.i.g Bi.i.obacteri.m strai.s, alone or i. combi.ati.n wi.h other bac

关键词： i.testi.al mi.robi.ta Bi.i.obacteri.m Probi.ti.s Dysbi.si. i.flammatory bowel di.ease i.ri.able bowel syndrome Colorectal cancer Li.er di.ease Respi.atory di.ease Functi.nal foods

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Strategi.s of Mexi.an Rural Communi.i.s to Entry i. the Local and Global Markets

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Economi.s World 2018年第5期6卷 337-349页

作者： Ali.i. Sylvi. Gi.ón-Cruz rafael G. reyes-Morales i. Selene Benítez-ávi.a Nancy Yaneth Chávez-Méndez Uni.ersi.ad Autónoma Beni.o Juárez de Oaxaca State of Oaxaca Mexico Tecnológi.o Naci.nal de Méxi.o/i.sti.uto Tecnológi.o de Oaxaca State of Oaxaca Mexico

Thi. paper hi.hli.hts the mai. features of the economy of rural households i. Mexi.o and analyzes thei. strategi.sto entry i. local and global markets. i. bui.t a model of household economi.s usi.g ordi.ary least squaresregressi.n wi.h data collected through a probabi.i.ti. survey i. four communi.i.s. Especi.l care was taken to avoi.multi.olli.eari.y problems. The study communi.i.s are si.uated i. Oaxaca state, Mexi.o i. two contrasti.g cli.ati.envi.onments that present di.ferent condi.i.ns to access the markets. The resulti.g model not only i.enti.i.s thehouseholds＇ market strategi.s but also measures the i.pact of households＇ deci.i.n-maki.g about allocati.n ofresources on the household wellbei.g. Contrary to the di.course on Mexi.o-US mi.rati.n, thi. paper shows that therural households＇ labor for i.ternati.nal mi.rati.n i. shri.ki.g. A process of di.ersi.i.ati.n of i.come sources i.already goi.g on i. rural areas, therefore, households rely i.creasi.gly on wages, fami.y busi.esses, andgovernment transfers; besi.es, they complement thei. i.come wi.h subsi.tence producti.n and transfers from otherhouseholds. Fi.ally, i. was found that i. some cases the si.ultaneous allocati.n of materi.l and soci.-demographi.resources to economi. acti.i.i.s and labor markets could restri.t the i.crease i. household wellbei.g i. thedemographi. structure i. already altered.

关键词： market strategi.s i.pacts on household wellbei.g restri.ti.ns to allocati.n of resources

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Challenges at the early stages of the envi.onmental li.ensi.g procedure and potenti.l contri.uti.ns from geomorphology

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Geosci.nce Fronti.rs 2021年第6期12卷 36-45页

作者： Cri.ti.a i.Perei.a Celene B.Mi.anes rafael Sarda Benjami. Cuker Cami.o M.Botero Coastal Systems Research Group Playas Corporation Ltda.BogotáColombia Corporaci.n para el Desarrollo Sosteni.le del Urabá–CORPOURABA Barrio ManzanaresCl.92No 98-39ApartadóColombia Ci.i. and Envi.onmental Department Universidad de la CostaBarranquillaColombia Centro de Estudi.s Avanzados de Blanes Consejo Superior de Investigaciones CientíficasCEAB-CSICSpain Department of Mari.e and Envi.onmental Sci.nce Hampton UniversityHamptonVA 23668USA Uni.ersi.y Sergi. Arboleda School of LawSanta MartaColombia

Defi.i.g i.pact si.ni.i.ance i. the mai. techni.al task that i.fluences deci.i.n-maki.g duri.g the Envi.onmental Li.ensi.g Procedure(ELP).The ELP begi.s wi.h screeni.g to determi.e potenti.lly si.ni.i.ant i.pacts of the proposed *** then follows to address any i.terventi.ns deemed worthy of attenti.n i. the producti.n of an Envi.onmental i.pact Assessment(Ei.).Thi. wi.l i.clude consi.erati.n of relevant landforms and geomorphologi.al ***,preli.i.ary assessments of envi.onmental i.pacts often lack the sci.nti.i. robustness to procure substanti.e and transacti.e *** revi.w presents an exami.ati.n of the establi.hed practi.es of screeni.g and scopi.g whi.e hi.hli.hti.g the foremost challenges to i.prove the techni.al grounds of the *** analysi. of screeni.g and scopi.g practi.es stresses the need for novel methods that ensure the sequenti.l reasoni.g between thei. cri.eri. whi.e i.provi.g the preli.i.ary evaluati.n of i.pact *** the i.herent subjecti.i.y of di.creti.nary judgment requi.es sci.nti.i. methodologi.s that acknowledge the i.teracti.n between the natural system and human i.terventi.ns,whi.h has been addressed by geomorphologi.al *** knowledge consoli.ated i. thi. revi.w opens the gate to explore the compati.i.i.y between the Uni.ed Nati.ns strategy of Ecosystem Approach(EA)wi.h the ELP through a novel geomorphologi.al i.terpretati.n of the ***,thi. di.gnosi. demonstrate that screeni.g and scopi.g practi.es would benefi. from reli.ble methods that balance the precauti.nary pri.ci.le wi.h the effi.i.nt character requi.ed i. the ELP.

关键词： Ei. effecti.eness Screeni.g and scopi.g practi.es Landforms Geomorphologi.al processes Ecosystem approach

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Proteomi.s and the geneti.s of sperm chromati. condensati.n

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Asi.n Journal of Andrology 2011年第1期13卷 24-30页

作者： rafael Oli.a Judi. Casti.lo Human Geneti.s Research Group IDI BAPS Department of Ciencias Fisiologicas I Faculty of Medicine University of Barcelona Barcelona 08036 Spain Bi.chemi.try and Molecular Geneti.s Servi.e Hospital Clinic i Provincial Barcelona 08036 Spain

Spermatogenesi. i.volves extremely marked cellular, geneti. and chromati. changes resulti.g i. the generati.n of the hi.hly speci.li.ed sperm cell. Proteomi.s allows the i.enti.i.ati.n of the protei.s that compose the spermatogeni. cells and the study of thei. functi.n. The recent developments i. mass spectrometry （MS） have markedly i.creased the throughput to i.enti.y and to study the sperm protei.s. Catalogs of thousands of testi. and spermatozoan protei.s i. human and di.ferent model speci.s are becomi.g avai.able, setti.g up the basi. for subsequent research, di.gnosti. appli.ati.ns and possi.ly the future development of speci.i. treatments. The present revi.w i.tends to summari.e the key geneti. and chromati. changes at the di.ferent stages of spermatogenesi. and i. the mature sperm cell and to comment on the presently avai.able proteomi. studi.s.

关键词： epi.eneti. i.pri.ti.g protami.e proteome spermatozoa

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i.terplay between post-translati.nal cyclooxygenase-2 modi.i.ati.ns and the metaboli. and proteomi. profi.e i. a colorectal cancer cohort

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World Journal of Gastroenterology 2019年第4期25卷 433-446页

作者： Patri.i. Pri.to rafael i.Jaén Dani.l Calle María Gómez-Serrano Estefanía Nú?ez María Fernández-velasco Paloma Martín-Sanz Sergi. Alonso Jesús Vázquez Sebasti.n Cerdán Mi.uel ángel Pei.ado Li.ardo Boscá Department of Metaboli.m and Physi.pathology of i.flammatory Di.eases Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM) Centro de i.vesti.aci.n Bi.médi.a en Red de Enfermedades Cardi.vasculares (Ci.er-CV) Instituto de Salud Carlos III (ISCIII) Laboratori. de i.agen Médi.a Hospital Universitario Gregorio Mara?ón Laboratori. de Proteómi.a Cardi.vascular Centro Nacional de Investigaciones Cardiovasculares (CNIC) i.sti.uto de i.vesti.aci.n Sani.ari. del Hospi.al Uni.ersi.ari. la Paz(i.i.az) Programa de Medi.i.a Predi.ti.a y Personali.ada del Cáncer (PMPPC) Fundación Instituto de investigación en ciencias de la salud Germans Trias i PujolCtra Can Ruti

BACKGROUND Colorectal cancer(CRC) i. the second most common cause of cancer death worldwi.e. i. i. broadly descri.ed that cyclooxygenase-2(COX-2) i. mai.ly overexpressed i. CRC but less i. known regardi.g post-translati.nal modi.i.ati.ns of thi. enzyme that may regulate i.s acti.i.y, i.tracellular locali.ati.n and stabi.i.y. Si.ce metaboli. and proteomi. profi.e analysi. i. essenti.l for cancer prognosi. and di.gnosi., our hypothesi. i. that the analysi. of correlati.ns between these speci.i. parameters and COX-2 state i. tumors of a hi.h number of CRC pati.nts could be useful for the understandi.g of the basi. of thi. cancer i. *** To analyze COX-2 regulati.n i. colorectal cancer and to perform a detai.ed analysi. of thei. metaboli. and proteomi. *** Bi.psi.s from both healthy and pathologi.al colorectal ti.sues were taken under i.formed consent from pati.nts duri.g standard colonoscopy procedure i. the Uni.ersi.y Hospi.al of Bellvi.ge(Barcelona, Spai.) and Germans Tri.s i.Pujol Uni.ersi.y Hospi.al(Campus Can Ruti.(Barcelona, Spai.). Western blot analysi. was used to determi.e COX-2 levels. Deglycosylati.n assays were performed i. both cells and tumor samples i.cubati.g each sample wi.h pepti.e N-glycosi.ase F(PNGase F). Prostaglandi. E2(PGE2) levels were determi.ed usi.g a speci.i. ELi.A. 1 H hi.h resoluti.n magi. angle spi.ni.g(HRMAS) analysi. was performed usi.g a Bruker AVi.i.500 MHz spectrometer and proteomi. analysi. was performed i. a nano-li.ui. chromatography-tandem mass spectrometer(nano LC-MS/MS) usi.g a QExacti.e HF orbi.rap *** Our data show that COX-2 has a di.ferenti.l expressi.n profi.e i. tumor ti.sue of CRC pati.nts vs the adjacent non-tumor area, whi.h correspond to a glycosylated and less acti.e state of the protei.. Thi. fact was associ.ted to a lesser PGE2 producti.n i. tumors. These results were corroborated i. vi.ro performi.g deglycosylati.n assays i. HT29 cell li.e where COX-2 protei. profi.e was modi.i.d after PN

关键词： Colon Carci.oma Cyclooxygenase Prostaglandi. Proteomi.s Hi.h resoluti.n magi. angle spi.ni.g

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Non-alcoholi. steatohepati.i. and ri.k of hepatocellular carci.oma

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Chi.ese Medi.al Journal 2021年第24期134卷 2911-2921页

作者： rafael S.Ri.s Kenneth i.Zheng Mi.g-Hua Zheng NAFLD Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China

The emergence of non-alcoholi. fatty li.er di.ease(NAFLD)as the leadi.g chroni. li.er di.ease worldwi.e rai.es some *** parti.ular,NAFLD i. closely ti.d to sedentary li.estyle habi.s and associ.ted wi.h other metaboli. di.eases,such as obesi.y and *** the end of the di.ease spectrum,non-alcoholi. steatohepati.i.(NASH)may progress to ci.rhosi. and hepatocellular carci.oma(HCC),representi.g a seri.us health problem to modern ***,an i.creasi.g number of HCC cases ori.i.ati.g from thi. progressi.e di.ease spectrum have been i.enti.i.d,wi.h di.ferent levels of severi.y and *** the current gui.eli.es by placi.g a bi.ger focus on thi. emergi.g cause and hi.hli.hti.g some of i.s uni.ue features i. ***,the dri.ers of the di.ease are complex and multi.actori.l,i. order to i.prove future outcomes,havi.g a better understandi.g of NASH progressi.n i.to HCC may be *** ri.ks that can promote di.ease progressi.n and currently avai.able management strategi.s employed to moni.or and treat NASH-related HCC make up the bulk of thi. revi.w.

关键词： Non-alcoholi. fatty li.er di.ease Non-alcoholi. steatohepati.i. Li.er di.ease Hepatocellular carci.oma i.suli. resi.tance Oxi.ati.e stress Metaboli. associ.ted fatty li.er di.ease

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Post-translati.nal modi.i.ati.ns of prostaglandi.-endoperoxi.e synthase 2 i. colorectal cancer:An update

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World Journal of Gastroenterology 2018年第48期24卷 5454-5461页

作者： rafael i.Jaén Patri.i. Pri.to Marta Casado Paloma Martín-Sanz Li.ardo Boscá Department of Metaboli.m and Physi.pathology of i.flammatory Di.eases Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM) Department of Bi.medi.i.e Instituto de Biomedicina de Valencia (CSIC) Centro de i.vesti.aci.n Bi.médi.a en Red de Enfermedades Cardi.vasculares y Hepáticas y DigestivasISCⅢ Uni.ad Asoci.da i.BMULPGC Universidad de las Palmas de Gran Canaria (ULPGC)

The bi.synthesi. of prostanoi.s i. i.volved i. both physi.logi.al and pathologi.al processes. The expressi.n of prostaglandi.-endoperoxi.e synthase 2(PTGS2; also known as COX-2) has been tradi.i.nally associ.ted to the onset of several pathologi.s, from i.flammati.n to cardi.vascular, gastroi.testi.al and oncologi. events. For thi. reason, the search of selecti.e PTGS2 i.hi.i.ors has been a focus for therapeuti. i.terventi.ns. i. addi.i.n to the classi. non-steroi.al anti.i.flammatory drugs, selecti.e and speci.i. PTGS2 i.hi.i.ors, termed coxi.s, have been generated and wi.ely used. PTGS2 acti.i.y i. less restri.ti.e i. terms of substrate speci.i.i.y than the homeostati. counterpart PTGS1, and i. accounts for the elevated prostanoi. synthesi. that accompani.s several pathologi.s. The mai. regulati.n of PTGS2 occurs at the transcri.ti.n level. i. addi.i.n to thi., the stabi.i.y of the mRNA i. fi.ely regulated through the i.teracti.n wi.h several cytoplasmi. elements, rangi.g from speci.i.mi.roR NAs to protei.s that control mR NA degradati.n. Moreover, the protei. has been recogni.ed to be the substrate for several post-translati.nal modi.i.ati.ns that affect both the enzyme acti.i.y and the targeti.g for degradati.n vi. proteasomal and non-proteasomal mechani.ms. Among these modi.i.ati.ns, phosphorylati.n, glycosylati.n and covalent modi.i.ati.ns by reacti.e li.i.i. i.termedi.tes and by free radi.als associ.ted to the proi.flammatory condi.i.n appear to be the mai. changes. i.enti.i.ati.n of these post-translati.nal modi.i.ati.ns i. relevant to better understand the role of PTGS2 i. several pathologi.s and to establi.h a correct analysi. of the potenti.l functi.n of thi. protei. i. di.eases progress. Fi.ally, these modi.i.ati.ns can be used as bi.markers to establi.h correlati.ns wi.h other parameters, i.cludi.g the i.munomodulati.n dependent on molecular pathologi.al epi.emi.logy determi.ants, whi.h may provi.e a better frame for potenti.l therapeuti. i.terventi.ns.

关键词： Prostaglandi.s Prostaglandi.-endoperoxi.e synthase 2 Post-translati.nal modi.i.ati.ns Glycosylati.n Colorectal cancer i.flammati.n

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The Peri.queductal Gray and i.s Extended Parti.i.ati.n i. Drug Addi.ti.n Phenomena

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Neurosci.nce Bulleti. 2021年第10期37卷 1493-1509页

作者： Pri.ci.a Vazquez-Leon Abraham Mi.anda-Paez Jesus Chavez-reyes Gonzalo Allende Pauli.o Barragan-i.lesi.s Bruno A.Mari.hal-Canci.o Departamento de Fi.i.logi. y Farmacologi. Centro de Ciencias BasicasUniversidad Autonoma de AguascalientesCiudad Universitaria20131 AguascalientesAgs.Mexico Departamento de Fi.i.logi. Escuela Nacional de Ciencias BiologicasInstituto Politecnico NacionalWilfrido Massieu esq.Manuel Stampa s/n Col.Nueva Industrial Vallejo07738 Gustavo A.MaderoMexico CityMexico

The peri.queductal gray(PAG)i. a complex mesencephali. structure i.volved i. the i.tegrati.n and executi.n of acti.e and passi.e self-protecti.e behavi.rs agai.st i.mi.ent threats,such as i.mobi.i.y or fli.ht from a *** acti.i.y i. also associ.ted wi.h the i.tegrati.n of responses agai.st physi.al di.comfort(e.g.,anxi.ty,fear,pai.,and di.gust)whi.h occurs pri.r an i.mi.ent attack,but also duri.g wi.hdrawal from drugs such as morphi.e and *** PAG sends and recei.es projecti.ns to and from other well-documented nuclei.li.ked to the phenomenon of drug addi.ti.n i.cludi.g:(i.the ventral tegmental area;(i.)extended amygdala;(i.i.medi.l prefrontal cortex;(i.)ponti.e nucleus;(v)bed nucleus of the stri. termi.ali.;and(vi.*** models have suggested that the PAG contri.utes to the modulati.n of anxi.ty,fear,and noci.epti.n(all of whi.h may produce physi.al di.comfort)li.ked wi.h chroni. exposure to drugs of *** produced by the major pharmacologi.al classes of drugs of abuse i. medi.ted through acti.ns that i.clude parti.i.ati.n of the *** support of thi.,there i. evi.ence of functi.nal,pharmacologi.al,***/or geneti. alterati.ns i. the PAG duri.g the i.pulsi.e/compulsi.e i.take or wi.hdrawal from a *** to i.s small si.e,i. i. di.fi.ult to assess the anatomi.al parti.i.ati.n of the PAG when usi.g classi.al neuroi.agi.g techni.ues,so i.s phys-i.pathology i. drug addi.ti.n has been underesti.ated and poorly *** thi. theoreti.al revi.w,we di.cuss the i.volvement of the PAG i. drug addi.ti.n mai.ly vi. i.s role as an i.tegrator of responses to the physi.al di.comfort associ.ted wi.h drug wi.hdrawal.

关键词： Peri.queductal gray Reward ci.cui. Anti.eward ci.cui. Alcohol Caffei.e Cannabi. Opi.i.s Sti.ulants

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Heterogeneous catalysi. under flow for the 21st century fi.e chemi.al i.dustry

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Green Energy & Envi.onment 2021年第2期6卷 161-166页

作者： Rosari. Ci.i.i.na Mari. Pagli.ro rafael Luque i.ti.uto per i. Studi. dei.Mate ri.li.Nanostnuturati CNRwia U.La Malfa 15390146PulemoItaly Deparamento de Qui.i.a Orgi.i.a Univeridad de CordobaCampus de RabonalesEdificio Marie Curie(C-3)Cra Nnal IV-Akm 396Cordoba14014Spain Peoples Fri.ndshi. Uni.ersi.y of Russi.(RUDN Uni.ersi.) 6 Miklukho Maklaya St117198MoscowRussia

Due to metal leachi.g and poor catalyst stabi.i.y, the chemi.al i.dustry's fi.e chemi.al and pharmaceuti.al sectors have been hi.tori.ally reluctant to use supported transi.i.n metal catalysts to manufacture fi.e chemi.als and acti.e pharmaceuti.al i.gredi.nts. Wi.h the advent of new generati.n supported metal catalysts and flow chemi.try, we argue i. thi. study, thi. si.uati.n i. poi.ed to qui.kly change. Alongsi.e heterogeni.ed metal nanoparti.les, both si.gle-si.e molecular and si.gle-atom catalyst wi.l become ubi.ui.ous. Thi. study offers a cri.i.al outlook taki.g i.to account both techni.al and economi. aspects.

关键词： Fi.e chemi.al Heterogeneous catalysi. Si.gle atom catalysi. Green chemi.try Chemi.al i.dustry

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PD-L1 expressi.n associ.ted wi.h better response to EGFR tyrosi.e ki.ase i.hi.i.ors

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Cancer Bi.logy & Medi.i.e 2015年第2期12卷 71-73页

作者： rafael Rosell Ramón Palmero Molecular Oncology Research (MORe) Foundati.n Catalan i.sti.ute of Oncology Hospital Germans Trias i Pujol Germans Tri.s i.Pujol Health Sci.nces i.sti.ute and Hospi.al Campus Can Ruti i.sti.uto Oncológi.o Dr Rosell Quiron Dexeus University Hospital Pangaea Bi.tech Thoraci. Oncology Uni. Department of Medical Oncology Catalan Institute of Oncology L'Hospitalet

Cancer evades host i.mune survei.lance by usi.g i.mune checkpoi.ts,w hi.h are i.hi.i.or y pathways cr uci.l for mai.tai.i.g *** cells express multi.le i.hi.i.ory li.ands,and tumor-i.fi.trati.g lymphocytes(Ti.)express ... 详细信息

关键词：酪氨酸激酶抑制剂 EGFR 细胞毒性T淋巴细胞宿主免疫肿瘤浸润 CTLA-4 程序性死亡抑制途径

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