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Platelet-rich plasma vs bone marrow aspirate concentrate:An overview of mechanisms of action and orthobiologic synergistic effects

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World Journal of Stem Cells 2021年第2期13卷 155-167页

作者： Joséfábio Santos Duarte Lana Lucas furtado da fonseca rafael da Rocha Macedo Tomas Mosaner William Murrell Ashok Kumar Joseph Purita Marco Antonio Percope de Andrade Department of Orthopedics The Bone and Cartilage InstituteIndaiatuba 13334-170SPBrazil Department of Orthopedics The Federal University of São PauloSão Paulo 04023-062SPBrazil Department of Orthopedics Rede D’Or Unit IFOR HospitalSão Bernardo do Campo 09715-021SPBrazil Department of Orthopaedics Healthpoint UAEAbu Dhabi 00000United Arab Emirates Department of Orthopaedics My Doc Specialist Medical CentreDubai 00000United Arab Emirates Department of Orthopedics Institute of Regenerative MedicineBoca RatonFL 33432United States Department of Orthopaedic Federal University of Minas GeraisBelo Horizonte 31270-901MGBrazil

The use of orthobiologics as a novel therapy for the treatment of numerous musculoskeletal disorders has increased considerably over the past ***,there are multiple alternatives available as suitable treatments;however,the use of autologous blood-derived products such as platelet-rich plasma(PRP),bone marrow aspirate(BMA)and BMA concentrate(BMAC),specifically,is *** many investigations attempted to demonstrate the effectiveness of these therapies,even with positive results,the literature lacks standardized protocols and overall accuracy in study designs,which leads to variance and difficulty in reproducibility of *** efficacy of PRP for the treatment of cartilage,bone and muscle tissues is well *** BMAC has generated optimistic results for the same purposes,its applicability in clinical trials is still relatively recent when compared to *** products demonstrate the potential to set forth reparative processes,each in their own distinct *** combination of these biological products has been previously proposed,yet little is known about their *** indicates that growth factor,cytokine,and chemokine profiles seen in both PRP and BMAC vary but are likely to work synergistically to enhance musculoskeletal *** products seem to work well without PRP;however,the addition of PRP to BMAC has been shown to act as a rich and natural source of culture medium for stem cells located either peripherally or in the bone marrow ***,additional variables associated with the use of BMAC and PRP in orthopedics must be further evaluated in order to consolidate the efficacy of this therapeutic strategy.

关键词： Orthobiologics Platelet-rich plasma Bone-marrow aspirate Regenerative medicine Musculoskeletal diseases Stem cells

Crystallographic Study of the TiO<sub>2</sub>Obtained by Different Synthesis Methods

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Journal of Materials Science and Chemical Engineering 2013年第6期1卷 30-37页

作者： fidel Alejandro Cortez-Lorenzo Miguel Galván ruiz Rufino Nava Mendoza Mario Enrique Rodriguez García Rodrigo rafael Velazquez Castillo Centro de física Aplicada y Tecnología Avanzada UNAM Campus Juriquilla Querétaro México División de Investigación y Posgrado Facultad de Ingeniería Universidad Autónoma de Querétaro Querétaro México División de Investigación y Posgrado Facultad de Ingeniería Universidad Autónoma de Querétaro Querétaro México CBTis 145 San Juan del Río Querétaro México

In this work, the crystal structure of titanium dioxide was studied, and the effect of the different synthesis routes on the microstructure and morphology of the nanostructures was analyzed. Samples characterization was carried out by X-ray diffraction by powders (XRD) to determine the different crystalline phases contented in the samples and using scanning electron microscopy (SEM), the morphology and topology of all samples were studied. XRD results were analyzed through Eva provided by Bruker to determine the average crystallite size. The results portrayed here showed that all the synthesis process produced anatase nanostructures with an average crystallite size smaller than 27 nm. Synthesized powders presented similar morphologies in all cases and they were homogeneous in their chemical composition.

关键词： Anatase Sol-Gel Hydrothermal Assisted Microwaves Crystallization

Grasshoppers Sphenarium Purpurascens Ch Source of Proteins and Essential Amino Acids

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Journal of Chemistry and Chemical Engineering 2015年第7期9卷 472-476页

作者： Melo-ruiz Virginia Quirino-Barreda Tomas Garcia-Nunez Maritza Diaz-Garcia rafael Sanchez-Herrera Karina Schettino-Bermudez Beatriz Departament of Biological Systems Universidad Autonoma Metropolitana-Xochimilco Mexico D. F. 04960 Mexico

Protein malnutrition is quite common worldwide; its deficiency has adverse effects in all organs. Edible insect＇s traditional cultural food, commonly consumed in rural communities, now intake is also being incorporated in some countries. Grasshoppers comprise proteins, the building blocks of AA （amino acids）, that are one of the five classes of complex biomolecules found in cells and tissues that play an important role in human metabolism and nutrition. This research was conducted to determine proximal composition of Sphenarium purpurascens Ch, grasshoppers, focused on proteins and AA. Sampling was performed during autumn, 2013, in Oaxaca State. Dry raw adult insects were ground and proceeded to macro molecules proximal analysis, protein by Kjeldahl AOAC （Association of Official Analytical Chemists） method and essential AA in a Beckman 6300 equipment. Obtained data were： total proteins 71.56%; lipids 8.14%; minerals 3.52%; fiber 7.48%; soluble carbohydrates 9.30%. Essential AA （mg/16 g-N）： isoleucine 4.5; leucine 8.1; lysine 5.4; methionine ＋ cysteine 5.1; phenylalanine ＋ tyrosine 8.5; threonine 3.5; tryptophan 0.6; valine 5.5. Sphenarium purpurascens Ch, Grasshoppers represent a good source of proteins and essential AA that can grow almost everywhere, available mostly all year round and affordable to all social groups, thus being a good option to improve human health.

关键词： Proteins essential AA nutrition grasshoppers Sphenarium purpurascen.

Effective use of fibroTest to generate decision trees in hepatitis C

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World Journal of Gastroenterology 2009年第21期15卷 2617-2622页

作者： Dana Lau-Corona Luís Alberto Pineda Héctor Hugo Avilés Gabriela Gutiérrez-Reyes Blanca Eugenia farfan-Labonne rafael Núez-Nateras Alan Bonder Rosalinda Martínez-García Clara Corona-Lau Marco Antonio Olivera-Martínez Maria Concepción Gutiérrez-ruiz Guillermo Robles-Díaz David Kershenobich Department of Experimental Medicine School of MedicineUniversidad Nacional Autonoma de MexicoGeneral Hospital of Mexico Department of Computer Sciences Institute for Applied Mathematics and SystemsUniversidad Nacional Autonoma de Mexico Department of Gastroenterology Lomas Altas Clinic

AIM： To assess the usefulness of fibroTest to forecast scores by constructing decision trees in patients with chronic hepatitis C.METHODS： We used the C4.5 classification algorithm to construct decision trees with data from 261 patients with chronic hepatitis C without a liver biopsy. The fibroTest attributes of age, gender, bilirubin, apolipoprotein, haptoglobin, α2 macroglobulin, and γ-glutamyl transpeptidase were used as predictors, and the fibroTest score as the target. for testing, a 10-fold cross validation was used.RESULTS： The overall classification error was 14.9% （accuracy 85.1%）. fibroTest＇s cases with true scores of fO and f4 were classified with very high accuracy （18/20 for fO, 9/9 for fO-1 and 92/96 for f4） and the largest confusion centered on f3. The algorithm produced a set of compound rules out of the ten classification trees and was used to classify the 261 patients. The rules for the classification of patients in fO and f4 were effective in more than 75% of the cases in which they were tested.CONCLUSION： The recognition of clinical subgroups should help to enhance our ability to assess differences in fibrosis scores in clinical studies and improve our understanding of fibrosis progression,

关键词： Hepatitis C fibroTest Decision trees C4.5algorithm Non-invasive biomarkers

Enhanced Catalytic Activity of Gold@Polydopamine Nanoreactors with Multi-compartment Structure Under NIR Irradiation

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Nano-Micro Letters 2019年第4期11卷 469-484页

作者： Shilin Mei Zdravko Kochovski rafael Roa Sasa Gu Xiaohui Xu Hongtao Yu Joachim Dzubiella Matthias Ballauff Yan Lu Soft Matter and functional Materials Helmholtz-Zentrum Berlin für Materialien und EnergieHahn-Meitner Platz 114109 BerlinGermany Department of Applied Physics I University of Málaga29071 MálagaSpain College of Materials Science and Engineering Nanjing Tech UniversityNanjing 210000People’s Republic of China Institute of Physics University of Freiburg79104 FreiburgGermany Simulation of Energy Materials Helmholtz-Zentrum Berlin für Materialien und EnergieHahn-Meitner Platz 114109 BerlinGermany Institut für Physik Humboldt-Universitat zu BerlinNewtonstr.1512489 BerlinGermany Institute of Chemistry University of Potsdam14476 PotsdamGermany

Photothermal conversion(PTC)nanostructures have great potential for applications in many fields,and therefore,they have attracted tremendous ***,the construction of a PTC nanoreactor with multi-compartment structure to achieve the combination of unique chemical properties and structural feature is still challenging due to the synthetic ***,we designed and synthesized a catalytically active,PTC gold(Au)@polydopamine(PDA)nanoreactor driven by infrared irradiation using assembled PS-b-P2VP nanosphere as soft *** particles exhibit multi-compartment structure which is revealed by 3D electron tomography characterization *** feature permeable shells with tunable shell *** kinetics for the reduction reaction of 4-nitrophenol has been investigated using these particles as nanoreactors and compared with other reported ***,a remarkable acceleration of the catalytic reaction upon near-infrared irradiation is demonstrated,which reveals for the first time the importance of the synergistic effect of photothermal conversion and complex inner structure to the kinetics of the catalytic *** ease of synthesis and fresh insights into catalysis will promote a new platform for novel nanoreactor studies.

关键词： Gold@polydopamine 3D tomography Nanoreactor Catalysis Photothermal conversion

Identification of SUMO Targets by a Novel Proteomic Approach in Plants

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Journal of Integrative Plant Biology 2013年第1期55卷 96-107页

作者： Gema López-Torrejón Davide Guerra rafael Catal Julio Salinas Juan C. del Pozo Centro de Biotecnología y Genómica de Plantas (INIA-UPM) Campus de Montegancedo CRA-Genomics Research Centre (GPG) Centro de Investigaciones Biológicas (CSIC) Campus de la Ciudad Universitaria de Madrid

Post-translational modifications （PTMs） chemically and physically alter the properties of proteins, including their folding, subcellular localization, stability, activity, and consequently their function. In spite of their relevance, studies on PTMs in plants are still limited. Small Ubiquitin-like Modifier （SUMO） modification regulates several biological processes by affecting protein-protein interactions, or changing the subcellular Iocalizations of the target proteins. Here, we describe a novel proteomic approach to identify SUMO targets that combines 2-D liquid chromatography, immunodetection, and mass spectrometry （MS） analyses. We have applied this approach to identify nuclear SUMO targets in response to heat shock. Using a bacterial SUMOylation system, we validated that some of the targets identified here are, in fact, labeled with SUMO1. Interestingly, we found that GIGANTEA （GI）, a photoperiodic-pathway protein, is modified with SUMO in response to heat shock both in vitro and in vivo.

关键词： Mass spectrometry plants post-translational modification proteomics SUMO.

Effect of alumina content and heat treatment on microstructure and upconversion emission of Er^(3+)ions in oxyfluoride glass-ceramics

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Journal of Rare Earths 2012年第12期30卷 1228-1234页

作者： Mohammad Hasan Imanieh Bijan Eftekhari Yekta Vahak Marghussian Inocencio rafael Martin Benenzuela Alberto Hernandez Creus Saeed Shakhesi Esmaeil Eslami Department of Materials Ceramic DivisionIran University of Science and Technology Nanotechnology Department Engineering Research Institute Department of física fundamental Electrónicay SistemasUniversity of La LagunaC.Astrofísico Francisco Sánchezs/n E-38206 La LagunaTenerifeSpain MALTA Consolider Team University of La LagunaC.Astrofísico Francisco Sánchezs/n E-38206 La LagunaTenerifeSpain Department of Química física Instituto de Materialesy NanotecnologíaUniversity of La Laguna38205-La LagunaTenerifeSpain Nanotechnology Department Engineering Research Institute Tehran Department of Physics Iran University of Science and Technology (IUST)NarmakTehranIran

The effect of alumina content and heat treatment temperature and time, on microstructure and Er3＋（0.5 mol.%） emission of oxyfluoride glass-ceramics were investigated in this research. Two values of 1.8 （SA1.8Er0.5） and 2.18 （SA2.18Er0.5） were selected in this research for SiO2/Al2O3 ratio. According to DTA results, precursor glasses were heat treated at 630, 660 and 690 ℃ for 4 h and some glasses were also heat treated at 630 ℃ for 48 and 72 h. The results indicated that alumina content had significant effect on phase separation and viscosity of the glasses. Therefore the size, size distribution, and volume concentration of nano Caf2 crystals which precipitated during the heat treatment depended on alumina content of the glass. Due to the much smaller size of the precipitated Caf2 crystals in the glasses of low alumina content, these samples maintained excellent transparency and had narrower crystal size distribution than the high alumina glasses. The crystal size was increased markedly with the temperature increasing from 630 to 690 ℃. On the other hand a slight increase was observed in the crystal size by raising the heat treatment time in both glasses. Results indicated that in low alumina content glass （SA2.18Er0.5） the size of Caf2 nanocrystals was controlled in one order of magnitude. The increase of heat treatment time and temperature led to the incorporation of Er3＋ ions into Caf2 crystalline phase, increasing significantly the upconversion intensity. After heat treatment at 690 ℃for 4 h, atomic force microscope （AfM） revealed the development of small crystals with an average size of 80 and 30 nm in SA1.8Er0.5 and SA2.18Er0.5 samples, respectively.

关键词： oxyfluorides glass-ceramic Caf2 nanocrystals SiO3/Al2O3 ratio rare earths

Hormonal modulation of reproduction and fertility signaling in polistine wasps

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Current Zoology 2021年第5期67卷 519-530页

作者： Cintia Akemi OI rafael Carvalho DA SILVA Ian STEVENS Helena Mendes fERREIRA fabio Santos NASCIMENTO Tom WENSELEERS Laboratory of Socioecology and Social Evolution KU LeuvenLeuven 3000Belgium faculdade de filosofia Ciencias e Letras de Ribeirao PretoDepartamento de BiologiaUniversidade de Sao Paulo—USPRibeirao PretoSP 14040-901Brazil

In social insects,it has been suggested that reproduction and the production of particular fertilitylinked cuticular hydrocarbons(CHC)may be under shared juvenile hormone(JH)control,and this could have been key in predisposing such cues to later evolve into full-fledged queen pheromone ***,to date,only few studies have experimentally tested this“hormonal pleiotropy”***,we formally test this hypothesis using data from four species of Polistine wasps,Polistes dominula,Polistes satan,Mischocyttarus metathoracicus,and Mischocyttarus cassununga,and experimental treatments with JH using the JH analogue methoprene and the anti-JH *** line with reproduction being under JH control,our results show that across these four species,precocene significantly decreased ovary development when compared with both the acetone solvent-only control and the methoprene *** with the hormonal pleiotropy hypothesis,these effects on reproduction were further matched by subtle shifts in the CHC profiles,with univariate analyses showing that in *** and *** the abundance of particular linear alkanes and mono-methylated alkanes were affected by ovary development and our hormonal *** results indicate that in primitively eusocial wasps,and particularly in Polistes,reproduction and the production of some CHC cues are under joint JH *** suggest that pleiotropic links between reproduction and the production of such hydrocarbon cues have been key enablers for the origin of true fertility and queen signals in more derived,advanced eusocial insects.

关键词： Polistinae wasps fertility cues queen pheromones cuticular hydrocarbons juvenile hormone

在背撑蹲起和单腿支撑蹲起过程中十字韧带的受力分析(下)

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中华骨科杂志 2009年第12期29卷 1185-1188页

作者： Naiquan Zheng rafael f.Escamilla Glenn S.fleisig 美国北卡罗来纳大学夏洛特机械工程和工程科学系生物医学工程中心美国加利福尼亚大学理疗系美国运动医学中心冠军运动医学中心安德鲁斯研究教育中心

结果 6为十字韧带力的平均值曲线,十字韧带力在三种蹲起之间差异有统计学意义(P<0.001),在10个膝关节屈曲角度之间差异有统计学意义(P<0.001),在蹲起的两相之间差异也有统计学意义(P<0.001).

关键词：单腿支撑过程十字韧带统计学意义差异屈曲角度均值曲线膝关节两相