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e.dosomal e.cape.of prote.n nanoparticle. e.gine.re. through humanize. histidine.rich pe.tide.

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Scie.ce.China Mate.ials 2020年第4期63卷 644-653页

作者： He.tor Lope.-Laguna rafael Cubarsi Ugutz Unzue.a Ramon Mangue. e.the. Vazque. Antonio Villave.de Institut de.Biote.nologia i de.Biome.icina Universitat Aut6noma de BarcelonaBellaterra08193 BarcelonaSpain De.artame.t de.Ge.e.ica i de.Microbiologia Universitat Aut6noma de BarcelonaBellaterra08193 BarcelonaSpain CIBe. de.Bioinge.ie.ia Biomateriales y Nanomedicina(CIBER-BBN)C/Monforte de Lemos 3-528029 MadridSpain De.artame.t de.Mate.atique. Universitat Politecnica de Catalunya08034BarcelonaSpain Institut d'Inve.tigacions Biome.ique. Sant Pau Hospital de la Santa Creu i Sant Pau08025 BarcelonaSpain

Poly-histidine.pe.tide. such as H6(HHHHHH)are.use. in prote.n biote.hnologie. as purification tags,prote.n-asse.bling age.ts and e.dosomal-e.cape.*** ple.otropic prope.tie. of such pe.tide. make.the. appe.ling to de.ign prote.n-base. smart mate.ials or nanoparticle. for imaging or drug de.ive.y to be.produce. in form of re.ombinant ***,the.clinical applicability of H6-tagge. prote.ns is re.tricte. by the.pote.tial immunoge.icity of the.e.*** this study,we.have.e.plore. se.e.al humanize. histidine.rich pe.tide. in tumor-targe.e. modular prote.ns,which can spe.ifically bind and be.inte.nalize. by the.targe. ce.ls through the.tumoral marke. *** we.e.particularly inte.e.te. in e.ploring how prote.n purification,se.f-asse.bling and e.dosomal e.cape.pe.form in prote.ns containing the.variant histidine.rich *** the.te.te. candidate.,the.pe.tide.H5 e.He.e.e.e.)is promising as a good promote. of e.dosomal e.cape.of the.associate. fullle.gth prote.n upon e.dosomal *** nume.ical mode.ling of ce.l pe.e.ration and e.dosomal e.cape.of the.te.te. prote.ns has re.e.le. a ne.ative.re.ationship be.we.n the.amount of prote.n inte.nalize. into targe. ce.ls and the.e.ficie.cy of cytoplasmic *** fact de.onstrate. that the.His-me.iate.,proton sponge.base. e.dosomal e.cape.saturate. at mode.ate.amounts of inte.nalize. prote.n,a fact that might be.critical for the.de.ign of prote.n mate.ials for cytosolic mole.ular de.ive.y.

关键词： prote.n mate.ials nanoparticle. ge.e.ic de.ign e.dosomal e.cape poly-histidine.

Se.e.tive.logging alte.s allome.ric re.ationships of five.tropical tre. spe.ie. in se.sonal se.i-de.iduous fore.ts

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Journal of Fore.try Re.e.rch 2019年第5期30卷 1633-1639页

作者： Die.o Re.e.de.Rodrigue. Yve. rafael Bovole.ta José Antonio Pime.ta e.milson Bianchini De.artame.to de.Biologia Animal e.Ve.e.al Centro de Ciências Biológicas Universidade Estadual de Londrina

In se.e.tive.y logge. fore.ts,tre.s are.more.like.y to e.pand the.r diame.e.s(D)at the.e.pe.se.of he.ght(H)growth,re.ulting in variations in H:D *** study e.amine. how se.e.tive.logging affe.ts the.H:D allome.ric re.ationships of five.common tre. spe.ie. and whe.he. the.e.fe.ts vary with functional groups(shade.intole.ant or shade.tole.ant)in se.sonal se.i-de.iduous *** of five.spe.ie. in a 3000 m^2(0.3 ha)plot we.e.marke. and he.ghts and diame.e.s *** of the.spe.ie.,with one.e.ce.tion,showe. gre.te. inve.tme.t in diame.e. pe. incre.e.t of he.ght compare. to an unlogge. fore.t,possibly be.ause.of the.gre.te. light *** study shows the.e.fe.ts of se.e.tive.logging on spe.ie. populations as e.ide.ce. by incre.se. in H:D *** of fore.t fragme.ts with diffe.e.t de.re.s of human impact is important be.ause.it allows us to unde.stand the.diffe.e.ce. in archite.tural characte.istics cause. by se.e.tive.logging.

关键词： Allome.ry Anthropic e.ploitation e.ological groups Luminosity Se.e.tive logging

Continuous Action Re.nforce.e.t Le.rning for Control-Affine.Syste.s with Unknown Dynamics

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Ie.e.CAA Journal of Automatica Sinica 2014年第3期1卷 323-336页

作者： Ale.sandra Faust Pe.e. Ruymgaart Molly Salman rafael Fie.ro Lydia Tapia the.De.artme.t of Compute. Scie.ce University of New Mexico the.Compute. Scie.ce.De.artme.t Austin College the.De.artme.t of e.e.trical and Compute. e.gine.ring University of New Mexico

Control of nonline.r syste.s is challe.ging in *** making,pe.forme. many time. pe. se.ond,must e.sure.syste. *** input to pe.form a task ofte. involve. solving a nonline.r syste. of diffe.e.tial e.uations,which is a computationally inte.sive.if not intractable.*** article.propose. sampling-base. task le.rning for controlaffine.nonline.r syste.s through the.combine. le.rning of both state.and action-value.functions in a mode.-fre. approximate.value.ite.ation se.ting with continuous inputs.A quadratic ne.ative.de.inite.state.value.function implie. the.e.iste.ce.of a unique.maximum of the.action-value.function at any *** allows the.re.lace.e.t of the.standard gre.dy policy with a computationally e.ficie.t policy approximation that guarante.s progre.sion to a goal state.without knowle.ge.of the.syste. *** policy approximation is consiste.t,i.e.,it doe. not de.e.d on the.action sample. use. to calculate.*** me.hod is appropriate.for me.hanical syste.s with high-dime.sional input space. and unknown dynamics pe.forming Constraint-Balancing *** ve.ify it both in simulation and e.pe.ime.tally for an Unmanne. Ae.ial Ve.icle.(UAVs) carrying a suspe.de. load,and in simulation,for the.re.de.vous of he.e.oge.e.us robots.

关键词： Control syste.s Nonline.r dynamical syste.s Robots Ve.icle.dynamics Function approximation Le.rning (artificial inte.lige.ce.

Light-drive. micro-tool e.uippe. with a syringe.function

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Light(Scie.ce.& Applications) 2016年第1期5卷 499-505页

作者： Mark Jayson Villangca Darwin Palima Andre. rafael Bañas Je.pe. Glückstad DTU Fotonik Department of Photonics EngineeringTechnical University of DenmarkDK-2800Kgs.LyngbyDenmark OptoRobotix ApS Scion DTUDiplomvej 381DK-2800Kgs.LyngbyDenmark

Le.e.aging de.e.opme.ts in microfabrication ope. ne. possibilitie. for optical *** the.structural de.ign fre.dom from thre.-dime.sional printing capabilitie. of two-photon polyme.ization,we.are.starting to se. the.e.e.ge.ce.of cle.e.ly shape.‘light robots’or optically actuate. micro-tools that close.y re.e.ble.the.r macroscopic counte.parts in function and some.ime. e.e. in *** this work,we.have.fabricate. a ne. type.of light robot that is capable.of loading and unloading cargo using photothe.mally induce. conve.tion curre.ts within the.body of the.*** have.de.onstrate. this using silica and polystyre.e.be.ds as *** flow spe.ds of the.cargo during loading and unloading are.significantly large. than whe. using optical force. *** ne. type.of light robot pre.e.ts a mode.of mate.ial transport that may have.a significant impact on targe.e. drug de.ive.y and nanofluidics inje.tion.

关键词： mate.ial transport optical manipulation the.mal conve.tion two-photon fabrication

e.fe.ts of natural mine.al-rich wate. consumption on the.e.pre.sion of sirtuin 1 and angioge.ic factors in the.e.e.tile.tissue.of rats with fructose.induce. me.abolic syndrome

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Asian Journal of Andrology 2014年第4期16卷 631-638页

作者： Cidalia D Pe.e.ra Milton Se.e.o Luisa rafael Maria Joao Martins De.minda Ne.e. De.artme.t of Bioche.istry Faculty of Medicine University of Porto De.artme.t of Clinical e.ide.iology Predictive Medicine and Public Health Faculty of Medicine University of Porto De.artme.t of Clinical Pathology Sao Joao Hospital Centre EPE De.artme.t of e.pe.ime.tal Biology Faculty of Medicine and Institute for Molecular and Cell Biology (IBMC) University of Porto Portugal.

Consuming a high-fructose.die. induce. me.abolic syndrome.（MS）-Iike.fe.ture., including e.dothe.ial dysfunction. e.e.tile.dysfunction is an e.rly manife.tation of e.dothe.ial dysfunction and syste.ic vascular dise.se. Be.ause.mine.al de.icie.cy inte.sifie. the.de.e.e.ious e.fe.ts of fructose.consumption and mine.al inge.tion is prote.tive.against MS, we.aime. to characte.ize.the.e.fe.ts of 8we.ks of natural mine.al-rich wate. consumption on the.structural organization and e.pre.sion of vascular growth factors and re.e.tors on the.corpus cave.nosum （CC） in 10% fructose.fe. Sprague.Dawle. rats （FRUCT）. Diffe.e.ce. we.e.not obse.ve. in the.organization of the.CC e.the. on the.e.pre.sion of vascular e.dothe.ial growth factor （Ve.F） or the.compone.ts of the.angiopoie.ins/Tie. syste.. Howe.e., opposing e.pre.sion patte.ns we.e.obse.ve. for Ve.F re.e.tors （an incre.se.and a de.re.se.for Ve.FR1 and Ve.FR2, re.pe.tive.y） in FRUCT animals, with the.e.patte.ns be.ng stre.gthe.e. by mine.al-rich wate. inge.tion. Mine.al-rich wate. inge.tion （FRUCTMIN） incre.se. the.proportion of smooth muscle.ce.ls compare. with FRUCT rats and induce. an upre.ulatory te.de.cy of sirtuin I e.pre.sion compare. with the.control and FRUCT groups. We.te.n blot re.ults we.e.consiste.t with the.dual immunofluore.ce.ce.e.aluation. Plasma oxidize. low-de.sity lipoprote.n and plasma te.toste.one.le.e.s we.e.similar among the.e.pe.ime.tal groups, although a te.de.cy for an incre.se.in the.forme. was obse.ve. in the.FRUCTMIN group. The.mine.al-rich wate.-tre.te. rats pre.e.te. change. similar to those.obse.ve. in rats tre.te. with MS-prote.tive.polyphe.ol-rich be.e.age. or subje.te. to e.e.gy re.triction, which le. us to hypothe.ize.that the.e.fe.ts of mine.al-rich wate. consumption may be.more.vast than those.dire.tly obse.ve. in this study.

关键词： angiopoie.ins e.e.tile.tissue hype.saline.sodium-rich naturally sparkling mine.al wate. re.e.tors sirtuin 1 vasculare.dothe.ial growth factor

ACe.Score.Ide.tifie. HBe.g-ne.ative.Inactive.Carrie.s at a Single.point e.aluation,Re.ardle.s of HBV Ge.otype

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Journal of Clinical and Translational He.atology 2022年第6期10卷 1068-1076页

作者： Luisa Roade.Mar Rive.ro-Barcie.a Adriana Palom Francisco Rodrígue.-Frías Marta Be. Ariadna Rando María Te.e.a Salce.o Rosario Casillas e.e.a Vargas-Accarino David Tabe.ne.o Silvia Saule.a rafael e.te.an María Buti Live. Unit Internal Medicine DepartmentHospital Universitari Vall d’HebronVall d’Hebron Barcelona Hospital CampusBarcelonaSpain Unive.sitat Autònoma de.Barce.ona(UAB) Department of MedicineBarcelonaSpain Unive.sitat Au-tònoma de.Barce.ona(UAB) Department of Biochemistry and Molecular BiologyBarcelonaSpain Ce.tro de.Inve.tigación Biomédica e. Re. de.e.fe.me.ade. He.áticas y Dige.tivas(CIBe.e.d) Instituto de Salud Carlos IIIMadridSpain Live. Pathology Lab Biochemistry and Microbiology Departments(Clinical Laboratories)Hospital Universitari Vall d’HebronVall d’Hebron Barcelona Hospital CampusBarcelonaSpain Vall d’He.ron Institut de.Re.e.ca(VHIR) Liver Diseases GroupBarcelonaSpain Transfusion Safe.y Laboratory Banc de Sang i TeixitsServei Catalàde la SalutBarcelonaSpain De.partme.t of Pathology Hospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelonaSpain

Background and Aims:He.atitis B virus(HBV)biomark-e.s have.be.n use. for a be.te. cate.orization of patie.ts,e.e. though the.lack of simple.algorithms and the.impact of ge.otype. limit the.r *** aim was to asse.s the.use.ulne.s of noninvasive.marke.s for the.ide.tification of HBV inactive.carrie.s(ICs)in a single.point e.aluation and to de.ign a pre.ictive.mode. for the.r ***-ods:This re.rospe.tive.prospe.tive.study include. 343 conse.utive.HBe.g-ne.ative.***,analytical,and virological data we.e.colle.te.,and a live. biopsy was pe.forme. if *** we.e.classifie. at the.e.d of follow-up as ICs,chronic he.atitis B and gray zone.A pre.dictive.mode. was constructe.,and validate. by 1000-boot-strap ***:Afte. 39 months of follow-up,298 subje.ts we.e.ICs,36 we.e.chronic he.atitis B CHB,and nine.we.e.gray ***-nine.25.9%)individuals re.quire. a live. *** HBV DNA hazard ratio(HR)6.0,pe.re.ate. antige.(HBcrAg)(HR 6.5,pe.astography(HR 4.6,pe.e.inde.pe.de.tly associate. with the.IC *** ACe.score.HBV DNA,HBcrAg,e.astography),obtaine. by bootstrapping,yie.de. an are. unde. the.re.e.ve. ope.ating characte.is-tics(AUROC)of 0.925(95%CI:0.880-0.970,pe.tification of *** AUROC for ge.otype.D was 0.95,0.96 for A,0.90 for e.and 0.88 for H/*** ACe.score.ofe.pre.ictive.value.of 99.5%,and a score.12 points had a diagnostic accuracy of 93.8%.Conclusions:Low base.ine.HBV DNA,HBcrAg,and live. stiffne.s we.e.in-de.e.de.tly associate. with the.IC phase.A score.including those.variable. ide.tifie. ICs at a single.point e.aluation,and might be.applie. to imple.e.t le.s inte.sive.follow-up strate.ie..

关键词： He.atitis B virus Inactive.carrie. Live. stiffne.s HBV DNA Quan-titative.HBsAg Core.re.ate. antige..

Simulations on the.multi-she.l targe. ignition drive. by radiation pulse.in Z-pinch dynamic hohlraum

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Chine.e.Physics B 2021年第11期30卷 411-418页

作者：陈诗佳马燕云吴福源杨晓虎袁赟崔野 rafael Ramis De.artme.t of Physics National University of Defense TechnologyChangsha 410073China IFSA Collaborative.Innovation Ce.te. Shanghai Jiao Tong UniversityShanghai 200240China Colle.e.of Advance. Inte.disciplinary Studie. National University of Defense TechnologyChangsha 410073China Laboratory of Lase. Plasmas School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China e.T.S.I.Ae.onautica y de. e.pacio Universidad Politecnica de MadridSpain

We.pre.e.t the.first simulation re.ults of a multi-she.l targe. ignition drive. by Z-pinch dynamic hohlraum radiation *** radiation pulse.is produce. with a spe.ial Z-pinch dynamic hohlraum configuration,whe.e.the.hohlraum is compose. of a single.me.al line.,a low-Z plastic foam,and a high-Z me.allic *** implosion dynamics of a hohlraum and a multi-she.l targe. are.inve.tigate. se.arate.y by the.one.dime.sional code.*** the.pe.k drive.curre.t is 50 MA,simulations sugge.t that an x-ray pulse.with ne.rly constant radiation te.pe.ature.-310 e.)and a duration about 9 ns can be.obtaine..A small multi-she.l targe. with a radius of 1.35 mm drive. by this radiation pulse.is able.to achie.e.volume.ric ignition with an e.e.gy gain(G)about 6.19,whe.e.G is the.ratio of the.yie.d to the.absorbe. *** this re.e.rch,we.be.te. unde.stand the.e.fe.ts of non-uniformitie. and hydrodynamics instabilitie. in Z-pinch dynamic hohlraum.

关键词： Z-pinch dynamic hohlraum radiation pulse volume.ric ignition

Primary colonic type.ade.ocarcinoma of the.ce.al appe.dix pre.e.te. as obstructive.acute.abdominal syndrome

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The.Chine.e.Ge.man Journal of Clinical Oncology 2006年第6期5卷 458-459页

作者： Gabrie. J.Arisme.di-Morillo rafael e.Ae.-More.o Mary C.Fe.nánde.-Abre. De.artme.t of Pathology Hospital General del Sur "Dr.Pedro Iturbe"Maracaibo-Venezuela Institute of Biological Investigations-Electron Microscopy LaboratoryFaculty of MedicineUniversity of ZuliaMaracaibo-Venezuela De.artme.t of Surge.y Hospital General del Sur "Dr.Pedro Iturbe"Maracaibo-Venezuela De.artme.t of Inte.nal Me.icine Hospital General del Sur "Dr.Pedro Iturbe"Maracaibo-Venezuela

We.re.orte. a case.with an obstructive.acute.abdome.,and e.e.ge.cy e.ploratory laparotomy was ***-pe.dice.l ne.plasm was obse.ve. adhe.e. to the.ile.m,and an ile.he.icole.tomy was *** the.histopathological point of vie. the.ne.plasm was an infiltrating colonic type.ade.ocarcinoma of the.appe.dix,with e.te.sion to the.pe.iape.dicular adipose.tissue.and fixation of an adjace.t ile.l loop se.ondary to infiltration of the.inte.tinal *** tumor produce. a mode.ate.luminal ste.osis of the.inte.tine.this e.plaine. the.clinical manife.tations of the.***-ope.ative.e.olution was satisfac-tory and the.e.had be.n no signs of re.urre.ce.in the.5 ye.rs since.the.*** upon the.comparison of clinical char-acte.istics,pathological be.avior(in re.ation to the.growth and disse.ination),and the.ape.tic conside.ations,possibly colonic type.ade.ocarcinoma of the.appe.dix is a ne.plasm similar to the.carcinomas of asce.ding colon.

关键词：结肠阑尾肿瘤回肠组织病理学

高密度等离子体喷流高速对撞的二维辐射流体模拟研究

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物理学报 2022年第22期71卷 192-200页

作者：杨孟奇吴福源陈致博张翼翔陈一张晋川陈致真方志凡 rafael Ramis 张杰上海交通大学物理与天文学院激光等离子体教育部重点实验室上海200240 上海交通大学致远学院上海200240 上海交通大学IFSA协同创新中心上海200240 西班牙马德里理工大学航空航天学院马德里28040

等离子体喷流对撞是天体物理和激光等离子体物理中常见的流体力学现象.构建对撞等离子体状态和喷流初始条件的流体定标关系,对于相关实验的物理设计和数据分析具有重要意义.本文采用最新升级的二维自由拉格朗日辐射流体模拟程序MULTI-2D... 详细信息

等离子体喷流对撞是天体物理和激光等离子体物理中常见的流体力学现象.构建对撞等离子体状态和喷流初始条件的流体定标关系,对于相关实验的物理设计和数据分析具有重要意义.本文采用最新升级的二维自由拉格朗日辐射流体模拟程序MULTI-2D,研究了高速(≥100 km/s)、高密度(≥10 g/cm^(3))条件下的喷流对撞过程.基于不同条件下等离子体喷流高速对撞过程的模拟数据,通过机器学习中的贝叶斯推断方法构建了描述等离子体喷流对撞过程的流体定标规律.研究结果表明:锥形等离子体喷流对撞易于形成等容分布的高密度等离子体;提高喷流的初始密度和速度,有利于提高对撞等离子体的密度和温度;提高喷流的初始温度,有利于提高对撞后的温度,但会降低对撞后的等离子体密度.当等离子体喷流的初始密度、温度和速度分别设定为15 g/cm^(3), 30 e.和300 km/s时,对撞后的等离子体密度可以达到300 g/cm^(3)以上,这对于双锥对撞点火方案中的快电子加热过程非常重要.

关键词：等离子体喷流机器学习流体定标律双锥对撞点火