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Production, Detection and Cross-Reactivity of Anti-Polysaccharide Antibodies from Environmental Fungi

Advances in Bioscience and Biotechnology 2014年第10期5卷 815-822页

作者： rafael andrade menolli Thais Soprani Ayala Pablo Rodrigo da Rosa Claudia Rejane Lima de Macedo Costa Erica Fernanda Osaku Rosiane G. Mello Zibetti Centro de Ciências Médicas e Farmacêuticas Universidade Estadual do Oeste do Paraná Cascavel Brasil Centro de Ciências Biológicas e da Saúde Universidade Estadual do Oeste do Paraná Cascavel Brasil Faculdades Pequeno Príncipe Curitiba Brasil

The diagnosis of Invasive Fungal Disease (IFD) is difficult because the sensitivity of conventional culture and cytology methods for the detection of Aspergillus is poor, and because serological methods exhibit cross-reactivity with environmental fungi. Fungal polysaccharides are of particular interest in the serologic diagnosis of IFD, especially galactomannan (GM) and glucan, which have been recognized as useful tools for the diagnosis of fungal infections. Further investigation into polysaccharide antibody cross-reactivity is important in improving diagnostic tests. Our aim was to verify the production of antibodies against fungal antigens in mice immunized with exopolysaccharides (EPS) obtained from three fungal species (Aspergillus terreus, Paecilomyces variotii and Curvularia brachyspora). ELISA assays were performed to evaluate homologous and heterologous reactions and showed anti-polysaccharide antibodies production. EPS from A. terreus was immunogenic enough to immunize the animal and lead to antibody production against this EPS. In addition, no cross-reactivity was observed with EPS obtained from P. variotii and C. brachyspora. The EPS from P. variotii did not exhibit good immunogenicity, whereas EPS from C. brachyspora showed good immunogenicity, and heterologous reactions were detected on the ELISA assays performed using the EPS from this species. The results indicate that immunization can occur for environmental fungal polysaccharides, generating antibodies may be interfere in serological diagnosis that are based on detection of fungal polysaccharides, mainly glucans and galactomannans.

关键词： Exopolysaccharides Environmental Fungi Immunization

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Inductive Model Generation for Text Classification Using a Bipartite Heterogeneous Network

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Journal of Computer Science & Technology 2014年第3期29卷 361-375页

作者： rafael Geraldeli Rossi Alneu de andrade Lopes Thiago de Paulo Faleiros Solange Oliveira Rezende Institute of Mathematics and Computer Science University of So PauloSo CarlosBrasil

Algorithms for numeric data classification have been applied for text classification. Usually the vector space model is used to represent text collections. The characteristics of this representation such as sparsity and high dimensionality sometimes impair the quality of general-purpose classifiers. Networks can be used to represent text collections, avoiding the high sparsity and allowing to model relationships among different objects that compose a text collection. Such network- based representations can improve the quality of the classification results. One of the simplest ways to represent textual collections by a network is through a bipartite heterogeneous network, which is composed of objects that represent the documents connected to objects that represent the terms. Heterogeneous bipartite networks do not require computation of similarities or relations among the objects and can be used to model any type of text collection. Due to the advantages of representing text collections through bipartite heterogeneous networks, in this article we present a text classifier which builds a classification model using the structure of a bipartite heterogeneous network. Such an algorithm, referred to as IMBHN （Inductive Model Based on Bipartite Heterogeneous Network）, induces a classification model assigning weights to objects that represent the terms for each class of the text collection. An empirical evaluation using a large amount of text collections from different domains shows that the proposed IMBHN algorithm produces significantly better results than k-NN, C4.5, SVM, and Naive Bayes algorithms.

关键词： heterogeneous network text classification inductive model generation

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Bifid pancreatic tail as cause of acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 480-481页

作者： Hanna rafaela Ferreira Dalla Pria rafael andrade Santiago Fernanda Garozzo Velloni Giuseppe D’ippolito Department of Imaging Universidade Federal de Sao PauloSao PauloBrazil Diagnos ticos da Ametica S.A.DASA. Sao PauloBrazil Grupo Fleury Sao PauloBrazil

To the Editor:Wepresentacaseofa22-year-oldwomanwithrecurrent episodes of acute pancreatitis. The patient had no known risk factors such as history of alcoholism, smoking, pre-existing medical conditions, family member... 详细信息

关键词： pre-existing medicall dilatation or cholelithiasis

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Contribution of inrush current to mechanical failure of power transformers windings

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High Voltage 2019年第4期4卷 300-307页

作者： rafael M.R.Barros Edson Gda Costa Jalberth F.Araujo Filipe L.Mde andrade Tarso V.Ferreira Department of Electrical Engineering Federal University of Campina GrandeAprigio Veloso St.882Campina GrandeBrazil

This work presents a study regarding the contribution of inrush current to the occurrence of mechanical fatigue in windings of a power transformer and,consequently,the impact of that phenomenon on the equipment's *** order to perform the study,electromagnetic transient simulations were used to determine the inrush current in a three-phase transformer ***,three-dimensional simulations,based on the finite element method,were performed to determine the electromechanical stresses in the equipment windings,under the effect of the inrush ***,the methods of critical plans and Palmgren–Miner were applied to perform the fatigue *** the results,the impact of inrush current on the integrity of the transformer's windings was determined,as well as,to estimate the reduction of lifespan of the equipment due to inrush *** number of inrushes needed for the total reduction of lifespan of the equipment due to mechanical fatigue was also *** results can be used in the transformers design stage,with the purpose of assisting the evaluation of mechanical withstand of equipment,which can minimise the possibility of failure and increase its lifespan.

关键词： winding fatigue power

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Multidimensional Projections for Visual Analysis of Social Networks

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Journal of Computer Science & Technology 2012年第4期27卷 791-810页

作者： rafael Messias Martins Gabriel Faria Andery Henry Heberle Fernando Vieira Paulovich Alneu de andrade Lopes Helio Pedrini Rosane Minghim Institute of Mathematics and Computer Science University of Sao PauloSao Carlos 13566-590Brazil CPM Braxis Capgemini Sao Paulo 04543-900Brazil Institute of Computing University of CampinasCampinas-SP 13083-852Brazil

Visual analysis of social networks is usually based on graph drawing algorithms and tools. However, social networks are a special kind of graph in the sense that interpretation of displayed relationships is heavily dependent on context. Context, in its turn, is given by attributes associated with graph elements, such as individual nodes, edges, and groups of edges, as well as by the nature of the connections between individuals. In most systems, attributes of individuals and communities are not taken into consideration during graph layout, except to derive weights for force-based placement strategies. This paper proposes a set of novel tools for displaying and exploring social networks based on attribute and connectivity mappings. These properties are employed to layout nodes on the plane via multidimensional projection techniques. For the attribute mapping, we show that node proximity in the layout corresponds to similarity in atgribute, leading to easiness in locating similar groups of nodes. The projection based on connectivity yields an initial placement that forgoes force-based or graph analysis algorithm, reaching a meaningful layout in one pass. When a force algorithm is then applied to this initial mapping, the final layout presents better properties than conventional force-based approaches. Numerical evaluations show a number of advantages of pre-mapping points via projections. User evaluation demonstrates that these tools promote ease of manipulation as well as fast identification of concepts and associations which cannot be easily expressed by conventional graph visualization alone. In order to allow better space usage for complex networks, a graph mapping on the surface of a sphere is also implemented.

关键词： social network visual exploration multidimensional visualization

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Gastric mucosa-associated lymphoid tissue lymphomas and Helicobacter pylori infection:A Colombian perspective

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World Journal of Gastroenterology 2012年第7期18卷 685-691页

作者： Sally Yepes Maria Mercedes Torres Carlos Saavedra rafael andrade Institute of Genetics Universidad Nacional de Colombia14490 Bogotá DCColombia Department of Pathology Fundación Santa Fe de Bogotá220246 Bogotá DCColombia Human Genetics Laboratory Universidad de los Andes4976 Bogotá DCColombia Faculty of Medicine Universidad Nacional de Colombia14490 Bogotá DCColombia

AIM： To assess the significance of chromosome translo- cation t（11;18）（q21;q21）, B-cell lymphoma 10 （BCL-10） protein and He/icobacter py/ori （H. py/on） infection in gastric mucosa-associated lymphoid tissue ... 详细信息

关键词： Mucosa-associated lymphoid tissue lympho-ma Helicobacter pylori Treatment t(11 18)(q21 q21 ) B-cell lymphoma 10

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Perspectives of nano-carrier drug delivery systems to overcome cancer drug resistance in the clinics

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Cancer Drug Resistance 2021年第1期4卷 44-68页

作者： Anna Ulldemolins Joaquin Seras-Franzoso Fernanda andrade Diana rafael Ibane Abasolo Petra Gener Simo Schwartz Jr Drug Delivery and Targeting Group Molecular Biology and Biochemistry Research Centre for Nanomedicine(CIBBIM-Nanomedicine)Vall d’Hebron Institut de RecercaUniversitat Autonoma de BarcelonaBarcelona 08035Spain Networking Research Centre for Bioengineering Biomaterialsand Nanomedicine(CIBER-BBN)Instituto de Salud Carlos IIIZaragoza 50009Spain

Advanced cancer is still considered an incurable disease because of its metastatic spread to distal organs and progressive gain of *** though considerable treatment progress and more effective therapies have been achieved over the past years,recurrence in the long-term and undesired side effects are still the main drawbacks of current clinical ***,a majority of chemotherapeutic drugs are highly hydrophobic and need to be diluted in organic solvents,which cause high toxicity,in order to reach effective therapeutic *** limitations of conventional cancer therapies prompted the use of nanomedicine,the medical application of nanotechnology,to provide more effective and safer cancer *** of nanomedicines to overcome resistance,ameliorate solubility,improve pharmacological profile,and reduce adverse effects of chemotherapeutical drugs is thus highly *** use in the clinical setting has increased over the last *** the various existing nanosystems,nanoparticles have the ability to transform conventional medicine by reducing the adverse effects and providing a controlled release of therapeutic ***,their small size facilitates the intracellular ***,we provide a closer review of clinical prospects and mechanisms of action of nanomedicines to overcome drug *** significance of specific targeting towards cancer cells is debated as well.

关键词： Drug delivery systems resistance nanomedicine cancer treatment

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Technological Perspectives for Propulsion on Nuclear Attack Submarines

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World Journal of Nuclear Science and Technology 2018年第1期8卷 1-10页

作者： rafael Radé Pacheco Delvonei Alves de andrade Nuclear and Energy Research Institute Instituto de Pesquisas Energéticas e Nucleares S&atilde o Paulo Brazil

This work aims to present the historical context in which the current understanding of the phenomenon of the direct contact condensation started to call the scientific society attention. The development of nuclear power plants Light Water Reactors demanded a safe way to collect and treat the water used to cool the reactor. Some characteristics of this water in a high energetic thermodynamic state made it unsuitable to be directly discharged in the atmosphere. Small room relieves tanks were developed to contain this discharge. These tanks were partially fulfilled with water, and the vapor injection created a vapor plume. In the interface of liquid and vapor, the thermal exchange would be increased by the characteristic turbulence of this region.

关键词： Direct Contact Condensation DCC Relief Tank Nuclear Power Plants Vapor Discharge

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Using a Health Level 7 Interoperability Bus to Support Legacy Systems in the Health Domain

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E-Health Telecommunication Systems and Networks 2013年第4期2卷 72-80页

作者： rafael andrade Aldo von Wangenheim Alexandre Savaris Karine Petry INCoD Brazilian Digital Convergence Institute Federal University of Santa Catarina—UFSC Florianopolis Brazil INCoD Brazilian Digital Convergence Institute Federal University of Santa Catarina—UFSC Florianopolis Brazil Federal Institute of Santa Catarina—IFSC Florianopolis Brazil

In order to reduce the effort in the integration and actualization of heterogeneous healthcare legacy systems that should share a common database, we propose the creation of an interoperability bus using the HL7 standard—the HL7Middleware. This interoperability bus is an intermediate layer responsible for the communication between a database, health information systems and medical equipment, called HL7Server. Connected systems use the HL7 messaging semantics to store and retrieve data from the database. We validate our approach with respect to two different criteria: performance and integration costs. Benchmark tests were executed with and without the use of HL7Middleware and with different network bandwidths. These results demonstrated that the performance of the interoperability bus is higher when compared to traditional database access for larger volumes of data and when the bandwidth of the user is considerably lower than the bandwidth of the connection between HL7Server and database. The overall development and deployment cost was considered low and the reusability degree of wrapper code was considered high, thus suggesting a progressive reduction of the integration costs of additional services and subsystems of an organization.

关键词： Middleware Healthcare Interoperability Bus Legacy System HL7 Telemedicine

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Platelet-rich plasma vs bone marrow aspirate concentrate:An overview of mechanisms of action and orthobiologic synergistic effects

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World Journal of Stem Cells 2021年第2期13卷 155-167页

作者： JoséFábio Santos Duarte Lana Lucas Furtado da Fonseca rafael da Rocha Macedo Tomas Mosaner William Murrell Ashok Kumar Joseph Purita Marco Antonio Percope de andrade Department of Orthopedics The Bone and Cartilage InstituteIndaiatuba 13334-170SPBrazil Department of Orthopedics The Federal University of São PauloSão Paulo 04023-062SPBrazil Department of Orthopedics Rede D’Or Unit IFOR HospitalSão Bernardo do Campo 09715-021SPBrazil Department of Orthopaedics Healthpoint UAEAbu Dhabi 00000United Arab Emirates Department of Orthopaedics My Doc Specialist Medical CentreDubai 00000United Arab Emirates Department of Orthopedics Institute of Regenerative MedicineBoca RatonFL 33432United States Department of Orthopaedic Federal University of Minas GeraisBelo Horizonte 31270-901MGBrazil

The use of orthobiologics as a novel therapy for the treatment of numerous musculoskeletal disorders has increased considerably over the past ***,there are multiple alternatives available as suitable treatments;however,the use of autologous blood-derived products such as platelet-rich plasma(PRP),bone marrow aspirate(BMA)and BMA concentrate(BMAC),specifically,is *** many investigations attempted to demonstrate the effectiveness of these therapies,even with positive results,the literature lacks standardized protocols and overall accuracy in study designs,which leads to variance and difficulty in reproducibility of *** efficacy of PRP for the treatment of cartilage,bone and muscle tissues is well *** BMAC has generated optimistic results for the same purposes,its applicability in clinical trials is still relatively recent when compared to *** products demonstrate the potential to set forth reparative processes,each in their own distinct *** combination of these biological products has been previously proposed,yet little is known about their *** indicates that growth factor,cytokine,and chemokine profiles seen in both PRP and BMAC vary but are likely to work synergistically to enhance musculoskeletal *** products seem to work well without PRP;however,the addition of PRP to BMAC has been shown to act as a rich and natural source of culture medium for stem cells located either peripherally or in the bone marrow ***,additional variables associated with the use of BMAC and PRP in orthopedics must be further evaluated in order to consolidate the efficacy of this therapeutic strategy.

关键词： Orthobiologics Platelet-rich plasma Bone-marrow aspirate Regenerative medicine Musculoskeletal diseases Stem cells

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