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Simulation of the oxidative metabolization pattern of netupitant,an NK1 receptor antagonist,by electrochemistry coupled to mass spectrometry

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Journal of Pharmaceutical Analysis 2021年第5期11卷 661-666页

作者： Ruxandra Chira Jens Fangmeyer Ioan O.Neaga Valentin Zaharia Uwe Karst Ede Bodoki radu oprean Analytical Chemistry Department “Iuliu Hat¸ieganu”University of Medicine and Pharmacy400349Cluj-NapocaRomania University of Münster Institute of Inorganic and Analytical Chemistry48149MünsterGermany Organic Chemistry Department “Iuliu Hat¸ieganu”University of Medicine and Pharmacy400012Cluj-NapocaRomania

Considering the frequent use of netupitant in polytherapy,the elucidation of its oxidative metabolization pattern is of major ***,there is a lack of published research on the redox behavior of this novel neurokinin-1 receptor ***,this study was performed to simulate the intensive hepatic biotransformation of netupitant using an electrochemically driven *** of the known enzyme-mediated reactions occurring in the liver(i.e.,N-dealkylation,hydroxylation,and Noxidation)were successfully mimicked by the electrolytic cell using a boron-doped diamond working *** products were separated by reversed-phase high-performance liquid chromatography and identified by high-resolution mass *** from its ability to pinpoint formerly unknown metabolites that could be responsible for the known side effects of netupitant or connected with any new perspective concerning future therapeutic indications,this electrochemical process also represents a facile alternative for the synthesis of oxidation products for further in vitro and in vivo studies.

关键词： Netupitant Oxidative metabolism Neurokinin-1 antagonist EC/LC/MS

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Collaborating remotely:an evaluation of immersive capabilities on spatial experiences and team membership

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International Journal of Digital Earth 2018年第4期11卷 420-436页

作者： Danielle oprean Mark Simpson Alexander Klippel Department of Architecture The Pennsylvania State UniversityUniversity ParkPAUSA Department of Geography The Pennsylvania State UniversityUniversity ParkPAUSA

Today’s workforce environments are steadily becoming more distributed across the globe,calling for improved ways of facilitating collaborations at a distance,including geo-collaborations or collaborations at critical *** technology is allowing distributed teams to move away from traditional conference rooms,taking collaborations into the field and giving remote teams more information about the *** idea of situating a remote collaborator’s experiences in the field,virtually,promises to enhance the understanding of geographically remote *** technologies in virtual reality(VR)hold promise for providing mobile spatial experiences in real-time,without being tied to fixed hardware,such as systems in conference *** exploratory study using VR technology on remote user experiences in a collaboration was conducted to identify the added value for remote *** findings suggest immersive capabilities improve feelings of presence in the remote locations and perceptions of being in the remote location increase feelings of team membership.

关键词： Presence geo-collaboration virtual reality

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Where are we now?Re-visiting the Digital Earth through human-centered virtual and augmented reality geovisualization environments

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International Journal of Digital Earth 2019年第2期12卷 119-122页

作者： Arzu Çöltekin Danielle oprean Jan Oliver Wallgrün Alexander Klippel University of Zurich Switzerland University of Missouri The Pennsylvania State University USA

The original Digital Earth concept,formulated by Al Gore(1998),is essentially a virtual reality *** this(imagined)system,users are able to freely explore all possible recorded knowledge or information about the Earth though an interactive *** we imagine such an interface primarily as visual for now,it can be expected that in the future other senses will be engaged,allowing for even more realistic virtual *** though‘realism’in the experience is desirable(i.e.,it feels real),immersive experiences provided by visualization environments can go beyond reality,as they can be enhanced with queryable *** course one can also create fictitious experiences and simulations in such environments;including information about possible pasts(e.g.,ancient Rome)and futures(e.g.,a planned neighborhood);or spaces that we cannot(easily)directly experience(e.g.,the Moon,Mars,other far-away spaces,under the oceans,core of the earth,etc.).

关键词： neighborhood centered essentially

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