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Autologous cord blood vs individualized supplements in autistic spectrum disorder:CORDUS study results

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World Journal of Clinical Pediatrics 2025年第1期14卷 101-112页

作者： Felician A Stancioiu Raluca Bogdan Bogdan Ivanescu radu Dumitrescu Department of Clinical Research Bio-Forum FoundationBucharest 040245BucurestiRomania Department of Pediatrics Medicover Hospital BucharestBucharest 013982BucurestiRomania Doctor MiT Clinic Bucharest 013929BucurestiRomania Department of Anesthesiology and Intensive Therapy Medicover HospitalBucharest 013982BucurestiRomania

BACKGROUND Cellular therapies have started an important new therapeutic direction in autistic spectrum disorder(ASD),and the ample diversity of ASD pathophysiology and the different types of cell therapies prompt an equally ample effort to employ clinical studies for studying the ASD causes and cell *** cells have yielded so far mixed results in clinical trials,and at patient level the results varied from impressive to no *** this context we have administered autologous cord blood(ACB)and a non-placebo,material intervention repre-sented by an individualized combination of supplements(ICS)to ASD *** CORDUS clinical study is a crossover study in which both oral ICS and intravenous ACB were sequentially administered to 56 children;ACB was infused as an inpatient *** efficacy was evaluated pre-treatment and post-treatment at 6 months by an independent psychotherapist with Autism Treatment Evaluation Checklist,Quantitative Checklist for Autism in Toddlers and a 16-item comparative table score,after interviewing the children’s parents and *** and after each intervention participants had a set of blood tests including inflammatory,metabolic and oxidative markers,and the neuronal specific *** No serious adverse reactions were noted during and after cord blood or supplement *** improved evaluation scores in 78%of children with age 3–7-years(n=28),but was much less effective in kids older than 8 years or with body weight of more than 35 kg(n=28;only 11%of children improved scores).ICS yielded better results than ACB in 5 cases out of 28,while in 23 kids ACB brought more improvement than ICS(P<0.05);high initial levels of inflammation and ferritin were associated with no *** individual differences were noted in children's progress,and statistically significant improvements were seen after ACB on areas such as verbalization and social interaction,but not on irritability or

关键词： Autistic spectrum disorder Cord blood Stem cells Neuroinflammation Autologous stem cell treatment Neuronal specific enolase

Alpha decay of heavy and super heavy nuclei with a generalized electrostatic potential

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Chinese Physics C 2020年第12期44卷 114-122页

作者： R.budaca A.I.budaca “Horia Hulubei”National Institute for Physics and Nuclear Engineering Str.Reactorului 30RO-077125POB-MG6 Bucharest-MǎgureleRomania

Half-lives ofαdecay for Z≥84 nuclei are calculated based on the WKB theory applied for a phenomenological potential barrier composed of a centrifugal contribution and a screened electrostatic interaction represented by a Hulthen *** favored decays,the model has a single adjustable parameter associated with the screening of the electrostatic *** description of half lives for unfavored decays requires an additional hindrance term.A good agreement with experimental data is obtained in all considered *** evolution of the screening parameter for each nucleus revealed its dependence on shell *** model is also used for theoretical predictions on a few nuclei with uncertain or incomplete decay information.

关键词： half-lives alpha decay superheavy elements

Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 199-206页

作者： radu Cristian Poenaru Elena Milanesi Andrei Marian Niculae Anastasia-Maria Dobre Catalina Vladut Mihai Ciocîrlan Daniel Vasile Balaban Vlad Herlea Maria Dobre Mihail Eugen Hinescu Faculty of Medicine Carol Davila University of Medicine and PharmacyBucharest 050474Romania Department of Radiobiology Victor Babes National Institute of PathologyBucharest 050096Romania Department of Pathology Victor Babes National Institute of PathologyBucharest 050096Romania Department of Gastroenterology Prof.Dr.Agrippa Ionescu Clinical Emergency HospitalBucharest 011356Romania Department of Pathology Fundeni Clinical InstituteBucharest 022258Romania

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is an aggressive lethal malignancy with limited options for treatment and a 5-year survival rate of 11%in the United *** for other types of tumors,such as colorectal cancer,aberrant de novo lipid synthesis and reprogrammed lipid metabolism have been suggested to be associated with PDAC development and *** To identify the possible involvement of lipid metabolism in PDAC by analyzing in tumoral and non-tumoral tissues the expression level of the most relevant genes involved in the long-chain fatty acid(FA)import into *** A gene expression analysis of FASN,CD36,SLC27A1,SLC27A2,SLC27A3,SLC27A4,SLC27A5,ACSL1,and ACSL3 was performed by qRT-PCR in 24 tumoral PDAC tissues and 11 samples from non-tumoral pancreatic tissues obtained via fine needle aspiration or via surgical *** genes were considered significantly dysregulated between the groups when the p value was<0.05 and the fold change(FC)was≤0.5 and≥*** We found that three FA transporters and two long-chain acyl-CoA synthetases genes were significantly upregulated in the PDAC tissue compared to the non-tumoral tissue:SLC27A2(FC=5.66;P=0.033),SLC27A3(FC=2.68;P=0.040),SLC27A4(FC=3.13;P=0.033),ACSL1(FC=4.10;P<0.001),and ACSL3(FC=2.67;P=0.012).We further investigated any possible association between the levels of the analyzed mRNAs and the specific characteristics of the tumors,including the anatomic location,the lymph node involvement,and the presence of metastasis.A significant difference in the expression of SLC27A3(FC=3.28;P=0.040)was found comparing patients with and without lymph nodes involvement with an overexpression of this transcript in 17 patients presenting tumoral cells in the lymph *** Despite the low number of patients analyzed,these preliminary results seem to be *** lipid metabolism through a broad strategy could be a beneficial way to treat this *** in vitro and in vivo s

关键词： Carcinoma Pancreatic ductal Fatty acid transport Gene expression Biomarkers

Evaluation of the seismic hazard for 20 cities in Romania using Monte Carlo based simulations

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Earthquake Engineering and Engineering Vibration 2017年第3期16卷 513-523页

作者： Florin Pavel radu Vacareanu Seismic Risk Assessment Research Center Technical University of Civil Engineering Bucharest Romania

This work focuses on the evaluation of the seismic hazard for Romania using earthquake catalogues generated by a Monte Carlo approach. The seismicity of Romania can be attributed to the Vrancea intermediate-depth seismic source and to 13 other crustal seismic sources. The recurrence times of large magnitude seismic events（both crustal and subcrustal）, as well as the moment release rates are computed using simulated earthquake catalogues. The results show that the largest contribution to the overall moment release for the crustal seismic sources is from the seismic regions in Bulgaria, while the seismic regions in Romania contribute less than 5% of the overall moment release. In addition, the computations show that the moment release rate for the Vrancea subcrustal seismic source is about ten times larger than that of all the crustal seismic sources. Finally, the Monte Carlo approach is used to evaluate the seismic hazard for 20 cities in Romania with populations larger than 100,000 inhabitants. The results show some differences between the seismic hazard values obtained through Monte-Carlo simulation and those in the Romanian seismic design code P100-1/2013, notably for cities situated in the western part of Romania that are influenced by local crustal seismic sources.

关键词： seismic sources uncertainty seismic moment GMPE percentile

Investigation on regional attenuation of Vrancea (Romania) intermediate-depth earthquakes

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Earthquake Engineering and Engineering Vibration 2018年第3期17卷 501-509页

作者： Florin Pavel radu Vacareanu Seismic Risk Assessment Research Center Technical University of Civil Engineering

This paper aims at investigating possible regional attenuation patterns in the case of Vrancea（Romania） intermediate-depth *** 500 pairs of horizontal components recorded during 13 intermediate-depth Vrancea earthquakes are employed in order to evaluate the regional attenuation *** recordings are grouped according to the azimuth with regard to the Vrancea seismic source and subsequently,Q models are computed for each azimuthal zone assuming similar geometrical ***,the local soil amplification which was disregarded in a previous analysis performed for Vrancea intermediate-depth earthquakes is now clearly *** results show minor differences between the four regions situated in front of the Carpathian Mountains and considerable differences in attenuation of seismic waves between the forearc and backarc regions（with regard to the Carpathian Mountains）.Consequently,an average Q model of the type Q（f） = 115×f^1.25 is obtained for the four forearc regions,while a separate Q model of the type Q（f） = 70×f^0.90 is computed for the backarc *** results highlight the need to evaluate the seismic hazard of Romania by using ground motion models which take into account the different attenuation between the forearc/backarc regions.

关键词： Fourier amplitude spectrum azimuth dependency source-to-site distance Q model local soil conditions

Expectation-maximisation for speech source separation using convolutive transfer function

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CAAI Transactions on Intelligence Technology 2019年第1期4卷 47-53页

作者： Xiaofei Li Laurent Girin radu Horaud INRIA Grenoble Rhoe-Alpes Montbonnot Saint-MartinFrance GIPSA-lab Saint-Martin d’HèresFrance UniversitéGrenoble Alpes Saint-Martin d’HèresFrance

This study addresses the problem of under-determined speech source separation from multichannel microphone signals,*** convolutive mixtures of multiple *** time-domain signals are first transformed to the short-time Fourier transform(STFT)*** represent the room filters in the STFT domain,instead of the widely used narrowband assumption,the authors propose to use a more accurate model,*** convolutive transfer function(CTF).At each frequency band,the CTF coefficients of the mixing filters and the STFT coefficients of the sources are jointly estimated by maximising the likelihood of the microphone signals,which is resolved by an expectation-maximisation *** show that the proposed method provides very satisfactory performance under highly reverberant environments.

关键词： STFT CTF

Bi-normalized response spectra and seismic intensity in Bucharest for 1986 and 1990 Vrancea seismic events

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Earthquake Engineering and Engineering Vibration 2014年第1期13卷 125-135页

作者： Florin Pavel radu Vacareanu Cristian Neagu Andrei Pricopie Department of Reinforced Concrete Structures Technical University of Civil Engineering BucharestRomania Department of Strength of Materials Bridges and TunnelsTechnical University of Civil Engineering BucharestRomania

The Vrancea subcrustal earthquakes of August 30,1986 and May 30,1990 are the two most recent seismic events that have occurred in Romania with moment magnitudes M W ≥ *** spectral analysis of the strong ground motions recorded in Bucharest reveals that despite small differences in magnitude between the 1986 and 1990 earthquakes,their frequency contents are very different,sometimes even *** main focus of this study is to conduct a comparative analysis of the response spectra in terms of the bi-normalized response spectra(BNRS) proposed by Xu and Xie(2004 and 2007) for strong ground motions recorded in Bucharest during these two seismic *** mean absolute acceleration and relative velocity response spectra for the two earthquakes are discussed and ***,the mean bi-normalized absolute acceleration and normalized relative velocity response spectra with respect to the control period T C are computed for the ground motions recorded in Bucharest in 1986 and *** predominant period T P is also used in this study for the normalization of the spectral period ***,the methodology proposed by Martinez-Perreira and Bommer(1998) is applied in order to estimate the seismic intensity of the two *** results are discussed and several conclusions regarding the possibility of using the bi-normalized response spectra(BNRS) are given.

关键词： response spectra bi-normalized response spectra dynamic amplifi cation factor control period damage potential parameters

Difficulties in diagnosing anorectal melanoma: A case report and review of the literature

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World Journal of Clinical Cases 2021年第36期9卷 11369-11381页

作者： Raluca Cristina Apostu Elena Stefanescu radu Razvan Scurtu Gabriel Kacso radu Drasovean Department of Surgery "Iuliu Hatieganu"University of Medicine and PharmacyCluj-Napoca 400006Romania Department of Anesthesia and Intensive Care Emergency County Clinical HospitalCluj-Napoca 400006Romania Department of Surgery University of Medicine and Pharmacy"Iuliu Hatieganu"Cluj-NapocaCluj Napoca 400006Romania Department of Medical Oncology and Radiotherapy “Iuliu Hatieganu”University of Medicine and PharmacyCluj-Napoca 400006Romania

BACKGROUND Anorectal melanoma is a tumour that is difficult to identify due to its rarity and variability of *** data published in the literature do not allow for diagnostic and treatment guidelines to be *** melanoma has the worst prognosis among mucosal melanomas and is frequently misdiagnosed by standard identification *** SUMMARY A 66-year-old woman presented with intermittent anal bleeding,pain,and tenesmus in the past month,with no associated weight *** revealed a cauliflower-like tumour with a diameter of 1.5 cm,with exulcerated areas and an adherent clot but without *** results identified an inflammatory rectal polyp with nonspecific chronic *** markers CA 19-9 and CEA were within the normal *** 6 mo,due to the persistence of symptoms,a pelvic magnetic resonance imaging scan was performed.A lesion measuring 2.8 cm×2.7 cm×2.1 cm was identified at the anorectal junction,along with two adjacent *** distant metastases were *** was performed on the second set of biopsies,and a diagnosis of anorectal melanoma was *** treatment by abdominoperineal resection was *** was marked by the appearance of lung metastases at 1 mo postoperatively,detected on a positron emission tomography-computer tomography scan,and perineal recurrence after 5 *** molecular testing,the patient was included in an immunotherapy *** This case highlights the difficulty of establishing a definitive early diagnosis of anorectal melanoma,the importance of performing histological analysis on a wellrepresented biopsy specimen,and the poor prognosis,even with radical surgery.

关键词： Mucosal melanoma Anorectal Immunohistochemistry Melanocytes Molecular targeted therapy Case report

Investigation on directional effects of Vrancea subcrustal earthquakes

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Earthquake Engineering and Engineering Vibration 2015年第3期14卷 399-410页

作者： Florin Pavel radu Vacareanu Mircea radulian Carmen Cioflan Seismic Risk Assessment Center Technical University of Civil Engineering Bucharest National Institute for Earth Physics (INFP)

This paper evaluates possible directional effects from strong ground motions recorded during the last four significant subcrustal earthquakes produced in the Vrancea seismic zone（Romania） in August 1986（Mw=7.1）,May 1990（Mw=6.9 and 6.4） and October 2004（Mw=6.0）.Several measures of the horizontal component of the ground motion given in the literature（Boore et al.,2006;Boore,2010） are computed and are related to the geometric mean of the as-recorded horizontal *** method is applied in order to quantify the influence of the earthquake magnitude and of the soil class on some strong ground motion parameters（*** intensity,PGV/PGA,or mean period TM）.The study of the directional effects is performed using the distribution of IJMAand of the rotation angle corresponding to a measure of the horizontal component of the ground motion（RotD 100） and the results reveal a visible directional pattern for IJMA,while in the case of RotD100 the directional patterns are less visible.

关键词： response spectra horizontal ground motion directio