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Investigation of Lipid Peroxidation Products and Antioxidant Enzyme Activities in End-Stage Renal Disease Patients

Advances in Chemical Engineering and Science 2014年第1期4卷 73-80页

作者： Bojana Kisic Dijana Miric radojica stolic Aleksandra Ilic Julijana Rasic Mirjana Miric Ilija Dragojevic Faculty of Medicine Pristina Institute of Biochemistry Settlement Kosovska Mitrovica Serbia Faculty of Medicine Pristina Institute of Pathophysiology Settlement Kosovska Mitrovica Serbia Faculty of Medicine Pristina Institute of Pharmacology Settlement Kosovska Mitrovica Serbia Faculty of Medicine Pristina Institute of Preventive Medicine (Medical Statistics and Informatics) Settlement Kosovska Mitrovica Serbia Internal Clinic Faculty of Medicine Pristina Settlement Kosovska Mitrovica Serbia

Background: Intravenous application of iron preparations which is a routine treatment of anemia in hemodialysis patients with end-stage renal disease can lead to iron overload in the body. Redox-active iron can catalyze the formation of hydroxyl radicals and initiation of lipid peroxidation, increase oxidative stress and speed up the development of complications in these patients. Objective: In this study, we determined the markers of lipid peroxidation, protein oxidation and antioxidant enzyme activities (superoxide dismutase, glutathione peroxidase, glutathione S-transferase) in serum of patients with end-stage renal disease on hemodialysis, who had received repeated treatment of iron supplementation. Patients and Methods: The study included 29 patients undergoing regular hemodialysis treatment. These patients were divided into three groups according to the serum ferritin levels: group I (serum ferritin between 100 and 300 mg/L);group II (serum ferritin between 301 and 600 mg/L), and group III (serum ferritin above 601 mg/L). Results: The serum of patients with the highest concentration of serum ferritin and iron contained significantly higher level of lipid peroxidation products, total hydroperoxides and malondialdehyde and advanced oxidation protein products and the lowest concentration of sulfhydryl groups, reduced glutathione and total antioxidant capacity. Conclusion: Based on the obtained results, it can be concluded that iron supplementation in hemodialysis patients and consequently body iron overload of exacerbated oxidative stress have already been present in these patients.

关键词： Oxidative Stress Hemodialysis Ferritin Antioxidant Enzymes Lipid Peroxidation

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Arteriovenous fistulas and digital hypoperfusion ischemic syndrome in patients on hemodialysis

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World Journal of Nephrology 2013年第2期2卷 26-30页

作者： radojica V stolic Goran Z Trajkovic Dijana J Miric Bojana Kisic Zorana Djordje Goran Lj Azanjac Marijana S Stanojevic Dragica Z stolic Medical Faculty University of Pristina Clinical Center Kragujevac Faculty of Medicine University of Kragujevac Health Center Pristina

AIM： To determine survival parameters as well as char-acteristics of patients with this syndrome. METHODS： The investigation was conducted over a period of eight years, as a prospective, non-random-ized, clinical study which included 204 patients, treated by chronic hemodialysis. Most patients received hemo-dialysis 12 h per week. As vascular access for hemodi-alysis all subjects had an arteriovenous fstulae. Based on surveys the respondents were divided into groups of patients with and without digital hypoperfusion isch-emic syndrome. Gender, demographic and anthropo-metric characteristics, together with comorbidity and certain habits, were recorded. During this period 34.8% patients ***： Patients with digital hypoperfusion ischemic syndrome were older than those without ischemia （P = 0.01）. Hemodialysis treatment lasted signifcantly lon-ger in the patients with digital hypoperfusion ischemic syndrome （P = 0.02）. The incidence of cardiovascular disease （P 〈 0.001） and diabetes mellitus （P = 0.01）, as well as blood fow through the arteriovenous fstula （ P = 0.036）, were higher in patients with digital hypoper-fusion ischemic syndrome. Statistically significant dif-ferences also existed in relation to oxygen saturation （P = 0.04）. Predictive parameters of survival for patients with digital hypoperfusion ischemic syndrome were： adequacy of hemodialysis （B = -3.604, P 〈 0.001）, hypertension （B = -0.920, P = 0.018）, smoking （B = -0.901, P = 0.049）, diabetes mellitus （B = 1.227, P = 0.005）, erythropoietin therapy （B = 1.274, P = 0.002） and hemodiafltration （B = -1.242, P = 0.033）. Kaplan-Meier survival analysis indicated that subjects with and without digital hypoperfusion ischemic syndrome dif-fered regarding the length of survival （P 〈 0.001）, i.e. , patients with confrmed digital hypoperfusion ischemic syndrome died ***： Survival was signifcantly longer in the patients without digital hypoperfusion ischemic syn-drome.

关键词： Digital hypoperfusion ischemic syndrome Predictive parameters Survival Arteriovenous fistula Hemodialysis

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