检索结果-南通市图书馆

Use of rifaximin in gastrointestinal and liver diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第29期22卷 6638-6651页

作者： Rani H Shayto rachel Abou Mrad Ala I Sharara Division of Gastroenterology Department of Internal Medicine American University of Beirut Medical Center

Rifaximin is a broad spectrum oral antibiotic with antimicrobial activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. It is poorly absorbed and thus has a highly favorable safety profile. Rifaximin has been shown to be effective in the treatment of traveler’s diarrhea, functional bloating and irritable bowel syndrome, small bowel bacterial overgrowth and in the prevention of recurrent overt hepatic encephalopathy. In addition, there is emerging evidence for a possible beneficial effect of rifaximin in the treatment of uncomplicated diverticular disease and in the prevention of recurrent diverticulitis. The use of rifaximin is associated with a low incidence of development, or persistence of spontaneous bacterial mutants. Moreover, the development of important drug resistance among extra-intestinal flora during rifaximin therapy is unlikely because of minimal systemic absorption and limited cross-resistance of rifaximin with other antimicrobials. This review addresses the current and emerging role of rifaximin in the treatment of gastrointestinal and liver disorders.

关键词： Irritable bowel syndrome Inflammatory bowel disease Hepatic encephalopathy Bacterial overgrowth Diverticular disease

Incorporating novelty and novel ecosystems into restoration planning and practice in the 21st century

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ecological Processes 2013年第1期2卷 175-182页

作者： Michael P Perring rachel J Standish Richard J Hobbs Ecosystem Restoration and Intervention Ecology Research Group School of Plant BiologyThe University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia

Novelty pervades the *** some cases,potentially irreversible abiotic and/or biotic changes have led to the crossing of thresholds and thus the formation of“novel ecosystems.”Their widespread emergence(particularly on land)and the presence of continued environmental change challenge a traditional restoration goal of restoring an historical ***,we argue that restoration could broaden its frame of reference to consider how novel ecosystems might be used to maintain global biodiversity and provide ecosystem services and,in doing so,save potentially wasted efforts in attempting to fulfil traditional *** we explore this contention in more depth by addressing:Are novel ecosystems innovative planning or lowering the bar?We show that novel ecosystems were not innovative planning in their original *** the contrary,they were recognized as ecosystems that were recalcitrant to traditional restoration approaches,coupled with an awareness that they had arisen inadvertently through deliberate human activity,either on-or *** recalcitrance to traditional restoration suggests that alternative goals may exist for these ecosystems using sometimes innovative *** management may include biodiversity conservation or restoration for ecological *** elucidate the latter aspect with reference to an experiment in the wheatbelt of Western Australia—The Ridgefield Multiple Ecosystem Services Experiment—the design of which has been informed by ecological theory and the acceptance of novelty as an ecosystem *** novel ecosystems do provide opportunities to broaden restoration planning and practice,and ultimately maintain and conserve global biodiversity in this era of environmental change,they necessarily“lower the bar”in restoration if the bar is considered to be the historical ***,in these times of flux,such a bar is increasingly ***,careful and appropriate interventions are required

关键词： No-analogue ecosystem Biodiversity conservation Ecosystem function Ecological restoration Restoration baseline Ridgefield multiple ecosystem services experiment York gum woodland

Effect of Niobium on Transformations From Austenite to Ferrite in Low Carbon Steels

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2011年第S1期18卷 208-212页

作者： Parker Sally Rose Andrew West Geoff Thomson rachel Steel Metallurgy Department Tata Steel RD and TSwinden Technology CentreRotherhamS60 3ARUK Department of Materials Loughborough UniversityLoughboroughLE11 3TUUK

Niobium has an important effect on the transformation behaviour,grain size refinement and precipitation strengthening during hot rolling and subsequent cooling in low carbon steels,with even a low content of niobium having a strong effect on the transformation rate from austenite to ***,the effects of niobium on transformation behaviour have not been fully characterised and understood to *** paper examines in detail austenite grain growth as a function of austenitisation time in high strength low alloy (HSLA) steels with three different niobium contents,together with the effect of niobium on the isothermal transformation kinetics from austenite to ferrite as a function of *** is shown that austenite has the slowest grain growth rate in the steel with the highest niobium *** austenite grain sizes are consistent,the steel with the highest niobium content was found to have the slowest transformation rate from austenite to ferrite.

关键词： niobium transformation kinetics austenite grain growth low carbon steels

Design of finger gestures for locomotion in virtual reality

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Virtual Reality & Intelligent Hardware 2019年第1期1卷 1-9页

作者： rachel HUANG Carisa HARRIS-ADAMSON Dan ODELL David REMPEL Department of Bioengineering University of CaliforniaBerkeleyCA 94804USA Department ofPublic Health University of CaliforniaBerkeleyCA 94804USA

Background Within a virtual environment(VE)the control of locomotion(e.g.,self-travel)is critical for creating a realistic and functional *** the direction of locomotion,whileusing a head-mounted display(HMD),is determined by the direction the head is pointing and the forwardor backward motion is controlled with a hand held ***,hand held devices can be difficultto use while the eyes are covered with a *** hand gestures,that are tracked with a camera or ahand data glove,have an advantage of eliminating the need to look at the hand controller but the design ofhand or finger gestures for this purpose has not been well *** This study used a depth-sensing camera to track fingertip location(curling and straightening the fingers),which was converted toforward or backward self-travel in the *** position was converted to self-travel velocity using amapping function with three parameters:a region of zero velocity(dead zone)around the relaxed handposition,a linear relationship of fingertip position to velocity(slope orβ)beginning at the edge of the deadzone,and an exponential relationship rather than a linear one mapping fingertip position to velocity(exponent).Using a HMD,participants moved forward along a virtual road and stopped at a target on theroad by controlling self-travel velocity with finger flexion and *** of the 3 mapping functionparameters was tested at 3 *** measured included usability ratings,fatigue,nausea,and timeto complete the *** Twenty subjects participated but five did not complete the study due *** size of the dead zone had little effect on performance or *** preferred lower β values which were associated with better subjective ratings of control and reduced time to complete thetask,especially for large *** values of 1.0 or greater were preferred and reduced the time tocomplete the task,especially for small ***

关键词： Human computer interaction Virtual environment Gesture design

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Power button

Drafting and negotiating computer contracts 2nd ed 2nd ed.

作者： rachel Plotnick.

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Inhibition of retroviral Gag assembly by non-silencing miRNAs promotes autophagic viral degradation

2005年

作者： Burnett rachel

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Protein & Cell 2018年第7期9卷 640-651页

作者： Na Qu Zhao Ma Mengrao Zhang Muaz N. Rushdi Christopher J. krueger Antony K. Chen Department of Biomedical Engineering College of Engineering Peking University Beijing 100871 China Wallace H Coulter Department of Biomedical-Engineering Georgia Institute of Technology Atlanta GA 30332 USA

We recently reported an unconventional mechanism by which miRNAs inhibit HIV-1 viral production. This occurs when miRNAs bind nonspecifically to the viral structural protein Gag, interfering with viral RNA-medi- ated Gag assembly at the plasma membrane. Conse- quently, misassembled viral complexes are redirected into the endocytic pathway where they are delivered to lysosomes for degradation. In this study, we demon- strate that autophagy is a critical mediator of the viral degradation pathway and that this pathway is not HIV-1 specific. Misassembled viral complexes were found to colocalize extensively with LC3 and p62 in late endo- somesllysosomes, demonstrating a convergence of autophagy with functional degradative compartments. Knocking down autophagosome formation machineries reduced this convergence, while treatment with autop- hagy-inducer rapamycin enhanced the convergence. Furthermore, similar autophagy-dependent nonspecific miRNA inhibition of murine leukemia virus （MLV） assembly was shown. Overall, these results reveal autophagy as a crucial regulator of the retroviral degradation pathway in host cells initiated by non- specific miRNA-Gag interactions. These findings could have significant implications for understanding how cells may regulate retroviral complex assembly by miRNA expression and autophagy, and raise the possi- bility that similar regulations can occur in other biolog- ical contexts.

关键词： microRNA Gag protein autophagy

Implications of Pediatric Chest Wall Surgery on the Risk of Developing of Scoliosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimal expression of Hh1-like response requires IL-4 at early stage of experimental autoimmune uveitis (EAU)

Open Journal of Pediatrics（儿科学期刊） 2024年第3期 623页

作者： rachel White Michael Ginzburg

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 1999年第5期 85-86页

作者： rachel R CASPI Bethesda Laboratory of Immunology MD 20892 USA National Eye Institute National Institutes of Health

IL-4 is a Th2-type cytokine which plays a major role in determining the Tho-type cell differentiation towards Th2-type

关键词： EAU IRBP IL