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Going global Management of colour-measuring instrumentation is the key to successful colour management

城市漫步(GBA版) 2024年第6期 8页

作者： rachel Weiss

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涂料工业 2007年第B7期37卷 53-55页

作者： Peter rachel Sales Director Central Europe at X-Rite Incorporated

It is no secret in the industry that even the best spectrophotometers exhibit colour drift with *** solutions are now available that can eliminate this drift and also use different manufacturers' drivers to calibrate literally all of the instruments involved in the colour *** makes colour communications more accurate and more effective.

关键词：计量仪表分光光度计色彩涂料质量分析

Exploring the potential impact of nutritionally actionable genetic polymorphisms on idiopathic male infertility:a review of current evidence

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Asian Journal of Andrology 2021年第5期23卷 441-449页

作者： Sinda Mahbouli Charlotte Dupont Yaelle Elfassy Eric Lameignere rachel Levy FabLife 104 Avenue Albert lerRueil-Malmaison 92500France Sorbonne University Saint Antoine Research CentreINSERM Genetic and Acquired Lipodystrophies TeamReproductive Biology and CECOSAP-HPTenon HospitalParis F-75020France Reproductive Biology and CECOS AP-HPTenon HospitalParis F-75020France

Infertility affects about 15%of the world's *** 40%-50%of infertile couples,a male factor underlies the problem,but in about 50%of these cases,the etiology of male infertility remains *** clinical data show that lifestyle interventions may contribute to male reproductive *** of unhealthy habits is suggested for preserving male fertility;there is growing evidence that most preexisting comorbidities,such as obesity and metabolic syndrome,are highly likely to have an impact on male *** analysis of genetic polymorphisms implicated in metabolic activity represents one of the most exciting areas in the study of genetic causes of male *** these polymorphisms are not directly connected with male infertility,they may have a role in specific conditions associated with it,that is,metabolic disorders and oxidative stress pathway genes that are potentially associated with an increased risk of male infertility due to DNA and cell membrane *** studies have examined the impact of individual genetic differences and gene-diet interactions on male infertility,but their results have not been *** review the current research to identify genetic variants that could be tested to improve the chances of conceiving spontaneously through personalized diet and/or oral vitamin and mineral supplementation,by examining the science of genetic modifiers of dietary factors that affect nutritional status and male fertility.

关键词： energy metabolism genetic polymorphisms idiopathic male infertility lifestyle factors nutrition oxidative stress semen quality

The Origin of Modern East Asians

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人类学学报 2013年第4期32卷 377-398页

作者： Milford H Wolpoff rachel Caspari Department of Anthropology University of Michigan Ann Arbor M148109 USA T Department Sociology Anthropology and Social Work Central Michigan University Mount Pleasant M148859 USA

With the development of paleogenetics in the past decade, it has become evident that modern humans do not have a phylogenetic origin in the appearance of a new species Homo sapiens; therefore, anatomical, behavioral and genetic aspects of modernity are not the consequence of the same, single event. In this paper, we examine the evidence for anatomical, behavioral and genetic modernity in East Asia. In each case, modernity can be understood as part of a multiregional evolutionary process, rather than as an entity. Although these three aspects of modernity are somewhat independent, each evolving at different times, they are linked through demographic changes that began in the late Pleistocene - increased survivorship and population expansions that changed the course of human evolution.

关键词：人口变化社会学化石遗传学进化过程

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阶梯停车场芬兰郝尔辛基

世界建筑导报 2024年第2期39卷 117-119页

作者： uho Grönholm Antti Nousjoki Samuli Woolston Pekka Tainio Tuulikki Tanska rachel Murray Anssi Luodemäki Harri Humppi Tuomas Uusheimo(摄影) Marc Goodwin(摄影) ALA建筑师事务所不详

新的五角形、五层高的Saukonlaituri停车设施包括六条流线,可停放600辆私家车,中央庭院被布满巨石、苔藓和蕨类植物的景观环绕。其中五个停车场有顶棚,第六个停车场位于屋顶。庭院具有双重功能:它既是一个采光井,阳光可通过庭院照射到... 详细信息

新的五角形、五层高的Saukonlaituri停车设施包括六条流线,可停放600辆私家车,中央庭院被布满巨石、苔藓和蕨类植物的景观环绕。其中五个停车场有顶棚,第六个停车场位于屋顶。庭院具有双重功能:它既是一个采光井,阳光可通过庭院照射到较低的停车场,又是雨水蓄水池和积雪堆积地。建筑的南侧从入口广场后退,将地面公共空间延伸为阶梯式公园,一直延伸到屋顶。这种解决方案使周围公寓楼的居民可以沿着阶梯走到正确的楼层取车,而不是乘坐电梯。阶梯区域也可以用于野餐和日光浴。

关键词：入口广场空间延伸采光井停车设施公寓楼停车场阶梯式电梯

Neuronal activity controls the development of interneurons in the somatosensory cortex

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Frontiers in Biology 2016年第6期11卷 459-470页

作者： rachel Babij Natalia De Marco Garcia Center for Neurogenetics Brain and Mind Research Institute Weill Cornell Medical College New York NY 10065 USA Weill Cornell/Rockefeller/Sloan Kettering Tri-lnstitutional MD-PhD Program New York USA

BACKGROUND： Neuronal activity in cortical areas regulates neurodevelopment by interacting with defined genetic programs to shape the mature central nervous system. Electrical activity is conveyed to sensory cortical areas via intracortical and thalamocortical neurons, and includes oscillatory patterns that have been measured across cortical regions. OBJECTIVE： In this work, we review the most recent findings about how electrical activity shapes the developmental assembly of functional circuitry in the somatosensory cortex, with an emphasis on intemeuron maturation and integration. We include studies on the effect of various neurotransmitters and on the influence of thalamocortical afferent activity on circuit development. We additionally reviewed studies describing network activity patterns. METHODS： We conducted an extensive literature search using both the PubMed and Google Scholar search engines. The following keywords were used in various iterations：＂intemeuron＂, ＂somatosensory＂, ＂development＂, ＂activity＂, ＂network patterns＂, ＂thalamocortical＂, ＂NMDA receptor＂, ＂plasticity＂. We additionally selected papers known to us from past reading, and those recommended to us by reviewers and members of our lab. RESULTS： We reviewed a total of 132 articles that focused on the role of activity in interneuronal migration, maturation, and circuit development, as well as the source of electrical inputs and pattems of cortical activity in the somatosensory cortex. 79 of these papers included in this timely review were written between 2007 and 2016. CONCLUSIONS： Neuronal activity shapes the developmental assembly of functional circuitry in the somatosensory cortical interneurons. This activity impacts nearly every aspect of development and acquisition of mature neuronal characteristics, and may contribute to changing phenotypes, altered transmitter expression, and plasticity in the adult. Progressively changing oscillatory network patterns contribute to this activity in the earl

关键词： interneuron neurodevelopment neuroplasticity thalamocortical NMDA receptors neuronal maturation

Analysis of residual crosslinking agent content in UV cross-linked poly(ethylene oxide) hydrogels for dermatological application by gas chromatography

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Journal of Pharmaceutical Analysis 2016年第5期6卷 307-312页

作者： rachel Shet Hui Wong Mark Ashton Kalliopi Dodou Department of Pharmacy Health and Wellbeing Faculty of Applied Sciences University of Sunderland Science Complex

Acrylates have been widely used in the synthesis of pharmaceutical polymers. The quantitation of residual acrylate monomers is vital as they are strong irritants and allergens, but after polymerization, are relatively inert, causing no irritation and allergies. Poly(ethylene oxide)(PEO) hydrogels were prepared using pentaerythritol tetra-acrylate(PETRA) as UV crosslinking agent. A simple, accurate, and robust quantitation method was developed based on gas chromatographic techniques(GC), which is suitable for routine analysis of residual PETRA monomers in these hydrogels. Unreacted PETRA was initially identified using gas chromatography–mass spectrometry(GC–MS). The quantitation of analyte was performed and validated using gas chromatography equipped with a flame ionization detector(GC–FID). A linear relationship was obtained over the range of 0.0002%–0.0450%(m/m) with a correlation coefficient(r2)greater than 0.99. The recovery( 4 90%), intra-day precision(%RSD o 0.67), inter-day precision(%RSD o2.5%), and robustness(%RSD o1.62%) of the method were within the acceptable values. The limit of detection(LOD) and limit of quantitation(LOQ) were 0.0001%(m/m) and 0.0002%(m/m), *** assay provides a simple and quick way of screening for residual acrylate monomer in hydrogels.

关键词： Poly(ethylene oxide) (PEO) Residual monomer HydrogelGas chromatography–mass spectrometry (GC–MS) Gas chromatography–flame ionization detection (GC–FID)

An information theoretic method to identify combinations of genomic alterations that promote glioblastoma

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分子细胞生物学报:英文版 2015年第3期7卷 203-213页

作者： rachel D.Melamed Jiguang Wang Antonio Iavarone Raul Rabadan Department of Systems Biology Columbia University College of Physicians and SurgeonsNew YorkNYUSA Department of Biomedical Informatics Columbia University College of Physicians and SurgeonsNew YorkNYUSA Institute for Cancer Genetics Columbia University College of Physicians and SurgeonsNew YorkNYUSA Department of Pathology and Cell Biology Columbia University College of Physicians and SurgeonsNew YorkNYUSA Department of Neurology Columbia University College of Physicians and SurgeonsNew YorkNYUSA

Tumors are the result of accumulated genomic alterations that cooperate synergistically to produce uncontrollable cell *** identifying recurrent alterations among large collections of tumors provides a way to pinpoint genes that endow a selective advantage in oncogenesis and progression,it fails to address the genetic interactions behind this selection process.A non-random pattern of co-mutated genes is evidence for selective forces acting on tumor cells that harbor combinations of these genetic *** existing methods have successfully identified mutually exclusive gene sets,no current method can systematically discover more general genetic *** develop Genomic Alteration Modules using Total Correlation(GAMToC),an information theoretic frameworkthat integrates copynumberandmutation datato identify genemodules with any non-randompattern of joint ***,wepresent theSeed-GAMToCprocedure,which uncoversthe mutational context of any putative cancer *** software is publicly *** to glioblastoma multiforme samples,GAMToC results show distinct subsets of co-occurring mutations,suggesting distinct mutational routes to cancer and providing new insight into mutations associated with proneural,proneural/G-CIMP,and classical types of the *** results recapitulate known relationships such as mutual exclusive mutations,place these alterations in the context of other mutations,and find more complex relationships such as conditional mutual exclusivity.

关键词： genomics sequencing entropy copy number cancer cancer genetics

Research on Prostate MRI Segmentation with Random Walker and GAN

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Research on Prostate MRI Segmentation with Random Walker and...

作者： Nubwimana rachel 河北工业大学

学位级别：硕士

前列腺癌是男性第二常见的恶性肿瘤,仅次于肺癌,在发达国家的发病率更高。前列腺癌早期可能无症状,病程缓慢,只有在癌症进展时才会出现症状。因此,如果早发现、早诊断、早治疗,治愈率可以大大提高。前列腺癌的诊断和治疗主要采用MRI图... 详细信息

前列腺癌是男性第二常见的恶性肿瘤,仅次于肺癌,在发达国家的发病率更高。前列腺癌早期可能无症状,病程缓慢,只有在癌症进展时才会出现症状。因此,如果早发现、早诊断、早治疗,治愈率可以大大提高。前列腺癌的诊断和治疗主要采用MRI图像检测技术,其中许多问题包括腹部MRI中前列腺的准确性和自动分割,这对临床应用至关重要。目前,大多数现有的前列腺分割方法都是通过一系列的程序进行的,每一步都需要手动经验参数调整,且存在分割效率低和精度低等问题,为此,研究有利于计算机辅助诊断、适用于有限样本图像集的全自动算法是非常有意义的。此外,由于存在腺体边界模糊,分割不足或过度等问题,以及大数据处理的需要,研究前列腺MRI图像分割的深度学习方法非常必要,尤其是生成性对抗网络(GAN)由于其灵活的结构和强大的功能,已逐渐应用于各种图像处理任务。为此,本论文针对上述问题开展了以下工作。(1)基于随机游走算法的前列腺MRI图像分割研究。为解决分割效率低、轮廓不完整、分割泄漏和偏差大等问题,并适应于有限的图像集和全自动处理,提出一种改进的随机游走算法,即多图谱RW进行图像分割,其算法步骤如下:选择具有可见前列腺轮廓的切片,生成其真值(正确的标注值),用于图谱和多图谱生成。在此过程中,真值图像被采样成相同的像素大小和图像大小,然后,所有真值图像被叠加到一个单独的图像空间中。在堆叠过程之后,在该图像空间中生成概率图,并选择两个概率级别来提取内部种子(前景种子)和外部种子(背景种子)。生成的种子被作为随机行走算法的自动种子。通过实验分析,将提出的多图谱RW与图谱RW的和基本RW进行比较,并使用形状相似性进行评估,平均Dice相似系数(DSC)分别为0.72、0.62和0.52,平均Jaccard相似系数(JSC)分别为0.71、0.62和0.54。同样使用距离和体积差进行评估,Hausdorff距离(H)分别为4.87、5.93和5.89,相对体积差(RVD)分别为0.36、0.48和0.57。研究结果表明提出的多图谱RW是切实可行且行之有效的。(2)基于生成对抗网络(GAN)的前列腺MRI图像分割研究。为克服腺体边界模糊,前列腺内组织的异质性导致的分割不足或过度,以及患者或病理学之间的生理差异等问题,并适应于大数据图集处理,提出一种基于端到端深度学习生成对抗网络(GAN)的前列腺分割模式(PGAN),其任务是区分结构分割过程中使用的真值掩模和分割掩模,具有EM距离的生成对抗网络(GAN)进行像素级语义分割。然后将PGAN模式应用于四种不同的GAN结构,即带有基本鉴别器的PGAN、带有早期融合网络的PGAN、带有回归网络的PGAN和带有乘积网络的PGAN。在实验分析中,使用Dice相似系数(DSC)、Jaccard相似系数、相对体积差异(RVD)和Hausdorff距离(H)等多种指标对前列腺分割进行比较,并在一个数据集上进行评估,该数据集包含493个磁共振成像作为训练数据,98个磁共振成像作为实验测试数据。研究结果表明,所提出的带回归网络的PGAN的DSC平均值为0.97,JSC平均值为0.97,RVD平均值为0.01,H平均值为2.93。显然,它优于基本GAN和随机Walker等分割方法,是一种适合大数据处理的分割方法。

关键词：磁共振图像前列腺图像分割随机行走算法生成对抗网络

BRCA mutated pancreatic cancer:A change is coming

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World Journal of Gastroenterology 2021年第17期27卷 1943-1958页

作者： Michael N Rosen rachel A Goodwin Michael M Vickers Faculty of Medicine The University of OttawaOttawa K1H 8L6OntarioCanada The Ottawa Hospital Cancer Center The University of OttawaOttawa K1H 8L6OntarioCanada

Pancreatic cancer remains a leading cause of cancer-related death with few available therapies for advanced ***,patients with germline BRCA mutations have received increased attention due to advances in the management of BRCA mutated ovarian and breast *** BRCA mutations significantly increase risk of developing pancreatic cancer and can be found in up to 8%of patients with sporadic pancreatic *** patients with germline BRCA mutations,platinum-based chemotherapies and poly(ADP-ribose)polymerase inhibitors are effective treatment options which may offer survival *** review will focus on the molecular biology,epidemiology,and management of BRCA-mutated pancreatic ***-more,we will discuss future directions for this area of research and promising active areas of research.

关键词： Pancreatic cancer Systemic therapy Platinum chemotherapy BRCA Deoxyribonucleic acid repair Poly(ADP-ribose)polymerase inhibitors