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Supply and quality of colonoscopy according to the characteristics of gastroenterologists in the French population-based colorectalcancer screening program

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World Journal of Gastroenterology 2023年第9期29卷 1492-1508页

作者： AkoïKoïvogui catherine Vincelet Gaëlle Abihsera Hamou Ait-Hadad Hélène Delattre Tu Le Trung Agnès Bernoux rachel Carroll Jérôme Nicolet Site de Seine-Saint-Denis Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Bondy 93146France Site des Yvelines Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Le Chesnay Cedex 78153France Site du Val-de-Marne Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Joinville-le-Pont 94340France Site de Seine-et-Marne Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Lieusaint 77763France Site des Hauts-de-Seine Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Nanterre 92000France site du Val-d’Oise Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Cergy Saint-Christophe 95800France Site de l’Essonne Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Fontenay-Les-Briis 91640France Siège Paris Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France(CRCDC-IDF)Paris 75015France

BACKGROUND Since its complete roll-out in 2009,the French colorectal cancer screening program(CRCSP)experienced 3 major constraints[use of a less efficient Guaiac-test(gFOBT),stopping the supply of Fecal-Immunochemical-Test kits(FIT),and suspension of the program due to the coronavirus disease 2019(COVID-19)]affecting its *** To describe the impact of the constraints in terms of changes in the quality of screeningcolonoscopy(Quali-Colo).METHODS This retrospective cohort study included screening-colonoscopies performed by gastroenterologists between Jan-2010 and Dec-2020 in people aged 50-74 living in Ile-de-France(France).The changes in Quali-colo(Proportion of colonoscopies performed beyond 7 mo(Colo_7 mo),Frequency of serious adverse events(SAE)and Colonoscopy detection rate)were described in a cohort of Gastroenterologists who performed at least one colonoscopy over each of the four periods defined according to the chronology of the constraints[gFOBT:Normal progress of the CRCSP using gFOBT(2010-2014);FIT:Normal progress of the CRCSP using FIT(2015-2018);STOP-FIT:Year(2019)during which the CRCSP experienced the cessation of the supply of test kits;COVID:Program suspension due to the COVID-19 health crisis(2020)].The link between each dependent variable(Colo_7 mo;SAE occurrence,neoplasm detection rate)and the predictive factors was analyzed in a two-level multivariate hierarchical *** The 533 gastroenterologists(cohort)achieved 21509 screening colonoscopies over gFOBT period,38352 over FIT,7342 over STOP-FIT and 7995 over COVID *** frequency of SAE did not change between periods(gFOBT:0.3%;FIT:0.3%;STOP-FIT:0.3%;and COVID:0.2%;P=0.10).The risk of Colo_7 mo doubled between FIT[adjusted odds ratio(aOR):1.2(1.1;1.2)]and STOPFIT[aOR:2.4(2.1;2.6)];then,decreased by 40%between STOP-FIT and COVID[aOR:2.0(1.8;2.2)].Regardless of the period,this Colo_7 mo’s risk was twice as high for screening colonoscopy performed in a public hospital[aOR:2.

关键词： Colorectal cancer screening Screening colonoscopy Faecal immunochemical test Guaiac faecal occult blood test Quality of colonoscopy Severity of tumor lesions

MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth

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Journal of Molecular Cell Biology 2018年第3期10卷 195-204页

作者： rachel Xi-Yeen Ho Rosana D. Meyer Kevin B. Chandler Esma Ersoy Michael Park Philip A. Bondzie Nima Rahimi Huihong Xu catherine E. Costello Nader Rahimi Department of Pathology School of Medicine Boston University Medical Campus Boston MA 02118 USA Department of Biochemistry and Center for Biomedical Mass Spectrometry School of Medicine Boston University Medical Campus Boston MA 02118 USA

内在地混乱的蛋白质(IDP )/intrinsically 未组织的蛋白质被缺乏描绘修理或稳定的第三级的结构，并且逐渐地在信号 transduction 和 transcriptional 规定与主要角色作为蛋白质的一个重要的班被认出。在这研究，我们报导鉴定和功能的描... 详细信息

内在地混乱的蛋白质(IDP )/intrinsically 未组织的蛋白质被缺乏描绘修理或稳定的第三级的结构，并且逐渐地在信号 transduction 和 transcriptional 规定与主要角色作为蛋白质的一个重要的班被认出。在这研究，我们报导鉴定和功能的描述一以前 uncharacterized 蛋白质(UPF0258/KIAA1024 ) ，主要内在地混乱的联系 Notch2 的受体 1 (MINAR1 ) 。当 MINAR1 带一个单个 transmembrane 领域和一个短细胞质的领域时，它有不与已知的蛋白质序列分享类似的一个大细胞外的领域。Uncharacteristically， MINAR1 是一高度，有将近 70% 它的氨基酸的 IDP 定序未组织。我们证明 MINAR1 身体上与 Notch2 交往，它到 Notch2 的绑定增加它的稳定性和函数。MINAR1 广泛地包括胸的上皮的房间和血容器的 endothelial 房间在各种各样的纸巾被表示。当它在房间文化并且在塞子和 zebrafish angiogenesis 建模的老鼠 matrigel 禁止 angiogenesis， MINAR1 在 angiogenesis 起一个否定作用。而且，当 MINAR1 高度在正常的人的胸被表示时，它的表示是显著地，在先进人的乳癌的 downregulated 和它在乳癌房间的重新表示禁止了肿瘤生长。我们的学习证明 MINAR1 是否定地调整乳癌细胞的 angiogenesis 和生长的 IDP。

关键词：蛋白质序列肿瘤生长癌细胞约束力乳 IDP 稳定性房间

T cell immune responses to SARS-CoV-2 and variants of concern(Alpha and Delta)in infected and vaccinated individuals

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Cellular & Molecular Immunology 2021年第11期18卷 2554-2556页

作者： Stanley C.Jordan Bong-Ha Shin Terry-Ann M.Gadsden Maggie Chu Anna Petrosyan catherine N.Le rachel Zabner Jillian Oft Isabel Pedraza Susan Cheng Ashley Vo Noriko Ammerman Jasmine Plummer Shili Ge Max Froch Anders Berg Mieko Toyoda Ruan Zhang Comprehensive Transplant Center Transplant Immunology LaboratoryCedars-Sinai Medical CenterLos AngelesCAUSA Division of Infectious Diseases Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Cardiology Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Bioinformatics&Functional Genomics Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Pathology&Laboratory Medicine Cedars-Sinai Medical CenterLos AngelesCAUSA

Our understanding of immune responses to SARS-CoV-2 and variants of concern(VOCs)has been primarily acquired through analysis of Spike-specific IgG ***,a more comprehensive understanding of the breadth and longevity of immune responses after infection and vaccination requires analysis of cellular ***,we report on T cell immunity in infected and vaccinated individuals,identifying CD4+/CD8+T cell cytokine responses to SARS-CoV-2 and variant peptides(Alpha,B.1.1.7 and Delta,B.1.617.2).

关键词： Alpha infected immunity

美国耐甲氧西林金黄色葡萄球菌感染治疗临床治疗指南(一)

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今日药学 2011年第8期21卷 465-467页

作者：罗明琍吴新荣 catherine Liu Arnold Bayer Sara E.Cosgrove Robert S.Daum Scott K.Fridkin rachel J.Gorwitz Sheldon L.Kaplan Adolf W.Karchmer Donald P.Levine Barbara E.Murray MichaelJ.Rybak DavidA.Talan Henry F.Chambers 广州军区广州总医院药学部广东广州510010 Department of Medicine Division of Infectious DiseasesUniversity of California-San Francisco Division of Infectious Diseases Harbor-UCLA Medical Center Department of Medicine David Geffen School of Medicine at University of California Los Angeles Division of Infectious Diseases Johns Hopkins Medical Institutions Department of Pediatrics Section of Infectious DiseasesUniversity of Chicago Division ofHealthcare Quality Promotion Center for Emerging and Zoonotic Infectious DiseasesCenters for Disease Control and Prevention Department of Pediatrics Section of Infectious DiseasesBaylor College of Medicine Division of Infectious Diseases Beth Israel Deaconess Medicine CenterHarvard Medical School Department of Medicine Division of Infectious DiseasesWayne State UniversityDetroit Receiving Hospital and University Health Center Division of Infectious Diseases and Center for the Study of Emerging and Re-emerging Pathogens University of Texas Medical School Deparment of Pharmacy Practice Wayne State University Divisions of Emergency Medicine and Infectious Diseases Olive View-UCLA Medical Center Division of Infectious Diseases San Francisco General Hospital

美国感染病学会（IDSA）制订了治疗耐甲氧西林金黄色葡萄球菌（MRSA）患者的循证指南。该指南用于指导MRSA感染患者的治疗。该指南就多种与MRSA疾病相关的临床症状的治疗进行了论述,包括：皮肤和软组织感染（SSTI）、菌血症和感染性心... 详细信息

美国感染病学会（IDSA）制订了治疗耐甲氧西林金黄色葡萄球菌（MRSA）患者的循证指南。该指南用于指导MRSA感染患者的治疗。该指南就多种与MRSA疾病相关的临床症状的治疗进行了论述,包括：皮肤和软组织感染（SSTI）、菌血症和感染性心内膜炎、肺炎、骨和关节感染、中枢神经系统（CNS）感染等。该指南重点介绍了关于万古霉素用量及监测,以及对万古霉素低敏的耐甲氧西林金黄色葡萄球菌菌株感染的治疗方案及治疗失败的处置。

关键词：耐甲氧西林金黄色葡萄球菌感染临床治疗指南美国感染性心内膜炎中枢神经系统感染患者 MRSA 万古霉素