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艺术与设计 2024年第1期 122-125页

作者：楚琦无不详广州设计三年展

新年之初,“广州设计三年展2024”的开幕可谓是2024年开年第一场“设计盛宴”。无论从平面设计、产品设计,或是建筑设计及设计思维方面,来自27个国家的100位/组设计师,都围绕“有温度的设计”这一展览主题给出了自己的答案。

关键词：建筑设计平面设计产品设计设计思维展览主题温度设计师

Spinal Analgesia with Intrathecal Morphine versus Conventional Analgesia after Laparoscopic Colectomy: A Retrospective Cohort Study

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Open Journal of Anesthesiology 2024年第7期14卷 159-174页

作者： Lionel Diyamona Manon Colin Marc Léone Laurent Zieleskiewicz Joseph Nsiala Wilfrid Mbombo rachel Mbala Bruno Pastene Chris Nsituavibidila Dan Kankonde Gracia Likinda Jean Claude Mubenga Khazy Anga Noelly Mukuna Christel Isengingo Department of Anaesthesia and Intensive Care University Clinics of Kinshasa University of Kinshasa Kinshasa Democratic Republic of the Congo Department of Anaesthesia and Intensive Care Marseilles Nord Hospital Marseille France General Hospital of Kinshasa ex Mama Yemo Kinshasa Democratic Republic of the Congo Department of Anaesthesia and Intensive Care Monkole Hospital Centre Kinshasa Democratic Republic of the Congo

Objective: Postoperative pain (POP) following abdominal surgery can vary from a few hours to several days. This acute, unrelieved pain can become chronic, requiring patients to take analgesics on an almost daily basis for comfort. Analgesia using general opioids has many side effects and intrathecal morphine is a good alternative. This study was conducted to evaluate the efficacy of intrathecal morphine (ITM) versus conventional analgesia in the management of postoperative pain in colectomy performed by laparoscopic surgery. Methods: Cohort study conducted at the Hôpital Nord in Marseille, from 01 January to 31 July 2021 in patients aged at least 18 years undergoing anaesthesia for scheduled colectomy by laparoscopic surgery. The primary endpoint was postoperative pain intensity and the secondary endpoints were morphine consumption, treatment side effects and length of hospital stay. Statistical analysis was performed using XLSTAT software. Results: We included 193 patients: 131 in the control group (conventional analgesia) and 62 in the ITM group. We observed: a significant decrease in pain (assessed by numerical scale) in favour of the ITM group in the post-anaesthetic care room, i.e. 3 (±4) vs 1 (±2), p 0 and H2: 2 (±2) vs. 1 (±2);p Conclusion: These results suggest that intrathecal morphine (ITM) in laparoscopic colectomy provides effective postoperative analgesia with low morphine consumption, and a reduction in morphine side-effects compared with conventional analgesia.

关键词： Intrathecal Morphine Colectomy Laparoscopy Conventional Analgesia

The key piece of the airway remodeling puzzle revealed-LIGHT signaling in the lung

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Genes & Diseases 2023年第4期10卷 1131-1132页

作者： Ziyan rachel Chen Jim Hu Programmes in Translational Medicine Research InstituteHospital for Sick ChildrenTorontoOntario M5G 0A4Canada Department of Laboratory Medicine and Pathobiology University of TorontoTorontoOntario M5S 1A8Canada Department of Paediatrics University of TorontoTorontoOntario M5S 1A8Canada

Asthma is a chronic lung disease that primarily affects the lower respiratory tract in more than 300 million people *** is often triggered by exposure to certain substances or conditions,such as allergens or cold *** overreaction to the allergens causes inflammation and narrowing of the airway,which leads to episodic or persistent symptoms including shortness of breath,nocturnal cough,chest tightness,and wheezing.

关键词： airway lung inflammation

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2024年日光奖:裹着光的建筑

艺术与设计 2024年第5期 112-115页

作者：楚琦日光奖(图) 不详

时隔两年,在2024年联合国教科文组织国际光日(5月16日)这一天,我们得以再次见证日光带给建筑的奇妙之感。今年的日光奖(The Daylight Award)评委会将建筑日光类荣誉授予了来自西班牙的建筑师兼教授阿尔伯托·坎波·巴埃萨(Alberto Campo... 详细信息

时隔两年,在2024年联合国教科文组织国际光日(5月16日)这一天,我们得以再次见证日光带给建筑的奇妙之感。今年的日光奖(The Daylight Award)评委会将建筑日光类荣誉授予了来自西班牙的建筑师兼教授阿尔伯托·坎波·巴埃萨(Alberto Campo Baeza),他用近乎洁白明亮的建筑空间紧紧裹住了充满温暖的自然日光。

关键词：阿尔伯托·坎波·巴埃萨日光联合国教科文组织建筑师

The role of copper in enhancing the performance of heteronuclear diatomic catalysts for the electrochemical CO_(2)conversion to C_(1) chemicals

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Journal of Energy Chemistry 2023年第10期85卷 490-500,I0013页

作者： Qi Zhao rachel Crespo-Otero Devis Di Tommaso Department of Chemistry School of Physical and Chemical SciencesQueen Mary University of LondonLondon E14NSUK Department of Chemistry University College LondonLondon WC1H 0AJUK

Diatomic catalysts(DACs)with two adjacent metal atoms supported on graphene can offer diverse functionalities,overcoming the inherent limitations of single atom catalysts(SACs).In this study,density functional theory calculations were conducted to investigate the reactivity of the carbon dioxide(CO_(2))reduction reaction(CO_(2)RR)on metal sites of both DACs and SACs,as well as their synergistic effects on activity and *** of the Gibbs free energies of CO_(2)RR and associated values of the limiting potentials to generate C_(1) products showed that Cu acts as a promoter rather than an active catalytic centre in the catalytic CO_(2)conversion on heteronuclear DACs(CuN_(4)-MN_(4)),improving the catalytic activity on the other metal compared to the related SAC MN_(4).Cu enhances the initial reduction of CO_(2)by promoting orbital hybridization between the key intermediate*COOH 2p-orbitals and the metals 3d-orbitals around the Fermi *** degree of hybridization in the DACs CuN_(4)-MN_(4) decreases from Fe to Co,Ni,and *** work demonstrates how Cu regulates the CO_(2)RR performance of heteronuclear DACs,offering an effective approach to designing practical,stable,and high-performing diatomic catalysts for CO_(2)electroreduction.

关键词： Electrocatalytic CO_(2)reduction Single atom catalysts Diatomic catalysts Graphene Density functional theory calculations

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濒死的意识体验

环球科学 2024年第13期 40-47页

作者：蕾切尔·努维尔金烨(翻译) 不详

濒死体验是一根能够揭示意识和大脑最本质真相的为探寻那些生命隐藏在最深处的秘密带来一丝光芒。几十年来,弗朗索瓦·德达斯基(Francois d'Adesky)从未向任何人讲述过自己的濒死体验(near-death experience)。这名生活在比利时布鲁塞... 详细信息

濒死体验是一根能够揭示意识和大脑最本质真相的为探寻那些生命隐藏在最深处的秘密带来一丝光芒。几十年来,弗朗索瓦·德达斯基(Francois d'Adesky)从未向任何人讲述过自己的濒死体验(near-death experience)。这名生活在比利时布鲁塞尔的退休外交官兼公务员经历濒死体验时只有13岁,当时他因为急性阑尾炎被送进了医院。德达斯基生动地回忆起当时他看到自己的身体躺在手术台上,然后他穿过了一条隧道,在那里遇到了奇异的生灵,他们全身散发着光辉与神性。“你的死期还没到”,其中一位长者这么告诉他,德达斯基直觉地认为“他”就是上帝,后者说:“你在地球上的使命还没开始。”

关键词：濒死体验急性阑尾炎弗朗索瓦达斯意识体验

SIMAP500: A novel risk score to identify recipients at higher risk of hepatocellular carcinoma recurrence following liver transplantation

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World Journal of Transplantation 2024年第3期14卷 132-143页

作者： Amr Alnagar Nekisa Zakeri Konstantinos Koilias Rosemary E Faulkes rachel Brown Owen Cain M Thamara P R Perera Keith J Roberts Rebeca Sanabria-Mateos David C Bartlett Yuk Ting Ma Shivan Sivakumar Shishir Shetty Tahir Shah Bobby V M Dasari Department of HBP and Liver Transplantation Surgery Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Centre for Liver Research Institute of Biomedical ResearchBirmingham B152TTUnited Kingdom Department of Hepatology Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Department of Pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Department of Oncology Queen Elizabeth HospitalUniversity Hospitals of BirminghamBirmingham B152GWUnited Kingdom

BACKGROUND Recurrence of hepatocellular carcinoma(HCC)following liver transplantation(LT)has a devastating influence on recipients’survival;however,the risk of recur-rence is not routinely *** stratification is vital with a long LT waiting time,as that could influence the recurrence despite strict listing *** This study aims to identify predictors of recurrence and develop a novel risk pre-diction score to forecast HCC recurrence following *** A retrospective review of LT for HCC recipients at University Hospitals Bir-mingham between July 2011 and February *** and multivariate analyses were performed to identify recurrence predictors,based on which the novel SIMAP500(satellite nodules,increase in size,microvascular invasion,AFP>500,poor differentiation)risk score was *** 234 LTs for HCC were performed with a median follow-up of 5.3 *** developed in 25 patients(10.7%).On univariate analyses,RETREAT score>3,α-fetoprotein(AFP)at listing 100-500 and>500,bridging,increased tumour size between imaging at the listing time and explant histology,increase in the size of viable tumour between listing and explant,presence of satellite nodules,micro-and macrovascular invasion on explant and poor differentiation of tumours were significantly associated with recurrence,based on which,the SIMAP500 risk score is *** SIMAP500 demonstrated an excellent predictive ability(c-index=0.803)and outper-formed the RETREAT score(c-index=0.73).SIMAP500 is indicative of the time to disease *** SIMAP500 risk score identifies the LT recipients at risk of HCC *** stratification allows patient-centric post-transplant surveillance *** validation of the score is recommended.

关键词： Liver transplantation Hepatocellular carcinoma Recurrence Survival

Regulation of enolase activation to promote neural protection and regeneration in spinal cord injury

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Neural Regeneration Research 2023年第7期18卷 1457-1462页

作者： Hannah MMcCoy rachel Polcyn Naren LBanik Azizul Haque Department of Microbiology and Immunology Medical University of South CarolinaCharlestonSCUSA Department of Neurosurgery Medical University of South CarolinaCharlestonSCUSA Ralph H.Johnson Veterans Administration Medical Center CharlestonSCUSA

Spinal cord injury(SCI)is a debilitating condition characterized by damage to the spinal cord resulting in loss of function,mobility,and sensation with no *** and Drug Administration-approved ***,a multifunctional glycolytic enzyme upregulated after SCI,promotes pro-and anti-inflammatory events and regulates functional recovery in *** is normally expressed in the cytosol,but the expression is upregulated at the cell surface following cellular injury,promoting glial cell activation and signal transduction pathway ***-induced microglia activation triggers pro-inflammatory mediators at the injury site,activating other immune cells and metabolic events,i.e.,Rho-associated kinase,contributing to the neuroinflammation found in *** surface expression also activates cathepsin X,resulting in cleavage of the C-terminal end of neuron-specific enolase(NSE)and non-neuronal enolase(NNE).Fully functional enolase is necessary as NSE/NNE C-terminal proteins activate many neurotrophic processes,i.e.,the plasminogen activation system,phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B,and mitogen-activated protein kinase/extracellular signal-regulated *** here suggest an enolase inhibitor,ENOblock,attenuates the activation of Rho-associated kinase,which may decrease glial cell activation and promote functional recovery following ***,ENOblock inhibits cathepsin X,which may help prevent the cleavage of the neurotrophic C-terminal protein allowing full plasminogen activation and phosphatidylinositol-4,5-bisphosphate 3-kinase/mitogen-activated protein kinase *** combined NSE/cathepsin X inhibition may serve as a potential therapeutic strategy for preventing neuroinflammation/degeneration and promoting neural cell regeneration and recovery following *** role of cell membrane-expressed enolase and associated metabolic events should be investigated to determine if the same strategies can be applied to other neu

关键词： cathepsin X ENOblock enolase glia mitogen-activated protein kinase/extracellular signal-regulated kinase neurodegeneration neuroinflammation phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B Rho-associated protein kinase spinal cord injury

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阶梯停车场芬兰郝尔辛基

世界建筑导报 2024年第2期39卷 117-119页

作者： uho Grönholm Antti Nousjoki Samuli Woolston Pekka Tainio Tuulikki Tanska rachel Murray Anssi Luodemäki Harri Humppi Tuomas Uusheimo(摄影) Marc Goodwin(摄影) ALA建筑师事务所不详

新的五角形、五层高的Saukonlaituri停车设施包括六条流线,可停放600辆私家车,中央庭院被布满巨石、苔藓和蕨类植物的景观环绕。其中五个停车场有顶棚,第六个停车场位于屋顶。庭院具有双重功能:它既是一个采光井,阳光可通过庭院照射到... 详细信息

新的五角形、五层高的Saukonlaituri停车设施包括六条流线,可停放600辆私家车,中央庭院被布满巨石、苔藓和蕨类植物的景观环绕。其中五个停车场有顶棚,第六个停车场位于屋顶。庭院具有双重功能:它既是一个采光井,阳光可通过庭院照射到较低的停车场,又是雨水蓄水池和积雪堆积地。建筑的南侧从入口广场后退,将地面公共空间延伸为阶梯式公园,一直延伸到屋顶。这种解决方案使周围公寓楼的居民可以沿着阶梯走到正确的楼层取车,而不是乘坐电梯。阶梯区域也可以用于野餐和日光浴。

关键词：入口广场空间延伸采光井停车设施公寓楼停车场阶梯式电梯

Microstructure refinement in biodegradable Zn-Cu-Ca alloy for enhanced mechanical properties,degradation homogeneity,and strength retention in simulated physiological condition

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Journal of Materials Science & Technology 2022年第30期125卷 1-14页

作者： Nan Yang Nagasivamuni Balasubramani Jeffrey Venezuela Helle Bielefeldt-Ohmann rachel Allavena Sharifah Almathami Matthew Dargusch Queensland Centre for Advanced Materials Processing and Manufacturing(AMPAM)School of Mechanical and Mining Engineering The University of QueenslandAdvanced Engineering BuildingBld 49Staff House Rd.St LuciaQLD 4072Australia School of Veterinary Science The University of QueenslandGattonQLD 4343Australia School of Chemistry and Molecular Biosciences The University of QueenslandQLD 4072Australia

Zn-1.0Cu-0.5Ca(TA15)alloy has shown promising characteristics of enhanced mechanical properties and biodegradability for absorbable cardiovascular stents,endovascular devices,and wound closure devices *** this study,the TA15 alloy for bioabsorbable biomedical applications is *** the conventionally cast TA15(TA15-C)alloy,CaZn_(13) phase are present as a large dendritic network with an average size of 73.25±112.84μm,Hot rolling of the TA15-C alloy has broken the long and dendritic network of the CaZn_(13) phases,however,the refined phases are observed as segregations and the distribution is *** segregated CaZn_(13) suffered heavy localised corrosion which lead to poor mechanical properties in the as-fabricated condition and after *** treatment(UST)during casting is identified as an effective technique for the refinement and redistribution of CaZn_(13) particles in TA15 alloy,which successfully reduce the size of the CaZn_(13) phase to 10.91±4.65μm in the as-solidified *** hot rolling,the UST processed TA15(TA15-UST)shows improved mechanical properties due to grain refinement and the reduction in microstructural defects,*** broken CaZn_(13) *** of 8-week immersion corrosion tests showed that both alloys possess very similar corrosion ***,TA15-UST has markedly improved corrosion homogeneity compared to TA15-N which favours the retention of mechanical properties even after prolonged exposure to physiological fluids.

关键词： Biodegradable Zn alloy Peritectic phase refinement In vitro corrosion Mechanical property retention Cytocompatibility