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Epidemiological and Diagnostic Profile of Patients with Chronic Hepatitis B Virus from 2017 to 2021 in Parakou, Republic of Benin

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Advances in Infectious Diseases 2024年第1期14卷 147-161页

作者： Khadidjatou Saké Cossi Angelo Attinsounon Aboudou raϊmi Kpossou Morayo Omm Ani Salami Astrid Alexandrine Hountondji Kofi-Mensa Savi de Tovè Rhonel Ahanhanzo-Glèlè Kpémahoun René Kèkè Sossa Edmond Gbédo Jean Sehonou Nicolas Kodjoh Department of Medicine and Medical Specialties Faculty of Medicine University of Parakou Parakou Benin Department of Medicine and Medical Specialties Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin Health Program to Fight AIDS Cotonou Benin National Program for the Control of Hepatitis Cotonou Benin

Introduction: Viral hepatitis B is a public health problem worldwide. The objective of this study was to determine the epidemiological and diagnostic profile of chronic carriers of hepatitis B virus seen for gastroenterology consultations in Parakou, Republic of Benin. Patients and Methods: This was a cross-sectional and descriptive study with retrospective data collection. Patients seen for gastroenterology consultations from January 1, 2017 to June 30, 2021 at the Regional Teaching Hospital of Borgou/Alibori (CHUD-B/A) and having been diagnosed as chronic carriers of hepatitis B virus were included. A minimum initial assessment was required to be included. The minimum sample size was calculated with Schwartz formula. The variable of interest was the detection of HBsAg twice and at least 6 months apart. The other variables studied were sociodemographic, clinical and paraclinical data. The data collected were analyzed using SPSS 17 software. Results: A total of 2786 patients were seen for gastroenterology consultations, including 1126 (40.4%) HBsAg-positive patients. Among them, 417 patients met the inclusion criteria and were the subject of the present study. The average age of the patients was 34.8 ± 10.5 years. Two hundred and forty-seven patients (65.7%) were male, representing a sex ratio of 1.9. The discovery of positive HBsAg status was made during systematic screening in 231 patients (55.4%). Scarifications were noted in 373 patients (89.4%). Asthenia was reported in 184 patients (44.1%). Co-infections with human immunodeficiency virus, hepatitis C and D viruses were 0% (0 in 92), 2.8% (4 in 146) and 14.3% (2 in 146), respectively. During the initial assessment, 274 patients (65.7%) were sero-negative for chronic HBeAg infection, 21 (5%) had clinically significant fibrosis including 16 (3.8%) at the stage of cirrhosis and 7 patients (5.4%) had hepatocellular carcinoma. Conclusion: In Parakou, chronic hepatitis B virus infection is common and affects young pe

关键词： Chronic Infection HBV Epidemiology Diagnosis Parakou

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Emphysematous Cystitis: Report of Two Cases and Review of the Literature

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Health 2024年第4期16卷 309-318页

作者： Roland Bertile Banga-Mouss Nestor Ghislain Andzouana Mbamognoua Yanick Dimi Nyanga Armel Melvin Atipo Ondongo Steve Aristid Ondziel-Opara raïssa Laure Mayanda Ohouanda Nick Arnaud Monabeka Evariste Bouenizabila Anani Séverin Wences Odzébé Prosper Alain Bouya Urology Department University Hospital of Brazzaville Brazzaville Republic of the Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo Department of Metabolic and Endocrine Diseases University Hospital of Brazzaville Brazzaville Republic of the Congo

Emphysematous cystitis is a rare complication of lower urinary tract infection whose prognosis is conditioned by the delay in treatment. The predisposition of diabetic patients to urinary infections caused by gas-producing bacteria is considered one of the most common factors in the occurrence of emphysematous cystitis. The currently recommended diagnostic test is CT scanning, which has definite value in assessing gas accumulation in the bladder wall and lumen. The authors report the observations of two patients aged 68 and 80 who were treated for emphysematous cystitis complicating diabetes mellitus. The evolution was favorable under treatment with antibiotic therapy, insulin therapy and bladder drainage.

关键词： Emphysematous Cystitis Computed Tomography Lower Urinary Tract Infection Diabetes Mellitus

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Soil quality assessment for desertification based on multi-indicators with the best-worst method in a semi-arid ecosystem

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Journal of Arid Land 2023年第7期15卷 779-796页

作者： Orhan DENGİZ İnci DEMİraĞTUraN Department of Soil Science and Plant Nutrition Faculty of AgricultureOndokuz Mayıs UniversitySamsun-55139Turkey Department of Geography Faculty of EconomicAdministrative and Social SciencesSamsun UniversitySamsun-55030Turkey

Since there are some signs of land degradation and desertification showing how soil sustainability is threatened, it is crucial to create a soil quality index(SQI) model in the semi-arid ?orum Basin, situated between the Black Sea and Anatolia Region, Central Turkey. The primary aims of the study are:(1) to determine SQI values of the micro-basin in terms of land degradation and ***, the best-worst method(BWM) was used to determine the weighting score for each parameter;(2) to produce the soils' spatial distribution by utilizing different geostatistical models and GIS(geographic information system) techniques;and(3) to validate the obtained SQI values with biomass reflectance values. Therefore, the relationship of RE-OSAVI(red-edge optimized soil-adjusted vegetation index) and NDVI(normalized difference vegetation index) generated from Sentinel-2A satellite images at different time series with soil quality was examined. Results showed that SQI values were high in the areas that had almost a flat and slight slope. Moreover, the areas with high clay content and thick soil depth did not have salinity problems, and were generally distributed in the middle parts of the basin. However, the areas with a high slope, poor vegetation, high sand content, and low water holding capacity had low SQI ***, a statistically high positive correlation of RE-OSAVI and NDVI indices with soil quality was found, and NDVI had the highest correlative value for June(R~2=0.802) compared with RE-OSAVI.

关键词： soil quality land degradation desertification best-worst method remote sensing

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Stellar structure model in hydrostatic equilibrium in the context of f(R)-gravity

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Research in Astronomy and Astrophysics 2017年第12期17卷 31-40页

作者： raíla Andr Gilberto M.Kremer Departamento de Fisica Universidade Federal do Parana81531-980 CuritibaBrazil Manipal Centre for Natural Sciences Manipal UniversityManipal 576104India

In this work we present a stellar structure model from the f（R）-gravity point of view capable of describing some classes of stars（white dwarfs, brown dwarfs, neutron stars, red giants and the Sun）. This model is based on f（R）-gravity field equations for f（R） = R ＋ f2R2, hydrostatic equilibrium equation and a polytropic equation of state. We compare the results obtained with those found by Newtonian theory. It has been observed that in these systems, where high curvature regimes emerge,stellar structure equations undergo modifications. Despite the simplicity of this model, the results are satisfactory. The estimated values of pressure, density and temperature of the stars are within those determined by observations. This f（R）-gravity model has proved to be necessary to describe stars with strong fields such as white dwarfs, neutron stars and brown dwarfs, while stars with weaker fields, such as red giants and the Sun, are best described by Newtonian theory.

关键词： cosmology:theory stars:general massive brown dwarfs white dwarfs neutron

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ROBUST HIGH ORDER CONVERGENCE OF AN OVERLAPPING SCHWARZ METHOD FOR SINGULARLY PERTURBED SEMILINEAR REACTION-DIFFUSION PROBLEMS

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Journal of Computational Mathematics 2013年第5期31卷 509-521页

作者： S. Chandra Sekhara ra~ Sunil Kumar Department of Mathematics Indian Institute of Technology Delhi Hauz khas New Delhi-110016 India

In this article we propose an overlapping Schwarz domain decomposition method for solving a singularly perturbed semilinear reaction-diffusion problem. The solution to this problem exhibits boundary layers of width O（√ε ln（1/√ε）） at both ends of the domain due to the presence of singular perturbation parameter ε. The method splits the domain into three overlapping subdomains, and uses the Numerov or Hermite scheme with a uniform mesh on two boundary layer subdomains and a hybrid scheme with a uniform mesh on the interior subdomain. The numerical approximations obtained from this method are proved to be almost fourth order uniformly convergent （in the maximum norm） with respect to the singular perturbation parameter. Furthermore, it is proved that, for small ε, one iteration is sufficient to achieve almost fourth order uniform convergence. Numerical experiments are given to illustrate the theoretical order of convergence established for the method.

关键词： Singular perturbation Semilinear reaction-diffusion Overlapping Schwarzmethod Robust convergence Numerov scheme.

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Periodic Solutions of Evolution Variational Inequalities—a Method of Guiding Functions

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Chinese Annals of Mathematics,Series B 2009年第3期30卷 261-272页

作者： Samir ADLY Daniel GOELEVEN Michel THra Département de Math'ematiques et Informatique Laboratoire XLIM(Unité Mixte 6172 du CNRS)Université de Limoges123 Avenue A.Thomas87060 Limoges CedexFrance. Laboratoire d' Informatique et de Mathématiques Université de La Réunion97400 Saint-DenisFrance.

This paper focuses on a part of the presentation given by the third author at the Shanghai Forum on Industrial and Applied Mathematics(Shanghai 2006).It is related to the existence of a periodic solution of evolution ... 详细信息

关键词： Variational inequality Differential inclusion Topological degree Guiding function Periodic solution

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Future prospectives for the management of chronic hepatitis B

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World Journal of Gastroenterology 2007年第18期13卷 2554-2567页

作者： WF Leemans HLA Janssen ra de Man Department of Gastroenterology & Hepatology Erasmus MC University Medical Center Rotterdam The Netherlands

Chronic hepatitis B virus infection affects about 400 million people around the globe and causes approximately a million deaths a year. Since the discovery of interferon-α as a therapeutic option the treatment of hepatitis B has evolved fast and management has become increasingly complicated. The amount of viral replication reflected in the viral load （HBV-DNA） plays an important role in the development of cirrhosis and hepatocellular carcinoma. The current treatment modalities for chronic hepatitis B are immunomodulatory （interferons） and antiviral suppressants （nucleoside and nucleotide analogues） all with their own advantages and limitations. An overview of the treatment efficacy for both immunomodulatory as antiviral compounds is provided in order to provide the clinician insight into the factors influencing treatment outcome. With nucleoside or nucleotide analogues suppression of viral replication by 5-7 log10 is feasible, but not all patients respond to therapy. Known factors influencing treatment outcome are viral load, ALT levels and compliance. Many other factors which might influence treatment are scarcely investigated. Identifying the factors associated with response might result in stopping rules, so treatment could be adapted in an early stage to provide adequate treatment and avoid the development of resistance. The efficacy of compounds for the treatment of mutant virus and the cross-resistance is largely unknown. However, genotypic and phenotypic testing as well as small clinical trials provided some data on efficacy in this population. Discontinuation of nucleoside or nucleotide analogues frequently results in viral relapse; however, some patients have a sustained response. Data on the risk factors for relapse are necessary in order to determine when treatment can be discontinued safely. In conclusion： chronic hepatitis B has become a treatable disease; however, much research is needed to tailor therapy to an individual patient, to predict the susta

关键词： Hepatitis B virus Cirrhosis Treatment Interferon Nucleoside analogues Nucleotide analogues Lamivudine Adefovir Entecavir Telbivudine Tenofovir Resistance Genotype

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Is there a potential of circulating miRNAs as biomarkers in rheumatic diseases?

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Genes & Diseases 2023年第4期10卷 1263-1278页

作者： Klára Prajzlerová Ladislav Senolt Mária Filková Institute of Rheumatology Prague 12800Czech Republic Department of Rheumatology First Faculty of MedicineCharles UniversityPrague 12800Czech Republic

t MicroRNAs(miRNAs)are small non-coding single-stranded RNAs of about 22 nucle-otides in length that act as post-transcriptional regulators of gene *** on the complementarity between miRNA and target mRNA,cleavage,destabilization,or transla-tional suppression of mRNA occurs within the RISC(RNA-induced silencing complex).As gene expression regulators,miRNAs are involved in a variety of biological *** of miRNAs and their target genes contribute to the pathophysiology of many diseases,including autoimmune and inflammatory *** are also present extracellularly in their sta-ble form in body *** incorporation into membrane vesicles or protein complexes with Ago2,HDL,or nucleophosmin 1 protects them against ***-free miRNAs can be deliv-ered to another cell in vitro and maintain their functional ***,miRNAs can be considered mediators of intercellular *** remarkable stability of cell-free miRNAs and their accessibility in body fluid makes them potential diagnostic or prognostic bio-markers and potential therapeutic *** we provide an overview of the potential role of circulating miRNAs as biomarkers of disease activity,therapeutic response,or diagnosis in rheumatic *** circulating miRNAs reflect their involvement in the pathogenesis,while for plenty,their pathogenetic mechanisms remain to be *** miRNAs described as biomarkers were also shown to be of therapeutic potential,and some miRNAs arealready tested in clinical trials.

关键词： Biomarker Diagnosis miRNA Rheumatic diseases Therapy

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Existence Results for a Class of Periodic Evolution Variational Inequalities

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Chinese Annals of Mathematics,Series B 2007年第6期28卷 629-650页

作者： Samir ADLY Daniel GOELEVEN Michel THra DMI-XLIM UMR-CNRS 6172Université de Limoges123 Avenue A.Thomas87060 Limoges CedexFrance. IREMIA Université de La Réunion97400 Saint-DenisFrance.

In this paper, using the Brouwer topological degree, the authors prove an existence result for finite variational inequalities. This approach is also used to obtain the existence of periodic solutions for a class of e... 详细信息

关键词： Variational inequalities Differential inclusions Topological degree Guiding functions Periodic solutions

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Prevalence, Maternal and Perinatal Prognosis of Breech Delivery Compared to That of the Vertex in 242 Cases for 484 Controls at Ségou Hospital in Malti

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Open Journal of Obstetrics and Gynecology 2024年第9期14卷 1414-1421页

作者： Tidiani Traoré Famakan Kané Abdoulaye Kassogué Seydou Traoré Seydou Z. Dao Balilé Harber Sabré Koné Kassoum Sidibé Brahima Donigolo Babou Traoré Adama Coulibaly Abdrhamane Diarisso Alima Sidibé Mamadou Sima Augustin Théra Youssouf Traoré Ibrahima Teguété Niani Mounkoro Ministry of Health in Bamako Nianakoro Fomba Hospital Segou Mali Regional Health Department of Segou District Hospital Bla Mali Regional Health Department of Koutiala Reference Health Center Koutiala Mali Regional Health Department of Bamako Reference Health Center Commune II Bamako Mali Ministry of Health in Bamako Fousseyni Daou Hospital Kayes Mali Ministry of Health in Bamako Point G University Hospital Center Bamako Mali Ministry of Health in Bamako Gabriel Toure University Hospital Center Bamako Mali

Introduction: Breech birth has always been a subject of great interest because of its risks of perinatal morbidity and mortality. Aim: The aim of our study was to compare the maternal and perinatal prognosis of breech delivery with that of vertex delivery. Patients and Method: This was a retrospective case-control analytical study carried out in the obstetrics and gynaecology department of Ségou hospital over a 2-year period from 1 January 2020 to 31 December 2021, involving 242 breech deliveries compared with 484 top deliveries with a live single foetus without foetal malformation of gestational age ≥ 35 SA. The statistical tests used were: chi² (p Results: The frequency of breech delivery was 3.3%, with a predominance of caesarean section for breech presentation (64.88%) compared with 32.85% for vertex (P: 0.00;CI: (0.191 - 0.367). The perinatal prognosis of fetuses with breech presentations was marked by a higher rate of neonatal asphyxia (Apgar score Conclusion: Breech birth is relatively rare in our department. It carries a higher risk of maternal morbidity and neonatal morbidity than breech delivery. However, the vital prognosis for the mother was identical in both groups.

关键词： Delivery Breech Vertex Prognosis Mali

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