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TNFα和Il-6体外对颗粒物的反应：随颗粒物大小、季节、多环芳烃和土壤含量的变化

环境与职业医学 2016年第12期33卷 1202-1208页

作者： Natalia Manzano-león Jesús Serrano-lomelin Brisa N.Sánchez raúl quintana-belmares Elizabeth Vega Inés Vázquez-lópez leonora Rojas-Bracho Maria Tania lópez-Villegas Felipe Vadillo-Ortega Andrea De Vizcaya-Ruiz Irma Rosas Perez Marie S.O’Neill Alvaro R.Osornio-Vargas 季麟(翻译) 金泰廙(审校) Departamento de Investigacion Basica Instituto Nacional de CancerologiaMexicoDFMexico School of Public Health University of AlbertaEdmontonAlbertaCanada Department of Environmental Health Sciences Department of Epidemiology School of Public HealthUniversity of MichiganAnn ArborMichiganUSA Direccion de Investigacion y Posgrado Instituto Mexicano del PetroleoMexicoDFMexico Gerencia de Ciencias Ambientales Instituto Nacional de Investigaciones NuclearesLa MarquesaOcoyoacacEstado de MexieoMexico Instituto Nacional de Ecologta y Cambio Climatico MexicoDFMexico National Autonomous University of Mexico(UNAM)at the National Institute of Genomic Medicine MexicoDFMexico Departamento de Toxicologla CinvestavMexicoDFMexico Centro de Ciencias de la Atmosfera UNAMMexicoDFMexico Department of Paediatrics University of AlbertaEdmontonAlbertaCanada 不详

[背景]颗粒物(PM)与人类健康之间的关联随着季节变化而不同,这种现象可能与颗粒物的成分以及毒性相关的季节性交互作用有关。[目的]检测PM成分的季节性变化,并使用多个PM样本评估PM的体外促炎症可能性。[方法]以5个污染源不同的城市地... 详细信息

[背景]颗粒物(PM)与人类健康之间的关联随着季节变化而不同,这种现象可能与颗粒物的成分以及毒性相关的季节性交互作用有关。[目的]检测PM成分的季节性变化,并使用多个PM样本评估PM的体外促炎症可能性。[方法]以5个污染源不同的城市地区为采集地点,每周采集样本,在多雨温暖季节和干燥寒冷季节累积采集90份PM_(10)和PM_(2.5)样本。对其中检测到的元素、多环芳烃(PAHs)和内毒素进行主成分分析(PCA)。在人单核细胞(THP-1)中检测PM诱导肿瘤坏死因子α(TNFα)和白介素6(Il-6)分泌的可能性,并用组分评分建立促炎症反应的模型。[结果]PM的成分随其大小和季节而变化。PCA确定了PM中两种随季节变化的主要组分。燃烧相关的成分(如钒、苯并(a)芘、苯并(a)蒽)组成组分1(C_1),土壤相关的成分(如内毒素、硅、铝)组成组分2(C_2)。多雨温暖季节采集的PM中C_2含量较高,而干燥寒冷季节采集的PM(尤其是PM_(2.5))中C_1含量较高。细胞因子生成水平与PM_(10)和C_2(多雨温暖季节)正相关,但与PM_(2.5)和C_1(干燥寒冷季节)负相关。C_2含量较高的PM暴露水平越高,TNFα分泌越多;样本含有≥0.1%的C_1相关PAHs时,无论样本中C_2含量高低,暴露于该样本后TNFα对PM的反应性分泌都会降低。Il-6检测结果提示PM成分和颗粒大小之间存在复杂的交互作用。[结论]TNFα分泌具有季节性并与PM大小相关,PM中的土壤含量及PAH含量的变化是其根本原因。这些结果提示,流行病学研究中一些健康结局与PM之间关联的季节性差异能用PM组分的混合物来解释。

关键词：多环芳烃主成分分析内毒素检测采集样流行病学研究细胞因子城市地区肿瘤坏死因子α 变异系数苯并

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Tri-axial accelerometry allows to determine parental food provisioning behaviour in a marine bird

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Avian Research 2024年第3期15卷 345-351页

作者： Monserrat Del Caño Flavio quintana Giacomo Dell’Omo Agustina Gómez-laich Instituto de Biología de Organismos Marinos(IBIOMAR) CONICETBoulevard Brown 2915U9120ACDPuerto MadrynChubutArgentina Ornis Italica Piazza Crati 1500199RomeItaly Departamento de Ecología Genética y Evolución(EGE)and Instituto de EcologíaGenética y Evolución de Buenos Aires(IEGEBA)CONICETFacultad de CienciasExactas y NaturalesUniversidad de Buenos AiresPabellón II Ciudad UniversitariaC1428EGACiudad Autónoma de Buenos AiresArgentina

The study of parental food provisioning is essential for understanding the breeding ecology of *** conducted the first study using accelerometry to detect food provisioning in birds,using Support Vector Machine(SVM)models to identify when adults feed chicks of three different age *** were attached to the head of adult female Imperial Shags(leucocarbo atriceps),and various attributes derived from the acceleration signals were used to train SVM models for each chick age *** performance improved with chick age class,with SVM models achieving high overall accuracy(>88%)and highest sensitivity in older chick categories(>91%).However,precision values,especially for younger chicks,remained relatively low(between 26%and 45%).The application of a time filter based on the minimum duration of the observed food provisioning behaviours for each chick age category,improved model performance by reducing false provisioning behaviours,particularly in the model for older chicks,which showed the highest precision(72.4%).This study highlights the effectiveness of accelerometry and machine learning in studying parental food provisioning in birds,providing a rapid and accurate data collection method to complement traditional *** described methodology can be applied to any bird species that exhibits distinctive movements while feeding its offspring and has suitable characteristics for attaching an accelerometer to the body part that best captures this ***,it is hoped that the results of this study will contribute to future research on key questions in parental investment theory and reproductive strategies in birds.

关键词： Accelerometry Food provisioning Imperial shag leucocarbo atriceps Seabird Support vector machine

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Approach to traumatic cardiac arrest in the emergency department: a narrative literature review for emergency providers

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World Journal of Emergency Medicine 2024年第1期15卷 3-9页

作者： rashed Alremeithi Quincy K.Tran Megan T.quintana Soroush Shahamatdar Ali Pourmand Department of Emergency Medicine George Washington University School of Medicine and Health SciencesWashington DC 20037USA Department of Emergency Medicine University of Maryland School of MedicineBaltimore 21201USA Program in Trauma the R Adams Cowley Shock Trauma CenterUniversity of Maryland School of MedicineBaltimore 21201USA Center for Trauma and Critical Care Department of Surgerythe George Washington University School of Medicine&Health SciencesWashington DC 20037USA

BACKGROUND:Traumatic cardiac arrest(TCA)is a major contributor to mortality and morbidity in all age groups and poses a significant burden on the healthcare *** there have been advances in treatment modalities,survival rates for TCA patients remain *** narrative literature review critically examines the indications and eff ectiveness of current therapeutic approaches in treating ***:We performed a literature search in the PubMed and Scopus databases for studies published before December 31,*** search was refi ned by combining search terms,examining relevant study references,and restricting publications to the English *** the search,943 articles were retrieved,and two independent reviewers conducted a screening ***:A review of various studies on pre-and intra-arrest prognostic factors showed that survival rates were higher when patients had an initial shockable *** were conflicting results regarding other prognostic factors,such as witnessed arrest,bystander cardiopulmonary resuscitation(CPR),and the use of prehospital or in-hospital *** thoracotomy was found to result in more favorable outcomes in cases of penetrating trauma than in those with blunt *** endovascular balloon occlusion of the aorta(REBOA)provides an advantage to emergency thoracotomy in terms of occupational safety for the operator as an alternative in managing hemorrhagic *** implemented in the setting of aortic occlusion,emergency thoracotomy and REBOA resulted in comparable mortality ***-venous extracorporeal life support(V-V EClS)and veno-arterial extracorporeal life support(V-A EClS)are viable options for treating respiratory failure and cardiogenic shock,*** the context of traumatic injuries,V-V EClS has been associated with higher rates of survival to discharge than V-A ***:TCA remains a signifi cant challenge for emergency medical services due to its high m

关键词： Traumatic cardiac arrest Emergency thoracotomy Resuscitative endovascular balloon occlusion of the aorta

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Doping engineering of lithium-aluminum layered double hydroxides for high-efficiency lithium extraction from salt lake brines

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Nano Research 2024年第3期17卷 1646-1654页

作者： lingjie Zhang Tingting Zhang Yunliang Zhao Guangfeng Dong Shuaike lv Songliang Ma Shaoxian Song Mildred quintana School of Chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China Facultad de Ciencias Universidad Autonoma de San Luis PotosiAv.Parque Chapultepec 1570San Luis Potosi 78210Mexico Wuhan Clayene Technology Co. Ltd.Wuhan 430223China State Development Investment Xinjiang lop Nur Potash Corporation Hami 839000China

lithium-aluminum layered double hydroxides(liAl-lDH)have been be successfully applied in commercial-scale for lithium extraction from salt lake brine,however,further advancement of their applications is hampered by suboptimal li^(+)adsorption performance and ambiguous extraction ***,a doping engineering strategy was developed to fabricate novel Zn^(2+)-doped liAl-lDH(liZnAl-lDH)with remarkable higher li^(+)adsorption capacity(13.4 mg/g)and selectivity(separation factors of 213,834,171 for li^(+)/K^(+),li^(+)/Na^(+),li^(+)/Mg^(2+),respectively),as well as lossless reusability in luobupo brine compared to the pristine ***,combining experiments and simulation calculations,it was revealed that the specific surface area,hydrophilic,and surface attraction for li^(+)of liZnAl-lDH were significantly improved,reducing the adsorption energy(Ead)and Gibbs free energy(ΔG),thus facilitating the transfer of li^(+)from brine into interface followed by insertion into ***,the intrinsic oxygen vacancies derived from Zn-doping depressed the diffusion energy barrier of li^(+),which accelerated the diffusion process of li^(+)in the internal bulk of *** work provides a general strategy to overcome the existing limitations of li^(+)recovery and deepens the understanding of li^(+)extraction on liAl-lDH.

关键词： lithium extraction salt lake brines doping engineering lithium-aluminum layered double hydroxides density functional theory

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Prevalence of visual impairment and estimation of refractive errors among school children in Kakamega,Kenya

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 932-939页

作者： Isabel Signes-Soler Alfred ragot Sheilah Nangena Andrew Wekesa raúl Montalbán llamusí Department of Optics and Optometry and Vision Sciences Universidat de ValènciaBurjassotValencia 46010Spain NGO Vision Without Borders(Visio Sense Fronteres VSF)Calpe 03710AlicanteSpain Masinde Muliro University of Science and Technology P.O Box 190-50100KakamegaKenya Clinica Baviera Alicante C/Ausóy Monzó 16Alicante 03006Spain

AIM:To investigate the prevalence of visual impairment(VI)and provide an estimation of uncorrected refractive errors in school-aged children,conducted by optometry students as a community ***:The study was *** 3343 participants were included in the *** initial examination involved assessing the uncorrected distance visual acuity(UDVA)and visual acuity(VA)while using a+2.00 D *** inclusion criteria for a subsequent comprehensive cycloplegic eye examination,performed by an optometrist,were as follows:a UDVAl(0.20 logMAR)and/or a VA with+2.00 D≥0.8 decimal(0.96 logMAR).RESUlTS:The sample had a mean age of 10.92±2.13y(range 4 to 17y),and 51.3%of the children were female(n=1715).The majority of the children(89.7%)fell within the age range of 8 to *** the ethnic groups,the highest representation was from the luhya group(60.6%)followed by luo(20.4%).Mean logMAR UDVA choosing the best eye for each student was 0.29±0.17(range 1.70 to 0.22).Out of the total,246 participants(7.4%)had a full eye *** estimated prevalence of myopia(defined as spherical equivalent≤-0.5 D)was found to be 1.45%of the total *** around 0.18%of the total sample had hyperopia value exceeding+1.75 *** astigmatism(cillence was 1.26%of the total *** our cases of VI,76.2%could be attributed to uncorrected refractive *** was detected in 0.66%(22/3343)of the screened *** was no statistically significant correlation observed between age or gender and refractive ***:The primary cause of VI is determined to be uncorrected refractive errors,with myopia being the most prevalent refractive error *** findings underscore the significance of early identification and correction of refractive errors in school-aged children as a means to alleviate the impact of VI.

关键词： visual impairment refractive errors myopia amblyopia sustainable development goals

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An Adaptive Data-driven Method Based on Fuzzy logic for Determining Power System Voltage Status

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 707-718页

作者： Sirwan Shazdeh Hêmin Golpîra Hassan Bevrani the SMGRC University of KurdistanSanandajIran Power Systems Modeling&Simulation lab Department of Electrical EngineeringUniversity of KurdistanKurdistanSanandaj 66177-15175Iran

This paper proposes an adaptive method based on fuzzy logic that utilizes data from phasor measurement units(PMUs) to assess and classify generating-side voltage trajectories. The voltage variable and its associated derivatives are used as the input variables of a fuzzy-logic block. In addition, the voltage trajectory is compared with the pre-selected pilot-bus voltage to make a reliable decision about the voltage operational state. Different types of short-term voltage dynamics are considered in the proposed method. The fuzzy membership functions are determined using a systematic method that considers the current situation of the voltage trajectory. Finally, the voltage status is categorized into four classes to determine appropriate remedial actions. The proposed method is validated on a IEEE 73-bus power system in a MATlAB environment.

关键词： Fuzzy logic fault-induced delayed voltage recovery phasor measurement unit(PMU) short-term voltage stability situational awareness voltage classification

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Virtual Transmission Solution Based on Battery Energy Storage Systems to Boost Transmission Capacity

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 466-474页

作者： Matías Agüero Jaime Peralta Eugenio quintana Victor Velar Anton Stepanov Hossein Ashourian Jean Mahseredjian Roberto Cárdenas Coordinador Eléctrico Nacional SantiagoChile PGSTech Montreal Canada Ecole Polytechnique de Montréal Montréal Canada University of Chile Santiago Chile IEEE

The increasing penetration of variable renewable energy(VRE)generation along with the decommissioning of conventional power plants in Chile,has raised several operational challenges in the Chilean National Power Grid(NPG),including transmission congestion and VRE *** mitigate these limitations,an innovative virtual transmission solution based on battery energy storage systems(BESSs),known as grid booster(GB),has been proposed to increase the capacity of the main 500 kV corridor of the *** paper analyzes the dynamic performance of the GB using a wide-area electromagnetic transient(EMT)model of the *** GB project,composed of two 500 MVA BESS units at each extreme of the 500 kV corridor,allows increasing the transmission capacity for 15 min during N-1 contingencies,overcoming transmission limitations under normal operation conditions while maintaining system stability during *** dynamic behavior of the GB is also analyzed to control power flow as well as voltage *** results show that the GB is an effective solution to allow greater penetration of VRE generation while maintaining system stability in the NPG.

关键词： Battery energy storage system(BESS) grid booster transient stability voltage stability electromagnetic transient(EMT)

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Chi-square automatic interaction detection(CHAID)analysis of the use of safety goggles and face masks as personal protective equipment(PPE)to protect against occupational biohazards

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Journal of Biosafety and Biosecurity 2024年第2期6卷 125-133页

作者： raúl Aguilar-Elena Juán JoséAgún-González Universidad Internacional de Valencia ValenciaSpain

Background:This study represents the first Spanish investigation to rigorously evaluate compliance with the use of safety goggles and face masks as essential personal protective equipment(PPE)in companies with workplaces involving exposure to biological ***:This study aimed to examine the degree of use of face masks and safety goggles as personal protective equipment(PPE),the factors that influence their use,and the profile of workers exposed to occupational biological agents in Spanish companies in the health sector,farming sector,meat industry,waste treatment plants,food industry,and veterinary ***:We conducted a cross-sectional descriptive study involving 590 Spanish workers from 51 *** developed a 34-item questionnaire to assess workers’perception of risk related to exposure to biological agents in their *** the questions,three were designed to measure the degree of use of key protective equipment in sectors with biological agent exposure:protective gloves,safety goggles or face *** only analyzed safety goggles and face *** performed various statistical analyses,including Cronbach’s alpha,frequency of endorsement,content validity ratio using lawshe’s method,varimax rotation,the Kaiser-Meyer-Olkin test,and Bartlett’s sphericity test,to assess the internal consistency and reliability of the ***,we employed a chi-square automatic interaction detection(CHAID)segmentation analysis,using workers’responses regarding their attitudes toward safety goggles and face mask usage as PPE for protection against biological risks,with demographic variables as independent ***:In the current study,CHAID analysis revealed that workers exposed to group 2 biological agents used more safety goggles and face shields compared with workers exposed to other groups of biological ***,workers in laboratories and the food industry used face masks more than workers of other ***

关键词： PPE Safety googles and breath mask CHAID Biological Agents Occupational Biosafety

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lack of evidence for germline WWP1 pathogenic variants in gastrointestinal polyposis and other phenotypes suggestive of PTEN-hamartoma-tumor syndrome

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Genes & Diseases 2024年第2期11卷 524-527页

作者： Noemi Gonzalez-Abuin Tirso Pons Teresa Fuster Isabel quintana Mariona Terradas Gemma Aiza Joan Brunet Gabriel Capellá Heather Hampel laura Valle Hereditary Cancer Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain Department of Immunology and Oncology National Center for BiotechnologySpanish National Research Council (CNB-CSIC)Madrid 28049Spain Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) Madrid 28029Spain Catalan Institute of Oncology IDIBGiGirona 17007Spain Division of Clinical Cancer Genomics Department of Medical Oncology & Therapeutic ResearchCity of Hope National Cancer CenterDuarteCA 91010USA

Germline activating variants in WWP1,which encodes an E3 ubiquitin ligase that antagonizes PTEN tumor suppressive function,have been proposed as an alternative mechanism of PTEN inactivation in PTEN-hamartoma-tumor syndrome(PHTS)-like patients with wildtype PTEN.1 More specifically,heterozygous,potentially activating wwP1 variants were first identified by lee et al in patients affected with gastrointestinal oligopolyposis,including adenomatous,hyperplastic/serrated,and hamartomatous polyps,and occasionally with colorectal cancer(Table 1).Subsequently,based on the PHTS phenotypic features,wWP1 mutational screening was performed in patients with thyroid nodules,2 or normocephalic autism spectrum disorder(ASD),3 where germline WWP1 variants were also identified(Table S1).

关键词： WWP1 gastrointestinal polyposis

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Sodium-glucose cotransporter-2 inhibitors protect tissues via cellular and mitochondrial pathways:Experimental and clinical evidence

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World Journal of Experimental Medicine 2024年第2期14卷 46-52页

作者： raúl lelio Sanz Sebastián García Menéndez Felipe Inserra leon Ferder Walter Manucha Department of Pathology Facultad de Ciencias MédicasUniversidad Nacional de CuyoMendoza 5500Argentina Department of Pharmacology Instituto de Medicina y Biología Experimental de CuyoCentro Científico TecnológicoMendoza 5500Argentina Department of Nephrology Universidad de MaimónidesCiudad Autónoma de Buenos Aires C1405Argentina Department of Cardiology Universidad de MaimónidesCiudad Autónoma de Buenos Aires C1405Argentina

Mitochondrial dysfunction is a key driver of cardiovascular disease(CVD)in metabolic syndrome and *** dysfunction promotes the production of reactive oxygen species(ROS),which cause oxidative stress and *** II,the main mediator of the renin-angiotensin-aldosterone system,also contributes to CVD by promoting ROS *** activity of sirtuins(SIRTs),a family of proteins that regulate cellular metabolism,also worsens oxidative *** of energy production by mitochondria is a common feature of all metabolic *** SIRT levels and 5’adenosine monophosphate-activated protein kinase signaling stimulate hypoxia-inducible factor 1 beta,which promotes ***,in turn,increases autophagy and mitophagy,processes that clear cells of debris and protect against *** cotransporter-2 inhibitors(SGlT2i),a class of drugs used to treat type 2 diabetes,have a beneficial effect on these *** clinical trials have shown that SGlT2i improves cardiac function and reduces the rate of cardiovascular and renal ***2i also increase mitochondrial efficiency,reduce oxidative stress and inflammation,and strengthen *** findings suggest that SGlT2i hold great potential for the treatment of ***,they are proposed as anti-aging drugs;however,rigorous research is needed to validate these preliminary findings.

关键词： Sodium-glucose cotransporter-2 inhibitors Cardiovascular diseases Sirtuins Oxidative stress Inflammation Mitochondrial dysfunction

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