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Phenotypic Characterization of Extended Spectrum Beta-lactamase, Class C Cephalosporinase and Carbapenemase-Producing Klebsiella Species Isolated from Patients Consulted at Four Yaounde-Based Hospitals

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Open Journal of Medical Microbiology 2024年第2期14卷 105-119页

作者： Emilia Enjema lyonga Mbamyah Mangum Patience Kumcho michel Toukam Dieudonné Sedena Florence Anjabie Enyeji Aime-Caesar Teukam Modestine Djuissi Martha Tongo Mesembe George Mondinde Ikomey Agnes Bedie Eyoh Hortense Kamga Gonsu Faculty of Medicine and Biomedical Sciences The University of Yaounde 1 Yaounde Cameroon Center for the Study and Control of Communicable Diseases Faculty of Medicine and Biomedical Sciences The University of Yaounde 1 Yaounde Cameroon Department of Microbiology School of Health Sciences Catholic University of Central Africa Yaounde Cameroon Faculty of Science University of Buea Buea Cameroon Bacteriology Unit Yaounde University Teaching Hospital Yaounde Cameroon

Background: Klebsiella spp. are bacteria of medical importance for their role in opportunistic infections which are often difficult to treat because of resistance to one or several antimicrobials. The aim of this study was to determine antimicrobial resistance due to Extended Spectrum Beta-lactamase (ESBl), Class C cephalosporinase (AmpC) and carbapenemase enzymes in Klebsiella spp. isolated from patients consulted at four hospitals. Methodology: The study was cross-sectional and descriptive. A total of 4190 non-repetitive patients specimens from 13 types of clinical specimens were analysed from February to November 2020. Two hundred and twenty-five (225) Klebsiella spp isolates were identified using API 20E and antimicrobial susceptibility testing done according to the Kirby Bauer disc diffusion method. ESBl and AmpC phenotypes were determined by the combination disc method and carbapenemases by double disc synergy method, referenced by EUCAST guidelines for the resistance testing. Results: The frequency of the species was Klebsiella pneumoniae (69%, 155/255), K. oxytoca (14%, 31/255), K. ozaenae (12%, 27/225) and K. rhinoscleromatis (5%, 11/225). Isolates were most resistant to sulphomethoxazole trimethoprim (84%, 189/225), cepaholosporins (80%, 180/225), and least resistant to carbapenems (10.7%, 24/225). Two K. oxytoca and one K. pneumoniae were resistant to all antibiotics tested. Klebsiella pneumoniae had the most multidrug resistant isolates (59.4%, 134/225). Most isolates (83.6%, 188/225) expressed at least one enzyme, while 63.6% (143/225) of the isolates expressed at least two enzymes. Some isolates were ESBl (71.6%, 161/225), carbapenemase (10.7%, 24/225) and AmpC (6.6%, 15/225) producers. Three carbapenemases (Klebsiella pneumoniae carbapenemase-KPC, Metallo-Beta lactamase-MBl and OXA-48) were detected. Conclusion: These results revealed that resistance of Klebsiella spp. to cephalosporins is high and this may be exacerbated by co-expression of AmpC and

关键词： Klebsiella Spp. Multidrug Resistance ESBl AmpC Carbapenemase

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小行星表面风化层跨尺度迁移的离散元建模

小行星表面风化层跨尺度迁移的离散元建模

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北京力学会第30届学术年会

作者：宋志军于洋 Stefania Soldini 程彬 Patrick michel

本文以小行星表面风化层颗粒的跨尺度迁移过程为背景,针对传统离散元法(DEM)在模拟这一过程所面临的困难,提出一种小行星表面风化层跨尺度迁移的离散元建模方法。模拟结果表明,该方法能够准确高效地追踪小行星表面风化层材料的连续跨尺... 详细信息

本文以小行星表面风化层颗粒的跨尺度迁移过程为背景,针对传统离散元法(DEM)在模拟这一过程所面临的困难,提出一种小行星表面风化层跨尺度迁移的离散元建模方法。模拟结果表明,该方法能够准确高效地追踪小行星表面风化层材料的连续跨尺度迁移过程。

关键词：离散元小行星风化层迁移跨尺度建模

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Conditions for Set Agreement with an Application to Synchronous Systems

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Journal of Computer Science & Technology 2009年第3期24卷 418-433页

作者： Francois Bonnet michel raynal IRISA University of Rennes35042 Rennes CedexFrance

The k-set agreement problem is a generalization of the consensus problem： considering a system made up of n processes where each process proposes a value, each non-faulty process has to decide a value such that a decided value is a proposed value, and no more than k different values are decided. While this problem cannot be solved in an asynchronous system prone to t process crashes when t≥ k, it can always be solved in a synchronous system; [t/k]＋1 is then a lower bound on the number of rounds （consecutive communication steps） for the non-faulty processes to decide. The condition-based approach has been introduced in the consensus context. Its aim was to both circumvent the consensus impossibility in asynchronous systems, and allow for more efficient consensus algorithms in synchronous systems. This paper addresses the condition-based approach in the context of the k-set agreement problem. It has two main contributions. The first is the definition of a framework that allows defining conditions suited to the l-set agreement problem and the second is a generic synchronous k-set agreement algorithm based on conditions.

关键词： agreement problem condition efficiency lower bound synchronous system

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Seismic vulnerability evaluation of axially loaded steel built-up laced members II:evaluations

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Earthquake Engineering and Engineering Vibration 2008年第2期7卷 125-136页

作者： Kangmin lee michel Bruneau Department of Architectural Engineering Chungnam National University Department of Civil Structuraland Environmental EngineeringUniversity at BuffaloState University of New York

The test results described in Part 1 of this paper （lee and Bruneau, 2008） on twelve steel built-up laced members （BlMs） subjected to quasi-static loading are analyzed to provide better knowledge on their seismic behavior. Strength capacity of the BlM specimens is correlated with the strength predicted by the AISC lRFD Specifications. Assessments of hysteretic properties such as ductility capacity, energy dissipation capacity, and strength degradation after buckling of the specimen are performed. The compressive strength of BlMs is found to be relatively well predicted by the AISC lRFD Specifications. BlMs with smaller kl/r were ductile but failed to reach the target ductility of 3.0 before starting to fracture, while those with larger kl/r could meet the ductility demand in most cases. The normalized energy dissipation ratio, EC/ET and the normalized compressive strength degradation, Cr″/Cr of BlMs typically decrease as normalized displacements δ/δb,exp increase, and the ratios for specimens with larger kl/r dropped more rapidly than for specimens with smaller kl/r; similar trends were observed for the monolithic braces. The BlMs with a smaller slenderness ratio, kl/r, and width-to-thickness ratio, b/t, experienced a larger number of inelastic cycles than those with larger ratios.

关键词： seismic vulnerability built-up compression member strength capacity ductility capacity energy dissipation strength degradation

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Profile of Extra-Pulmonary Tuberculosis in Internal Medicine

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Open Journal of Internal Medicine 2024年第1期14卷 64-73页

作者： Mouhamed Dieng Djiby Sow Demba Diédhiou michel Assane Ndour Boundia Djiba Mouhamed Almahy Niang Matar Ndiaye Oumar Boun Khattab Diouf Fatou Kiné Gadji Anna Sar Maïmouna Ndour Mbaye Clinique Médicale II H&ocircpital Aristide Abass Ndao Université Cheikh Anta Diop Dakar Sénégal

Introduction: Tuberculosis is an infectious disease that mainly affects the lung. Extrapulmonary localizations are a reason for hospitalization in our health facilities. The objective of this study was to describe the epidemiological, clinical, paraclinical and evolutionary aspects of extra pulmonary tuberculosis (EPT) at the Abass Ndao Hospital Center. Patients and Methods: This was a descriptive cross-sectional study conducted over a period of 11 years (January 1, 2010 to December 30, 2021). All patients with extrapulmonary tuberculosis hospitalized in the department of internal medicine during the recruitment period were included. Results: Fifty-two (52) patients were collected. The year 2019 recorded the most cases 23.08% (n = 20). The mean age of the patients was 40.56 ± 18.24 years. The age group 20 - 34 years 42.31% (n = 22) was the most represented. Females were in the majority 61.54% (n = 32) with a sex ratio (M/F) was 0.63. Housewives were in the majority 40.38% (n = 21). 60.87% of the cases (n = 14) came from a health facility. 38.46% of the cases had been infected. 21.74% (n = 9) were smokers. The reasons for consultation were dominated by fever (67.44%), AEG (62.79%) and cough (41.86%). Eighteen patients (40.91%) had fever. The mean time to consultation was 77.37 ± 90.3 days with extremes of 3 and 365 days. The median was 45 days. More than half of the patients 61.90% (n = 26) had anemia. Positive retroviral serology was noted in 21.43% of cases. All patients had a CRP greater than 6. More than half of the patients 51.92% (n = 27) had multifocal tuberculosis. The peritoneum 44.23% (n = 23) was the main organ affected. The average hospital stay was 9.8 ± 4.9 days with extremes of 1 and 19 days. All patients had received the protocol in force at the national level. Death was noted in 4 patients (9.52%). Conclusion: EPT is characterized in our context by a notorious diagnostic difficulty due to the multiplicity of clinical presentations, the complexity of

关键词： Extrapulmonary Tuberculosis Epidemiology Diagnosis Senegal

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Proportional fuzzy feed-forward architecture control validation by wind tunnel tests of a morphing wing

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Chinese Journal of Aeronautics 2017年第2期30卷 561-576页

作者： michel Joёl Tchatchueng Kammegne Ruxandra Mihaela Botez lucian Teodor Grigorie Mahmoud Mamou Youssef Mebarki Ecole de Technologie Superieure Montreal H3C1K3 Canada University of Craiova Craiova Dolj 200585 Romania Aerodynamics laboratory NRC Aerospace National Research Council Canada Ottawa K1AOR6 Canada

In aircraft wing design,engineers aim to provide the best possible aerodynamic performance under cruise flight conditions in terms of lift-to-drag *** control surfaces such as flaps,ailerons,variable wing sweep and spoilers are used to trim the aircraft for other flight *** appearance of the morphing wing concept launched a new challenge in the area of overall wing and aircraft performance improvement during different flight segments by locally altering the flow over the aircraft＇s *** paper describes the development and application of a control system for an actuation mechanism integrated in a new morphing wing *** controlled actuation system includes four similar miniature electromechanical actuators disposed in two parallel actuation *** experimental model of the morphing wing is based on a full-scale portion of an aircraft wing,which is equipped with an *** upper surface of the wing is a flexible one,being closed to the wing tip;the flexible skin is made of light composite *** four actuators are controlled in unison to change the flexible upper surface to improve the flow quality on the upper surface by delaying or advancing the transition point from laminar to turbulent *** actuators transform the torque into vertical *** bases are fixed on the wing ribs and their top link arms are attached to supporting plates fixed onto the flexible skin with *** actuators push or pull the flexible skin using the necessary torque until the desired vertical displacement of each actuator is *** four vertical displacements of the actuators,correlated with the new shape of the wing,are provided by a database obtained through a preliminary aerodynamic optimization for specific flight *** control system is designed to control the positions of the actuators in real time in order to obtain and to maintain the desired shape of the wing for a specified flight *** feas

关键词： Actuators Control Experimental validation Morphing wing Wind tunnel test

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雄高尔《圣安东尼的磨难》——其图像学以及对德国艺术的影响

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美术 2024年第9期 122-135页

作者： [法]让·米歇尔·马桑赵津(译) 赵成清(译) 剑桥大学艺术史系中央民族大学四川大学艺术学院

德国画家、雕塑家雄高尔的《圣安东尼的磨难》是描绘圣安东尼被恶魔攻击的经典作品,其创作灵感源自《安东尼传》中关于圣安东尼的描述。通过将圣安东尼置于空中受恶魔攻击的场景,雄高尔成功展现了圣徒的冷静与从容。该作品对后世德国、... 详细信息

德国画家、雕塑家雄高尔的《圣安东尼的磨难》是描绘圣安东尼被恶魔攻击的经典作品,其创作灵感源自《安东尼传》中关于圣安东尼的描述。通过将圣安东尼置于空中受恶魔攻击的场景,雄高尔成功展现了圣徒的冷静与从容。该作品对后世德国、意大利等地的艺术家产生了深远影响。本文通过详细分析雄高尔的版画风格、恶魔形象以及与其他艺术作品的关联,探讨其在恶魔图式发展中的独特贡献。

关键词：雄高尔圣安东尼的磨难恶魔图式德国艺术

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Ahlfors-regular curves and Carleson measures

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Science China Mathematics 2020年第6期63卷 1057-1064页

作者： Huaying Wei michel Zinsmeister Department of Mathematics and Statistics Jiangsu Normal UniversityXuzhou 21116China IDP Universite d'OrleansOrleans 45067France

We study the relation between the boundary of a simply connected domainΩbeing Ahlfors-regular and the invariance of Carleson measures under the push-forward operator induced by a conformal mapping from the unit disk△onto the domainΩ.As an application,we characterize the chord-arc curves with small norms and the asymptotically smooth curves in terms of the complex dilatation of some quasiconformal reflection with respect to the curve.

关键词： Ahlfors-regular curve Carleson measure push-forward operator chord-arc curve asymptotically smooth curve

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Simulation of unconventional well tests with the finite volume method

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Petroleum Science 2012年第3期9卷 317-329页

作者： CANCEllIERE michel VERGA Francesca Politecnico di Torino DITAGTorino (TO) 10129 Italy

The finite volume method has been successfully applied in several engineering fields and has shown outstanding performance in fluid dynamics simulation. In this paper, the general framework for the simulation ofnear-wellbore systems using the finite volume method is described. The mathematical model and the numerical model developed by the authors are presented and discussed. A radial geometry in the vertical plane was implemented so as to thoroughly describe near-wellbore phenomena. The model was then used to simulate injection tests in an oil reservoir through a horizontal well and proved very powerful to correctly reproduce the transient pressure behavior. The reason for this is the robustness of the method, which is independent of the gridding options because the discretization is performed in the physical space. The model is able to describe the phenomena taking place in the reservoir even in complex situations, i.e. in the presence of heterogeneities and permeability barriers, demonstrating the flexibility of the finite volume method when simulating non-conventional tests. The results are presented in comparison with those obtained with the finite difference numerical approach and with analytical methods, if possible.

关键词： Finite volume method numerical methods horizontal well modeling injection testing gridding

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Enhanced Userspace and In-Kernel Trace Filtering for Production Systems

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Journal of Computer Science & Technology 2016年第6期31卷 1161-1178页

作者： Suchakrapani Datt Sharma michel Dagenais Department of Computer and Software Engineering Ecole Polytechnique de Montrdal Montreal H3T 1J4 Canada

Trace tools like lTTng have a very low impact on the traced software as compared with traditional debuggers. However, for long runs, in resource constrained and high throughput environments, such as embedded network switching nodes and production servers, the collective tracing impact on the target software adds up considerably. The overhead is not just in terms of execution time but also in terms of the huge amount of data to be stored, processed and analyzed offiine. This paper presents a novel way of dealing with such huge trace data generation by introducing a Just-In-Time （JIT） filter based tracing system, for sieving through the flood of high frequency events, and recording only those that are relevant, when a specific condition is met. With a tiny filtering cost, the user can filter out most events and focus only on the events of interest. We show that in certain scenarios, the JIT compiled filters prove to be three times more effective than similar interpreted filters. We also show that with the increasing number of filter predicates and context variables, the benefits of JIT compilation increase with some JIT compiled filters being even three times faster than their interpreted counterparts. We further present a new architecture, using our filtering system, which can enable co-operative tracing between kernel and process tracing VMs （virtual machines） that share data efficiently. We demonstrate its use through a tracing scenario where the user can dynamically specify syscall latency through the userspace tracing VM whose effect is reflected in tracing decisions made by the kernel tracing VM. We compare the data access performance on our shared memory system and show an almost 100 times improvement over traditional data sharing for co-operative tracing.

关键词： tracing debugging filtering operating system interpreter

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