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Evidence-Based Complementary and Alternative Medicine Effects of Capybara Oil on Cardiac Remodeling of C57bl/6 Mice

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Journal of Biosciences and Medicines 2024年第5期12卷 213-232页

作者： Rafael M. Almeida Wagner D. Giannetti Guilherme R. Silveira Carolina R. Castilho Renata V. Lisboa Bianca T. Ciambarella rodrigo N. Ferreira Jorge José de Carvalho Laboratory of Ultrastructure and Tissue Biology Institute of Biology State University of Rio de Janeiro Rio de Janeiro Brazil Higher Education Center of Valenç a Dom Andr&#233 Arcoverde Educational Foundation Valen&#231a Brazil

Cardiovascular diseases are the main cause of morbidity and mortality in the world, and obesity and the metabolic syndrome are risk factors for its development. One of the therapies to reduce cardiovascular risk is the use of polyunsaturated fatty acids. In Brazil, a source of such acid is the oil extracted from the fat of the capybara. The objective of this work is to study the effects of the capybara oil on lipid and glucose metabolism, as well as its effects on the adipose tissue and cardiac remodeling. We assessed the effects of capybara oil treatment on body mass, lipid and carbohydrate metabolism, systolic blood pressure, adipose tissue and cardiac remodeling, and performed an ultrastructural evaluation of the myocardium in C57Bl/6 mice treated with high-fat diet. Treatment with capybara oil reduced total cholesterol and triglyceride levels, systolic blood pressure, visceral and subcutaneous adipose tissue, and adipocyte diameter. In addition, cardiac remodeling was attenuated, preserving cardiomyocytes, increasing vascularization, reducing cardiomyocyte hypertrophy and the extracellular matrix, and preserving the morphological integrity of mitochondria. Capybara oil has several beneficial effects on the cardiovascular and metabolic system, and further studies are needed to better understand its role in the prevention or treatment of cardiovascular diseases.

关键词： Capybara Oil Cardiac Remodeling Polyunsaturated Fatty Acids Obesity Metabolic Syndrome

Sarcopenia and Anemia Are Predictors of Poor Prognostic in Cervical Cancer Patients

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 693-704页

作者： Leandro Santos de Araujo Resende Francine Vilela de Amorim Miguel Soares Conceição rodrigo Menezes Jales Patrick Nunes Pereira Luis Otávio Sarian Glauco Baiocchi Sophie Derchain Agnaldo Lopes da Silva Filho Department of Gynecology and Obstetrics Botucatu Medical School S&#227o Paulo State University UNESP S&#227o Paulo Brazil Department of Health Sciences University of Sao Francisco S&#227o Paulo Brazil Department of Obstetrics and Gynecology School of Medical Science State University of Campinas (UNICAMP) Campinas Brazil Department of Gynecologic Oncology AC Camargo Cancer Center Sao Paulo Brazil Department of Gynecology and Obstetrics School of Medicine of the Federal University of Minas Gerais Belo Horizonte Brazil

Objective: Evaluate pretreatment sarcopenia and anemia as prognostic factors in women undergoing treatment for cervical cancer (CC) with concurrent chemoradiotherapy (CCRT). Methods: 151 women with CC were analysed in this cohort study. Pretreatment computed tomography (CT) images were analysed to assess skeletal muscle index (SMI). Hazard ratios (HR) and multivariate Cox proportional HR were used to analyse association between low SMI, age, body mass index (BMI), haemoglobin levels, histological type, and International Federation of Gynaecology and Obstetrics (FIGO) stage with PFS and OS. Results: A total of 151 patients were included, 53 (35.1%) presented pretreatment sarcopenia;51 (34%) stage I/II and 100 (66%) stage III/IV. Among those patients in advanced stage (III/IV) 37 (70%) (p = 0.28) were sarcopenic at the beginning of treatment. Sarcopenia was associated with worse progression-free survival (PFS) and overall survival (OS) in our cohort [HR 0.97 (p = 0.01)] [HR 0.73 (p = 0.001)], as well as anemia [HR 0.73 (p = 0.001)] [HR 0.78 (p = 0.001)]. Linear regression models indicated that despite showing no association with age, neutrophil or platelet counts, sarcopenia was associated with pretreatment anemia levels (p = 0.01). After a multivariate analysis, only haemoglobin (anemia) and complete CCRT remained associated with PFS and OS. Sarcopenia and anemia were associated with worse PFS and OS in FIGO stage I/II. Conclusion: Pretreatment sarcopenia was significantly associated with low haemoglobin levels. Anemia and incomplete CCRT were independently associated with poor prognosis in women with CC. Pretreatment sarcopenia, as low SMI, was a predictor of poor prognostic in early stages of CC.

关键词： Cervical Cancer Sarcopenia Anemia Chemoradiotherapy

Meningeal T-cells in the cross-talk between memory consolidation and sleep

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Neural Regeneration Research 2023年第12期18卷 2687-2688页

作者： rodrigo Pacheco Valentina Ugalde Laboratorio de Neuroinmunología Centro Científico y Tecnológico de Excelencia Ciencia&VidaFundación Ciencia&VidaSantiagoChile Facultad de Medicina y Ciencia Universidad San SebastiánSantiagoChile

Some years ago,the infiltration of T-cells into the central nervous system(CNS) was considered a pathological condition ***,during the last two decades,a growing body of studies has shown that T-cells are essential pl... 详细信息

关键词： behavior. sleep consolidation

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Endoscopic ultrasound-guided gastroenterostomy for gastric outlet obstruction in Mexico

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World Journal of Surgical Procedures 2024年第3期14卷 15-20页

作者： Massiel Madelin Rosario-Morel rodrigo Soto-Solis Katia Picazo-Ferrera Miriam Idalia Torres-Ruiz JoséAlberto Estradas-Trujillo Mario Alberto Gallardo-Ramírez Gerardo Akram Darwich-del Moral Luis Ariel Waller-González Department of Endoscopy Centro Médico Nacional“20 de Noviembre”ISSSTEMexico City 03229Mexico Department of Gastroenterology HospitalÁngeles PedregalMexico City 10700Mexico Department of Endoscopy Centro Médico ABCMexico City 01120Mexico Department of Endoscopy Hospital General de México“Dr.Eduardo Liceaga”Mexico City 06720Mexico

BACKGROUND Endoscopic ultrasound-guided gastroenterostomy(EUS-GE)has recently emerged as an alternative treatment for gastric outlet obstruction(GOO)in selected *** To report the initial experience of EUS-GE in patients with *** This study was a retrospective,observational,multicenter study in which the data from 10 patients who underwent EUS-GE due to GOO between September 2021 and May 2023 were *** analyzed technical success,clinical success,adverse events,and *** success was defined as adequate positioning and deployment of the *** success was defined as the patient’s ability to tolerate oral intake without vomiting 7 d after the *** adverse events were *** Eleven procedures in 10 patients with GOO were *** mean age of the patients was 67.5 years(range:56-77 years).Malignant GOO was present in 9 *** success was achieved in 9/11 procedures(82%).Among them,clinical success was achieved in 9 patients(100%).Adverse events occurred in 1 patient(9%).The median survival was 3 months(n=7;range:1-8 months).CONCLUSION EUS-GE is a feasible therapeutic option in the treatment of GOO.

关键词： Endoscopic ultrasound-guided gastroenterostomy Gastric outlet obstruction Lumen apposing metal stent Interventional endoscopic ultrasound Gastrojejunostomy Duodenal stenting

Tailored optical propulsion forces for controlled transport of resonant gold nanoparticles and associated thermal convective fluid flows

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Light(Science & Applications) 2020年第1期9卷 256-266页

作者： Jose A.rodrigo Mercedes Angulo Tatiana Alieva Facultad de Ciencias Fisicas Ciudad Universitaria s/nUniversidad Complutense de Madrid28040 MadridSpain

Noble metal nanoparticles illuminated at their plasmonic resonance wavelength turn into heat *** phenomenon has prompted the development of numerous applications in science and *** optical manipulation of such resonant nanoparticles could certainly extend the functionality and potential applications of optothermal *** this article,we experimentally demonstrate optical transport of single and multiple resonant nanoparticles(colloidal gold spheres of radius 200 nm)directed by tailored transverse phase-gradient forces propelling them around a 2D optical *** show how the phase-gradient force can be designed to efficiently change the speed of the *** have found that multiple hot nanoparticles assemble in the form of a quasi-stable group whose motion around the laser trap is also controlled by such optical propulsion *** assembly experiences a significant increase in the local temperature,which creates an optothermal convective fluid flow dragging tracer particles into the ***,the created assembly is a moving heat source controlled by the propulsion force,enabling indirect control of fluid flows as a micro-optofluidic *** existence of these flows,probably caused by the temperature-induced Marangoni effect at the liquid water/superheated water interface,is confirmed by tracking free tracer particles migrating towards the *** propose a straightforward method to control the assembly size,and therefore its temperature,by using a nonuniform optical propelling force that induces the splitting or merging of the group of *** envision further development of microscale optofluidic tools based on these achievements.

关键词： thermal fluid transport

Study of Branes with Variable Tension

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Communications in Theoretical Physics 2017年第11期67卷 595-599页

作者： rodrigo Aros Milko Estrada Departamento de Ciencias Fisicas Universidad Andres Bello Department of Physics Universidad de Antofagasta Instituto de Matematica Fisica y Estadistica Universidad de las Americas

In this work we study a brane world model with variable tension, which gives rise to four-dimensional cosmologies. The brane worlds obtained correspond to E?tv?s branes whose(internal) geometry can be casted as either a four-dimensional(A)dS_4 or a standard radiation period cosmology. The matter dominated period is discussed as well.

关键词： Randall–Sundrum brane world de Sitter hierarchy problem brane tension

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Green economy and waste management: An inevitable plan for materials science

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Progress in Natural Science:Materials International 2022年第1期32卷 1-9页

作者： Suman Nandy Elvira Fortunato rodrigo martins i3N/CENIMAT Department of Materials ScienceFaculty of Science and Technology Universidade NOVA de Lisboa and CEMOP/UNINOVA Campus de Caparica

Covid is giving us many lessons among which one must be to realize that this is the time to act for sustainable future. The smart world around us has made it inevitable to have an alarming situation regarding the uncontrolled growth of waste products such as plastic and electronic wastes. Both are immense threats to the health of human,wildlife and environment, that eventually affect the societal and economic structures as evident from recent Covid-crisis. The proper management of these wastes and innovating ideas for new sustainable technologies are the need of the hour. Circular economy act with green technology(green economy) is the way to tackle this challenge. Current perspective presents the overview of the scenario regarding these burgeoning issues and demonstrates some measures that are taken or being considered to depend on to come out of them.

关键词： Plastic waste management Medical waste management Electronic waste management Circular economy Green technology Sustainable world

Response to Commentary by Dr. Matthew J. Clarkson on

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Journal of Sport and Health Science 2024年第5期13卷 670-671页

作者： Hugo de Luca Corrêa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araújo Carmen Tzanno-martins Fernanda Silveira Tavares Luiz Sinésio Silva Neto Cláudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitória Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil g Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Dear editor:We sincerely thank Matthew *** for his insightful commentary1 on our recent publication in the Journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFR) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFR exercise among hemodialysis patients.

关键词： patients application flow

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Interfacial Strategies for Smart Slippery Surfaces

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Journal of Bionic Engineering 2020年第4期17卷 633-643页

作者： Glen McHale rodrigo Ledesma-Aguilar Gary George Wells Smart Materials&Surfaces Laboratory Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle upon TyneNE18STUK

The problem of contact line pinning on surfaces is pervasive and contributes to problems from ring stains to ice *** we provide a single conceptual framework for interfacial strategies encompassing five strategies for modifying the solid-liquid interface to remove pinning and increase droplet *** biomimetic strategies are included,(i)reducing the liquid-solid interfacial area inspired by the Lotus effect,(ii)converting the liquid-solid contact to a solid-solid contact by the formation of a liquid marble inspired by how galling aphids remove honeydew,and(iii)converting the liquid-solid interface to a liquid-lubricant contact by the use of a lubricant impregnated surface inspired by the Nepenthes Pitcher *** further strategies are,(iv)converting the liquid-solid contact to a liquid-vapor contact by using the Leidenfrost effect,and(v)converting the contact to a liquid-liquid-like contact using slippery omniphobic covalent attachment of a liquid-like coating(SOCAL).Using these approaches,we explain how surfaces can be designed to have smart functionality whilst retaining the mobility of contact lines and ***,we show how droplets can evaporate at constant contact angle,be positioned using a Cheerios effect,transported by boundary reconfiguration in an energy invariant manner,and drive the rotation of solid components in a Leidenfrost heat *** conceptual framework enables the rationale design of surfaces which are slippery to liquids and is relevant to a diverse range of applications.

关键词： superhydrophobicity SLIPS liquid marbles leidenfrost SOCAL