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Chinese Journal of Structural Chemistry 2021年第12期40卷 1647-1654,1554页

作者： ren hui-dong LI Kang-Ming YI Yang-Jie WANG Man YE Jiao HU Ai-Xi CHEN Yun OU Xiao-Ming LI Jian-Ming College of Chemistry and Chemical Engineering Hunan UniversityChangsha 410082China National Pesticide Creation Engineering Technology Research Center Hunan Research Institute of Chemical Industry Co.Ltd.Changsha 410007China

Four novel 2-methoxyimino phenylacetate derivatives containing 1,3,4-oxadiazole ring were designed and synthesized from the key intermediate of Trifloxystrobin or Azoxystrobin via intermediate derivatization and active structure *** chemical structures of the target compounds were confirmed by]H NMR,13C NMR and elemental *** crystal structure of methyl(E)-2-(methoxyimino)-2-(2-(((5-((4-methoxyphenoxy)methyl)-1,3,4-oxadiazol-2-yl)thio)methyl)phenyl)acetate(Al)was determined by single-crystal X-ray *** A1 belongs to triclinic system,space group Pi with two molecules in each unit *** benzene ring plane C(2)-C(3)-C(4)-C(5)-C(6)-C(7)and oxazole ring plane are nearly parallel with the dihedral angle of 6.4°.The benzene ring plane C(12)-C(13)-C(14)-C(15)-C(16)-C(17)and oxazole ring plane are not perpendicular with the dihedral angle of 49.4°.The crystal of compound Al is stabilized by π-π stacking *** fungicidal activities of the target compounds against four plant pathogenic fungi in vitro were tested,and some of them had good *** DFT calculation was carried out to study the structure-activity relationship of the title derivatives using Gasian 09 and Multiwfii 3.6.

关键词： 2-methoxyimino phenylacetate derivatives synthesis crystal structure fungicidal activities DFT calculation

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-Xiao Yi hui ren Woon Genevieve Saw Li Zeng Eng King Tan Zhi dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

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新形势下高等院校图书馆的机构设置

内蒙古科技与经济 2010年第1期 143-144页

作者：任惠栋呼和浩特市民族学院内蒙古呼和浩特010051

文章利用调研法、网络搜索及呼和浩特市民族学院图书馆机构设置实践分析,探讨了新形势下高等院校图书馆机构设置的合理性,并得出了合理的设置机构能够保障图书馆工作职能实现,提高效率的结论。

关键词：高校图书馆机构设置

小夹板外固定治疗上肢骨折应用护理干预对患者功能恢复的影响

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系统医学 2018年第1期3卷 124-125,128页

作者：任栋慧烟台市烟台山医院创伤骨科山东烟台264001

目的观察小夹板外固定治疗上肢骨折应用护理干预对患者功能恢复的影响。方法对该院2016年9月—2017年9月收治的112例上肢骨折患者资料加以探究,依据护理方案的不同分为2组,对照组(52例)行常规护理,实验组(60例)行护理干预,比对两组心理... 详细信息

目的观察小夹板外固定治疗上肢骨折应用护理干预对患者功能恢复的影响。方法对该院2016年9月—2017年9月收治的112例上肢骨折患者资料加以探究,依据护理方案的不同分为2组,对照组(52例)行常规护理,实验组(60例)行护理干预,比对两组心理状态、关节功能恢复及生活质量情况。结果护理后实验组HAMA(31.63±1.52)分等分值均比对照组更高(t=22.895 4,P<0.05);实验组关节功能恢复优良率96.67%较之对照组更高(χ~2=7.359 5,P<0.05);实验组社会功能(86.35±8.51)分等维度分值均较之对照组更高(t=10.556 5,P<0.05)。结论护理干预应用于行小夹板外固定治疗的上肢骨折患者中可取得满意效果,有效促进关节功能恢复。

关键词：小夹板外固定上肢骨折护理干预功能恢复

Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling Wang Jing ren Chenguang Zheng Jiajia Yang dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

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CF6140车床的PLC改造

煤炭技术 2009年第7期28卷 34-34页

作者：任东辉鸡西永益煤矿机械制造有限公司黑龙江鸡西158100

经过PLC的电器改造后,基本实现了无故障修理,编程简单易懂,减少了电器元件备件的费用。为其他设备的改造积累了经验。

关键词： PLC控制继电器逻辑控制车床延时 PLC程序

Iron-handling solute carrier SLC22A17 as a blood-brain barrier target after stroke

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Neural Regeneration Research 2025年第11期20卷 3207-3208页

作者： Xueqi ren Wenlu Li Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

The pathophysiology of ischemic stroke is complex and multifactorial,involving various forms of cell death such as apoptosis,autophagy,and necrosis.A recent study suggests that oxidative and inflammatory stress can induce ferroptosis,a specialized form of cell death characterized by the accumulation of lipid peroxides dependent on intracellular iron overload(Li and Jia,2023).

关键词： death specialized barrier

Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan ren Fei Zheng Tingwei Cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

基于油气支承自由边界模拟的全箭模态试验技术研究

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导弹与航天运载技术 2020年第4期 107-111页

作者：张永亮侯京锋苏里任冬辉贾文成北京强度环境研究所北京100076

为了验证基于油气支承自由边界模拟开展全箭模态试验的工程应用,分别开展了基于小型油气支承系统验证方法和全箭模态试验应用可行性研究,对油气支承单元和系统进行了验证方案设计和实施,并对油气支承系统的关键设计指标、系统功能、稳... 详细信息

为了验证基于油气支承自由边界模拟开展全箭模态试验的工程应用,分别开展了基于小型油气支承系统验证方法和全箭模态试验应用可行性研究,对油气支承单元和系统进行了验证方案设计和实施,并对油气支承系统的关键设计指标、系统功能、稳定性和可靠性进行测量验证。最后开展某型号运载火箭的油气支承自由边界模拟和弹簧钢索悬挂自由边界模拟的全箭模态验证对比试验,验证了试验技术的可行性和有效性,也为未来大型运载火箭的研制提供试验技术支撑并积累了工程经验。

关键词：大型运载器油气支承模态试验支承系统设计

小鼠白细胞介素18在大肠杆菌中的表达、纯化及抗肿瘤作用研究

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生物工程学报 2001年第5期17卷 548-552页

作者：周虎赵惠仁裴冬生陆梁胡书群徐州医学院生物化学与分子生物学研究中心徐州221002

用RT PCR从小鼠肝脏细胞中扩增出小鼠白细胞介素 18(mIL 18)的cDNA ,克隆到表达载体pJW2中 ,经热诱导后在大肠杆菌JM10 9中表达。表达的重组mIL 18(rmIL 18)主要以包涵体形式存在 ,占菌体总蛋白质的 18%。包涵体用 5mol L尿素溶解后 ,经... 详细信息

用RT PCR从小鼠肝脏细胞中扩增出小鼠白细胞介素 18(mIL 18)的cDNA ,克隆到表达载体pJW2中 ,经热诱导后在大肠杆菌JM10 9中表达。表达的重组mIL 18(rmIL 18)主要以包涵体形式存在 ,占菌体总蛋白质的 18%。包涵体用 5mol L尿素溶解后 ,经SephadexG 10 0柱纯化。纯化的蛋白质经透析复性 ,在 0 5mg LConA存在的条件下 ,能够对小鼠脾细胞具有剂量依赖的IFN γ诱生作用。以 1× 10 5 H2 2 肝癌细胞腹腔注射昆明小鼠 ,构建小鼠H2 2 肝癌腹水瘤模型。分别在肿瘤细胞接种后 1、4和 8d ,用 10 μg纯化产物对荷瘤小鼠进行腹腔注射。结果显示rmIL 18注射组小鼠死亡速率延缓 ,生存率显著提高 (P <0 .0 1) ,达到 6 2 5 %。首次证明mIL 18对小鼠H2 2 肝癌具有显著的抑制作用 ,经rmIL 18作用后存活小鼠具有对H2 2

关键词：小鼠白细胞介素18 克隆表达纯化复性 H22肝癌抗肿瘤作用