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Phytochemically Functionalized Cu and Ag Nanoparticles Embedded in MWCNTs for Enhanced Antimicrobial and Anticancer Properties

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Nano-Micro Letters 2016年第2期8卷 120-130页

作者： S.Yallappa J.Manjanna B.L.Dhananjaya u.Vishwanatha B.ravishankar H.Gururaj P.Niranjana B.S.Hungund Department of Industrial Chemistry Kuvempu University Department of Chemistry Rani Channamma University Toxicology and Drug Discovery Centre for Emerging Technologies Jain University SDM Centre for research in Ayurveda and Allied Sciences Department of Electronics Kuvempu University Department of Biochemistry Kuvempu University Department of Biotechnology B.V.B.College of Engineering & Technology

Nanomedicine is an emerging field concerned with the use of precision engineered nanomaterials, which leads to the development of novel remedial and diagnostic modalities for human use. In this study, Cu(NO_3)_2 and Ag NO_3 precursors were reduced to copper nanoparticles(Cu NPs) and silver nanoparticles(Ag NPs) using Terminalia arjuna bark extracts under microwave irradiation in the presence of well-dispersed multi-walled carbon nanotubes(MWCNTs) in aqueous medium. The formation of Cu NPs or Ag NPs and their functionalization with MWCNTs via bioactive molecules of plant extract were evidenced from uV–Vis spectra, XrD, FTIr, FESEM, EDX, and TEM images. The phytochemically functionalized Cu-MWCNTs and Ag-MWCNTs nanomaterials showed enhanced biocide activity, and the inhibitory activity for bacteria was higher than that of fungus. Furthermore, these biohybrid nanomaterials are non-toxic to normal epithelial cells(Vero), whereas they are highly toxic for tested human cancer cells of MDA-MB-231, He La, Si ha, and Hep-G2. The cell viability was found to decrease with the increasing dose from 10 to 50 lg m L^(-1), as well as incubation time from 24 to 72 h. For instance, the cell viability was found to be *91 % for normal Vero cells and *76 % for cancer cells for lower dose of 10 lg m L^(-1).

关键词： Cu-MWCNTs Ag-MWCNTs Terminalia arjuna bark extract Antimicrobial activity Anticancer activity

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In situ sol-gel synthesis of hyaluronan derivatives bio-nanocomposite hydrogels

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regenerative Biomaterials 2019年第5期6卷 249-258页

作者： u.D’Amora A.ronca M.G.raucci S.M.Dozio H.Lin Y.Fan X.Zhang L.Ambrosio Institute of Polymers Composites and BiomaterialsNational Research CouncilNaplesItaly Institute of Science and Technology for Ceramics National Research CouncilFaenzaItaly School of Advanced Study“G.D’Annunzio” University of Chieti-PescaraChieti Italy National Engineering research Center for Biomaterials Sichuan UniversityChengduChina

The main driving idea of the present study was the comparison between two different chemical modifications of hyaluronic acid(ha)followed by the development of nanocomposite hydrogels directly in situ by biomineralization of photocrosslinkable ha polymers through sol-gel *** this way,it has been possible to overcome some limitations due to classical approaches based on the physical blending of inorganic fillers into polymer *** this aim,methacrylated and maleated ha,synthesized with similar degree of substitution(DS)were compared in terms of mechanical and physico-chemical *** success of in situ biomineralization was highlighted by reflect Fourier transform infrared spectroscopy and thermogravimetric ***,mechanical characterization demonstrated the reinforcing effect of inorganic fillers evidencing a strong correlation with *** swelling behavior resulted to be correlated with filler ***,the cytotoxicity tests revealed the absence of toxic components and an increase of cell proliferation over culture time was observed,highlighting these bio-nanocomposite hyaluronan derivatives as biocompatible hydrogel with tunable properties.

关键词： hyaluronic acid derivatives photocrosslinking sol-gel nanocomposites

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大黄及其有效成分抗炎作用的研究进展

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中草药 2023年第1期54卷 303-316页

作者：韩思琪哈伟师彦平中国科学院兰州化学物理研究所中国科学院西北特色植物资源化学重点实验室甘肃省天然药物重点实验室甘肃兰州730000 中国科学院大学北京100049

大黄为廖科植物药用大黄rheum officinale、掌叶大黄r. palmatu或唐古特大黄r. tanguticum的干燥根和根茎,具有泻下攻积、清热泻火、凉血解毒、逐瘀通经、利湿退黄等功效,是我国用药历史悠久的大宗中药材。现代药理学研究表明大黄药材... 详细信息

大黄为廖科植物药用大黄rheum officinale、掌叶大黄r. palmatu或唐古特大黄r. tanguticum的干燥根和根茎,具有泻下攻积、清热泻火、凉血解毒、逐瘀通经、利湿退黄等功效,是我国用药历史悠久的大宗中药材。现代药理学研究表明大黄药材、提取物和单体化合物具有优良的抗炎活性,可调节炎症小体的激活,其主要通过调控氧化应激、细胞凋亡、免疫应答等细胞过程,以及调控炎症相关蛋白和相关炎症通路等多种途径对心血管、胃肠道和中枢神经系统相关疾病表现出显著的药理活性,特别是具有较好的抗神经炎症效果。总结了大黄提取物和蒽醌类、鞣质类、二苯乙烯类成分在炎症相关疾病中的药理活性及作用机制的研究进展,并对其发展趋势进行了展望,为大黄的临床应用、进一步开发利用和新药研发提供理论支持。

关键词：大黄抗炎大黄素大黄酸大黄素甲醚芦荟大黄素大黄酚没食子酸儿茶素表儿茶素表儿茶素没食子酸酯白藜芦醇

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The effect of platyspondyly and pubertal growth spurt on the stature of patients with β-thalassaemia major

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Chinese Medical Journal 1998年第8期 59-63页

作者： Chungkai Low, Yinwah Kwan, Pikto Cheung, Mingchun Li, Sauyin ha Yulung Lau and Johan Karlberg 

Objective To study the effect of the body proportion and pubertal growth spurt on the stature of children with β-thalassaemia *** An abnormal u:L ratio was commonly observed in patients with β-thalassaemia major and may be one factor contributing to the short stature of these patients. Abnormal puberty was present in a significant proportion of children and the lack of a pubertal growth spurt was found to be detrimental to adult height.

关键词： The

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Topographic species-habitat associations of tree species in a heterogeneous tropical karst seasonal rain forest, China

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Journal of Plant Ecology 2017年第3期10卷 450-460页

作者： Yili Guo Bin Wang Azim u.Mallik Fuzhao Huang Wusheng Xiang Tao Ding Shujun Wen Shuhua Lu Dongxing Li Yunlin He Xiankun Li Guangxi Key Laboratory of Plant Conservation and restoration Ecology in Karst Terrain Guangxi Institute of BotanyGuangxi Zhuang Autonomous Region and Chinese Academy of SciencesGuilin 541006China Guangxi Youyiguan Forest Ecosystem National research Station Pingxiang 532600China Department of Biology Lakehead UniversityThunder BayOntario P7B 5E1Canada

Aims Tropical and subtropical karst forests of south China are under increas-ing pressure from over-exploitation causing widespread habitat degra-dation and biodiversity *** research has demonstrated that topography,as a proxy for resource availability,plays an important role in shaping tree species distributions in tropical ***,the association between growth stages and habitats types has not been considered in this *** aim was to examine the differences among different habitat types to determine whether tree species show similar species-habitat associations at young and mature life *** We used multivariate regression tree analysis to examined species-habitat associations among eight topographically defined *** results were tested with a torus-translation test and canonical correspondence analysis(CCA)for 74 species in a 15 ha karst tropi-cal seasonal rain forest at the Nonggang National Natural reserve in south *** considered two life stages(young and mature)of trees species that showed a positive association with *** Findings We found marked differences in community characteristics and number of associations among the eight *** the 74 species subjected to torus-translation test,63 had significant positive and 70 had significant negative associations with one or more of the eight *** associations were more frequent in higher elevation habitats and negative associations were more frequent in lower eleva-tion *** suggests that edaphic and hydrological variation related to topography play important roles in habitat partitioning in heterogeneous karst *** the 63 tree species with significant positive associations to at least one habitat,40 of them had the same positive association at young and mature life *** CCA revealed that the six topographic variables considered had consistent relation-ships with species distribution among all individuals and the

关键词： multivariate regression tree torus-translation test canonical correspondence analysis niche differentiation dispersal limitation environmental heterogeneity

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Impact of Different Spacings of Cooking Banana Intercropped with rubber on Soil Fertility Attributes and Maturity rate of the Trees in a Humid Forest Area of South Eastern Nigeria

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Open Journal of Forestry 2012年第2期2卷 65-70页

作者： Timothy u. Esekhade Ikokwu K. Okore rubber research Institute of Nigeria Benin City Nigeria

The impact of four spacing of cooking banana (CB) within the immature rubber avenues on some soil fertility attributes, maturity rate of rubber trees and dry rubber content (DrC) during the initial six years after planting (YAP) were evaluated in a humid forest area of South Eastern Nigeria relative to sole rubber. The CB spacings within immature rubber avenues were 6.7 × 3.4 m;4.0 × 2.0 m, 3.0 × 3.0 m and 2.0 × 2.0 m, while the sole rubber was at 6.7 × 3.4 m, all laid out in randomized complete block design with five replications. Quantities of soil organic C, extractable P, Ca, Mg and earthworm activities were significantly higher in the intercrops, with the highest value coming from the 4 × 2 m CB spaced plots. However a significantly higher value of K stock was observed in the sole rubber plot and declined as the CB spacing narrowed. While the highest proportion (>90%) of matured hevea tree at six YAP was observed in the 2 × 2 m CB spaced plots;the highest DrC of 1.7 t?ha–1?yr–1 was obtained from CB 4 × 2 m treatment. Consequently, with some of the observed soil fertility attributes and DrC recorded, 4 × 2 m CB spacing seems to be a more suitable CB spacings within immature rubber avenues, especially in view of the levels of K in the 2 × 2 CB plots.

关键词： Cropping System Nutrient Stock Dry rubber Content Earth Warm

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Effect of Combined Microwave-ultrasonic Pretreatment on Anaerobic Biodegradability of Primary, Excess Activated and Mixed Sludge

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Computational Water, Energy, and Environmental Engineering 2013年第3期2卷 7-11页

作者： Anteneh Mesfin Yeneneh Tushar Kanti Sen Siewhui Chong ha Ming Ang Ahmet Kayaalp Department of Chemical Engineering Curtin University GPO Box U1987 Perth 6845 Australia Water Corporation of Western Australia West Leederville 6007 Australia

This work deals with the effect of combined microwave-ultrasonic pretreatment on the anaerobic biodegradability of primary, excess activated and mixed sludge. The characteristics, biodegradability and anaerobic digester performance for untreated primary, excess activated and mixed sludge were compared to combined microwave-ultrasonic pretreated primary, excess activated and mixed sludge. All sludge samples were subjected to Microwave treatment at 2450 MHz, 800 W and 3 min followed by ultrasonic treatment at a density of 0.4 W/mL, amplitude of 90%, Intensity of 150 W, pulse of 55/5 for 6min. Methane production in pretreated primary sludge was significantly greater (11.9 ml/g TCOD) than the methane yield of the untreated primary sludge (7.9 ml/g TCOD). Cumulative methane production of pretreated Excess Activated Sludge (EAS) was higher (66.5 ml/g TCOD) than the methane yield from pretreated mixed sludge (44.1 ml/g TCOD). Furthermore, digested EAS showed significantly higher dewaterability (201 s) than digested primary sludge (305 s) or mixed sludge (522 s). The average Methane: Carbondioxide ratio from EAS (1.85) was higher than that for mixed untreated sludge (1.24). VS reduction was also higher for EAS than the other two sludge types. However, pretreatment of EAS resulted in significant reduction in dewaterability due to higher percentage of fine floc particles in the pretreated EAS.

关键词： Biodegradability Combined Microwave-ultrasonic Dewaterability Primary Excess Activated Sludge Mixed Sludge

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正常青年人不同语料测试基频的研究

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听力学及言语疾病杂志 2015年第6期23卷 575-577页

作者： Kim ha-kyung 赵风云刘晓明黄昭鸣华东师范大学言语听觉康复科学系上海200062 华东师范大学言语听觉科学教育部重点实验室北京联合大学特殊教育学院

目的分析正常青年人不同语料测试的平均基频,探讨适合测试言语基频的语料形式。方法应用Praat软件对60例正常青年人(男22例,女38例)发元音/a/、/i/、/u/和朗读短文的声样进行录音,并选取稳定段分析其基频。结果正常青年人发/u/和/i/的... 详细信息

目的分析正常青年人不同语料测试的平均基频,探讨适合测试言语基频的语料形式。方法应用Praat软件对60例正常青年人(男22例,女38例)发元音/a/、/i/、/u/和朗读短文的声样进行录音,并选取稳定段分析其基频。结果正常青年人发/u/和/i/的平均基频最高,/a/次之,朗读短文的基频最低;男生发/u/、/i/、/a/及朗读短文的平均基频依次为148.47、146.77、136.33、132.85 Hz,女生依次为:257.39、250.52、239.43、222.16Hz,男生发/a/音的平均基频低于发/i/、/u/音,差异有统计学意义(P0.01),女生不同语料测试的平均基频之间差异均有统计学意义(P<0.01)。结论朗读短文的形式可更准确地反映正常人的习惯基频,而测试语料为元音时,元音/a/更合适。

关键词：基频元音短文

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丙三醇溶液声致发光中的黑体辐射谱

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光谱学与光谱分析 2010年第3期30卷 621-624页

作者：何寿杰哈静刘立芳王龙河北大学物理科学与技术学院河北保定071002 河北农业大学理学院河北保定071001 中国科学院物理研究所北京100080

利用u型管圆锥泡声致发光装置,测量到了丙三醇溶液中圆锥泡声致发光的光谱和光脉冲。结果表明,测量得到的发光光谱为光滑的连续谱,且与理论模拟得到的黑体辐射谱相吻合,拟合温度分布于2 600~3 500 K范围内。文章从空间和时间两方面分析... 详细信息

利用u型管圆锥泡声致发光装置,测量到了丙三醇溶液中圆锥泡声致发光的光谱和光脉冲。结果表明,测量得到的发光光谱为光滑的连续谱,且与理论模拟得到的黑体辐射谱相吻合,拟合温度分布于2 600~3 500 K范围内。文章从空间和时间两方面分析了圆锥泡空化发光中存在黑体辐射的原因：较大的气泡体积（气泡塌缩半径为1.4 cm）与较长的发光时间（几十微秒）。另外,实验研究表明随着发光波长的增长,光脉冲宽度变宽,从而进一步证明了圆锥泡声致发光中的黑体辐射机制。最后,利用测量得到的发光光谱和脉冲计算得到了发光光强为0.18 J,远远高于其他方式得到的声致发光光强。

关键词：声致发光光脉冲光谱黑体辐射光强

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辅助人员对科研生产力的影响——以中国科学院为例

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华东师范大学学报（教育科学版） 2019年第1期37卷 83-94,168页

作者：哈巍于佳鑫北京大学教育学院北京100871 北京大学城市与环境学院北京100871

在创建国家创新体系的进程中,提高科研机构和高校的科研生产力是最为关键的环节。目前,国内外关于科研生产力影响因素的研究大多集中于科研人员自身特点,鲜少有研究关注辅助人员(指行政管理干部和工人,下同)的配置对科研生产力的影响。... 详细信息

在创建国家创新体系的进程中,提高科研机构和高校的科研生产力是最为关键的环节。目前,国内外关于科研生产力影响因素的研究大多集中于科研人员自身特点,鲜少有研究关注辅助人员(指行政管理干部和工人,下同)的配置对科研生产力的影响。本文利用《中国科学院统计年鉴》的动态面板数据,运用系统GMM估计方法,验证辅助人员对科研生产力的影响。研究发现:辅助人员对科研产出(国际和国内发表论文数)的影响呈现倒"u"型即边际效益递减;在一定范围内,控制专业技术人员数量,增加辅助人员数量,对科研生产力有正向促进作用。

关键词：科研生产力辅助人员中国科学院

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