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Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites

World Journal of Hepatology 2017年第7期9卷 391-400页

作者： Neeta K Venepalli Mary V Modayil stephanie A Berg Tad D Nair Mayur Parepally Priyanka rajaram ron C Gaba James T Bui Yue huang Scott J Cotler Department of Medicine Section of Hematology/OncologyUniversity of Illinois at Chicago Applied research and Evaluation Services Department of Evaluation and AnalyticsPrimary Health CareAlberta Health Services Department of Medicine Division Hematology OncologyLoyola University Medical Center Department of radiology Section of Interventional RadiologyUniversity of Illinois at Chicago Department of Medicine Division of HepatologyLoyola University Medical Center

AIM To compare features of hepatocellular carcinoma(HCC) in Hispanics to those of African Americans and *** Patients treated for HCC at an urban tertiary medical center from 2005 to 2011 were identified from a tumor registry. Data were collected retrospectively, including demographics, comorbidities, liver disease characteristics, tumor parameters, treatment, and survival(OS) outcomes. OS analyses were performed using Kaplan-Meier *** One hundred and ninety-five patients with HCC were identified: 80.5% were male, and 22% were age 65 or older. Mean age at HCC diagnosis was 59.7 ± 9.8 years. Sixty-one point five percent of patients had Medicare or Medicaid; 4.1% were uninsured. Compared to African American(31.2%) and White(46.2%) patients, Hispanic patients(22.6%) were more likely to have diabetes(P = 0.0019), hyperlipidemia(P = 0.0001), nonalcoholic steatohepatitis(NASH)(P = 0.0021), end stage renal disease(P = 0.0057), and less likely to have hepatitis C virus(P r a smoking history(P red to African Americans, Hispanics were more likely to meet criteria for metabolic syndrome(P = 0.0491), had higher median MELD scores(P = 0.0159), ascites(P = 0.008), and encephalopathy(P = 0.0087). Hispanic patients with HCC had shorter OS than the other racial groups(P = 0.020), despite similarities in HCC parameters and treatment. CONCLUSION In conclusion, Hispanic patients with HCC have higher incidence of modifiable metabolic risk factors including NASH, and shorter OS than African American and White patients.

关键词： Hepatocellular carcinoma Epidemiology Treatment pattern Survival Hispanics

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Glutamate acts as a repressor for heat-induced leaf senescence involving chlorophyll degradation and amino acid metabolism in creeping bentgrass

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Grass research 2021年第1期1卷 23-32页

作者： stephanie rossi Cathryn Chapman Bo Yuan Bingru huang Department of Plant Biology RutgersThe State University of New JerseyNew BrunswickNJ 08901USA

Leaf senescence is accelerated by prolonged exposure to high temperatures in cool-season plants and is characterized by loss of chlorophyll and adjustment in amino acid *** objectives of this study included ascertaining how glutamate may affect the tolerance of cool-season grass species to heat stress in relation to leaf senescence through the regulation of leaf chlorophyll(Chl)and amino acid *** bentgrass(Agrostis stolonifera L.)plants were maintained for 35d under optimal growth temperature(22/18℃,day/night,non-stress control)or heat stress(35/30℃,day/night)in growth chambers,and glutamate(60 mM)or water(untreated control)was applied weekly as a foliar *** heat stress,turf quality(TQ),photochemical efficiency(Fv/Fm),and Chl content were significantly higher in plants treated with glutamate at 14-35 d,7-28 d,and 7-35 d,respectively,compared to untreated *** application significantly reduced the activities of chlorophyll-degrading peroxidase and chlorophyllase,two Chl-degrading enzymes,at 14,21,and 35 d of heat stress,whereas activity of the rate-limiting Chl synthesis enzyme,porphobilinogen deaminase,was not significantly *** treatment significantly increased the endogenous content of serine,threonine,lysine,aspartate,glutamate,and GABA under heat stress,while methionine,asparagine,isoleucine,and histidine were significantly up-regulated exclusively under heat *** findings suggest that glutamate could serve as a repressor for heat-accelerated leaf senescence by suppressing Chl degradation and activating amino acid metabolism involved in energy production,antioxidant defense,and nitrogen balance.

关键词： metabolism season creep

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肺癌的下一代测序技术

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中国肺癌杂志 2014年第1期17卷 I0003-I0014页

作者： Kehua Wu r.stephanie huang Larry House William Chi Cho 南娟曹志成 Department of Medicine University of Chicago Department of Clinical Oncology Queen Elizabeth Hospital 天津医科大学总医院天津市肺癌研究所天津市肺癌转移与肿瘤微环境重点实验室香港特别行政区伊利沙伯医院临床肿瘤科

肺癌在生物学上具有侵袭性,并且是癌症相关死亡的主要原因。根据临床特征、预后、对治疗的反应和耐受性,每一例肺癌患者的进展均是独特的。传统上基于毛细管的单基因测序的第一代技术(如Sanger测序法)已被允许大量平行测序且成本更低、... 详细信息

肺癌在生物学上具有侵袭性,并且是癌症相关死亡的主要原因。根据临床特征、预后、对治疗的反应和耐受性,每一例肺癌患者的进展均是独特的。传统上基于毛细管的单基因测序的第一代技术(如Sanger测序法)已被允许大量平行测序且成本更低、通量更高的下一代测序技术(next-generation sequencing,NGS)所替代。与传统方法相比,NGS技术取得显著进步。我们希望这些方法可全面地解释癌症全球图谱,并提供更多信息以满足个体化用药的需求。本综述包括对不同NGS技术的简要说明,NGS在肺癌研究进展中的应用和重要发现的总结,包括对已知靶基因(EGFr、ALK和KrAS)的进一步探索、其它肺癌突变的鉴定和癌症基因组研究的全局协调。

关键词：肺癌下一代测序全外显子组测序全基因组测序全转录组测序

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信息诊断系统设计思路:人工核查、广众参与和人工智能的三合一运用

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全球传媒学刊 2021年第1期8卷 35-62页

作者：曾姿颖黄煜张引宋韵雅周琳香港浸会大学传播系香港浸会大学传理学院香港浸会大学新闻系

当前对虚假新闻治理的研究较少出于技术逻辑的思路。真假新闻的界限在实践中通常微妙以及难以辨别,加上人们对真假新闻往往有着不同的见解和解读。本文基于来自香港的实证数据分析以及本地虚假新闻核查平台的初步实践经验,提出“人工核... 详细信息

当前对虚假新闻治理的研究较少出于技术逻辑的思路。真假新闻的界限在实践中通常微妙以及难以辨别,加上人们对真假新闻往往有着不同的见解和解读。本文基于来自香港的实证数据分析以及本地虚假新闻核查平台的初步实践经验,提出“人工核查—广众参与—人工智能”的协同核查模式,以最大限度优化社交平台虚假新闻的治理效果。

关键词：虚假新闻信息诊断人工智能事实核查

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DIFFErENTIAL CErEBrAL rESPONSE TO SOMATOSENSOrY STIMULATION OF AN ACUPUNCTUrE POINT VErSUS TWO NONACUPUNCTUrE POINTS MEASUrED WITH fMrI

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Journal of Integrative Medicine 2014年第3期 219-219页

作者： Daniel Pach Till Nierhaus Wenjing huang Xiangyu Long Vitaly Napadow stephanie roll Fanrong Liang Burkhard Pleger Arno Villringer Claudia M.Witt Institute for Social Medicine Epidemiologyand Health EconomicsCharité-Universittsmedizin Berlin Mind-Brain Institute and Berlin School of Mind and Brain Charité-Universittsmedizin Berlin and Humboldt-University Max Planck Institute for Human Cognitive and Brain Sciences Chengdu University of Traditional Chinese Medicine Athinoula A.Martinos Center for Biomedical Imaging Department of RadiologyMassachusetts General Hospital 6. Department of RadiologyLogan College of Chiropractic 7. Center for Integrative MedicineUniversity of Maryland School of Medicine

Objective: To evaluate whether different point locations chosen for a somatosensory stimulation with acupuncture needles differently change the brain activity in healthy ***: We used event-related fMrI, and resting-state functional connectivity fMrI to assess neural responses to standardized manual needle stimulation of the acupuncture point ST36(lower leg) and two control point locations(CP1 same dermatome, and CP2 different dermatome) that are not *** responses were expected to differ for stimulation in two different dermatomes(CP2 different from ST36 & CP1), or stimulation at the acupuncture point versus the control *** scans all healthy subjects(n=22) received manual needle stimulation at all 3 points in a randomized *** needle stimulation consisted of 6-minute intermittent penetrating needle manipulation on one *** sensation was measured by the Massachusetts General Hospital Acupuncture Sensation Scale(MASS) and correlated with fMrI ***: The fMrI analysis found that insula and S2 activation was more pronounced with ST36 stimulation, and there was increased S2 connectivity to thalamus and brainstem following ST36 *** in needle sensation between ST36 ***1 and ST36 ***2 were statistically significant(pairwise t-test, P=0.009 and P=0.005, respectively).No correlation was found when exploring the relationship between the MASS index and the β values of the fMrI BOLD ***: Our results suggest that stimulation at acupoints may modulate somatosensory and saliency processing regions more readily.

关键词： fMrI DIFFErENTIAL CErEBrAL rESPONSE TO SOMATOSENSOrY STIMULATION OF AN ACUPUNCTUrE POINT VErSUS TWO NONACUPUNCTUrE POINTS MEASUrED WITH fMrI ST

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stephanie呼吸机原理及故障维修六例

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中国医疗设备 2013年第2期28卷 113-114页

作者：黄毅漳州市医院器械科福建漳州363000

本文介绍了德国史蒂芬stephanie呼吸机的结构原理及常见故障的分析和维修方法。

关键词：呼吸机呼吸机原理呼吸机维修

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成比例辅助通气治疗早产儿呼吸窘迫综合征的疗效

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实用儿科临床杂志 2010年第2期25卷 121-122页

作者：刘郴州刘东郭青云关浩锋黄碧茵上官明江门市中心医院中山大学附属江门医院儿科重症监护室广东江门529070

目的观察成比例辅助通气(PAV)治疗早产儿呼吸窘迫综合征(ArDS)的疗效。方法使用stephanie3.3型呼吸机PAV模式,采用自身前后对照,对2007年8月-2009年3月收住本科首先使用持续呼吸道正压通气(CPAP)疗效不佳且符合病例纳入标准的18例ArDS... 详细信息

目的观察成比例辅助通气(PAV)治疗早产儿呼吸窘迫综合征(ArDS)的疗效。方法使用stephanie3.3型呼吸机PAV模式,采用自身前后对照,对2007年8月-2009年3月收住本科首先使用持续呼吸道正压通气(CPAP)疗效不佳且符合病例纳入标准的18例ArDS患儿改用PAV治疗,参数:呼气末正压(PEEP)为0.29～0.59kPa;后备通气设计呼吸暂停最长允许时间为10s,呼气压峰值为1.77～2.45kPa,PEEP为0.29～0.59kPa,呼吸频率(rr)为30～50次·min-1,吸气时间(TI)为0.3～0.5s,流量(Fr)为8～12L·min-1;弹性阻力卸载值为50～150kPa·L-1,呼吸道黏性阻力卸载值为2.45～7.35kPa·L-1·s-1;呼出潮气量的最低容量为患儿体质量×5mL,呼出最高容量限制为患儿体质量×10mL,PIP限定为2.94kPa,最长吸气时间限定为0.7s。对比其前后1h的平均血压、rr、心率、血气分析,观察治疗效果。结果18例患儿使用PAV前后平均血压变化不明显(t=0.78,P>0.05),rr、心率明显减慢(t=11.80、8.80,Parr和血气分析渐接近正常或者正常。结论成比例辅助通气可有选择性试用于ArDS的治疗。

关键词：成比例辅助通气呼吸窘迫综合征婴儿,早产

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广西地不容种质离体保存技术研究

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广西科学 2007年第2期14卷 155-159页

作者：付传明黄宁珍赵志国唐凤鸾李锋广西植物研究所广西桂林541006

以广西地不容(stephanie kwangsiensis ***))试管苗为材料,研究室温(25±2)℃光照2000lx(12h/d)条件下,培养基中不同无机盐水平(MS、1/2MS、1/4MS)、蔗糖浓度(0、20、40、60g/L)和植物生长抑制剂CCC(0.4、0.8、1.2、1.6、2.0、2.5mg/L)、PP333(0.2、0.5、1.0、2.0、4.0、8.0mg/L)、ABA(0.2、0.5、1.0、2.0、4.0、8.0mg/L)、MH(0.2、0.5、1.0、2.0、4.0、8.0mg/L)对广西地不容试管苗保存存活率的影响。结果表明,MS添加蔗糖20～40g/L适合作为广西地不容离体保存的基本培养基,附加一定浓度的CCC、PP333、ABA和MH能有效抑制试管苗的旺盛生长,长时间保存后的存活率高;ABA易引起试管苗早衰,保存效果不佳。对广西地不容试管苗保存效果较好的两个培养基配方为:MS+CCC0.4～2.5mg/L+蔗糖30g/L和MS+PP3330.2～0.5mg/L+蔗糖30g/L,这两个配方可以不继代连续保存360～380d,存活率60%～80%。

关键词：广西地不容离体保存生长抑制剂矮壮素多效唑脱落酸青鲜素

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Abstracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr Luying Yan Keisha roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu Jie Chen Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Frances rucker.stephanie Britton Stephan Hanowsky Molly Spatcher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim rupal L. Shah Cathy Williams Jinglei Yang Peter S. reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel rathbun Frank Schaeffel Ladan Ghodsi William K. Stell Machelle T. Pardue ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee Erica G. Landis Michael A. Bergen Curran Sidhu Samer Hattar richard A. Stone ravi Metlapally ruiqin Li Qinglin Xu Hong Zhong Chenglin Pan Weizhong Lan Xiaoning Li Ling Chen Zhikuan Yang Scott A. read Seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong huang Xiong-Li Yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden Thomas Chuen Lam Samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit Li Quan Liu Chi-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu Carol Ho Eileen Phan Abraham Hang Emily Eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory Cultivation Base and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(r14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

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