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Etoposide sensitizes CT26 colorectal adenocarcinoma to radiation therapy in BALB/c mice

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World Journal of Gastroenterology 2005年第31期11卷 4895-4898页

作者： Chia-Yuan Liu Hui-Fen Liao Tsang-En Wang shee-Chan Lin Shou-Chuan Shih Wen-Hsuing Chang Yuh-Cheng Yang Ching-Chung Lin Yu-Jen Chen Division of Gastroenterology Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan China Department of Medical research Mackay Memorial HospitalTaipei Taiwan China Department of Molecular Biology and Biochemistry National Chiayi University Chiayi 300 Taiwan China Nursingand Management College Taipei Taiwan China Department of radiation Oncology Mackay Memorial Hospital Taipei Taiwan China

AIM： To investigate the combined effect of etoposide and radiation on CT26 colorectal adenocarcinoma implanted into BALB/c mice. METHODS： We evaluated the radiosensitizing effect of etoposide on CT26 colorectal adenocarcinoma in a syngeneic animal model. BALB/c mice were subcutaneously implanted with CT26 cells and divided into four groups： Gonlyol （intra-peritoneal saline×2） group, etoposide （5 mg/kg intra-peritoneally×2） group, radiation therapy （rT 5 Gy×2 fractions） group, and combination therapy with etoposide （5 mg/kg intra-peritoneally 1 h before radiation） group. rESULTS： Tumor growth was significantly inhibited by rT and combination therapy. The effect of combination therapy was better than that of rT. No significant changes were noted in body weight, plasma alanine aminotransferase, or creatinine in any group. The leukocyte count significantly but transiently decreased in the rT and combination therapy groups, but not in the etoposide and control groups. There was no skin change or hair loss in the rT and combination therapy groups. CONCLUSION： Etoposide can sensitize CT26 colorectal adenocarcinoma in BALB/c mice to rT without significant toxicity.

关键词： Etoposide (VP-16) Colorectal adenocarcinoma CT26 BALB/c mice radiosensitization

南非芬什金伯利岩中产出的两个含金刚石的橄榄岩捕虏体

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地球与环境 1984年第5期 24-29页

作者： S.r.shee 晨枫

尽管金刚石有重大的经济意义,并且每年回收大量金刚石,但其天然形成过程仍有争论。虽然假定大多数金刚石是岩浆成因的,并且与金伯利岩事件有联系,但是金伯利岩中某些捕虏体内金刚石的存在表明,至少有些金刚石是捕获晶。这种非同源成因... 详细信息

尽管金刚石有重大的经济意义,并且每年回收大量金刚石,但其天然形成过程仍有争论。虽然假定大多数金刚石是岩浆成因的,并且与金伯利岩事件有联系,但是金伯利岩中某些捕虏体内金刚石的存在表明,至少有些金刚石是捕获晶。这种非同源成因的金刚石的比例是目前争论问题之一。

关键词：金刚石晶体平衡条件橄榄石斜方辉石晶面八面体岛状硅酸盐矿物正辉石面(晶体) 晶种多面体橄榄岩捕虏体包体超基性岩金伯利岩角砾云母橄榄岩产出非洲南非

Transcatheter arterial embolization treatment in patients with hepatocellular carcinoma and risk of pulmonary metastasis

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World Journal of Gastroenterology 2003年第6期9卷 1208-1211页

作者： shee-Chan Lin Shou-Chuan Shih Chin-roa Kao Sun-Yen Chou Division of Gastroenterology Department of Internal MedicineMackay Memorial HospitalTaipeiTaiwanChina

AIM: To investigate the relationship between transcatheterarterial embolization (TAE) and pulmonary metastasis insubjects with hepatocellular carcinoma (HCC).METHODS: A total of 287 patients with HCC followed upfor more than 1 week were included. 102 patients underwenttranscatheter arterial embolization (TAE group) and 185received conservative treatment(control group). Thepatients' chest x-rays and chest CT scans were examinedfor pulmonary ***: Patients with TAE had a median survival of 19.3months while that of the control group was only 10.0 months(P＜0.05). Pulmonary metastasis occurred in 14 (13.7 %)patients in the TAE group and 14 (7.6 %) patients in the control group, there was no significant difference (P＞0.05).The 1-year, 2-year and 5-year cumulative incidence of pulmonary metastasis was 11.8 %, 17.6 % and 24.0 % in the TAE group and 7.0 %, 13.0 % and 21.7 % in the control group, respectively (P＞0.05). On the univariate analysis,tumor size, abnormal serum alanine aminotransferase levels and heterogeneity on sonography were significantly associated with pulmonary metastasis. However, on the multivariate analysis, only tumor size was significantly predictive of pulmonary ***: TAE is effective on prolonging survival of patients with HCC. It does not significantly increase the risk of pulmonary metastasis. Tumor size is the only significant predictive factor associated with lung metastasis.

关键词：肝细胞癌选择性动脉栓塞治疗肺转移癌危险因素

Clinical manifestations and prognostic factors in patients with gastrointestinal stromal tumors

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World Journal of Gastroenterology 2003年第12期9卷 2809-2812页

作者： shee-ChanLin Ming-JerHuang Chen-YuanZeng Tzang-InWang Zen-LiangLiu ray-KuanShiay DivisionofGastroenterology DepartmentofInternalMedicineMackayMemorialHospitalTaipeiTaiwanandMackayJuniorCollegeofNursingTaipeiTaiwanChina DivisionofHematology-Oncology DepartmentofInternalMedicineMackayMemorialHospitalTaipeiTaiwanChina DepartmentofPathology MackayMemorialHospitalTaipeiTaiwanChina DepartmentofSurgery MackayMemorialHospitalTaipeiTaiwanandMackayJuniorCollegeofNursingTaipeiTaiwanChina

AIM: To investigate the incidence of CD117-positive immunohistochemical staining in previously diagnosed gastrointestinal (GI) tract stromal tumors (GTST) and to analyze the tumors' clinical manifestations and prognostic ***: We retrospectively reviewed 91 cases with a previous diagnosis of GI stromal tumor, leiomyoma, or leiomyosarcoma. Tissue samples were assessed with CD117, CD34, SMA and S100 immunohistochemical staining. Clinical and pathological characteristics were analyzed for prognostic ***: CD117 was positive in 81 (89 %) of 91 tissue samples. There were 59 cases (72.8 %) positive for CD34,13 (16 %) positive for SMA, and 12 (14.8 %) positive for S100. There was no gender difference in patients with CD117-positive GIST. Their mean age was 65 years. There were 44 (54 %) tumors located in the stomach and 29 (36 %)in the small intestine. The most frequent presenting symptoms were abdominal pain and GI bleeding. The mean tumor size was 7.5±5.7 cm. There were 35 cases (43.2 %)with tumors ＞5 cm. The tumor size correlated significantly with tumor mitotic count and resectability. Tumor size, mitotic count, and resectability correlated significantly with tumor recurrence and survival. There was recurrent disease in 39 % of our patients, and their mean survival after recurrence was 16.6 months. Most recurrences were at the primary site or metastatic to the liver. Twenty-six percent of our patients died of their ***: Traditional histologic criteria are not specific enough to diagnose GIST. This diagnosis must be confirmed with CD117 immunohistochemical staining. Prognosis is dependent on tumor size, mitotic count, and resectability.

关键词：胃肠道基质肿瘤临床表现预测因子早期诊断免疫组织化学

Expression patterns of transforming growth factor-beta and its receptors in gastric mucosa of patients with refractory gastric ulcer

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World Journal of Gastroenterology 2005年第1期11卷 136-141页

作者： Shou-Chuan Shih Kwang-Wen Tseng shee-Chan Lin Chin-roa Kao Sun-Yen Chou Horng-Yuan Wang Wen-Hsiung Chang Cheng-Hsin Chu Tsang-En Wang Chung-Liang Chien Division of Gastroenterology Department of Anatomy and Cell Biology

AIM: Transforming growth factor-β (TGF-β) plays a regulatory role in tissue repair. In a previous study, we found that TGF-β and its receptors were expressed in gastric mucosa of patients with well-healed gastric ulcers, as demonstrated by immunohistochemistry. To further characterize the role of TGF-β and its receptors in repairing gastric ulcers, we investigated the expression patterns of TGF-β and its receptors in gastric mucosa by in situ hybridization and reverse transcriptase-polymerase chain reaction (rT-PCr).METHODS: Seventy-four patients with endoscopically proven gastric ulcers were eligible for participation in this study. All patients had routine biopsies on initial endoscopy and were then treated for 12 wk with an H2 blocker. repeat endoscopy was then performed. There were 8 patients with poorly healed ulcers, and biopsies were taken from the margin of the residual ulcers. These tissue samples, along with biopsy of gastric mucosa near the original ulcers from 8 randomly selected patients with well-healed ulcers were examined for TGF-β and TGF-β receptor Ⅱ mrNA by rT-PCr and in situ hybridization, as well as ***: TGF-β and TGF-β receptor Ⅱ were strongly expressed in tissues from patients with well-healed *** of the 8 patients with poor healing had low or absent expression of TGF-β or TGF-β receptor Ⅱ mrNA. All cases positive by rT-PCr assay were confirmed by in situ hybridization as well as ***: It is suggested that TGF-β and its receptors are important for gastric ulcer healing. These results may have implications for further investigation of the healing process and in predicting response to therapy.

关键词： Gastric Ulcer Transforming growth factor-beta Transforming growth factor-beta receptor

Eosinophilic gastroenteritis: Clinical experience with 15 patients

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World Journal of Gastroenterology 2003年第12期9卷 2813-2816页

作者： Ming-Jen Chen Cheng-Hsin Chu shee-Chan Lin Shou-Chuan Shih Tsang-En Wang Division of Gastroenterology Department of Internal MedicineMackay Memorial HospitalMackay Junior College of NursingTaipeiTaiwanChina

AIM: To evaluate the clinic features of eosinophilicgastroenteritis and to examine the diagnosis, treatment,long-term outcome of this ***: Charts with a diagnosis of eosinophilicgastroenteritis from 1984 to 2002 at Mackay Memorial Hospital were reviewed retrospectively. There were 15 patients diagnosed with eosinophilic gastroenteritis. The diagnosis was established in 13 by histologic evaluation of endoscopic biopsy or operative specimen and in 2 by radiologic imaging and the presence of eosinophilic ***: All the patients had gastrointestinal symptoms and 12 (80 %) had hypereosinophilia (absolute eosinophil count 1 008 to 31 360/cm3). The most common symptoms were abdominal pain and diarrhea. Five of the 15 patients had a history of allergy. Seven patients had involvement of the mucosa, 2 of muscularis, and 6 of subserosa. One with a history of seafood allergy was successfully treated with an elimination diet. Another patient improved spontaneously after fasted for several days. The remaining 13 patients were treated with oral prednisolone, 10 to 40 mg/day initially,which was then tapered. The symptoms in all the patients subsided within two weeks. Eleven of the 15 patients were followed up for more than 12 months (12 to 104 months,mean 48.7), of whom 5 had relapses after discontinuing steroids (13 episodes). Two of these patients required longterm maintenance oral prednisolone (5 to 10 mg/day).CONCLUSION: Eosinophilic gastroenteritis is a rare condition of unclear etiology characterized by relapses and remissions. Short courses of corticosteroids are the mainstay of treatment, although some patients with relapsing disease require long-term low-dose steroids.

关键词：嗜曙红粒细胞增多性肠胃炎临床特点预后诊断药物疗法氢化泼尼松

Decision making in right-sided diverticulitis

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World Journal of Gastroenterology 2003年第3期9卷 606-608页

作者： Li-rung Shyung shee-Chan Lin Shou-Chuan Shih Chin-roa Kao Sun-Yen Chou Division of Gastroenterology Department of Internal MedicineMackay Memorial HospitalTaipeiTaiwanChina

AIM: To evaluate systematically our nine-year experience in treating right-sided diverticulitis of the colon, and to explore its clinical and radiological ***: The clinical and radiological data of 40 patients with colonic diverticulitis treated in Mackay Memorial Hospital,Taipei, from 1993 through 2002 were reviewed ***: The average age of the patients with right-sided diverticulitis was 53.1 years, which was 11.6 years younger than that of the patients with left-sided diverticulitis. The preoperative diagnosis of appendicitis was made in 8 of 13 right-sided diverticulitis patients. Nine (69 %) had right lower quadrant abdominal pain for more than 48 hours, and ten patients (77 %) presented with fever. CT findings suggesting acute right-sided diverticulitis including thickening of the intestinal wall and pericolonic inflammation were present in five ***: right-sided diverticulitis is easily confused with acute appendicitis because it occurs at a somewhat younger age than that in left-sided diverticulitis. Barium enema and CT are helpful for the early diagnosis of rightsided diverticulitis. While clearly not required in the majority of patients with right lower quadrant abdominal pain, barium enema and CT may be helpful in making the decision with a clinical history or physical examinations atypical of acute appendicitis.

关键词：右结肠憩室炎放射影像学临床特点 CT表现诊断

Fatty metamorphosis of the liver in patients with breast cancer:Possible associated factors

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World Journal of Gastroenterology 2003年第7期9卷 1618-1620页

作者： Cheng-Hsin Chu shee-Chan Lin Shou-Chuan Shih Chin-roa Kao Sun-Yen Chou Division of Gastroenterology Department of Internal MedicineMackay Memorial HospitalTaipeiTaiwanChina

AIM: To investigate the relationship between breast cancer and fatty liver in Chinese ***: The study group consisted of 217 patients with newly diagnosed breast cancers and the control group of 182 subjects undergoing routine health examination in the same hospital. All subjects were female and the groups were matched for date of study. Ultrasound scanning was performed by the same operator using a 3.5 mHz *** of the liver was diagnosed based on the criteria of Saverymuttu et al. Clinical variables were statistically ***: Fatty liver was diagnosed in 98 patients of the study group and 37 patients of the control group, a significant difference was found in incidence (98/217, 45.2 % and 37/182, 20.3 %; P＜0.0001). On univariate analysis, fatty liver in breast cancer patients was associated with overweight,hyperlipidemia, and hepatitis. On multivariate analysis in the same patients, obesity and hyperlipidemia were significantly associated with fatty ***: The cause of fatty liver in women with breast cancer may be multifactorial. The present study confirms its link with overweight and hyperlipidemia.

关键词：乳腺癌脂肪肝相关性超重高血脂

Clinical predictors of severe gallbladder complications in acute acalculous cholecystitis

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世界胃肠病学杂志：英文版 2003年第12期9卷 2821-2823页

作者： Ay-Jiun Wang Tsang-En Wang Ching-Chung Lin shee-Chan Lin Shou-Chuan Shih Division of GastrOenterology Department of Internal MedicineMackay Memorial HospitalTaipeiTaiwanChina

AIM: To evaluate the relationship between clinical information (including age, laboratory data, and sonographic findings) and severe complications, such as gangrene,perforation, or abscess, in patients with acute acalculous cholecystitis (AAC).METHODS: The medical records of patients hospitalized from January1997 to December 2002 with a diagnosis of acute cholecystitis were retrospectively reviewed to find those with AAC, confirmed at operation or by histologic examination. Data collected included age, sex, white blood cell count, AST, total bilirubin, alkaline phosphatase,bacteriology, mortality, and sonographic findings. The sonographic findings were recorded on a 3-point scale with 1 point each for gallbladder distention, gallbladder wall thickness ＞3.5 mm, and sludge. The patients were divided into 2 groups based on the presence (group A) or absence (group B) of severe gallbladder complications, defined as perforation, gangrene, or ***: There were 52 cases of AAC, accounting for 3.7% of all cases of acute cholecystitis. Males *** patients were diagnosed by ultrasonography (48 of 52) or computed tomography (17 of 52). Severe gallbladder complications were present in 27 patients (52 %, group A) and absent in 25(group B).Six patients died with a mortality of 12 %.Four of the 6 who died were in group *** in group A were significantly older than those in group A were significantly older than those in group B (mean 60.88 y vs. 54.12 y, P=0.04) and had a significantly higher white blood cell count (mean 15 885.19 vs. 9 948.40,P=0.0005). All the 6 patients who died had normal white blood cell counts with an elevated percentage of band *** most commonly cultured bacteria in both blood and bile were E. Coli and Klebsiella pneurnoniae. The cumulative sonographic points did not reliably distinguish between groups A and B, even though group A tended to have more ***: Older patients with a high white cell count are more li

关键词：急性胆囊炎并发症临床特点早期诊断急腹症